CN1233331C - Medicine for curing epilepsy by adopting head osmotic therapy - Google Patents

Abstract

The present invention relates to a medicine for treating epilepsy by head skin or acupuncture point permeation and the assistance of a proper quantity of oral administration medicines, and the medicine is developed according to the treating principle of a close choosing method of treating the brain disease cause from the brain. The medicine is made according to the basic prescription of the traditional Chinese medicines, such as pinellia tuber, bile arisaema, magnet, alum, scorpion, etc., by scientific processing. The whole prescription has the effects of sweeping the phlegm, perfusing the orifices, arresting the epilepsy by calming endogenous wind, eliminating the spasm for calming the mentality and promoting blood circulation to remove meridian obstruction. The present invention has an excellent effect on the aspect of treating epilepsy.

Description

With the head osmotherapy is the medicine of main treatment epilepsy

Content of the present invention belongs to the fabricating technology field of medicine, relates generally to the medicine of the treatment epilepsy that the pure Chinese medicine of a kind of usefulness makes.

Epilepsy is commonly called as " epilepsy ", it is the disease of the unusual over-discharge of a kind of cerebral neuron, clinical constitutional and the Secondary cases two big classes of being divided into, often cry when patient shows effect and faint on ground along with unexpected one, be accompanied by looking on the tic of the limbs, two, symptoms such as mandibular joint is tightly stung, lip salivation, urinary incontinence, but if the back daily life of waking up is all ordinary person.About the pathology cause of disease of epileptics, Chinese and western medicine theory has the common recognition of reaching the same goal by different routes.Doctor trained in Western medicine thinks that epilepsy causes that by brain birth defect, craniocerebral injury, the cerebral tumor, cerebrovascular disease, brain parasite, brain infection disease, brain degenerative disease etc. local cicatrix of brain and brain atrophy etc. cause; Motherland's traditional medicine is thought: epilepsy by, whenever by knot, disorder of emotion in the sputum, or intemperance of taking food, excessive fatigue, liver-wind are held the expectorant superinverse under the arm, stop up the amenorrhea network, are blocked clear key, so that break out.Because epileptics belongs to neural obstinate obstinate disease, very easily jeopardize patient's life, thereby epilepsy is arranged and do not control that fruit is difficult behind the person expects.Traditional doctor trained in Western medicine that is used for the treatment of epileptics medicine commonly used mainly contains phenobarbital, phenytoin Sodium, trimethadione etc., and traditional Chinese medical science medicine commonly used mainly contains decides epilepsy analgesia mixture, day anti-epilepsy sheet of Hu etc., and its route of administration is for oral administration or intramuscular injection.Above-mentioned traditional therapy has three big deficiencies in practical clinical: the one, and traditional therapeutic modality makes a large amount of Chinese medicine and western medicine flood irrigation whole bodies, so that arrive that old complaint---the medicine at brain position is few, and most of drug wastage is in other the anosis at all organ-tissue except that brain, cause the significant wastage of medicine, therefore producing little effect of traditional remedies causes very most epilepsy patient cannot be cured all one's life; The 2nd, traditional administering mode is owing to the deactivation of medicine through liver, and valid density is difficult in its blood estimates; The 3rd, above-mentioned traditional medication generally all has certain toxic and side effects to human body, in the time of with its treatment or Taking Control of Epilepsy disease, often may cause other disease because of its toxic and side effects, patient's old complaint is not eliminated and adds new disease.

Main purpose of the present invention is that at the aforementioned existing in prior technology weak point in this area providing a kind of serves as the main special-purpose medicine of realizing the effect of treatment epilepsy with skin of head or acupuncture point osmotherapy.

