CN103356723A - Cooling paste for children and preparation method thereof - Google Patents
Cooling paste for children and preparation method thereof Download PDFInfo
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- CN103356723A CN103356723A CN2013103402134A CN201310340213A CN103356723A CN 103356723 A CN103356723 A CN 103356723A CN 2013103402134 A CN2013103402134 A CN 2013103402134A CN 201310340213 A CN201310340213 A CN 201310340213A CN 103356723 A CN103356723 A CN 103356723A
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Abstract
The invention relates to a cooling paste for children and a preparation method thereof, and solves treatment and medication problems for children having a fever. The technical scheme is that the cooling paste is prepared from raw materials, by weight, comprising 10-14% of sodium polyacrylate, 2.2-6.2% of edible gelatin, 2-8% of sodium carboxymethylcellulose, 0.4-1% of citric acid, 4-26% of carbomer, 2-6% of astragalus polysaccharides, 10-20% of a distillate of the root of Chinese thorowax, 8-11% of kaolin or diatomite, 20-40% of glycerin, 6-12% of propylene glycol, 0.2-6.6% of menthol and 0.04-0.24% of disodium dihydrogen ethylenediaminetetraacetate. The cooling paste has advantages of scientific and reasonable components, abundant raw materials, easy production, usage convenience and good effects. The cooling paste can be effectively used for treating the children having a fever, and is an innovation in medicines used for treating the children having a fever.
Description
Technical field
The present invention relates to medicine, particularly a kind of children's antipyretic pastes and preparation method thereof.
Background technology
Infantile fever is common frdquently encountered disease, such as untimely treatment, can affect the healthy of children's, and human body is kept normal body temperature, is a very complicated plysiochemical process.The main heat radiation position of human body is skin.In heat time hot summer, children's is because of the body development imperfection, and the thermoregulation ability easily occurs take fever symptoms as main " febrile disease due to summer-heat pathogen ".In addition, during by pathogenic infection, the normal reaction of autoimmune system when protection oneself also can cause fever children's.At present to paste be simple Physical temperature-lowering to the children's antipyretic on the Chinese market mostly, and there are the shortcomings such as the skin affinity is poor, adhesive force Xiao Yi comes off in the quality of homemade goods, performance all not as overseas-funded enterprise's product.
Summary of the invention
For above-mentioned situation, for overcoming the defective of prior art, the present invention's purpose just provides a kind of children's antipyretic and pastes and preparation method thereof, can effectively solve the medicine for treatment problem of infantile fever.
The technical scheme that the present invention solves is, the present invention is defervescence plaster used by following weight percent meter: sodium polyacrylate 10-14%, edible Gelatinum oxhide 2.2-6.2%, sodium carboxymethyl cellulose 2-8%, citric acid 0.4-1%, carbomer 4-26%, astragalus polysaccharides 2-6%, Radix Bupleuri distillate 10-20%, Kaolin or kieselguhr 8-11%, glycerol 20-40%, propylene glycol 6-12%, Mentholum 0.2-6.6% and disodiumedetate 0.04-0.24% make as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing;
Described Radix Bupleuri distillate is: Radix Bupleuri is ground into coarse powder, the water that adds 10 times of weight, heating and refluxing extraction 2h, collect first distillate, collecting amount is 6 times of Radix Bupleuri weight, adds sodium chloride and makes mass concentration reach 15%, saltout and spend the night, carry out again redistillation, collect Radix Bupleuri and weigh 2 times of amount distillates, get the Radix Bupleuri distillate;
Described astragalus polysaccharides is: astragalus membranaceus powder is broken into coarse powder, adds the water of 10 times of weight, 90-100 ℃ are extracted 3 times, each 3 hours, filter, merging filtrate, being evaporated to 50 ℃ of relative densities is 1.1-1.3, the ethanol that adds volumetric concentration again and be 95%--100% to the volumetric concentration of alcohol reaches 80%, 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, get astragalus polysaccharides.
Component of the present invention is scientific and reasonable, and abundant raw material is easily produced, and is easy to use, effective, is effective to treat infantile fever, is the innovation on the treatment pediatrics febricide medicine.
The specific embodiment
Below in conjunction with embodiment the specific embodiment of the present invention is elaborated.
