CN101919829A - Hydrogel cataplasm for microneedle cutaneous penetration and preparation method thereof - Google Patents
Hydrogel cataplasm for microneedle cutaneous penetration and preparation method thereof Download PDFInfo
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- CN101919829A CN101919829A CN 201010273281 CN201010273281A CN101919829A CN 101919829 A CN101919829 A CN 101919829A CN 201010273281 CN201010273281 CN 201010273281 CN 201010273281 A CN201010273281 A CN 201010273281A CN 101919829 A CN101919829 A CN 101919829A
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- hydrogel
- chinese medicine
- cataplasma
- micropin
- microneedle cutaneous
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Abstract
The invention discloses hydrogel cataplasm for microneedle cutaneous penetration and a preparation method thereof. The preparation method comprises the following steps of: weighting and evenly mixing NP-700, NP-800, PVP-k90, EDTA (Ethylene Diamine Tetraacetic Acid), dihydroxyaluminum aminoacetate and kaolin in prescription quantity; adding the mixture into glycerin in prescription quantity, and evenly mixing the mixture and the glycerin to obtain a glycerin phase; weighting tartaric acid in prescription quantity and dissolving the tartaric acid into water to obtain an aqueous phase; adding the aqueous phase into the glycerin phase, adding and stirring Chinese herb extracts in prescription quantity to obtain medicine-bearing spare paste; coating the medicine-bearing spare paste on medical non-woven fabrics; and cutting, standing, crosslinking and packing to obtain the hydrogel cataplasm for microneedle cutaneous penetration. The hydrogel cataplasm for microneedle cutaneous penetration has large medicine loading, good biocompatibility with skin and comfortable application, has no irritancy and no allergy effect, and the like, and microneedles are used for cutaneous penetration to promote the percutaneous absorption of multiple traditional Chinese medicine components and increase the percutaneous absorption effect of the traditional Chinese medicine.
Description
Technical field
The present invention relates to a kind of microneedle cutaneous hydrogel cataplasma and preparation method thereof that is used for, belong to the Percutaneously administrable preparation field.
Background technology
Chinese medicine has the comprehensive function characteristics of multicomponent, many target spots, many effects, and its toxic and side effects low, be difficult for tolerific distinct advantages, form the focus of pursuing into people.Transdermal administration has unique advantage: 1. transdermal administration can be avoided the degraded to medicine of liver first-pass effect and gastrointestinal tract, and the absorption of medicine is not influenced by gastrointestinal factors; 2. medicine enters body for a long time with set rate, reduces administration number of times, prolongs action time; 3. the percutaneous rate of predeterminable medicine is kept stabilizing effective blood drug level, avoids paddy peak phenomenon, reduces toxic and side effects; 4. easy to use, interruption of the administration at any time, compliance is higher.Thereby Percutaneously administrable preparation becomes the fastest dosage form of growth rate in all novel forms, and therefore developing efficient Chinese medicine Percutaneously administrable preparation has great prospect.
The research of transdermal administration mainly is the horny layer obstacle that how to overcome skin, reduces medicine and enters the barrier of body, and developed many new methods, comprises practice of pharmacy, chemical method and physics method.Study maximum practice of pharmacy and be to use the Transdermal absorption penetrating agent to overcome the horny layer obstacle of skin, also have research to use particulate carriers such as liposome, carrier, pharmacosomes, nanoparticle, polymer micelle to promote the Transdermal absorption of medicine in recent years.Also have and drug molecule to be carried out chemical constitution modify, obtain having the chemical method of the prodrug molecule of better infiltration rate.Physical method comprises iontophoresis, ultrasound wave, electroporation and the micropin technology that occurs in recent years and gas injection etc., wherein micropin can directly pierce through keratodermatitis and on skin, stay the certain pore size size, really " microchannel " thus greatly promoted the Transdermal absorption of all kinds drug molecules.
Henry equals first micropin to be applied in 1998 the research of transdermal administration, and the theoretical research of micropin and applied research have been obtained considerable progress so far afterwards.Micropin is a brand-new medicine-feeding technology that injection and transdermal patch advantage is blended in one, has been widely used in the transdermal administration research of all types of drug molecules in recent years.
Micropin thrusts horny layer and forms real duct, greatly destroyed cuticular obstructive action, can promote various types of drug molecules to comprise that the microgranule drug-delivery preparation of albumen, polypeptide class macromole and " huge molecule " sees through skin, the micropin drug-supplying system almost can be applied to the transdermal administration of all drug molecules so, particularly is suitable for Chinese medicine multicomponent characteristics.
