CN108355065A - Plaster and preparation method thereof for treating rheumatism, osteoproliferation and the miscellaneous disease of internal medicine - Google Patents

Plaster and preparation method thereof for treating rheumatism, osteoproliferation and the miscellaneous disease of internal medicine Download PDF

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Publication number
CN108355065A
CN108355065A CN201810284262.3A CN201810284262A CN108355065A CN 108355065 A CN108355065 A CN 108355065A CN 201810284262 A CN201810284262 A CN 201810284262A CN 108355065 A CN108355065 A CN 108355065A
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weight
parts
plaster
osteoproliferation
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窦昭洋
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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Abstract

The present invention relates to a kind of plaster and preparation method thereof for treating rheumatism, osteoproliferation and the miscellaneous disease of internal medicine.Raw material includes Moschus, pangolin, Paris polyphylla, pilose antler, deer horn, deer's sinew, Yak Bone, hippocampus, donkey-hide gelatin, tortoiseshell, saussurea involucrata, agalloch eaglewood, Rhizoma Gastrodiae, long-noded pit viper, centipede, scorpio, stiff silkworm, leech, kylin dragon's blood, girald daphne bark, the rhizome of davallia, Radix Notoginseng, safflower, Cortex Eucommiae, teasel root, Sargent gloryvine, dark plum, berba aristolochiae mollissimae etc..Plaster of the present invention can effectively prevent acute and chronic rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, sciatica, lumbar muscle strain, Disc herniation caused by wind, cold, wet numbness, the diseases such as heavy tired, numb, movable unfavorable, neck rigidity of the pain caused by osteoproliferation, limbs；Also there is excellent prevention gout, trigeminal neuralgia, facial paralysis, dysmenorrhoea, irregular menstruation, the proliferation of mammary gland, prostatitis, bronchitis, flu, rhinitis, cerebral insufficiency, nervous headache, chronic gastritis, chronic enteritis and weakness of the spleen and the stomach and other effects.

Description

Plaster and preparation method thereof for treating rheumatism, osteoproliferation and the miscellaneous disease of internal medicine
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to one kind is for treating rheumatism, osteoproliferation and the miscellaneous disease of internal medicine Plaster and preparation method thereof.
Background technology
Rheumatism is one group of infringement joint, bone, muscle, blood vessel and in relation to the disease based on soft tissue or connective tissue, Morbidity is much more hidden and slow, and the course of disease is longer, and diagnosis and treatment acquire a certain degree of difficulty, and Symptoms are uncomfortable or disabled. For the symptom, most common therapy is treatment with western currently on the market；However, treatment with western side effect is big and sees Effect is slow, needs to alleviate the state of an illness up to even several years several months, drastically influences the normal life of people.
Osteoproliferation is a kind of common retrograde lesion of human body, which develops slowly, and performance symptom is in often gradual It aggravates.If arthralgia, numbness, swelling deformation, activity difficulty, function limitation occurs in patient, that is, form Hypertrophic When arthritis, just need to carry out positive treatment.The method of domestic treatment hyperostosis is substantially divided following several at present：1) straight Galvanic electricity drug iontophoresis, also referred to as physical therapy：Medicine ion mainly through skin sudoriferous duct mouth pore enter intradermal or transmucosal, Epithelial cell gap enters mucosal tissue, and physiologic therapy acts in addition to the function of current, mainly by the pharmacology of importing medicine ion Characteristic determines that galvanoiontophoresis method has given full play to the effect of drug；But it is liquid because importing drug, it is volatile, Drug effect is not lasting, limits the therapeutic effect of the method.2) ultraviolet therapy：Its therapeutic effect is mainly manifested in following side Face：(1) bactericidal effect；(2) antiinflammation；(3) analgesic effect；(4) promote wound healing effect；(5) desensitization；(6) promote Into the formation of vitamine D3；(7) body's immunity etc. is reconciled.3) massage and traction：Massage contributes to improvement local blood to follow Ring plays anti-inflammatory analgetic and is used as；Traction can mitigate the work that spur plays the compressing of local nerve, tissue respite pain With；Suitable for neck, lumbar hyperosteogency.However, massage and traction outer force effect completely, only treat part and are but neglected Depending on to integrally being adjusted in human body；Therefore, temporary analgesic effect can only be played, and cannot achieve the purpose that treatment.4) needle Moxibustion：Acupuncture clearing and activating the channels and collaterals and can have analgesic effect, can eliminate local oedema and inflammation, but for osteoproliferation, and acupuncture is only It can help out.5) western medicine：Doctor trained in Western medicine there is no effective medicine to this disease at present, frequently with anti symptom treatment, such as ache The medicine of some antipyretic-antalgics can be taken when pain；B family vitamin class drug can be selected in numb person；Arthroncus has hydrops, and person can give office Extract the therapies such as hydrops or partial closure in portion；But it facts have proved that these therapies are undesirable, only take stopgap measures without effecting a permanent cure, disease Feelings easily recur.6) operative treatment：Operative treatment is not the preferred therapy of osteoproliferation；When select expectant treatment invalid and the state of an illness compared with When again, seriously affecting minimal invasive treatment, it is contemplated that operative treatment.7) traditional Chinese medical herbal treatment：Since this disease belongs to frequently-occurring disease, common Disease, and Western medicine is without more satisfactory therapy, so recent year largely uses this disease of traditional Chinese medical herbal treatment, method is different, It is rich and varied, have made great progress, but still there are effects it is single, drug effect is insufficient the shortcomings of.
Therefore, there is an urgent need for the external used medicines of a kind of effective treatment rheumatism, osteoproliferation and the miscellaneous disease of internal medicine, to alleviate numerous patients Pain.
Invention content
For the defects in the prior art, the present invention is intended to provide one kind can be used in treat rheumatism, osteoproliferation with it is interior The plaster and preparation method thereof of the miscellaneous disease of section.Plaster provided by the invention can effectively prevent the various urgency caused by wind, cold, wet numbness Chronic rheumatoid, rheumatoid arthritis, scapulohumeral periarthritis, sciatica, lumbar muscle strain, Disc herniation, and because of osteoproliferation The symptoms such as heavy tired, numb, the movable unfavorable, neck rigidity of caused various pain, limbs；In addition, plaster of the present invention is also with excellent Different prevention gout, trigeminal neuralgia, facial paralysis, dysmenorrhoea, irregular menstruation, the proliferation of mammary gland, prostatitis, bronchitis, flu, nose The effect of inflammation, cerebral insufficiency, nervous headache, chronic gastritis, chronic enteritis and symptoms such as weakness of the spleen and the stomach.
