CN103505806A - Electret nanoparticle cutaneous penetration system - Google Patents
Electret nanoparticle cutaneous penetration system Download PDFInfo
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- CN103505806A CN103505806A CN201210580810.XA CN201210580810A CN103505806A CN 103505806 A CN103505806 A CN 103505806A CN 201210580810 A CN201210580810 A CN 201210580810A CN 103505806 A CN103505806 A CN 103505806A
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Abstract
The invention relates to the technical field of medicines, in particular to a medication system. An electret nanoparticle cutaneous penetration system comprises an isolated layer, wherein a drug-contained pressure-sensitive adhesive layer is arranged on the inner side of the isolated layer, an electret layer made of electret materials is arranged on the outer side of the isolated layer, and a controlled release film layer is arranged on the inner side of the drug-contained pressure-sensitive adhesive layer; the electret layer, the isolated layer, the drug-contained pressure-sensitive adhesive layer and the controlled release film layer are arranged in sequence from outside to inside to form a depot patch; tourmaline powder particles are distributed in the drug-contained pressure-sensitive adhesive layer. According to the electret nanoparticle cutaneous penetration system, the tourmaline powder particles are mixed into the drug-contained pressure-sensitive adhesive layer, so that the electret nanoparticle cutaneous penetration system has the advantages of promoting blood circulation of a human body, enhancing the vitality of cells, improving an electret electric field, replenishing mineral substance for the human body and the like.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of drug-supplying system.
Background technology
Transdermal drug delivery system refers in skin surface administration, makes medicine with constant rate of speed or approach constant rate of speed by skin, to enter body and circulate, and produces the novel form of whole body or local therapeutic effects.Its advantage applies exists: drug absorption is not affected by the factors such as PH in digestive tract, food, transhipment time; Avoid liver to be subject to effect; Overcome because absorbing the too high untoward reaction causing of too fast generation haemoconcentration; Sustainable control injection speed, flexible administration etc.
But existing transdermal drug delivery system is normal, exist defects such as drug molecule amount and polarity limit to some extent, also have the problems such as drug delivery dosage is not easy to control, breathability is poor.
Summary of the invention
The object of the invention is to, a kind of electret nanoparticle transdermal drug delivery system is provided, solve above technical problem.
Technical problem solved by the invention can realize by the following technical solutions:
Electret nanoparticle transdermal drug delivery system, comprise a sealing coat, be arranged on the pastille pressure-sensitive adhesive layer of described sealing coat inner side, it is characterized in that, the outside of described sealing coat is provided with the electret layer that an employing electret is made, and the inner side of described pastille pressure-sensitive adhesive layer is provided with a controlled release rete;
By outer and interior described electret layer, described sealing coat, described pastille pressure-sensitive adhesive layer and the described controlled release rete of being placed with successively, form a reservoir devices patch;
In described pastille pressure-sensitive adhesive layer, be distributed with tourmaline powder particle.
Tourmaline is called again tourmaline, has following features:
(1) forever electrical: nanometer bioplast sub-surface has the little crystal grain of many permanent electrical bodies, has positive and negative electrode. improved pH value and the electrical conductivity of water, deflection alkalescence, the pH value of desirable healthy water is 7-8.Forever electrically produce a large amount of negative oxygen ions simultaneously.Anion is called again [vitamin of air], has the effect of balance the body ionic equilibrium, can make body and mind loosen, and activating cell improves the effects such as nature cure rate, and anion is the material that modern is indispensable.
(2) reactivity: due in water, produce a large amount of anion (OH)-, anion and hydrone (H2O)-combination formation hydroxyl ion water (H3O2)-, make water form small-micelle water, can obtain the active function at interface, oxygen in water >=6mg/L), human body substantially must be with the form of ion or its soluble complexes to the absorption of inorganic elements, and most research all shows that trace element and people's health, disease, longevity, beauty treatment etc. is closely related.In our Drinking Water, (especially in natural water) contains multi mineral inorganic elements, functional activation water is compared with light water, the multi mineral inorganic elements (comprising trace element) with higher concentration, as calcium, ferrum, zinc, selenium etc., thereby human body is being brought into play to better physiology and medical care effect.