The preparation scheme of medicine of the present invention comes from motherland's medical science about traditional determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs thoughts such as " inner disease outer treat ", " treatment must aim at the pathogenesis of disease ", and it is that the designer obtains by concentrated summary development according to clinical practice for many years and on modern pharmacology scientific experiments basis.Epilepsy belongs to spirit in modern medicine, nervous system disease, its diseased region is unquestionable at brain, for this reason, designer of the present invention is off the beaten track, the proximal selection of points Therapeutic Principle of " old complaint is at brain; cure from brain " has been proposed, when the traditional remedies strong point is drawn in research, a kind of prescription science is developed in summary, easy to prepare, the special-purpose medicine of unique therapy for treating epilepsy of Tong Guo skin of head that has no side effect or acupuncture point infiltration, during clinical treatment, be used for the infiltration of patient's head based on this special-purpose medicine, and to be equipped with an amount of oral medicine be adjuvant drug, it is main using this head drug osmotic, oral medication is existing the radicallying reform of unique therapeutic modality of assisting, dig radical cure originally, come straight to the point, beating Serpentis takes the lead, the length of catching bandits first catch the ringleader, can reduce the loss (flood irrigation whole body) of medicine again to greatest extent, the waste of liver deactivation and the harm of toxic and side effects, the valid density that makes medicine go into patient's diseased region increases, and imitates merit doubly with patent medicine half.According to above-mentioned Therapeutic Principle and cooperate its therapy, drug effects that designer of the present invention is more selected are concentrated and easily be the Chinese medicine medication preparation Cheng Fang that absorption is infiltrated at skin of head or acupuncture point, side's Chinese medicine is made up of with principal agent and two groups of medicines of accessory drugs for oral use the head infiltration, and said head infiltration is processed by the medicine material Rhizoma Pinelliae, Arisaema Cum Bile, Scolopendra, Scorpio, Magnetitum, Cinnabaris, Alumen, Radix Curcumae with principal agent; Said accessory drugs for oral use is processed by medicine material Magnetitum, Alumen, Poria, the Rhizoma Pinelliae, Caulis Bambusae In Taenia, Pericarpium Citri Reticulatae, Radix Polygalae, Rhizoma Acori Graminei, Radix Glycyrrhizae.Whole pharmaceutical formulation of the present invention has eliminating phlegm inducing resuscitation, endogenous wind stopping and decides that epilepsy, relieving convulsion are allayed excitement, the effect of promoting blood circulation to remove obstruction in the collateral, aspect the treatment of epilepsy class sacred disease and prevention, having fabulous effect, can significantly reduce or eliminate the threat of epilepsy to health of people.

The infiltration of preparation head with each medicine material and the proportioning value thereof of principal agent is: 4～12 unit of weights of the Rhizoma Pinelliae, 3～9 unit of weights of Arisaema Cum Bile, 1～3 unit of weight of Scolopendra, 2～6 unit of weights of Scorpio, 5～20 unit of weights of Magnetitum, 0.3～1 unit of weight of Cinnabaris, 6～30 unit of weights of Alumen, 3～9 unit of weights of Radix Curcumae; Each medicine material and the proportioning value thereof that prepare accessory drugs for oral use are: 5～20 unit of weights of Magnetitum, 6～20 unit of weights of Poria, 6～10 unit of weights of the Rhizoma Pinelliae, 6～30 unit of weights of Alumen, 6～12 unit of weights of Caulis Bambusae In Taenia, 6～20 unit of weights of Pericarpium Citri Reticulatae, 3～12 unit of weights of Radix Polygalae, 4～12 unit of weights of Rhizoma Acori Graminei, 2～6 unit of weights of Radix Glycyrrhizae.

Use in the drug ratio of principal agent the Rhizoma Pinelliae, Arisaema Cum Bile, Alumen energy drying dampness to eliminate phlegm in head infiltration of the present invention; Scorpio, the kind relieving spasm by calming endogenous wind of Scolopendra; Magnetitum, tranquilizing cinnabar is relieving convulsion; The Radix Curcumae circulation of qi promoting, invigorate blood circulation, resolving depression, have one's ideas straightened out.In the pharmaceutical formulation of accessory drugs for oral use of the present invention, Poria eliminating dampness by diuresis spleen invigorating, reduce phlegm and allay excitement; Rhizoma Pinelliae normalizing the stomach by guiding QI downward, and Alumen drying dampness to eliminate phlegm; Caulis Bambusae In Taenia removing heat-phlegm, preventing or arresting vomiting relieving restlessness; The Pericarpium Citri Reticulatae expectorant of regulating the flow of vital energy makes expectorant with under the gas; Radix Polygalae, Rhizoma Acori Graminei are allayed excitement, reduce phlegm, are had one's ideas straightened out.Above-mentioned all medicines cooperate, and can receive the merit of tranquillizing the mind by relieving convulsion, dispersing the stagnated live-QI to relieve the stagnation of QI altogether, for controlling the efficacious prescriptions of epilepsy.

