CN1679823A - Babu paste of Chinese medicine for child to reduce fever and its making method - Google Patents
Babu paste of Chinese medicine for child to reduce fever and its making method Download PDFInfo
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- CN1679823A CN1679823A CNA2005100416287A CN200510041628A CN1679823A CN 1679823 A CN1679823 A CN 1679823A CN A2005100416287 A CNA2005100416287 A CN A2005100416287A CN 200510041628 A CN200510041628 A CN 200510041628A CN 1679823 A CN1679823 A CN 1679823A
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Abstract
A defervescent Chinese medicine in the form of picking for baby is prepared from aqueous gel as matrix, percutaneous absorption promoter, and 5 Chinese-medicinal materials including capejasmine fruit, gypsum, pueraria root, scorpion, etc. Its advantage is quickly taking its defervescent effect.
Description
Technical field
The invention belongs to medical technical field, particularly a kind of children's antipyretic Babu paste of Chinese medicine for child and preparation method thereof.
Background technology
Now child's medicine of bringing down a fever is a lot of on the market, but great majority are oral antibiotic and glucocorticoids bring down a fever Western medicine or injection, often be difficult to accept by the child, especially the not clear fever of general child, the functional heating that disorder causes as digestive tract function, viral upper respiratory tract infection etc. need not injected the injection of bringing down a fever.
Baihu Tang comes from Zhang Zhongjing " Treatise on Febrile and Miscellaneous Disease ", and its main component is made up of Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, Semen oryzae sativae.Can divide hyperpyrexia, rush down stomach-fire by clearing heat in QI system, be applicable to diseases such as hyperpyrexia, excessive thirst taking fluids profusely, profuse perspiration, full and large pulse.Add subtrahend flavor Chinese medicine in the Baihu Tang, can obtain the prescription of different efficacies.Babu paste is that medicine is coated the external preparation of making on the non-woven fabrics with suitable hydrophilic matrix mixing, and its drug loading is big, and water conservation is preserved moisture, and good permeability is good to skin adherence, no sensitization, zest.The Baihu Tang effective ingredient is made Babu paste type product do not see bibliographical information.
Summary of the invention
One of purpose of the present invention provides a kind of easy to use, comfortable, is the be willing to children's antipyretic Babu paste of Chinese medicine for child accepted of child, promptly with the children's antipyretic medicine of patch form, and the advantage of performance Baihu Tang Chinese medicinal formulae and Babu paste.
Another object of the present invention provides the preparation method of above-mentioned children's antipyretic Babu paste of Chinese medicine for child.
Technical scheme of the present invention is as follows:
A kind of children's antipyretic Babu paste of Chinese medicine for child comprises medicine, transdermal penetrating agent and hydrogel Babu paste substrate, and the composition and the umber of medicine Central Plains medicine are:
Gypsum Fibrosum 10~60 Rhizoma Anemarrhenaes 10~15
Fructus Gardeniae 10~20 Radix Puerariaes 10~15
Scorpio 5~10
Experiment showed, that Gypsum Fibrosum, Rhizoma Anemarrhenae decocting liquid have the reduction effect to typhoid fever, paratyphoid fever polyvalent vaccine pyrogenicity rabbit body temperature, not gypseous Baihu Tang there is no antipyretic effect; Clinical use Fructus Gardeniae treatment hyperpyrexia disease, clinical effectiveness is good; Prove the refrigeration function of Radix Puerariae similar to aspirin (seeing sage Liu, Chen Liming, heat clearing Chinese medicine modern pharmacology and clinical, Anhui science and technology publishing house) through pharmacological evaluation.
The weight percentage of said medicine, transdermal penetrating agent and hydrogel Babu paste substrate is:
Medicine 12-40%
Transdermal penetrating agent 1-8%
Hydrogel Babu paste substrate 55-80%
The transdermal penetrating agent is selected menthol and propylene glycol bi-component for use, and the weight ratio of menthol and propylene glycol is: 1~3: 2~6.