(3) dwindle hydrone bundle: hydrone (H2O) is individualism not, its molecule can mutually combine, form molecular beam, molecular beam can improve the penetration of health, water clusters little (Hz≤100), make the enhancing of media physiological function, can increase in diet nutrient substance and mineral without plain dissolving, accelerate the decomposition of oil substances, be beneficial to and carry nutrient and inorganic elements ion to see through cell, garbage is discharged, thereby there is the alimentation of promotion, help digest excretion, strengthen metabolic effect.
(4) far infrared effect: detect through national authority mechanism, nanometer vigor can efficiently be launched the far infrared of needed by human body, and at 8-15 micron, its band emission rate is up to 88%, and it is the light of the life of human body that scientist names this wave band.Far infrared can be penetrated into health deep layer position, warm cell, and blood circulation promoting, makes metabolism smooth and easy.Tourmaline far infrared emissivity nearly 98%, numerical value is high compared with other mineral.
(5) contain effective trace mineral: tourmaline, as Ore in, contains various natural mineral matters, wherein has many mineral necessary with the mankind identical, and hardness of water is moderate, and 50-200mg/L(is in calcium carbonate).By the effect of weak current, mineral is easily absorbed, and is splendid mineral origin.
The feature of the tourmaline based on above, is blended in tourmaline powder particle in described pastille pressure-sensitive adhesive layer in the present invention, has the blood circulation of human body of promotion, improves cytoactive, improves electret electric field, human body is carried out to the advantages such as mineral supplements.
A ultrasound wave genetic horizon is posted in described pastille pressure-sensitive adhesive layer outside, and ultrasound wave genetic horizon is connected with a ultrasonic output circuit.The ul-trasonic irradiation that ultrasound wave genetic horizon sends, in described pastille pressure-sensitive adhesive layer, can improve pharmaceutically active, improve water activity promotion drug absorption in skin.
The acoustic pressure that ultrasound wave produces simultaneously can act on pastille pressure-sensitive adhesive layer and skin, by acoustic pressure, impels drug absorption.
Described ultrasound wave genetic horizon can be arranged between described sealing coat and described pastille pressure-sensitive adhesive layer, also can be arranged between described electret layer and described sealing coat, or also can be arranged on described electret layer outside.
Described ultrasound wave genetic horizon adopts a piezoceramics layer.So that simplified structure and be beneficial to skin.
Described electret nanoparticle transdermal drug delivery system also comprises a flexible substrate, and described reservoir devices patch is arranged on described flexible substrate, and the area of described flexible substrate is greater than described reservoir devices patch area; Described ultrasonic output circuit is arranged on the described flexible substrate of described reservoir devices patch avris.
Described ultrasonic output circuit is provided with a power interface, by described power interface, connects a power supply.The present invention is internal battery on electret nanoparticle transdermal drug delivery system not preferably, to avoid, because battery fluid is revealed, causes environmental pollution.
In described pastille pressure-sensitive adhesive layer, be also distributed with permanent magnet powder granule.Permanent magnet powder granule can adopt Ru-Fe-Mn permanent magnet powder granule.By magnetic field, molecular activity can be promoted, the activity of hydrone in human body can be promoted especially.
Reservoir devices patch of the present invention can avoid peroral dosage form to stimulate gastrointestinal, has also overcome the use inconvenience of other short infiltration methods, to defects such as drug molecule amount and polarity limit to some extent; Can reduce whole body blood drug level, improve local affected part drug level simultaneously; Adjustment by administration area can be controlled dosage, and medicine is with Zero order controlled releasing, 24 hours sustained release medicines, thus make curative effect long lasting and stable; Only need throw off patch gets final product interruption of the administration, easy to use.Electret can standby storage space electric charge and dipole electric charge, and its chemical stability is good, moisture resistant performance is good, surface point position is high, charge stability good, driving force meets the specific (special) requirements of Transdermal absorption by force, completely.The present invention adopts electret as the physical regulating factor, can be used as ion-drive source and provides electrostatic field and micro-electric current to skin, the electret state of regulation and control skin, electric structure and enhancing ionic drug Transdermal absorption.
Drug-supplying system of the present invention possesses that preparation method is simple, transdermal effect good, dose composition is controlled and the six large features such as slow release, good permeability,, convenient operation non-stimulated to skin.
Described electret layer can adopt the electret layer of non-porous formula.Can adopt the electret layer of porous type.
