CN101129808A

CN101129808A - Externally used medicament for treating facial palsy and method of producing the same

Info

Publication number: CN101129808A
Application number: CNA2007100550942A
Authority: CN
Inventors: 李现杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2007-09-03
Filing date: 2007-09-03
Publication date: 2008-02-27
Anticipated expiration: 2027-09-03
Also published as: CN100558391C

Abstract

The invention discloses an externally-applied medicinal plaster for treating facial paralysis, which is prepared from Chinese herbs including gastrodia tuber, dahurian angelica root, ledebouriella root, seed of nuxvomica, hair, pricklyash peel, prepared aconite root, Chinese honey locust, Ligusticum wallichii, scorpion, centipede, magnetite, frankincense, myrrh, menthol, boneol, yellow lead and and plant oil through cleaning, disintegrating, extracting, making grease and tabletting.

Description

A kind of external used medicine for the treatment of facial paralysis and preparation method thereof

The present invention relates to the pharmaceutical industries that a kind of percutaneous dosing improves all kinds of facial neuritises or the agent of prosopoplegic external patch.Medicine oil and the pitchy plaster of Plumbum preparatium after specifically getting raw material of Chinese medicine and remove slag through the high temperature refining so that plant is fried, again with a certain proportion of fine drug powder mixing after extruding, cutting be placed on and mount the external patch agent of making on the backing material.Spread on skin of face, penetrate absorption by meridians conduction, skin and bring into play the function that dispelling wind and removing obstruction in the collateral, nourshing blood and promoting blood circulation, the QI invigorating of medicine are set upright, the meridians that alleviation causes because of venation inanition, wind and cold invasion and attack, QI and blood retardance lose supports, and muscle is not received, the facial paralysis rehabilitation of facial hemiparalysis.Advantages such as it is quick to have effect, and curative effect is sure, and is easy to use are welcome by numerous labouring people deeply.

The objective of the invention is at because of the venation inanition, the wind and cold invasion and attack so that through vapour lock stagnate, stagnate meridians that passages through which vital energy circulates causes of disharmony between QI and blood, the stasis of blood lose and support, muscle is vertical does not slowly receive a kind of percutaneous dosing patch agent that the ill crowd of the facial paralysis of facial hemiparalysis provides.The patch therapy is paid attention to by ancient Chinese medicine doctor, it is the great treasure-house of Chinese traditional medical science, because its easy, easy, effective, economic dispatch characteristics enjoy the welcome of doctor, trouble two families at all times, also be simultaneously that current therapy can not the scarce important component part in territory.Medical circle generally believes, plaster pastes can " rule all kinds of diseases and ailments ", is usually used in traditional Chinese medical science Ge Ke such as inside and outside, woman, youngster, skin, face clinically, established the rationale of " reason of treatment by oral administration of medicines is the reason of external treatment ".The famous external treatment expert of Qing Dynasty Wu Shangxian doctor widely collects forefathers' plaster essence, in conjunction with the practice of oneself, proposes the therapeutical effect that external treatment plaster and oral medicine have " that reaches the same goal by different routes is wonderful ".

The plaster treatment disease is a kind of approach of percutaneous dosing, he utilizes medicine to impose on a certain position of body appearance or partial effect, thereby penetrate absorption approach by meridians conduction and skin and reach therapeutic effect, its advantage is to have reduced the load of Liver and kidney internal organs and medicine to gastral zest, and old man and child's medication difficulty or be reluctant the pill taker.External treatment with Chinese medicine is learned and is thought that clinical treating disease is not really wanted to cooperate oral medicine to improve curative effect, and only both can be reached ideal therapeutic purposes with external treatment.Facial paralysis claims face nerve inflammation or idiopathic facial palsy again, is mostly that the neural nonspecific inflammation in a side causes the paralysis of facial muscle completeness.Face paralysis is because of a lot, and Most patients is to invade face because of the heresy of wind and cold, and promptly face was subjected to cold stimulation for a long time, and it is obstructed to cause facial meridian qi and blood to organize, nervus facialis is benumbed because of ischemia, is subjected to the facial expression muscle of nervus facialis domination dysfunction to occur because of undernutrition, causes facial paralysis.It is stiff to show as a side surface part, the strong side of bicker deflection, and eyes do not close, and face's one side is lax, and sialorrhea drops tears, and eyebrow can not lifted, pain etc. behind the ear.Because facial paralysis patient's eyes closed is incomplete, cornea exposes for a long time when sleep, just bitot's patches can take place, and causes ocular infection, the damage vision.Facial paralysis is mainly in winter-spring season, but summer, the patient increased year by year in recent years, and in the majority with youngster, and main cause is exactly because greedy cool.The summer weather sweltering heat, perspiring increases, and the pore of whole body is in open state, causes spasm easily after facial peripheral nerve blood vessel is subjected to cold stimulation, disturbance of blood circulation occurs, causes facial paralysis.The sickness rate of youngster facial paralysis is high, is mostly that figure is pleasantly cool not note mode, turns on the aircondition for a long time, temperature was set low, the big environment of temperature contrast of perhaps coming in and going out in the short time, in addition, motion back dripping sweat all is the common cause that causes facial paralysis facing to air-conditioning, the direct blowing of electric fan.Because facial paralysis directly has influence on appearance and life, the patient must treat, and based on local patholoic change, therefore, facial paralysis external patch of the present invention is reasonable in design, the research foundation is abundant.But traditional external patch preparation inconvenience, active ingredient is few, and drug effect is slow, easily pollutes clothes and skin, and it is poor to take off pulling property, defectives such as lead ion content height, the market share of having checked this external use plaster makes people have to select oral medicine to be treated.