For this purpose, the present invention provides the following technical solutions：
In a first aspect, the present invention provides a kind of Chinese medicine composition, raw material components include：Moschus, pangolin, Paris polyphylla, pilose antler, Deer horn, deer's sinew, Yak Bone, hippocampus, donkey-hide gelatin, tortoiseshell, saussurea involucrata, agalloch eaglewood, Rhizoma Gastrodiae, long-noded pit viper, centipede, scorpio, stiff silkworm, leech, Qi Unicorn dragon's blood, girald daphne bark, the rhizome of davallia, Radix Notoginseng, safflower, Cortex Eucommiae, teasel root, Sargent gloryvine, dark plum, berba aristolochiae mollissimae, lamiophlomis rotata, radix aconiti agrestis, monkshood, horse Qian Zi, Herba Lycopi, lycopodium calvatum, lopseed, semen brassicae, SEMEN SINAPIS ALBAE, Spiderflower Seed, radix scutellariae, radix tetrastigme, edible tulip, rhizoma atractylodis, the coptis, In Radix Isatidis, dandelion, Sculellaria barbata, Hedyotidis Diffusae, Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, folium artemisiae argyi, the stem of noble dendrobium, ganoderma lucidum, wild ginseng, cordyceps sinensis and asafoetide It is one or more.
Preferably, the raw material components of Chinese medicine composition by weight, including：5~20 parts by weight of Moschus, pangolin 5~ 20 parts by weight, 10~20 parts by weight of Paris polyphylla, 0.5~3 parts by weight of pilose antler, 2~10 parts by weight of deer horn, 1~5 parts by weight of deer's sinew, yak 5~10 parts by weight of ox bone, 5~10 parts by weight of hippocampus, 5~15 parts by weight of donkey-hide gelatin, 5~10 parts by weight of tortoiseshell, 2~10 weight of saussurea involucrata Part, 5~10 parts by weight of agalloch eaglewood, 3~9 parts by weight of Rhizoma Gastrodiae, 5~10 parts by weight of long-noded pit viper, 5~20 parts by weight of centipede, scorpio 5~20 Parts by weight, 5~20 parts by weight of stiff silkworm, 5~20 parts by weight of leech, 5~16 parts by weight of kylin dragon's blood, 5~20 parts by weight of the rhizome of davallia, 5~20 parts by weight of Radix Notoginseng, 5~18 parts by weight of safflower, 5~15 parts by weight of Cortex Eucommiae, 5~20 parts by weight of teasel root, 5~20 weight of Sargent gloryvine Part, 5~20 parts by weight of dark plum, 2~10 parts by weight of berba aristolochiae mollissimae, 5~20 parts by weight of lamiophlomis rotata, 3~8 parts by weight of radix aconiti agrestis, monkshood 1~ 5 parts by weight, 5~18 parts by weight of Herba Lycopi, 5~30 parts by weight of lycopodium calvatum, 5~18 parts by weight of lopseed, 5~20 weight of semen brassicae Part, 5~15 parts by weight of Spiderflower Seed, 5~20 parts by weight of radix scutellariae, 5~20 parts by weight of radix tetrastigme, 5~18 parts by weight of rhizoma atractylodis, the coptis 5~10 parts by weight, 5~20 parts by weight of Radix Isatidis, 5~20 parts by weight of dandelion, 5~20 parts by weight of Sculellaria barbata, Hedyotidis Diffusae 3~ 15 parts by weight, 5~20 parts by weight of Rhizoma Atractylodis Macrocephalae, 5~30 parts by weight of Radix Salviae Miltiorrhizae, 10~30 parts by weight of folium artemisiae argyi, 5~10 parts by weight of the stem of noble dendrobium, spirit 5~10 parts by weight of 2~10 parts by weight of sesame, 5~20 parts by weight of wild ginseng and cordyceps sinensis.
Preferably, the raw material components of Chinese medicine composition further include：1~5 parts by weight of vomiting nut, 5~20 parts by weight of girald daphne bark, 5~20 parts by weight of 5~20 parts by weight of SEMEN SINAPIS ALBAE, 5~20 parts by weight of edible tulip and asafoetide.
It should be noted that each bulk pharmaceutical chemicals for preparing Chinese medicine composition of the present invention are matched according to mass parts, producing When can according to corresponding ratio increase or reduce, as large-scale production can by kilogram or as unit of ton, small-scale production Can in grams, weight can increase or reduce, but the bulk pharmaceutical chemicals quality proportioning constant rate between each composition.
Using above-mentioned Chinese medicine composition protection scope of the present invention is also belonged to as drug made of active constituent.By will be above-mentioned Pharmaceutical composition is prepared after directly preparing or being added pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable Dosage form.Include by taking external preparation as an example：Solution, patch, vina, tincture, gelling agent, liniment, aerosol, spray, ointment Agent, suppository and plastics.The drug of above-mentioned various dosage forms can be prepared according to the conventional method of pharmaceutical field.
Second aspect, the present invention, which provides, a kind of pulling out wet plaster, the original of plaster for treating rheumatism, osteoproliferation and anti-inflammatory Material includes Chinese medicine composition and plaster substrate provided by the invention；Wherein, plaster substrate includes honey plaster substrate, medicine puree plaster It is one or more in the old plaster of matrix, medical pressure sensitive adhesive, alseodaphne hainanensis, magnetic moxibustion powder packet plaster and gel-type vehicle plaster.
The old preparation method of plaster of alseodaphne hainanensis includes：20 daytimes were immersed in sesame oil after 5000 parts of sesame oil and proportioned Chinese medicine are mixed Night, small fire are fried to extract medicine oil, pull residue, precipitation filtering out later；Medicine oil is subjected to oil refining tanning, gets 2500~2600 ready Red under part minium, then stirring is brewed into plaster.Honey plaster substrate is allocated using honey, vinegar, glycerine and vaseline etc.. In medical pressure sensitive adhesive, cross-linked type polyurethane pressure sensitive adhesive odorless, skin irritation are small, and adhesion strength is low, easily peelable, there is biodegradation Property, it is suitble to make sticking plaster etc.；The sweat-absorbing function that pressure sensitive adhesive has carried is made in the cooperations such as styrene rubber, stickup property and peeling Property.Gel-type vehicle plaster has many advantages, such as that drugloading rate is big, transdermal effect is good, good and nonirritant with skin-friendliness, is recognized For the new direction of transdermal delivery system development.