In described pastille pressure-sensitive adhesive layer, be provided with the substrate that contains medicine.Medicine is dispersed in substrate uniformly.The present invention goes for drug molecule amount from 1000 dalton to 30000 dalton, and lipophilic hydrophilic all can.
Described medicine can adopt molecular weight at the daltonian medicine of 1000 dalton to 30000.
Described medicine adopts liposomal encapsulated, and described medicine also can be prepared into carrier or solid lipid nanoparticle or microemulsion etc., is dispersed in described substrate.So that macromolecular drug can easily see through pastille pressure-sensitive adhesive layer.
Described substrate adopts water-free substrate, and described substrate comprises non-polar polymer and plasticizer.Moisture free substrate can improve the stability of medicine, and patch compliance is good, and adhesiveness is suitable.
In described pastille pressure-sensitive adhesive layer, be also provided with viscosifier, transdermal enhancer and the antioxidant being dispersed in described substrate.So that better collaborative urging oozed together.
Accompanying drawing explanation
Fig. 1 is part-structure schematic diagram of the present invention.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with concrete diagram, further set forth the present invention.
With reference to Fig. 1, electret nanoparticle transdermal drug delivery system, comprises a sealing coat 2, is arranged on the pastille pressure-sensitive adhesive layer 4 of sealing coat 2 inner sides, the outside of sealing coat 2 is provided with the electret layer 1 that an employing electret is made, and the inner side of pastille pressure-sensitive adhesive layer 4 is provided with a controlled release rete 5; By outer and interior electret layer 1, sealing coat 2, pastille pressure-sensitive adhesive layer 4 and the controlled release rete 5 of being placed with successively, form a reservoir devices patch; In pastille pressure-sensitive adhesive layer 4, be distributed with tourmaline powder particle 6.
Tourmaline is called again tourmaline, has following features:
(1) forever electrical: nanometer bioplast sub-surface has the little crystal grain of many permanent electrical bodies, has positive and negative electrode. improved pH value and the electrical conductivity of water, deflection alkalescence, the pH value of desirable healthy water is 7-8.Forever electrically produce a large amount of negative oxygen ions simultaneously.Anion is called again [vitamin of air], has the effect of balance the body ionic equilibrium, can make body and mind loosen, and activating cell improves the effects such as nature cure rate, and anion is the material that modern is indispensable.
(2) reactivity: due in water, produce a large amount of anion (OH)-, anion and hydrone (H2O)-combination formation hydroxyl ion water (H3O2)-, make water form small-micelle water, can obtain the active function at interface, oxygen in water >=6mg/L), human body substantially must be with the form of ion or its soluble complexes to the absorption of inorganic elements, and most research all shows that trace element and people's health, disease, longevity, beauty treatment etc. is closely related.In our Drinking Water, (especially in natural water) contains multi mineral inorganic elements, functional activation water is compared with light water, the multi mineral inorganic elements (comprising trace element) with higher concentration, as calcium, ferrum, zinc, selenium etc., thereby human body is being brought into play to better physiology and medical care effect.
(3) dwindle hydrone bundle: hydrone (H2O) is individualism not, its molecule can mutually combine, form molecular beam, molecular beam can improve the penetration of health, water clusters little (Hz≤100), make the enhancing of media physiological function, can increase in diet nutrient substance and mineral without plain dissolving, accelerate the decomposition of oil substances, be beneficial to and carry nutrient and inorganic elements ion to see through cell, garbage is discharged, thereby there is the alimentation of promotion, help digest excretion, strengthen metabolic effect.
(4) far infrared effect: detect through national authority mechanism, nanometer vigor can efficiently be launched the far infrared of needed by human body, and at 8-15 micron, its band emission rate is up to 88%, and it is the light of the life of human body that scientist names this wave band.Far infrared can be penetrated into health deep layer position, warm cell, and blood circulation promoting, makes metabolism smooth and easy.Tourmaline far infrared emissivity nearly 98%, numerical value is high compared with other mineral.
(5) contain effective trace mineral: tourmaline, as Ore in, contains various natural mineral matters, wherein has many mineral necessary with the mankind identical, and hardness of water is moderate, and 50-200mg/L(is in calcium carbonate).By the effect of weak current, mineral is easily absorbed, and is splendid mineral origin.