Embodiment 1
The present invention is in implementation, by following weight percent meter: sodium polyacrylate 12.5-13.5%, edible Gelatinum oxhide 2.5-6%, sodium carboxymethyl cellulose 4-7%, citric acid 0.65-0.8%, carbomer 10-20%, astragalus polysaccharides 2.5-5.5%, Radix Bupleuri distillate 14-16%, Kaolin or kieselguhr 9.5-10.5%, glycerol 26-35%, propylene glycol 7.5-10.5%, Mentholum 1.5-6% and disodiumedetate 0.08-0.22% make as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
Embodiment 2
The present invention is in implementation, by following weight percent meter: sodium polyacrylate 11%, edible Gelatinum oxhide 6.2%, sodium carboxymethyl cellulose 3.16%, citric acid 0.4%, carbomer 26%, astragalus polysaccharides 6%, Radix Bupleuri distillate 10%, Kaolin or kieselguhr 11%, glycerol 20%, propylene glycol 6%, Mentholum 0.2% and disodiumedetate 0.04% are made as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
Embodiment 3
The present invention is in implementation, by following weight percent meter: sodium polyacrylate 14%, edible Gelatinum oxhide 2.2%, sodium carboxymethyl cellulose 5%, citric acid 1%, carbomer 7%, astragalus polysaccharides 4%, Radix Bupleuri distillate 12%, Kaolin or kieselguhr 8%, glycerol 30%, propylene glycol 10%, Mentholum 6.6% and disodiumedetate 0.2% are made as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
Embodiment 4
The present invention is in implementation, by following weight percent meter: sodium polyacrylate 10%, edible Gelatinum oxhide 4%, sodium carboxymethyl cellulose 2%, citric acid 0.76%, carbomer 4%, astragalus polysaccharides 2%, Radix Bupleuri distillate 15%, Kaolin or kieselguhr 10%, glycerol 40%, propylene glycol 8%, Mentholum 4% and disodiumedetate 0.24% are made as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
Embodiment 5
The present invention is in implementation, by following weight percent meter: sodium polyacrylate 12%, edible Gelatinum oxhide 5%, sodium carboxymethyl cellulose 8%, citric acid 0.6%, carbomer 4.3%, astragalus polysaccharides 3%, Radix Bupleuri distillate 20%, Kaolin or kieselguhr 9%, glycerol 25%, propylene glycol 12%, Mentholum 1% and disodiumedetate 0.1% are made as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
Effective combination of said medicine is supported mutually, has the effect of Physical temperature-lowering, medicine antipyretic-antalgic and raising immunity of organism, is effective to fever of children and brings down a fever, and obtained satisfied useful technique effect through test, and interrelated data is as follows:
The pharma-toxicology experiment
Rat skin single administration acute toxicity testing, rat skin administration subacute toxicity test, the test of rabbit single administration skin irritation, multiple dosing is to the irritation test of damaged skin, allergic reaction on guinea pigs, and the result all shows: children's antipyretic pastes when adopting percutaneous drug delivery approach, used dosage, the used course for the treatment of, toxicity is little, non-stimulated, non-sensitization, safety range is large.
Rat chronic toxicity test: children's antipyretic pastes high dose (be equivalent to clinical Coming-of-Age Day consumption 250 times), middle dosage (be equivalent to clinical Coming-of-Age Day consumption 200 times), low dosage (be equivalent to clinical Coming-of-Age Day consumption 150 times) continuous 4 all skin administrations, the general status of animal, body weight, appetite, hematological indices no abnormality seen; The above-mentioned observation in 2 weeks of drug withdrawal is no abnormality seen also.Administration group result of the test and vehicle group compare, difference that there are no significant.Long-term toxicity test for animals shows, when children's antipyretic pasted clinical employing percutaneous drug delivery approach, used dosage, the used course for the treatment of, toxicity was little, safety range is large.Result of the test can find out that there is not the toxicology meaning in the present invention accordingly, and the clinical drug safety foundation that provides is provided.
Pharmacodynamic study
(1) zoopery
Get 6 of the qualified rabbit of body temperature, be divided at random 2 groups, 3 every group.Every rabbit is all from auricular vein bacterial injection endotoxin standard [60EU/ (mL/kg)] pyrogenicity.Test group 1h after pyrogenicity sticks in nape section that defervescence plaster used (every subsides 100mm * 50mm), blank group is not done any processing.Survey body temperature 1 time every 15min after test group sticked, survey body temperature 1 time every 30min behind the 1h, survey continuously 6h.