The third aspect, the present invention provide a kind of for treating the preparation side that wet plaster is pulled out in rheumatism, osteoproliferation and anti-inflammatory Method, including immersion, refinement, distillation, oil refining, it is lower it is red, release fire-toxin, dryness evil, unpacking and booth gone to apply；And specifically comprise the following steps： It impregnates：It is soaked in sesame oil after each raw material component of Chinese medicine composition is crushed, spring and summer five days, seven days autumn and winter；It refines：It will impregnate Product afterwards, which is boiled with slow boiling to medicine is withered and yellow, floats on pasta, and the removal dregs of a decoction are filtered from fire, during which uses five stirrings, and five packets Include peach, mulberry, Chinese scholartree, willow and elm branch；Distillation：Medicine oil after refinement is continued to refine using slow boiling, the filtering removal dregs of a decoction；Oil refining：It will Medicine oil after distillation tempers medicine oil to dropping into a bead shape with slow boiling；Lower pellet：Product after oil refining is heated to lower pellet with high heat, is waited for dense It uses slow boiling when cigarette emits most instead and continues stirring tanning to lotion color and luster darkly light tone, obtain boiled plaster；It releases fire-toxin：It will tanning Good plaster is soaked in water；Go dryness evil and unpacking：The plaster being soaked in water is dried in the shade, sealing preservation, unpacking is for use later；Beach It applies：After the plaster block water-bath that unpacking obtains is melted and stirred evenly, uniformly it is applied on plaster substrate, obtains for treating wind Wet plaster is pulled out in wet, osteoproliferation and anti-inflammatory.
It should be noted that the plaster of the present invention can also use other methods to prepare, such as：By each of Chinese medicine composition Raw material components are processed after crushing；Wild animal bone is put into 30 days in pot with the oil that smells good and is impregnated；It will after 30 days impregnate The animal oil period of the day from 11 a.m. to 1 p.m was in 120 DEG C of fryings 15 hours；Bone medicine oil is filtered, precipitates 7 days, is filtered sooner or later with crocus cloth daily primary.Will in Each raw material of drug composition, which is put into according to the ratio in animal oil, to be impregnated 20 days；Later by the drug period of the day from 11 a.m. to 1 p.m in 120 DEG C of fryings 15 hours；Filtering The dregs of a decoction take medicine oil, precipitate 7 days, are filtered sooner or later with crocus cloth daily primary；By medicine oil concentrated extract；The period of the day from 5 p.m. to 7 p.m carries out stir-bake to yellowish pellet, together When deep fat under red tanning, when tanning blow under cigarette agitation 400；10 days are impregnated at being put into after cream in the cold water that ice cube is added, one It changes 2 water, changes in water and constantly tears；2 meters of plaster embedment deep underground 15 days after full 10 sky and water are soaked, thoroughly to remove fire Poison；Chinese medicine is matched later, is put into marmite and is boiled, tanning every time boils 3 times for 2 hours, and 3 times decoction of medicinal ingredients small fires are boiled one day, It is condensed into decoction of medicinal ingredients lotion and dries in the shade into cream；Black lotion is put into low temperature in water-bath to melt, the condensed cream of decoction of medicinal ingredients is put into pot, then Chinese medicine is matched, Chinese medicine is subjected to stone mill grinding, sieving, medicinal powder reaches 200 mesh, medicinal powder is then added；Not by mixed plaster Disconnected stirring is carried out at the same time sharing, finally obtains plaster.
Fourth aspect, Chinese medicine composition provided by the invention are being prevented caused by wind, cold, wet numbness in various diseases drug Application.Wherein, disease specifically includes：Acute and chronic rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, sciatica, psoas labor Damage, Disc herniation, heavy tired, numb, the movable unfavorable, neck rigidity of the pain caused by osteoproliferation, limbs and gout, Trigeminal neuralgia, facial paralysis, dysmenorrhoea, irregular menstruation, the proliferation of mammary gland, prostatitis, bronchitis, flu, rhinitis, brain blood supply are not Foot, nervous headache, chronic gastritis, chronic enteritis and weakness of the spleen and the stomach.
In clinical application, semen brassicae, SEMEN SINAPIS ALBAE and Spiderflower Seed can will be reused in formula, there can be cold moxibustion to act on, it is such as straight Connect and stick site of disease, per note 15~24 hours, same position interval was pasted for 10 days again, is carefully taken off when taking off plaster, it is significant in efficacy and It is easy to use.
For acute and chronic rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, sciatica, lumbar muscle strain, gout, trident god Dysmenorrhoea, bronchitis, flu, rhinitis, cerebral insufficiency, nervous headache, chronic gastritis, chronic enteritis and weakness of the spleen and the stomach etc. Disease, plaster of the present invention have the effects that very strong detoxification, pull out wet, anti-inflammatory, pain of dispelling, adjust.During specifically sticking, about 5 hours It controls and skin irritation occurs, adhere to patch 15 hours or more enough, 20 hours or more more preferably, and the position of skin depth can paste 30 hours or more. If there is foaming phenomena, bubble is punctured into releasing venom, the skin after the one piece thick tissue-wrapped blistering of refolding with aseptic syringe needle Skin, to protect skin；Only, skin slowly forms a scab to fall off grows new skin to venom stream 3 days or so；Period pays attention to wrapping paper handkerchief protection Skin avoids staving with clothing friction.Plaster of the present invention includes sterilization material, and skin will not infect；And before malicious flow is to the greatest extent not It preferably tries out antiphlogistic or puts deposited emulsifiable paste on the skin, prevent venom from not flowing out.
The above technical solution of the present invention has the following advantages over the prior art：
(1) applicant has found by numerous studies：Plaster provided by the invention has nourishing the muscle and tendon honor arteries and veins, pulls out wet, promoting the circulation of qi by cold The effects that, Xiao Disorder dissipating binds of invigorating blood circulation, it can effectively prevent various acute and chronic rheumatism, rheumatoid joint caused by wind, cold, wet numbness Inflammation, scapulohumeral periarthritis, sciatica, lumbar muscle strain, Disc herniation, and the various pain caused by osteoproliferation, limbs are heavy The symptoms such as tired, numb, movable unfavorable, neck rigidity；In addition, plaster of the present invention also has excellent prevention gout, trigeminal neuralgia Bitterly, facial paralysis, dysmenorrhoea, irregular menstruation, the proliferation of mammary gland, prostatitis, bronchitis, flu, rhinitis, cerebral insufficiency, nerve The effect of headache, chronic gastritis, chronic enteritis and symptoms such as weakness of the spleen and the stomach.