In concrete the enforcement, the head infiltration is made the powdered adhesive wafer that can be used for sticking and the two kinds of products of aqueous spray that can be used for sprayed coating with the pharmaceutical dosage form of principal agent, the pharmaceutical dosage form of accessory drugs for oral use is made capsule by the essential drugs proportioning.The head infiltration divides two kinds with the preparation method of principal agent and accessory drugs capsule for oral use: wherein the method for making of I capsule is that described 3/10ths of the drug ratio total amount of respectively organizing is ground into impalpable powder, again with the extract mixing of impalpable powder with residue Chinese medicine, incapsulate about 0.3 gram of every capsules medicated powder net weight; The method for making of II capsule is that the medicine pulverize separately becomes fine powder, sieves, mixing, the corresponding capsule of packing at last with respectively organizing of providing by described proportional quantity, and every capsules medicated powder net weight still is about 0.3 gram.Head infiltration with the preparation method of the aqueous spray of principal agent is: the medical material of described proportional quantity is added water to flood, with slow fire boiling, when treating that water evaporates surfaces medical material, add water logging and do not have medical material to fry in shallow oil again, decoct so repeatedly three times, each 1～1.5 hour time spent, collecting decoction filters, make filtrate being concentrated to have only four/for the moment, it is cold to dry in the air, and adds antiseptic at last, promptly makes the spray medicinal liquid.

Clinical case is observed and curative effect

1026 examples of clinical observation case once in development process of the present invention, patient age is between 1～68 years old.

One, administrated method: comprise with the skin of head permeation medication serving as that main holding concurrently is auxilliary therapy and serves as that main to hold concurrently with oral medication be two kinds of auxilliary therapys with the head acupoint permeation medication with oral medication.

1, serve as that main holding concurrently with oral medication is to assist therapy with the skin of head permeation medication: at first scalp is cleaned, dried; Separate hair, the sprayed coating of concentrated solution medicine spray is comprised volume the patient, the top, temporo, hindbrain and occipitalia are at interior whole cranium brains place, or 6 I number or the infiltrations of 15 II number portions are sprinkling upon with the medicated powder in the principal agent capsule on whole cranium brain skins of patient afterwards that reuse water squirts into pasty state with medicated powder, concentrated spray is sprayed on and will forms the gesture of dropping down under thicker medicinal liquid of one deck and the one-tenth on the scalp during drug of topical application, after medicine applies and finishes, the reuse plastic paper covers or puts on the medicated cap that is lined with plastic paper, in case moisture becomes dry in the medicine, make medicine keep moistening, sprayed coating or application time are at 16～20 hours every day, after medicine remains to certain hour, medicine on the head is cleaned, to next time again sprayed coating in kind or spread deposited, once-a-day, application continuously, 30 days is a course of treatment.When making the skin of head permeation medication, the patient also should day clothes 3 times I number capsule for oral use (each 2) or II number capsule for oral use (each 5).

2, with the head acupoint permeation medication serves as that main holding concurrently with oral medication is to assist therapy: according to the human anatomy theory, the all caves of cranium brain all have the nerve and the tremulous pulse that directly or indirectly lead to brain to distribute, and from science of acupuncture and moxibustion angle, the Naokong of head, the Benshen, Meichong, the contract arteries and veins, wind pond, Yamen, Naohu, Qianghian, the top, back, sinciput, Baihui, the Shenting, five places, Qubin, te 23, there is good effect at all acupuncture points such as ear and sacrum to the treatment epilepsy, for this reason, choose above-mentioned place of patient's head or many places so that all the acupuncture point (select the cave many more as the drug osmotic acupuncture point, drug of topical application effect is good more), elder generation's water is cleaned scalp during treatment, dry; The hair at place, separately selected acupuncture point at selected place, acupuncture point, or is sprinkling upon the sprayed coating of concentrated solution medicine spray selected acupuncture point with 6 I number or 15 II number portions infiltrations with the medicated powder in the principal agent capsule and locates, and water squirts into pasty state; During with concentrated solution medicine spray or capsule sprayed coating, the diameter of drug of topical application area will have 20mm at least on the acupuncture point, every place, after medicine applies and finishes, the reuse plastic paper covers or puts on the medicated cap that is lined with plastic paper, so that the medicine maintenance is moistening, sprayed coating or application time are at 16～20 hours every day, and once-a-day, 30 days is a course of treatment.When making the skin of head permeation medication, the patient also should day clothes 3 times I number capsule for oral use (each 2) or II number capsule for oral use (each 5).