Experimental result shows, makes that defervescence plaster used to retreat thermal effect more obvious sticking 2.0h by oneself; In addition, at other times point the trend of bringing down a fever is arranged also, but not statistically significant (P〉0.05).Stick rear 5h, rabbit body temperature recovers normally substantially, proves that the defervescence plaster used induced by endotoxin of self-control causes the rabbit body temperature rising obvious cooling effect is arranged.
(2) clinical experiment
The clinical use of fever infant 178 people through a variety of causes is caused, wherein:
1 year old with interior child 38 people, 3--5 year child 95 people, 6--10 year child 45 people, during use, be affixed on forehead or temple, also can be applied to Arteria carotis communis, oxter, left and right sides tremulous pulse, left and right sides femoral artery place, changed once in every 6-8 hour, every day 1-3 time, observe the effect of bringing down a fever.
The result shows, body temperature on average descends 0.3 ℃ after using this defervescence plaster used 15min, along with the prolongation of time, and the body temperature continuous decrease, but the initial 15min of the speed ratio of temperature decline is little.Whenever posting the effect time is 6--8h, paste with during the successful of bringing down a fever, be conducive to treatment and the rehabilitation of infant fever, the effect of all ages and classes section use all has good cooling effect without significant difference.
Compatibility of the present invention is reasonable, determined curative effect is reliable, the large difficult drop-off of viscosity, and contain the hydroaropic substances such as a large amount of moisture, polysaccharide, glycerol, propylene glycol, be conducive to drug percutaneous skin Transdermal absorption, processing technology is simple, easy to use, good effect has actual clinical meaning, and economic and social benefit is remarkable.
Claims (6)
1. the children's antipyretic preparation method of pasting, it is characterized in that, by following weight percent meter: sodium polyacrylate 10-14%, edible Gelatinum oxhide 2.2-6.2%, sodium carboxymethyl cellulose 2-8%, citric acid 0.4-1%, carbomer 4-26%, astragalus polysaccharides 2-6%, Radix Bupleuri distillate 10-20%, Kaolin or kieselguhr 8-11%, glycerol 20-40%, propylene glycol 6-12%, Mentholum 0.2-6.6% and disodiumedetate 0.04-0.24% make as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing;
Described Radix Bupleuri distillate is: Radix Bupleuri is ground into coarse powder, the water that adds 10 times of weight, heating and refluxing extraction 2h, collect first distillate, collecting amount is 6 times of Radix Bupleuri weight, adds sodium chloride and makes mass concentration reach 15%, saltout and spend the night, carry out again redistillation, collect Radix Bupleuri and weigh 2 times of amount distillates, get the Radix Bupleuri distillate;
Described astragalus polysaccharides is: astragalus membranaceus powder is broken into coarse powder, adds the water of 10 times of weight, 90-100 ℃ are extracted 3 times, each 3 hours, filter, merging filtrate, being evaporated to 50 ℃ of relative densities is 1.1-1.3, the ethanol that adds volumetric concentration again and be 95%--100% to the volumetric concentration of alcohol reaches 80%, 4 ℃ leave standstill 8 hours after, centrifugal 10 minutes of 4000r/min gets polysaccharide precipitation, behind the polysaccharide precipitation drying under reduced pressure, get astragalus polysaccharides.