(2) Chinese medicine composition provided by the invention selects the Chinese medicinal material containing active skull cap components, prescription proportioning section It learns, does not add any Western medicine hormonal components, safe without toxic side effect, when use is flexible and convenient, and it is miscellaneous can to improve more than 80 kinds of difficulty Disease and common disease more play significant role at aspect of preventiveing treatment of disease.In addition, plaster of the present invention avoids mouth as external used medicine Medication object is seriously born to caused by human body stomach；It realizes Alcholic disease by skin, and muscle depth can be penetrated to particular acupoint Layer carries out the anti-inflammatory of detoxification strength and lesion is melted into water, and formation bubble extraction in outside is external, extracts bubble skin and is limited only to epidermis Without regard to muscle deep layer, therefore skin heals preventing from scar quickly, is stimulated by foaming, certain enzyme activities in skin is activated to make The nerve endings of skin and specific receptor enter active state.So as to promoting neurohumor to adjust, reflectivity inhibits pathology Excitatory state enables disease to restore, and then reaches a kind of inner disease outer therapy for purpose of curing the disease.
(3) it can only be absorbed by skin compared to traditional plaster, but disease sites, often in muscle deep layer, the drug of absorption passes through It crosses the seldom part of blood absorption and can be only achieved affected part；And plaster of the present invention uses cold moxibustion therapy, it, will by stimulating local organization Drug has by stimulating skin penetration muscle deep layer and expands local vascular, promote blood circulation, improve surrounding tissue nutrition, Other drugs are sent into lesion depths while realizing detoxification effect, to reach the work for improving channels and collaterals, anti-inflammation and stopping pain and Zhi Gen With.
(4) nerve of hyperplasia and compressing is treated by performing the operation compared to doctor trained in Western medicine, can be more suffered tremendous loss in strength or resources based on operation, and The blocked qi and blood passages through which vital energy circulates of surrounding is not dredged still, and QI-blood circulation can be more unsmooth, cloudy evil a large amount of products further in vivo It is poly-.And exactly because healthy tendency is deficient, blood vessels smooth cannot be run, and can just form disease；And if healthy tendency is sufficient, blood vessels are smooth, It just not will produce disease centainly.And plaster of the present invention uses cold moxibustion therapy stimulation to pass through in the corresponding skin zone of body surface acupuncture points on the human body The conduction and adjustment of channels and collaterals correct the inclined Sheng of internal organs negative and positive or decline partially, and the operation for improving meridian qi and blood reaches the mesh for eliminating disease 's.Plaster of the present invention penetrates the skin of acupuncture points on the human body, and active ingredient is gone directly diseased region by blood circulation, extracts internal wet The object of some filths of the others such as gas, cold air, inflammation, achievees the purpose that remove vivotoxin.It is based on pulling out for vivotoxin Go out, the circulation loop of blood vessels can be gradually unobstructed；And once circuit is unobstructed, pain will slow down and eliminate, affected part discomfort will in It is rapid to eliminate, because plaster of the present invention is a kind of thorough therapy.
(5) plaster of the present invention has excellent channels and collaterals stimulation and immunoregulation effect；Specifically, channels and collaterals stimulation is made With：Plaster mainly makes the various nerve endings on site of action skin enter active state by drug, so as to improve organizer The functional activity of official.Immunoregulation effect：Macrophage phagocytic function is improved, E- red rose pigments rate and lymphocyte are increased The Immune Functions such as conversion ratio；Meanwhile eosinophil significantly reduces in blood, immunoglobulin and Complement C_3 Content declines, hence it is evident that inhibits the allergic state of body, to inhibit hyperfunction, can also make the function of decline excited and become To physiological equilibrium state.Therefore, plaster of the present invention forms optimal stimulation by cold moxibustion therapy to human body, big to building up health There is benifit, no matter sick body, being healthy and strong and can use, so the use scope of plaster of the present invention is very extensive.In addition, plaster of the present invention Viscera function can be enlivened, vigorous metabolism generates antibody and immunity, and it is happy to make one body and mind, energetic and internal The function of excretory system also has significant adjustment effect, the also immune effect of bidirectional modulation to exempt from so as to adjust with enhancing human body Epidemic disease function achievees the purpose that prevent and cure diseases.
(6) preparation method provided by the invention is used, the same of each bulk pharmaceutical chemicals active constituent can retained to greatest extent When, the active ingredient in each raw medicinal material can be fully released, to make the Chinese medicine composition being finally prepared not Only there is good drug effect, and be easy to absorb, and then be rapidly achieved the purpose for curing various diseases.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description Obviously, or practice through the invention is recognized.
Specific implementation mode
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer Illustrate technical scheme of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
Experimental method in following embodiments is unless otherwise specified conventional method.
Test material as used in the following examples is unless otherwise specified to be commercially available from conventional reagent shop.
Quantitative test in following embodiment, is respectively provided with three repeated experiments, and data are the average value of three repeated experiments Or mean+SD.
Moschus as used in the following examples, pangolin, Paris polyphylla, pilose antler, deer horn, deer's sinew, Yak Bone, hippocampus, donkey-hide gelatin, tortoise It is plate, saussurea involucrata, agalloch eaglewood, Rhizoma Gastrodiae, long-noded pit viper, centipede, scorpio, stiff silkworm, leech, kylin dragon's blood, girald daphne bark, the rhizome of davallia, Radix Notoginseng, red Flower, Cortex Eucommiae, teasel root, Sargent gloryvine, dark plum, berba aristolochiae mollissimae, lamiophlomis rotata, radix aconiti agrestis, monkshood, vomiting nut, Herba Lycopi, lycopodium calvatum, lopseed, sinapsis alba Son, SEMEN SINAPIS ALBAE, Spiderflower Seed, radix scutellariae, radix tetrastigme, edible tulip, rhizoma atractylodis, the coptis, Radix Isatidis, dandelion, Sculellaria barbata, long-noded pit viper Grass, Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, folium artemisiae argyi, the stem of noble dendrobium, ganoderma lucidum, wild ginseng, cordyceps sinensis and asafoetide are meeting Chinese Pharmacopoeia (version in 2017) one just Pertinent regulations under each medicinal material item of text.Before feeding intake, by identification, ingredients material object is consistent with title, and quality complies with standard.