The feature of the tourmaline based on above, is blended in tourmaline powder particle 6 in pastille pressure-sensitive adhesive layer 4 in the present invention, has the blood circulation of human body of promotion, improves cytoactive, improves electret electric field, human body is carried out to the advantages such as mineral supplements.
A ultrasound wave genetic horizon is posted in pastille pressure-sensitive adhesive layer 4 outsides, and ultrasound wave genetic horizon is connected with a ultrasonic output circuit.The ul-trasonic irradiation that ultrasound wave genetic horizon sends, in pastille pressure-sensitive adhesive layer 4, can improve pharmaceutically active, improve water activity promotion drug absorption in skin.The acoustic pressure that ultrasound wave produces simultaneously can act on pastille pressure-sensitive adhesive layer 4 and skin, by acoustic pressure, impels drug absorption.
Ultrasound wave genetic horizon can be arranged between sealing coat 2 and pastille pressure-sensitive adhesive layer 4, also can be arranged between electret layer 1 and sealing coat 2, or also can be arranged on electret layer 1 outside.
Ultrasound wave genetic horizon adopts a piezoceramics layer 3.So that simplified structure and be beneficial to skin.
Electret nanoparticle transdermal drug delivery system also comprises a flexible substrate, and reservoir devices patch is arranged on flexible substrate, and the area of flexible substrate is greater than reservoir devices patch area; Ultrasonic output circuit is arranged on the flexible substrate of reservoir devices patch avris.
Ultrasonic output circuit is provided with a power interface, by power interface, connects a power supply.The present invention is internal battery on electret nanoparticle transdermal drug delivery system not preferably, to avoid, because battery fluid is revealed, causes environmental pollution.
In pastille pressure-sensitive adhesive layer 4, be also distributed with permanent magnet powder granule.Permanent magnet powder granule can adopt Ru-Fe-Mn permanent magnet powder granule.By magnetic field, molecular activity can be promoted, the activity of hydrone in human body can be promoted especially.
Reservoir devices patch of the present invention can avoid peroral dosage form to stimulate gastrointestinal, has also overcome the use inconvenience of other short infiltration methods, to defects such as drug molecule amount and polarity limit to some extent; Can reduce whole body blood drug level, improve local affected part drug level simultaneously; Adjustment by administration area can be controlled dosage, and medicine is with Zero order controlled releasing, 24 hours sustained release medicines, thus make curative effect long lasting and stable; Only need throw off patch gets final product interruption of the administration, easy to use.Electret can standby storage space electric charge and dipole electric charge, and its chemical stability is good, moisture resistant performance is good, surface point position is high, charge stability good, driving force meets the specific (special) requirements of Transdermal absorption by force, completely.The present invention adopts electret as the physical regulating factor, can be used as ion-drive source and provides electrostatic field and micro-electric current to skin, the electret state of regulation and control skin, electric structure and enhancing ionic drug Transdermal absorption.
Drug-supplying system of the present invention possesses that preparation method is simple, transdermal effect good, dose composition is controlled and the six large features such as slow release, good permeability,, convenient operation non-stimulated to skin.Electret layer 1 can adopt the electret layer 1 of non-porous formula.Can adopt the electret layer 1 of porous type.
In pastille pressure-sensitive adhesive layer 4, be provided with the substrate that contains medicine.Medicine is dispersed in substrate uniformly.The present invention goes for drug molecule amount from 1000 dalton to 30000 dalton, and lipophilic hydrophilic all can.Medicine can adopt molecular weight at the daltonian medicine of 1000 dalton to 30000.Medicine adopts liposomal encapsulated, and medicine also can be prepared into carrier or solid lipid nanoparticle or microemulsion etc., is dispersed in substrate.So that macromolecular drug can easily see through pastille pressure-sensitive adhesive layer 4.