2. the children's antipyretic according to claim 1 preparation method of pasting, it is characterized in that, by following weight percent meter: sodium polyacrylate 12.5-13.5%, edible Gelatinum oxhide 2.5-6%, sodium carboxymethyl cellulose 4-7%, citric acid 0.65-0.8%, carbomer 10-20%, astragalus polysaccharides 2.5-5.5%, Radix Bupleuri distillate 14-16%, Kaolin or kieselguhr 9.5-10.5%, glycerol 26-35%, propylene glycol 7.5-10.5%, Mentholum 1.5-6% and disodiumedetate 0.08-0.22% make as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
3. the children's antipyretic according to claim 1 preparation method of pasting, it is characterized in that, by following weight percent meter: sodium polyacrylate 11%, edible Gelatinum oxhide 6.2%, sodium carboxymethyl cellulose 3.16%, citric acid 0.4%, carbomer 26%, astragalus polysaccharides 6%, Radix Bupleuri distillate 10%, Kaolin or kieselguhr 11%, glycerol 20%, propylene glycol 6%, Mentholum 0.2% and disodiumedetate 0.04% are made as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
4. the children's antipyretic according to claim 1 preparation method of pasting, it is characterized in that, by following weight percent meter: sodium polyacrylate 14%, edible Gelatinum oxhide 2.2%, sodium carboxymethyl cellulose 5%, citric acid 1%, carbomer 7%, astragalus polysaccharides 4%, Radix Bupleuri distillate 12%, Kaolin or kieselguhr 8%, glycerol 30%, propylene glycol 10%, Mentholum 6.6% and disodiumedetate 0.2% are made as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
5. the children's antipyretic according to claim 1 preparation method of pasting, it is characterized in that, by following weight percent meter: sodium polyacrylate 10%, edible Gelatinum oxhide 4%, sodium carboxymethyl cellulose 2%, citric acid 0.76%, carbomer 4%, astragalus polysaccharides 2%, Radix Bupleuri distillate 15%, Kaolin or kieselguhr 10%, glycerol 40%, propylene glycol 8%, Mentholum 4% and disodiumedetate 0.24% are made as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
6. the children's antipyretic according to claim 1 preparation method of pasting, it is characterized in that, by following weight percent meter: sodium polyacrylate 12%, edible Gelatinum oxhide 5%, sodium carboxymethyl cellulose 8%, citric acid 0.6%, carbomer 4.3%, astragalus polysaccharides 3%, Radix Bupleuri distillate 20%, Kaolin or kieselguhr 9%, glycerol 25%, propylene glycol 12%, Mentholum 1% and disodiumedetate 0.1% are made as raw material, wherein:
(1), the water dissolution that disodiumedetate is added its 50 times of weight becomes disodium ethylene diamine tetra-acetic acid aqueous solution, after carbomer adds water-soluble the expanding of 2.5 times of its weight, add disodium ethylene diamine tetra-acetic acid aqueous solution, with sodium hydroxide or triethanolamine adjust pH to 7.0-9.0, get disodiumedetate, carbomer swelling solution; Add the water of its 3-5 times of weight in the edible Gelatinum oxhide, 35-60 ℃ of dissolvings get gelatin solution; Astragalus polysaccharides adds the water dissolution of its 5-10 times of weight, gets astragalus polyose solution; Gelatin solution, astragalus polyose solution and Radix Bupleuri distillate are joined in disodiumedetate, the carbomer swelling solution, and mix homogeneously gets the substrate I;
(2), glycerol and mixed with propylene glycol is even, add successively sodium carboxymethyl cellulose, sodium polyacrylate, citric acid, Kaolin or kieselguhr, behind the mixing the substrate II;
(3), with substrate I and substrate II in 40-60 ℃ of mix homogeneously, get mixed-matrix, the Mentholum of crossing 80 mesh sieves after pulverizing is joined in the mixed-matrix, mix homogeneously, coating is cut, packing.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103893271A (en) * | 2014-02-26 | 2014-07-02 | 高雄英 | Child fever cooling patch |
| CN104547023A (en) * | 2015-01-23 | 2015-04-29 | 广州九润生物科技有限公司 | Day and night fever-cooling patches |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105878315A (en) * | 2016-05-31 | 2016-08-24 | 四川德培源中药科技开发有限公司 | Radix bupleuri fever cooling patch and preparation technology thereof |
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| CN111297906A (en) * | 2019-11-14 | 2020-06-19 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893271A (en) * | 2014-02-26 | 2014-07-02 | 高雄英 | Child fever cooling patch |
| CN104547023A (en) * | 2015-01-23 | 2015-04-29 | 广州九润生物科技有限公司 | Day and night fever-cooling patches |
| CN105878218A (en) * | 2016-04-21 | 2016-08-24 | 吴美燕 | Preparation method of intelligent children's fever cooling patch |
| CN105878315A (en) * | 2016-05-31 | 2016-08-24 | 四川德培源中药科技开发有限公司 | Radix bupleuri fever cooling patch and preparation technology thereof |
| CN105920565A (en) * | 2016-06-24 | 2016-09-07 | 南阳医学高等专科学校第附属医院 | Infantile umbilical paste and preparation method thereof |
| CN111297906A (en) * | 2019-11-14 | 2020-06-19 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
| CN111297906B (en) * | 2019-11-14 | 2023-06-09 | 青岛兔护士海洋生物科技有限公司 | Bear gall cooling patch and preparation method thereof |
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