Facial paralysis patch of the present invention is made from the side of choosing to product, based on the understanding mechanism of the traditional Chinese medical science to facial paralysis, based on crude drug, violent medicine, incense drug, makes it " lead group medicine, relieving accumulation of pathogens is capable to stagnate, through its institute " in the side.But Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Typhonii expelling wind and cold in the side increase tissue metabolism; But Scolopendra, Scorpio, Rhizoma Gastrodiae, Semen Strychni dispelling wind and removing obstruction in the collateral are accelerated the meridian qi and blood operation; But Rhizoma Chuanxiong, Olibanum, Myrrha nourshing blood and promoting blood circulation wind dispelling, all medicines share, and can get the evil eutopic reduction that goes, and wind and cold must remove, and meridians must be supported, and blood vessels smoothness, facial paralysis are more.Add new and effective Percutaneous absorption enhancer of azone and biological magnetic therapy technology, have stronger surface activity, promote drug penetration through skin, improve clinical efficacy.

Another object of the present invention provides a kind of preparation method of facial paralysis patch.This product is at high temperature refined the plaster that forms with Plumbum preparatium with the fried material of getting it filled of plant after removing slag.It is qualified at first to press the prescription drug process of preparing Chinese medicine, and weighing is assorted, and Rhizoma Gastrodiae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, each 120 gram of Rhizoma Chuanxiong, Rhizoma Typhonii 100 grams and Olibanum, Myrrha, the Magnetitum powder that cleans is broken into impalpable powder, mixing for standby use; Secondly remaining Rhizoma Gastrodiae 30 grams, the Radix Angelicae Dahuricae 30 grams, Radix Saposhnikoviae 30 grams, Rhizoma Chuanxiong 20 grams, Rhizoma Typhonii 20 grams and Semen Strychni, Spina Gleditsiae, Pericarpium Zanthoxyli, hair, Scorpio, Scolopendra being got vegetable oil, to put in the iron pan heating fried withered, drags for except that residue, and get oil and filter, both be medicine oil; Its three, medicine oil is continued heating tempers, burning things which may cause a fire disaster is closed and withdrawn to oily temperature control in case catch fire, at 180～220 ℃, adds Plumbum preparatium and stir evenly to " dripping into pearl " and be degree, tack-free the getting final product of tearing; Its four, treat that the oil pill paste temperature is reduced to 150 ℃ after, get standby fine drug powder and Mentholum, Borneolum Syntheticum and add in the oil pill paste and stir, observe fine drug powder and become pitchy degree of being by yellowish-brown, soaked 30 minutes in the impouring cold water slowly while hot, take out and extract moisture content; Its five, machine on the oil pill paste that had soaked is made tablet by standard-required, be placed on and mount on the backing material, the packing, promptly.