Summary of the invention
The object of the present invention is to provide a kind of hydrogel cataplasma that promotes the efficient transdermal administration of Chinese medicine multicomponent, the hydrogel cataplasma becomes the carrier and the bank of Chinese medicine various active composition; With micropin pretreatment skin, stick Chinese medicine hydrogel cataplasma at the processing skin part then, thereby promote the efficient Transdermal absorption of active ingredient of Chinese herbs.
Another object of the present invention provides the above-mentioned preparation method that is used for microneedle cutaneous hydrogel cataplasma.
Implementation procedure of the present invention is as follows:
A kind ofly be used for microneedle cutaneous hydrogel cataplasma, be made up of water-soluble high-molecular material, Chinese medicine extract and distilled water, each component and weight percentage are as follows:
iscomate?NP-700 2%~6% Viscomate?NP-800 1.0%~4.5%
PVP-k90 4%~8% glycerol 30%~50%
Tartaric acid 0.2~0.6% dihydroxyaluminum aminoacetate 0.2~0.6%
EDTA 0.05~0.15% Kaolin 3%~8%
Chinese medicine extract 15~25% distilled water surplus.
Above-mentioned each component percentage composition sum is 100%.
Viscomate NP-700 and NP-800 are the polyacrylic acid that part is neutralized, and they are value key copolymers of acrylic acid and sodium acrylate.Viscomate NP-700 and NP-800 are the products that Japanese ShowaDenko K.K company produces.PVP-k90 is a polyvinylpyrrolidone.Dihydroxyaluminum aminoacetate has another name called aluminum glycinate or Dihydroxyaluminum Aminoacetate.
Above-mentioned Chinese medicine extract is paste or powdery.
The above-mentioned preparation method that is used for the conductive hydrogel patch of momentary pulse electric field transdermal administration comprises the steps:
(1) take by weighing NP-700, NP-800, PVP-k90, EDTA, dihydroxyaluminum aminoacetate, the Kaolin of recipe quantity, with its mix homogeneously, join in the glycerol of recipe quantity again, stirring obtains glycerol phase (A phase);
(2) it is soluble in water to take by weighing the tartaric acid of recipe quantity, obtains water (B phase);
(3) B is slowly joined mutually A mutually in, slow stirring at low speed 10~20min adds the Chinese medicine extract of recipe quantity again, slow stirring at low speed 10~15min obtains the standby mastic of medicine carrying again;
(4) mastic is coated on the medical adhesive-bonded fabric,, packing crosslinked through cutting, leaving standstill is prepared into Chinese medicine hydrogel cataplasma.
Above-mentioned micropin is meant with materials such as monocrystal silicon, titanium alloy, nickel and rustless steels and adopts micro electronmechanical technology etc. to be prepared into the pin of the solid micron order size of high 60~300um, wide 10~50um.
Advantage of the present invention and good effect: the various active composition of Chinese medicine is prepared into the hydrogel cataplasma, and it is the bank of Chinese medicine various active composition; The hydrogel cataplasma have drug loading big, with skin good biocompatibility, non-stimulated no allergy, stick characteristics such as comfortable; Micropin thrusts skin, forms real duct on keratodermatitis, has greatly destroyed cuticular obstructive action, thereby promotes the multicomponent Transdermal absorption of Chinese medicine, improves the Transdermal absorption effect of medicine.
The specific embodiment
Embodiment 1: the preparation of Chinese medicine hydrogel cataplasma
1. take by weighing NP-700 4g, NP-800 2g, EDTA 0.1g, dihydroxyaluminum aminoacetate 0.29g, Kaolin 3.5g, PVP-k905g, with its abundant mix homogeneously; Join in the glycerol of 38g, stirring obtains glycerol phase (A phase) again.
2. take by weighing tartaric acid 0.29g, join in the 30g water, stirring obtains water (B phase).
3. B is slowly joined mutually one by one A mutually in, slowly stirring at low speed 20min obtains heavy-gravity mastic.
4. take by weighing in the mastic of 15g Chinese medicine extract in joining 3., slowly 12min is closed in the stirring at low speed refining again, obtains standby mastic.
5. then standby mastic is evenly coated on the medical adhesive-bonded fabric, covered sealing coat; Cut into a certain size patch, under the purification condition of 25 ℃ of temperature, humidity 50%, place 48h and make mastic fully aging crosslinked, promptly get Chinese medicine hydrogel cataplasma of the present invention.
Embodiment 2: micropin promotes the method for transdermal administration
Use micropin, under usual pressure, push and do " rocking " action and push micropin, be stranded in about skin 1min, remove micropin with hands; Cataplasma with the embodiment preparation sticks on the skin of micropin into treatment sites again.