Hydrogel Babu paste substrate is made up of hydrophilic coherent matrix, cross-linking agent, cross-linking regulator, wetting agent, water, its water content 40%~65%, hydrophilic coherent matrix are selected from polyacrylic acid, sodium polyacrylate, polyacrylic acid potassium, ammonium polyacrylate, the sodium carboxymethylcellulose pyce that contracts, polyvinyl alcohol, gelatin; Cross-linking agent is selected from aluminium hydroxide, aluminium oxide, aluminum acetate, aluminium potassium sulfate, aluminum glycinate; Cross-linking regulator is selected from citric acid, hydroxyl succinic acid, lactic acid, tartaric acid; Wetting agent is selected from glycerol, propylene glycol, sorbitol.
A kind of preparation method of children's antipyretic Babu paste of Chinese medicine for child may further comprise the steps:
(1) with 10~60 parts of Gypsum Fibrosum, 10~15 parts of the Rhizoma Anemarrhenaes, 10~20 parts of Fructus Gardeniaes, 10~15 parts of Radix Puerariaes, Scorpio 5~10 adds water 400-700 part, is concentrated into 30~80 parts of extractum through water decoction-alcohol sedimentation;
(2) hydrophilic cohesiveness substrate, cross-linking agent, cross-linking regulator, wetting agent are dissolved in water and stir;
(3) drug extract, penetrating agent are joined in the Hydrophillia Babu agent patch substrate stir, the weight percentage of drug extract, transdermal penetrating agent and hydrogel Babu paste substrate is followed successively by 12-40%, 1-8%, 55-80%;
(4) outgasing, be applied to backing, overlay film, drying, section gets final product.
The used high aqueous hydrogel Babu paste substrate of children's antipyretic Babu paste of Chinese medicine for child is formed content can be as follows:
Phase | Component | Mass percent % (w/w) |
A phase B phase C phase D phase | Polyacrylic acid deionized water 30% sodium polyacrylate solution Sodium Polyacrylate powder glycerine hydroxysuccinic acid aluminum glycinate powder deionized water | ????1.0~5.0 ????30~70 ????5~30 ????2~8 ????10~40 ????1~8 ????1~8 ????2~10 |
The preparation method of Babu paste substrate is:
A. prepare A phase solution: polyacrylic acid is scattered in the deionized water, stirred 5 minutes;
B. prepare B phase solution: sodium polyacrylate is scattered in the deionized water, is mixed with 30% solution;
C. prepare C phase solution: under agitation add to sodium polyacrylate in the glycerol;
D. prepare D phase solution: with hydroxyl succinic acid, aluminum glycinate powder formation transparency liquid mixed with water;
E. B phase, C are mixed mutually, add the D phase again;
F. A is added to spread out in the mixture of B, C, D and is coated with.
Usage and dosage: can be with the patch of children's antipyretic Chinese medicine, stick DAZHUI acupoint place behind children's Yu oxter or femoribus internus and the neck, 1~2 subsides/day, in use, can uncover at a place, stick again in elsewhere, and can not lose viscosity.
Storage: airtight, put shady and cool place and preserve.
Compare with existing children's antipyretic medicine, the present invention has the following advantages:
(1) easy to use, comfortable, by the child is willing to accept;
(2) stick conveniently, do not pull out chaeta, non-stimulated allergic phenomena can stick at health repeatedly everywhere.Because the gel patch is high moisture, so drug transdermal is effective, brings down a fever rapidly, by statistics, effective percentage can reach more than 95%.
(3) this children's antipyretic Chinese herbs paste has used preferred penetrating agent, contains freshener in the penetrating agent again, and rapid-action, children's easily accepts, no pain, and it is convenient to store, and can be the standing medicine of family.
(4) children's antipyretic Babu paste of Chinese medicine for child of the present invention, its pharmaceutical formulation are the optimum formulas that filters out through orthogonal experiment on ancient prescription is brought down a fever the basis of efficacious prescriptions Baihu Tang, and penetrating agent also is the short system of oozing of two components that makes through the Transdermal absorption test.Pei Zhi the patch of bringing down a fever like this can be avoided the first pass effect of medicine, reduces the infringement that Liver and kidney causes because of drug metabolism, reduces the gastrointestinal upset of taking medicine and causing.Medicine is the worry that Chinese medicine compound is formed, had no drug resistance, and cost is low easily universal, thereby bigger use prospect is arranged.