Facial paralysis patch of the present invention has no side effect through the animal toxicology evidence.Acute oral toxicity test: these product are by Ministry of Public Health " cosmetics health standard " (version in 2002) " test method(s) of once limiting the quantity of in the acute oral toxicity test ", one time per os gives Kunming mouse, body weight 18g～22g, 20, irritate stomach dosage 5000mg/kg body weight, irritate stomach amount 20ml/kg, observed 14 days, experimental animal is not found poisoning manifestations, is not had death, puts to death the back and dissects obviously unusually, judges that these product are to the nontoxic level in the true border of chmice acute per os toxicity.The acute dermal toxicity test: these product are according to Ministry of Public Health " cosmetics health standard " (2002) second portion " acute dermal toxicity test " test method(s) of once limiting the quantity of, 20 of SD rats, male and female half and half, body weight 200g～300g, one time percutaneous is smeared 5000mg/kg body weight dosage, observes 14 days, does not find obvious poisoning symptom, does not have death, animal gross anatomy no abnormality seen judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.Acute skin irritation test: these product are according to 6.3 joints in Ministry of Public Health " cosmetics health standard " (2002) second portions " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, getting these product 0.5g directly spreads upon on the skin of animal left side (opposite side in contrast), adopt blocking test, 4 hours application time, after the off-test with the residual thing that tried of warm water washing, in remove tried thing after 1h, 24h, 48h and 72h observe animal respectively and are tried to distinguish dermoreaction with the check plot, the top average is " 0 ", judges that these product are to the animal skin nonirritant.

Facial paralysis patch of the present invention is to the 67 routine patients observation of providing follow-up care for a patient, and wherein sicken age was at 1 month to 2 years, and be 3 days one service time of pasting to administration time to half a year in 15 days.The result cures 21 examples, accounts for 30.9%, and produce effects 19 examples account for 27.9%, and effective 25 examples account for 36.8%, and invalid 3 examples account for 4.4%, and total effective rate reaches 95.6%.Therefore, this product is with topical, and is easy to use, lasting medicine, and curative effect is obvious, and toxic and side effects is little, has outstanding creativeness and advanced, and potentiality to be exploited is huge, and economic benefit and social benefit are considerable.

Claims

1. external used medicine for the treatment of facial paralysis is characterized in that it is the external patch agent of being made by following herbal raw material proportioning:

The Rhizoma Gastrodiae 150 gram Radixs Angelicae Dahuricae 150 gram Radix Saposhnikoviaes 150 KEMA Semen Strychni 20 grams

Hair 5 gram Pericarpium Zanthoxylies 10 gram Rhizoma Typhoniis 120 gram Spina Gleditsiaes 10 grams

5 Magnetitums of Rhizoma Chuanxiong 140 gram Scorpio, 10 gram Scolopendras, 5 grams

Olibanum 15 gram Myrrhas 15 gram Mentholums 5 gram Borneolum Syntheticums 15 grams

Plumbum preparatium 500 gram vegetable oil 1000 grams.

2. a kind of external used medicine for the treatment of facial paralysis according to claim 1 is characterized in that said dosage form is the external patch agent of percutaneous dosing.

3. the preparation method of the external used medicine of a treatment facial paralysis for preparing aforesaid right requirement 1 or 2, it is characterized in that earlier Rhizoma Gastrodiae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, each 120 gram of Rhizoma Chuanxiong, Rhizoma Typhonii 100 grams and Olibanum, Myrrha, the Magnetitum powder that cleans being broken into impalpable powder, mixing for standby use; Secondly remaining Rhizoma Gastrodiae 30 grams, the Radix Angelicae Dahuricae 30 grams, Radix Saposhnikoviae 30 grams, Rhizoma Chuanxiong 20 grams, Rhizoma Typhonii 20 grams and Semen Strychni, Spina Gleditsiae, Pericarpium Zanthoxyli, hair, Scorpio, Scolopendra being got vegetable oil, to put in the iron pan heating fried withered, drags for except that residue, and get oil and filter, both be medicine oil; Its three, medicine oil is continued heating tempers, burning things which may cause a fire disaster is closed and withdrawn to oily temperature control in case catch fire, at 180～220 ℃, adds Plumbum preparatium and stir evenly to " dripping into pearl " and be degree, tack-free the getting final product of tearing; Its four, treat that the oil pill paste temperature is reduced to 150 ℃ after, get standby fine drug powder and Mentholum, Borneolum Syntheticum and add in the oil pill paste and stir, observe fine drug powder and become pitchy degree of being by yellowish-brown, soaked 30 minutes in the impouring cold water slowly while hot, take out and extract moisture content; Its five, machine on the oil pill paste that had soaked is made tablet by standard-required, be placed on and mount on the backing material, the packing, promptly.