3, the comparison of skin of head osmotic therapeutic method and head acupoint osmotic therapeutic method: scalp osmotherapy and head acupoint osmotherapy all can be received peculiar curative effect, be in the past the traditional treatment method far can not and.Curative effect as for the two compares, and designer's of the present invention practice cognition is: scalp drug of topical application area is big more, and the medicine that then infiltrates cerebral tissue is many more, so effect is also just good more; Again because the drug of topical application area of scalp drug of topical application osmotherapy greater than the drug of topical application area of head acupoint drug of topical application osmotherapy, thereby the former curative effect also is better than the latter's curative effect.Scalp drug osmotic therapy is because all want the drug of topical application to whole scalp, and is also that selected acupuncture point in the head acupoint osmotherapy is coated interior naturally, avoided selecting the drawback of cave difficulty, trouble, and had better effect, so first elect it.

Two, criterion of therapeutical effect: divide recovery from illness, produce effects, improvement and invalid four kinds.Wherein by this medicine of clinical usefulness after five courses of treatment the state of an illness do not recur, be that physical examination results such as CT and electroencephalogram are normal, epilepsy transference cure person is recovery from illness; Medication is after five courses of treatment that corresponding physical examination result is normal substantially, the most of disappearance person of epilepsy symptom is produce effects; The epilepsy symptom person of taking a favorable turn is for taking a turn for the better after medication five courses of treatment; And have no variation person for invalid with five of this therapies above epilepsy symptom course of treatment.

Three, observed result: 1026 case patients of this group are after treatment, and 679 examples of fully recovering account for 66.2% of total treatment case load, and produce effects 296 examples account for 28.8%, and 38 examples that take a turn for the better account for 3.7%, and invalid 13 examples account for 1.3%.

Claims (4)

1, a kind of is the medicine of main treatment epilepsy with the head osmotherapy, form with principal agent and two groups of medicines of accessory drugs for oral use by the head infiltration, it is characterized in that preparing the head infiltration with each medicine material and the proportioning value thereof of principal agent is: 4～12 unit of weights of the Rhizoma Pinelliae, 3～9 unit of weights of Arisaema Cum Bile, 1～3 unit of weight of Scolopendra, 2～6 unit of weights of Scorpio, 5～20 unit of weights of Magnetitum, 0.3～1 unit of weight of Cinnabaris, 6～30 unit of weights of Alumen, 3～9 unit of weights of Radix Curcumae; Each medicine material and the proportioning value thereof that prepare accessory drugs for oral use are: 5～20 unit of weights of Magnetitum, 6～20 unit of weights of Poria, 6～10 unit of weights of the Rhizoma Pinelliae, 6～30 unit of weights of Alumen, 6～12 unit of weights of Caulis Bambusae In Taenia, 6～20 unit of weights of Pericarpium Citri Reticulatae, 3～12 unit of weights of Radix Polygalae, 4～12 unit of weights of Rhizoma Acori Graminei, 2～6 unit of weights of Radix Glycyrrhizae.

2, the medicine of treatment epilepsy as claimed in claim 1, it is characterized in that said head infiltration is capsule with the pharmaceutical dosage form of principal agent and accessory drugs for oral use, the preparation method of this capsule is: described 3/10ths of the drug ratio total amount of respectively organizing is ground into impalpable powder, with the extract mixing of impalpable powder, incapsulate again with residue Chinese medicine.

3, the medicine of treatment epilepsy as claimed in claim 1, it is characterized in that the infiltration of said head is capsule with the pharmaceutical dosage form of principal agent and accessory drugs for oral use, the preparation method of this capsule is: will the medicine pulverize separately becomes fine powder, sieves, mixing, incapsulate by respectively organizing of providing of described proportional quantity.

4, the medicine of treatment epilepsy as claimed in claim 1, it is characterized in that said head infiltration is aqueous spray with the pharmaceutical dosage form of principal agent, the preparation method of this spray is: the medical material of described proportional quantity is added water to flood, with slow fire boiling, when treating that water evaporates surfaces medical material, adding water logging does not have medical material to fry in shallow oil again, decoct so repeatedly three times, each 1～1.5 hour time spent, collecting decoction filters, and it is cold to make filtrate being concentrated to have only dry in the air for four/a period of time, add antiseptic at last, promptly make the spray medicinal liquid.