Specific implementation method
Embodiment 1
(1) takes by weighing Gypsum Fibrosum 55g, Rhizoma Anemarrhenae 15g, Fructus Gardeniae 20g, Radix Puerariae 15g, Scorpio 5g, 110g altogether, add 600g water, concentrate according to the decoction alcohol precipitation method of routine, about simmer down to extractum 40g;
(2) the short infiltration of preparation two components skin absorbent, the weight ratio of menthol and propylene glycol is 2: 5;
(3) according to the form below is prepared high aqueous hydrogel analgesic ointment prescription and configuration step, progressively is mixed with analgesic ointment substrate,
Phase | Component | Quality (g) |
A phase B phase C phase D phase | Polyacrylic acid deionized water 30% sodium polyacrylate solution Sodium Polyacrylate powder glycerine hydroxysuccinic acid aluminum glycinate powder deionized water | ????3 ????35 ????20 ????5 ????20 ????5 ????4 ????8 |
In order, A is mixed mutually with B, in stirring at low speed, add rapidly the C phase, add the D phase again after evenly;
(4) 30g drug extract, 5g penetrating agent are joined in the 80g Hydrophillia Babu agent patch substrate and to stir 5 minutes, the stand is applied on the lining cloth;
(5) be cut into 20 patches after solidifying, every agreement that contracts a film or TV play to an actor or actress 6cm * 12cm size adds cuticula, protects bag, sterilization, the shady and cool preservation.
Claims (5)
1. a children's antipyretic Babu paste of Chinese medicine for child comprises medicine, and transdermal penetrating agent and hydrogel Babu paste substrate is characterized in that the composition of medicine Central Plains medicine and umber are:
Gypsum Fibrosum 10~60 Rhizoma Anemarrhenaes 10~15
Fructus Gardeniae 10~20 Radix Puerariaes 10~15
Scorpio 5~10
2. a kind of children's antipyretic Babu paste of Chinese medicine for child according to claim 1 is characterized in that the weight percentage of medicine, transdermal penetrating agent and hydrogel Babu paste substrate is:
Medicine 12-40%
Transdermal penetrating agent 1-8%
Hydrogel Babu paste substrate 55-80%
3. a kind of children's antipyretic Babu paste of Chinese medicine for child according to claim 1 and 2 is characterized in that the transdermal penetrating agent selects menthol and propylene glycol bi-component for use, and the weight ratio of menthol and propylene glycol is: 1~3: 2~6
4. a kind of children's antipyretic Babu paste of Chinese medicine for child according to claim 1 and 2, it is characterized in that hydrogel Babu paste substrate is made up of hydrophilic coherent matrix, cross-linking agent, cross-linking regulator, wetting agent, water, its water content 40%~65%, hydrophilic coherent matrix are selected from polyacrylic acid, sodium polyacrylate, polyacrylic acid potassium, ammonium polyacrylate, the sodium carboxymethylcellulose pyce that contracts, polyvinyl alcohol, gelatin; Cross-linking agent is selected from aluminium hydroxide, aluminium oxide, aluminum acetate, aluminium potassium sulfate, aluminum glycinate; Cross-linking regulator is selected from citric acid, hydroxyl succinic acid, lactic acid, tartaric acid; Wetting agent is selected from glycerol, propylene glycol, sorbitol.
5. the preparation method of a children's antipyretic Babu paste of Chinese medicine for child may further comprise the steps:
(1) with 10~60 parts of Gypsum Fibrosum, 10~15 parts of the Rhizoma Anemarrhenaes, 10~20 parts of Fructus Gardeniaes, 10~15 parts of Radix Puerariaes, Scorpio 5~10 adds water 400-700 part, is concentrated into 30~80 parts of extractum through decoction alcohol precipitation method;
(2) hydrophilic cohesiveness substrate, cross-linking agent, cross-linking regulator, wetting agent are dissolved in water and stir;
(3) drug extract, penetrating agent are joined in the Hydrophillia Babu agent patch substrate stir, the weight percentage of drug extract, transdermal penetrating agent and hydrogel Babu paste substrate is followed successively by 12-40%, 1-8%, 55-80%;
(4) outgasing, be applied to backing, overlay film, drying, section gets final product.