It illustrates With reference to embodiment：
Embodiment one
The present embodiment provides a kind of wet plaster, including Chinese medicine composition are pulled out for treating rheumatism, osteoproliferation and anti-inflammatory And plaster substrate；Wherein, the raw material components of Chinese medicine composition by weight, including：20 parts by weight of Moschus, 5 weight of pangolin Part, 20 parts by weight of Paris polyphylla, 0.5 parts by weight of pilose antler, 10 parts by weight of deer horn, 1 parts by weight of deer's sinew, 10 parts by weight of Yak Bone, hippocampus 5~ 10 parts by weight, 5 parts by weight of donkey-hide gelatin, 10 parts by weight of tortoiseshell, 2 parts by weight of saussurea involucrata, 10 parts by weight of agalloch eaglewood, 3 parts by weight of Rhizoma Gastrodiae, long-noded pit viper 10 parts by weight, 5 parts by weight of centipede, 20 parts by weight of scorpio, 5 parts by weight of stiff silkworm, 20 parts by weight of leech, 5 parts by weight of kylin dragon's blood, bone 20 parts by weight of broken benefit, 5 parts by weight of Radix Notoginseng, 18 parts by weight of safflower, 5 parts by weight of Cortex Eucommiae, 20 parts by weight of teasel root, 5 parts by weight of Sargent gloryvine, crow 20 parts by weight of plum, 2 parts by weight of berba aristolochiae mollissimae, 20 parts by weight of lamiophlomis rotata, 3 parts by weight of radix aconiti agrestis, 5 parts by weight of monkshood, 5 parts by weight of Herba Lycopi, 30 parts by weight of lycopodium calvatum, 5 parts by weight of lopseed, 20 parts by weight of semen brassicae, 5 parts by weight of Spiderflower Seed, 20 parts by weight of radix scutellariae, three leaves Green 5 parts by weight, 18 parts by weight of rhizoma atractylodis, 5 parts by weight of the coptis, 20 parts by weight of Radix Isatidis, 5 parts by weight of dandelion, 20 weight of Sculellaria barbata Part, 3 parts by weight of Hedyotidis Diffusae, 20 parts by weight of Rhizoma Atractylodis Macrocephalae, 5 parts by weight of Radix Salviae Miltiorrhizae, 30 parts by weight of folium artemisiae argyi, 5~10 parts by weight of the stem of noble dendrobium, ganoderma lucidum 5 parts by weight of 2 parts by weight, 20 parts by weight of wild ginseng and cordyceps sinensis；Plaster substrate selects the old plaster of alseodaphne hainanensis.
The required plaster of the present invention is prepared using preparation method provided by the invention by above-mentioned raw materials component：
It impregnates：It is soaked in sesame oil after each raw material component of Chinese medicine composition is crushed, spring and summer five days, seven days autumn and winter；
It refines：Product after immersion slow boiling is boiled about 4 hours, five peach, mulberry, Chinese scholartree, willow, elm stirrings are used in combination, until medicine It is withered and yellow when floating on pasta, filter the removal dregs of a decoction from fire；
Distillation：Medicine oil after refinement is placed in again in refining container, continues to refine 1 hour using slow boiling, filtering removal The dregs of a decoction；
Oil refining：By in the medicine oil merging refining container after distillation, medicine oil is tempered to dropping into a bead shape with slow boiling；
Lower pellet：Product after oil refining is heated to lower pellet with high heat, five stirring 5~8 minutes clockwise are used in combination, wait for that dense smoke emits When to the greatest extent, uses slow boiling instead and continue stirring tanning to lotion color and luster darkly light tone, obtain boiled plaster；
It releases fire-toxin：Boiled plaster is poured into the well water got ready, impregnates 3~5 days, it is primary to change water daily；
Go dryness evil and unpacking：The plaster soaked is dried in the shade, is packed into terrine, tank mouth is sealed with beeswax, is embedded to shady and cool dry Locate 7~10 days or is put into cellar 15 days；Until identification of the plaster through character, smell, color and luster in terrine reaches requesting party and can use Go out and separately store, for use；
Beach：After the plaster block water-bath that unpacking obtains is melted and stirred evenly, uniformly it is applied on the old plaster substrate of alseodaphne hainanensis, It obtains pulling out wet plaster for treating rheumatism, osteoproliferation and anti-inflammatory.
Embodiment two
The present embodiment provides a kind of wet plaster, including Chinese medicine composition are pulled out for treating rheumatism, osteoproliferation and anti-inflammatory And plaster substrate；Wherein, the raw material components of Chinese medicine composition by weight, including：5 parts by weight of Moschus, 20 weight of pangolin Part, 10 parts by weight of Paris polyphylla, 3 parts by weight of pilose antler, 2 parts by weight of deer horn, 5 parts by weight of deer's sinew, 5 parts by weight of Yak Bone, hippocampus, donkey-hide gelatin 15 Parts by weight, 5 parts by weight of tortoiseshell, 10 parts by weight of saussurea involucrata, 5 parts by weight of agalloch eaglewood, 9 parts by weight of Rhizoma Gastrodiae, 5 parts by weight of long-noded pit viper, centipede 20 Parts by weight, 5 parts by weight of scorpio, 20 parts by weight of stiff silkworm, 5 parts by weight of leech, 16 parts by weight of kylin dragon's blood, 5 parts by weight of the rhizome of davallia, three 7 20 parts by weight, 15 parts by weight of Cortex Eucommiae, 5 parts by weight of teasel root, 20 parts by weight of Sargent gloryvine, 5 parts by weight of dark plum, seek bone at 5 parts by weight of safflower 10 parts by weight of wind, 5 parts by weight of lamiophlomis rotata, 8 parts by weight of radix aconiti agrestis, 1 parts by weight of monkshood, 18 parts by weight of Herba Lycopi, 5 parts by weight of lycopodium calvatum, 18 parts by weight of lopseed, 5 parts by weight of semen brassicae, 15 parts by weight of Spiderflower Seed, 5 parts by weight of radix scutellariae, 20 parts by weight of radix tetrastigme, rhizoma atractylodis 5 parts by weight, 10 parts by weight of the coptis, 5 parts by weight of Radix Isatidis, 20 parts by weight of dandelion, 5 parts by weight of Sculellaria barbata, 15 weight of Hedyotidis Diffusae Measure part, 5 parts by weight of Rhizoma Atractylodis Macrocephalae, 30 parts by weight of Radix Salviae Miltiorrhizae, 10 parts by weight of folium artemisiae argyi, the stem of noble dendrobium, 10 parts by weight of ganoderma lucidum, 5 parts by weight of wild ginseng and winter Worm summer 10 parts by weight of grass；Plaster substrate selects the old plaster of alseodaphne hainanensis.