Substrate adopts water-free substrate, and substrate comprises non-polar polymer and plasticizer.Moisture free substrate can improve the stability of medicine, and patch compliance is good, and adhesiveness is suitable.In pastille pressure-sensitive adhesive layer 4, be also provided with the viscosifier, transdermal enhancer and the antioxidant that are dispersed in substrate.So that better collaborative urging oozed together.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (9)
1. electret nanoparticle transdermal drug delivery system, comprise a sealing coat, be arranged on the pastille pressure-sensitive adhesive layer of described sealing coat inner side, it is characterized in that, the outside of described sealing coat is provided with the electret layer that an employing electret is made, and the inner side of described pastille pressure-sensitive adhesive layer is provided with a controlled release rete;
By outer and interior described electret layer, described sealing coat, described pastille pressure-sensitive adhesive layer and the described controlled release rete of being placed with successively, form a reservoir devices patch;
In described pastille pressure-sensitive adhesive layer, be distributed with tourmaline powder particle.
2. electret nanoparticle transdermal drug delivery system according to claim 1, is characterized in that, a ultrasound wave genetic horizon is posted in described pastille pressure-sensitive adhesive layer outside, and ultrasound wave genetic horizon is connected with a ultrasonic output circuit.
3. electret nanoparticle transdermal drug delivery system according to claim 2, is characterized in that, described ultrasound wave genetic horizon is arranged between described sealing coat and described pastille pressure-sensitive adhesive layer.
4. electret nanoparticle transdermal drug delivery system according to claim 2, is characterized in that, described ultrasound wave genetic horizon is arranged between described electret layer and described sealing coat.
5. electret nanoparticle transdermal drug delivery system according to claim 2, is characterized in that, described ultrasound wave genetic horizon is arranged on described electret layer outside.
6. according to the electret nanoparticle transdermal drug delivery system described in claim 2,3,4 or 5, it is characterized in that, described ultrasound wave genetic horizon adopts a piezoceramics layer.
7. electret nanoparticle transdermal drug delivery system according to claim 6, it is characterized in that, described electret nanoparticle transdermal drug delivery system also comprises a flexible substrate, and described reservoir devices patch is arranged on described flexible substrate, and the area of described flexible substrate is greater than described reservoir devices patch area; Described ultrasonic output circuit is arranged on the described flexible substrate of described reservoir devices patch avris.
8. electret nanoparticle transdermal drug delivery system according to claim 7, it is characterized in that, described ultrasonic output circuit is provided with a power interface, by described power interface, connect a power supply, internal battery on electret nanoparticle transdermal drug delivery system, does not cause environmental pollution to avoid because battery fluid is revealed.
9. electret nanoparticle transdermal drug delivery system according to claim 7, is characterized in that, in described pastille pressure-sensitive adhesive layer, is also distributed with permanent magnet powder granule.
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| CN201210580810.XA CN103505806B (en) | 2012-12-27 | 2012-12-27 | electret nanoparticle transdermal drug delivery system |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816442A (en) * | 2016-01-05 | 2016-08-03 | 中国人民解放军第二军医大学 | 5-fluorouracil nanoparticle transdermal drug delivery electret preparation for treating hypertrophic scars based on action of electric field |
| CN105816443A (en) * | 2016-01-05 | 2016-08-03 | 中国人民解放军第二军医大学 | GLP-1 sustained-release electret transdermal drug delivery system for treating diabetes |
| CN106074460A (en) * | 2016-07-12 | 2016-11-09 | 中国人民解放军第二军医大学 | A kind of electret and the Percutaneously administrable preparation of 5 fluorouracil associating Inhibiting proliferation cicatrix growth |
| TWI767024B (en) * | 2017-06-30 | 2022-06-11 | 南韓商愛茉莉太平洋股份有限公司 | Ultrasonic cosmetic device using nonconductive materials and manufacturing method of ultrasonic wave transmission |
| CN117462836A (en) * | 2023-12-26 | 2024-01-30 | 山东百多安医疗器械股份有限公司 | Functionalized ultrasonic controlled-release puncture dressing patch and preparation method thereof |
| CN117462836B (en) * | 2023-12-26 | 2024-04-26 | 山东百多安医疗器械股份有限公司 | Functionalized ultrasonic controlled-release puncture dressing patch and preparation method thereof |
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| CN117462836A (en) * | 2023-12-26 | 2024-01-30 | 山东百多安医疗器械股份有限公司 | Functionalized ultrasonic controlled-release puncture dressing patch and preparation method thereof |
| CN117462836B (en) * | 2023-12-26 | 2024-04-26 | 山东百多安医疗器械股份有限公司 | Functionalized ultrasonic controlled-release puncture dressing patch and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103505806B (en) | 2016-04-06 |
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