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101919829A (en) * | 2010-09-06 | 2010-12-22 | 西北大学 | Hydrogel cataplasm for microneedle cutaneous penetration and preparation method thereof |
CN103356723A (en) * | 2013-08-07 | 2013-10-23 | 河南中医学院 | Cooling paste for children and preparation method thereof |
CN103919846A (en) * | 2013-01-15 | 2014-07-16 | 江苏康倍得药业有限公司 | Hydrogel composition and preparation thereof |
CN103961522A (en) * | 2014-04-17 | 2014-08-06 | 柳州市妇幼保健院 | Traditional Chinese medicine-containing acupoint instant cooling patch and using method thereof |
CN104547023A (en) * | 2015-01-23 | 2015-04-29 | 广州九润生物科技有限公司 | Day and night fever-cooling patches |
CN105031479A (en) * | 2015-08-29 | 2015-11-11 | 梁万新 | Traditional Chinese medicine paste for allaying fever by being applied to acupuncture point of children |
CN105343884A (en) * | 2015-10-20 | 2016-02-24 | 华南农业大学 | Preparation method and application of galvanic-response transdermal drug delivery system |
CN107308253A (en) * | 2017-07-31 | 2017-11-03 | 武汉跃莱健康产业有限公司 | Effective lenitive easypro pain patch and preparation method thereof |
CN108392472A (en) * | 2018-04-23 | 2018-08-14 | 四川大学 | A kind of gel rubber plaster and preparation method containing Chinese medical extract |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1215831C (en) * | 2003-10-08 | 2005-08-24 | 西安千禾药业有限责任公司 | Chinese medicine cataplasm matrix and preparing technique thereof |
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2005
- 2005-01-14 CN CNB2005100416287A patent/CN100427128C/en not_active Expired - Fee Related
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101919829A (en) * | 2010-09-06 | 2010-12-22 | 西北大学 | Hydrogel cataplasm for microneedle cutaneous penetration and preparation method thereof |
CN103919846A (en) * | 2013-01-15 | 2014-07-16 | 江苏康倍得药业有限公司 | Hydrogel composition and preparation thereof |
CN103356723A (en) * | 2013-08-07 | 2013-10-23 | 河南中医学院 | Cooling paste for children and preparation method thereof |
CN103356723B (en) * | 2013-08-07 | 2015-06-03 | 河南中医学院 | Cooling paste for children and preparation method thereof |
CN103961522A (en) * | 2014-04-17 | 2014-08-06 | 柳州市妇幼保健院 | Traditional Chinese medicine-containing acupoint instant cooling patch and using method thereof |
CN104547023A (en) * | 2015-01-23 | 2015-04-29 | 广州九润生物科技有限公司 | Day and night fever-cooling patches |
CN105031479A (en) * | 2015-08-29 | 2015-11-11 | 梁万新 | Traditional Chinese medicine paste for allaying fever by being applied to acupuncture point of children |
CN105031479B (en) * | 2015-08-29 | 2019-02-22 | 梁万新 | A kind of children acupuncture point is brought down a fever Chinese herbs paste |
CN105343884A (en) * | 2015-10-20 | 2016-02-24 | 华南农业大学 | Preparation method and application of galvanic-response transdermal drug delivery system |
CN105343884B (en) * | 2015-10-20 | 2019-05-03 | 华南农业大学 | A kind of preparation method and applications of electricity reaction transdermal drug delivery system |
CN107308253A (en) * | 2017-07-31 | 2017-11-03 | 武汉跃莱健康产业有限公司 | Effective lenitive easypro pain patch and preparation method thereof |
CN108392472A (en) * | 2018-04-23 | 2018-08-14 | 四川大学 | A kind of gel rubber plaster and preparation method containing Chinese medical extract |
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