The required plaster of the present invention is prepared using preparation method provided by the invention by above-mentioned raw materials component：
It impregnates：It is soaked in sesame oil after each raw material component of Chinese medicine composition is crushed, spring and summer five days, seven days autumn and winter；
It refines：Product after immersion slow boiling is boiled about 4 hours, five peach, mulberry, Chinese scholartree, willow, elm stirrings are used in combination, until medicine It is withered and yellow when floating on pasta, filter the removal dregs of a decoction from fire；
Distillation：Medicine oil after refinement is placed in again in refining container, continues to refine 1 hour using slow boiling, filtering removal The dregs of a decoction；
Oil refining：By in the medicine oil merging refining container after distillation, medicine oil is tempered to dropping into a bead shape with slow boiling；
Lower pellet：Product after oil refining is heated to lower pellet with high heat, five stirring 5~8 minutes clockwise are used in combination, wait for that dense smoke emits When to the greatest extent, uses slow boiling instead and continue stirring tanning to lotion color and luster darkly light tone, obtain boiled plaster；
It releases fire-toxin：Boiled plaster is poured into the well water got ready, impregnates 3~5 days, it is primary to change water daily；
Go dryness evil and unpacking：The plaster soaked is dried in the shade, is packed into terrine, tank mouth is sealed with beeswax, is embedded to shady and cool dry Locate 7~10 days or is put into cellar 15 days；Until identification of the plaster through character, smell, color and luster in terrine reaches requesting party and can use Go out and separately store, for use；
Beach：After the plaster block water-bath that unpacking obtains is melted and stirred evenly, uniformly it is applied on the old plaster substrate of alseodaphne hainanensis, It obtains pulling out wet plaster for treating rheumatism, osteoproliferation and anti-inflammatory.
Embodiment three
The present embodiment is arranged on the basis of embodiment one.
The present embodiment provides a kind of wet plaster, including Chinese medicine composition are pulled out for treating rheumatism, osteoproliferation and anti-inflammatory And plaster substrate；Wherein, the raw material components of Chinese medicine composition by weight, including：20 parts by weight of Moschus, 5 weight of pangolin Part, 20 parts by weight of Paris polyphylla, 0.5 parts by weight of pilose antler, 10 parts by weight of deer horn, 1 parts by weight of deer's sinew, 10 parts by weight of Yak Bone, hippocampus 5~ 10 parts by weight, 5 parts by weight of donkey-hide gelatin, 10 parts by weight of tortoiseshell, 2 parts by weight of saussurea involucrata, 10 parts by weight of agalloch eaglewood, 3 parts by weight of Rhizoma Gastrodiae, long-noded pit viper 10 parts by weight, 5 parts by weight of centipede, 20 parts by weight of scorpio, 5 parts by weight of stiff silkworm, 20 parts by weight of leech, 5 parts by weight of kylin dragon's blood, bone 20 parts by weight of broken benefit, 5 parts by weight of Radix Notoginseng, 18 parts by weight of safflower, 5 parts by weight of Cortex Eucommiae, 20 parts by weight of teasel root, 5 parts by weight of Sargent gloryvine, crow 20 parts by weight of plum, 2 parts by weight of berba aristolochiae mollissimae, 20 parts by weight of lamiophlomis rotata, 3 parts by weight of radix aconiti agrestis, 5 parts by weight of monkshood, 5 parts by weight of Herba Lycopi, 30 parts by weight of lycopodium calvatum, 5 parts by weight of lopseed, 20 parts by weight of semen brassicae, 5 parts by weight of Spiderflower Seed, 20 parts by weight of radix scutellariae, three leaves Green 5 parts by weight, 18 parts by weight of rhizoma atractylodis, 5 parts by weight of the coptis, 20 parts by weight of Radix Isatidis, 5 parts by weight of dandelion, 20 weight of Sculellaria barbata Part, 3 parts by weight of Hedyotidis Diffusae, 20 parts by weight of Rhizoma Atractylodis Macrocephalae, 5 parts by weight of Radix Salviae Miltiorrhizae, 30 parts by weight of folium artemisiae argyi, 5~10 parts by weight of the stem of noble dendrobium, ganoderma lucidum 2 parts by weight, 5 parts by weight of vomiting nut, 5 parts by weight of girald daphne bark, 20 parts by weight of SEMEN SINAPIS ALBAE, 5 parts by weight of edible tulip, 20 weight of asafoetide Part, 5 parts by weight of 20 parts by weight of wild ginseng and cordyceps sinensis；Plaster substrate selects the old plaster of alseodaphne hainanensis.
The required plaster of the present invention is prepared using preparation method provided by the invention by above-mentioned raw materials component：
It impregnates：It is soaked in sesame oil after each raw material component of Chinese medicine composition is crushed, spring and summer five days, seven days autumn and winter；
It refines：Product after immersion slow boiling is boiled about 4 hours, five peach, mulberry, Chinese scholartree, willow, elm stirrings are used in combination, until medicine It is withered and yellow when floating on pasta, filter the removal dregs of a decoction from fire；
Distillation：Medicine oil after refinement is placed in again in refining container, continues to refine 1 hour using slow boiling, filtering removal The dregs of a decoction；
Oil refining：By in the medicine oil merging refining container after distillation, medicine oil is tempered to dropping into a bead shape with slow boiling；
Lower pellet：Product after oil refining is heated to lower pellet with high heat, five stirring 5~8 minutes clockwise are used in combination, wait for that dense smoke emits When to the greatest extent, uses slow boiling instead and continue stirring tanning to lotion color and luster darkly light tone, obtain boiled plaster；
It releases fire-toxin：Boiled plaster is poured into the well water got ready, impregnates 3~5 days, it is primary to change water daily；
Go dryness evil and unpacking：The plaster soaked is dried in the shade, is packed into terrine, tank mouth is sealed with beeswax, is embedded to shady and cool dry Locate 7~10 days or is put into cellar 15 days；Until identification of the plaster through character, smell, color and luster in terrine reaches requesting party and can use Go out and separately store, for use；
Beach：After the plaster block water-bath that unpacking obtains is melted and stirred evenly, uniformly it is applied on the old plaster substrate of alseodaphne hainanensis, It obtains pulling out wet plaster for treating rheumatism, osteoproliferation and anti-inflammatory.
Example IV
The present embodiment is arranged on the basis of embodiment two.