Claims (5)
1. one kind is used for microneedle cutaneous hydrogel cataplasma, is made up of water-soluble high-molecular material, Chinese medicine extract and distilled water, it is characterized in that each component and weight percentage are as follows:
Viscomate?NP-700 2%~6% Viscomate?NP-800 1.5%~4.5%
PVP-k90 4%~8% glycerol 30%~50%
Tartaric acid 0.2~0.6% dihydroxyaluminum aminoacetate 0.2~0.6%
EDTA 0.05~0.15% Kaolin 3%~8%
Chinese medicine extract 15~25% distilled water surplus.
2. according to claim 1ly be used for microneedle cutaneous hydrogel cataplasma, it is characterized in that Chinese medicine extract is paste or powdery.
3. the described preparation method that is used for microneedle cutaneous hydrogel cataplasma of claim 1 comprises the steps:
(1) take by weighing NP-700, NP-800, PVP-k90, EDTA, dihydroxyaluminum aminoacetate, the Kaolin of recipe quantity, with its mix homogeneously, join in the glycerol of recipe quantity again, stirring obtains glycerol phase (A phase);
(2) it is soluble in water to take by weighing the tartaric acid of recipe quantity, obtains water (B phase);
(3) B is slowly joined mutually A mutually in, slow stirring at low speed 10~20min adds the Chinese medicine extract of recipe quantity again, slow stirring at low speed 10~15min obtains the standby mastic of medicine carrying again;
(4) mastic is coated on the medical adhesive-bonded fabric,, packing crosslinked through cutting, leaving standstill is prepared into Chinese medicine hydrogel cataplasma.
4. according to claim 1ly be used for microneedle cutaneous hydrogel cataplasma, it is characterized in that: the pin of the solid micron order size of high 60~300um, wide 10~50um that described micropin is prepared into monocrystal silicon, titanium alloy, nickel and stainless steel material.
5. claim 1 is described is used for microneedle cutaneous hydrogel cataplasma using method, it is characterized in that: push micropin and do " rocking " action with hands, be stranded in about skin 1min, remove micropin, again Chinese medicine hydrogel cataplasma is sticked on the skin of micropin into treatment sites.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103505806A (en) * | 2012-12-27 | 2014-01-15 | 中国人民解放军第二军医大学 | Electret nanoparticle cutaneous penetration system |
CN105078645A (en) * | 2014-05-12 | 2015-11-25 | 天津卓普医疗器械有限公司 | Cold-compression patch with hydrogel as substrate and method for manufacturing cold-compression patch |
CN114340620A (en) * | 2019-06-28 | 2022-04-12 | 帕斯帕特技术有限公司 | Triptan microperforated delivery system |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1569146A (en) * | 2004-04-27 | 2005-01-26 | 陈明元 | Hippocampi contained transdermal plaster for treating contusions and strains and its preparation |
CN1679823A (en) * | 2005-01-14 | 2005-10-12 | 西北大学 | Babu paste of Chinese medicine for child to reduce fever and its making method |
CN1895311A (en) * | 2006-05-31 | 2007-01-17 | 武汉市海格尔科技有限公司 | Hydrophilic gel pleximetric paste and its preparation |
-
2010
- 2010-09-06 CN CN 201010273281 patent/CN101919829A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1569146A (en) * | 2004-04-27 | 2005-01-26 | 陈明元 | Hippocampi contained transdermal plaster for treating contusions and strains and its preparation |
CN1679823A (en) * | 2005-01-14 | 2005-10-12 | 西北大学 | Babu paste of Chinese medicine for child to reduce fever and its making method |
CN1895311A (en) * | 2006-05-31 | 2007-01-17 | 武汉市海格尔科技有限公司 | Hydrophilic gel pleximetric paste and its preparation |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103505806A (en) * | 2012-12-27 | 2014-01-15 | 中国人民解放军第二军医大学 | Electret nanoparticle cutaneous penetration system |
CN103505806B (en) * | 2012-12-27 | 2016-04-06 | 中国人民解放军第二军医大学 | electret nanoparticle transdermal drug delivery system |
CN105078645A (en) * | 2014-05-12 | 2015-11-25 | 天津卓普医疗器械有限公司 | Cold-compression patch with hydrogel as substrate and method for manufacturing cold-compression patch |
CN114340620A (en) * | 2019-06-28 | 2022-04-12 | 帕斯帕特技术有限公司 | Triptan microperforated delivery system |
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Application publication date: 20101222 |