The present embodiment provides a kind of wet plaster, including Chinese medicine composition are pulled out for treating rheumatism, osteoproliferation and anti-inflammatory And plaster substrate；Wherein, the raw material components of Chinese medicine composition by weight, including：5 parts by weight of Moschus, 20 weight of pangolin Part, 10 parts by weight of Paris polyphylla, 3 parts by weight of pilose antler, 2 parts by weight of deer horn, 5 parts by weight of deer's sinew, 5 parts by weight of Yak Bone, hippocampus, donkey-hide gelatin 15 Parts by weight, 5 parts by weight of tortoiseshell, 10 parts by weight of saussurea involucrata, 5 parts by weight of agalloch eaglewood, 9 parts by weight of Rhizoma Gastrodiae, 5 parts by weight of long-noded pit viper, centipede 20 Parts by weight, 5 parts by weight of scorpio, 20 parts by weight of stiff silkworm, 5 parts by weight of leech, 16 parts by weight of kylin dragon's blood, 5 parts by weight of the rhizome of davallia, three 7 20 parts by weight, 15 parts by weight of Cortex Eucommiae, 5 parts by weight of teasel root, 20 parts by weight of Sargent gloryvine, 5 parts by weight of dark plum, seek bone at 5 parts by weight of safflower 10 parts by weight of wind, 5 parts by weight of lamiophlomis rotata, 8 parts by weight of radix aconiti agrestis, 1 parts by weight of monkshood, 18 parts by weight of Herba Lycopi, 5 parts by weight of lycopodium calvatum, 18 parts by weight of lopseed, 5 parts by weight of semen brassicae, 15 parts by weight of Spiderflower Seed, 5 parts by weight of radix scutellariae, 20 parts by weight of radix tetrastigme, rhizoma atractylodis 5 parts by weight, 10 parts by weight of the coptis, 5 parts by weight of Radix Isatidis, 20 parts by weight of dandelion, 5 parts by weight of Sculellaria barbata, 15 weight of Hedyotidis Diffusae Measure part, 5 parts by weight of Rhizoma Atractylodis Macrocephalae, 30 parts by weight of Radix Salviae Miltiorrhizae, 10 parts by weight of folium artemisiae argyi, the stem of noble dendrobium, 10 parts by weight of ganoderma lucidum, 1 parts by weight of vomiting nut, ancestral 20 parts by weight of teacher fiber crops, 5 parts by weight of SEMEN SINAPIS ALBAE, 20 parts by weight of edible tulip, 5 parts by weight of asafoetide, 5 parts by weight of wild ginseng and cordyceps sinensis 10 Parts by weight；Plaster substrate selects the old plaster of alseodaphne hainanensis.
The required plaster of the present invention is prepared using preparation method provided by the invention by above-mentioned raw materials component：
It impregnates：It is soaked in sesame oil after each raw material component of Chinese medicine composition is crushed, spring and summer five days, seven days autumn and winter；
It refines：Product after immersion slow boiling is boiled about 4 hours, five peach, mulberry, Chinese scholartree, willow, elm stirrings are used in combination, until medicine It is withered and yellow when floating on pasta, filter the removal dregs of a decoction from fire；
Distillation：Medicine oil after refinement is placed in again in refining container, continues to refine 1 hour using slow boiling, filtering removal The dregs of a decoction；
Oil refining：By in the medicine oil merging refining container after distillation, medicine oil is tempered to dropping into a bead shape with slow boiling；
Lower pellet：Product after oil refining is heated to lower pellet with high heat, five stirring 5~8 minutes clockwise are used in combination, wait for that dense smoke emits When to the greatest extent, uses slow boiling instead and continue stirring tanning to lotion color and luster darkly light tone, obtain boiled plaster；
It releases fire-toxin：Boiled plaster is poured into the well water got ready, impregnates 3~5 days, it is primary to change water daily；
Go dryness evil and unpacking：The plaster soaked is dried in the shade, is packed into terrine, tank mouth is sealed with beeswax, is embedded to shady and cool dry Locate 7~10 days or is put into cellar 15 days；Until identification of the plaster through character, smell, color and luster in terrine reaches requesting party and can use Go out and separately store, for use；
Beach：After the plaster block water-bath that unpacking obtains is melted and stirred evenly, uniformly it is applied on the old plaster substrate of alseodaphne hainanensis, It obtains pulling out wet plaster for treating rheumatism, osteoproliferation and anti-inflammatory.
In addition, the effect of in order to further evaluate each embodiment plaster, carry out following experiment：
One, toxicity test
It is the small white mouse 40 (each 20 of male and female) of 18~22g to select weight, is divided into 4 groups, each 15 of every group of male and female, small white mouse Back unhairing exposes exocuticle, and unhairing range 2cm × 2cm smears the embodiment of the present invention one to example IV and is prepared respectively Plaster, dosage 5g, successive administration 30 days.When during administration and 1 week after being discontinued, white mouse growth conditions and activity are observed Diet, identification hematology, blood biochemical analysis, organ tissue structure and routine urinalysis etc..As a result, it has been found that all small white mouses are healthy Existence, it is without any side effects；Blood picture, liver function, each organs and tissues state, the indifference compared with normal small white mouse is dissected and observed It is different.It is demonstrated experimentally that plaster provided by the invention is nontoxic, drug safety is reliable.
Two, for the clinical test of osteoproliferation patient
It is well known that osteoproliferation is used as one kind with Articular cartilage degeneration, refer to vertebra edge articular surface or apophysis Place's bone trabecula increases to be increased with bone density, and joint margins form lip sample protrusion or form spur or spur, and synovial membrane increases in articular cavity Thickness is main pathological change.Its clinical manifestation includes：Pain：From being aggravated when slightly to severe pain, bearing a heavy burden and activity is more.It is stiff：Not Breath can be such that moderate anchylosis aggravates, and be a kind of elastic stiffness referred to as " gelatinization ".Swelling：Synovial membrane swelling and sepage occur once in a while In acute osteoarthritis, sometimes due to spur, can make epiphysis thickening, when having cyst synovial, may occur in which cystic mass.Active receiving Limit：Joint fibrosis, spur, articular surface are uneven or episome is embedded in, and range of motion can be made to reduce, had when movable thin or thick Fricative.Muscular atrophy：The muscular atrophy for large joint of being involved and Muscle tensility reduce, but myopathy does not occur.Deformity：Joint is to line It is bad, can be caused by the injustice of articular surface, X-ray film shows that joint space narrows left-right asymmetry, articular surface calcification or deformation；Newly Bon e formation such as marginality spur, bone ridge HeberdenShi tubercles, subperiosteum new bone formation bone bridge, interphalangeal joint surrounding cartilage tissue Ossification etc.；Paeudocyst is formed under articular surface, and articular mobile corpus exists, subluxation of joint.
Based on this, all kinds of cervical vertebras, lumbar vertebrae and each 400 of articulatio genus hyperosteogeny patient are collected, amounts to 1200；By each trouble Person is divided into 4 groups according to symptom, every group of 100 cervical vertebrae hyperosteogeny patients, 100 lumbar vertebrae hyperosteogeny patients and 100 knees Hyperosteogeny patient.First group to the 4th group of patient is tried out to the plaster of embodiment one and example IV respectively 2 weeks, often Day 2 times, each 3g；Curative effect is observed later, it is specific as shown in table 1.
Curative effect is judged as：It is effective：Joint and hyperplasia lesion pain are substantially reduced, and function of joint activity takes a favorable turn, X-ray film Hyperplasia lesion takes a favorable turn.Effectively：Joint and hyperplasia lesion pain relief, swelling, it is stiff substantially eliminate, functional activity improve, X Line piece hyperplasia lesion is controlled.In vain：Clinical symptoms, sign and X-ray film are before and after treatment without changer.
The effect of 1 cervical vertebra of table, lumbar vertebrae and articulatio genus hyperosteogeny patient statistical form/name
Three, for the clinical test of arthritic
Collect arthritic 1500；Wherein, light-duty phase, medium-sized phase and heavy each 500 of phase arthritic；Symptom It shows as：The light-duty phase：Petit mal, sick type is lighter, and the unexpected joint trick of early stage is ached 2~3 days, and no lump occurs；It is medium-sized Phase：It will shift to an earlier date 2~3 days on blowing and raining to break out, lump, pain or even trick meeting occurs in locality trick painful swelling of joints Numbness, it is weak；The heavy phase：Big breaking-out, in spite of blowing and raining, patient understand general joint tingle unbearably, trick The logical even modification of pain, movement is inconvenient, and whole body is uncomfortable, and patient can't take care of oneself.Specifically, all kinds of volunteers are divided into 5 groups, i.e., every group includes light-duty phase arthritic 100, medium-sized phase arthritic 100 and heavy phase arthritic 100.Wherein, first group to the 4th group difference trial edition inventive embodiments one to example IV plaster；5th group uses city Sell plaster.Plaster of the present invention is tried out after 7 days, observes result.
Wherein, observation of curative effect standard is divided into effective and invalid；Effectively：Symptom mitigates；In vain：Symptom is without any change.Respectively Arthritic is as shown in table 2 using the specific curative effect of plaster of the present invention：
2 each arthritic of table uses specific curative effect/name of plaster of the present invention
From list data as can be seen that plaster of the present invention has excellent healing arthritis and other effects.It is found by the applicant that：This The plaster that invention provides has extremely strong anti-inflammatory effect, the inflammation for killing joint can be removed, to rheumatoid, gout, hyperostosis Various joints, muscle, tissue caused by strain etc. are found in life, traumatic injury, sitting long has bacterium, without mushroom inflammation and some nothings Name swelling and pain have preferable specific aim curative effect.Secondly, plaster of the present invention has effects that very strong extraction is muddy：Plaster ingredient contains Have to blister and pull out wind, wet, turbid Chinese medicine, with the bactericidal antiphlogistic effect for closing plaster strength；It can dissolve joint delay The pathological products such as wind, wet, malicious, turbid, inflammation are simultaneously extracted in vitro by blistering；Therefore, there are dredging the channel, promoting blood circulation and removing blood stasis, softening hard masses The effect of dissipating bind.
It is well known that rheumatalgia pain is generated to the stimulation of human body in human body due to rheumatism virus, rheumatism is eradicated Pain must just eliminate the virus of the rheumatism in human body, and it is difficult to kill that rheumatism virus is equally just as common hepatitis virus 's.Past people treat the various drugs used in rheumatalgia pain, although can make human body sensory pain relief or disappearance, function is big Same small difference all can only be to body local nerve anesthesia or promoting blood circulation and removing obstruction in channels, to reach temporary analgesic effect, to internal wind substantially Diseases caused by dampness poison root originally can not be eliminated；Therefore, when after the medicine effect phase used, analgesic effect Lock-out, if again to the wind, cold day Gas, symptom will generate again, and people can only move in circles in this way, and morbidity is just controlled, but cannot always be effected a radical cure.Plaster of the present invention It points out to be with conventional medicament difference：It uses foaming to dial malicious therapy, not only has " analgesic " effect possessed by conventional medicament, " dialling poison " effect all not having with other medicines more importantly, and then internal rheumatism virus can be transferred to external.It changes Sentence is talked about, after plaster of the present invention, since internal rheumatism virus is transferred in vitro；Therefore, even if weather environment becomes later That changes is highly advantageous to rheumatism virus, but because without rheumatism virus in human body, all will not generate stimulation to human body makes Human body sensory pain, to achieve the effect that eradicate wind pain.
Four, for the clinical test of menalgia, irregular menstruation and proliferation of mammary gland patient
Female volunteers 400 of the call-up age in 25~50 one full year of life, premenstrual 7~10 days of the moon, there are bright by each volunteer Aobvious mood and/or uncomfortable, such as：Tired weak, emotional, abdominal distension gas and four limbs swell, anxiety/anxiety, swollen breasts, Emotional instability and depression etc..Specifically, each volunteer's stochastic averagina is divided into four groups, every group of 100 people；First group to the 4th Group tries out embodiment one to the plaster of example IV daily.After 15 days, observe as a result, concrete condition is as shown in table 3.Experimentation In, each volunteer continues usual nutrition habits normal diet.
Diagnostic criteria：Menstruation is delayed, few then step back ten day half a month, at most two or three months.Menstruation one is very then seen in a year or so Secondary (ultrasound diagnosis mostly cannot normally ovulate).More premenstrual small abdominal distension, pendant, the dim black, leucorrhea increasing of blood color, leukorrhea have fishy smell, waist and knee Acid is cold, four limbs are not warm.Two mammary swellings pain, chest is swollen, a small number of gastric disorder causing nauseas, and pole of feeling sick seemingly is pregnant reaction.Menalgia, menstruation color is black blood Block.Few patients' dysmenorrhoea reaches the degree for being difficult to endure.Some feel that underbelly is cool, and whole body is sent out cool.Criterion of therapeutical effect：It is effective：Menstruation Period restores normal, menses color is scarlet, the sour cold symptoms of waist and knee disappear, leukorrhea free from extraneous odour；Effectively：Waist and knee acid cold symptoms disappear, Menstrual cycle recovery is normal, menses color is scarlet, but leukorrhea has fishy smell；In vain：All symptoms of palace cold do not change.
The effect of 3 each embodiment plaster treatment menalgia of table, irregular menstruation and proliferation of mammary gland
It is effective Effectively In vain
Embodiment one 97 3 0
Embodiment two 98 2 0
Embodiment three 100 0 0
Example IV 100 0 0
Certainly, the case where being enumerated in addition to embodiment one to example IV, the type and weight percent of other raw material components, Condition and parameter in preparation process etc. are also possible.
Plaster provided by the invention can effectively prevent various acute and chronic rheumatism, rheumatoid caused by wind, cold, wet numbness Arthritis, scapulohumeral periarthritis, sciatica, lumbar muscle strain, Disc herniation, and various pain, limb caused by osteoproliferation The symptoms such as heavy tired, numb, the movable unfavorable, neck rigidity of body；In addition, plaster of the present invention also has excellent prevention gout, trident Neuralgia, facial paralysis, dysmenorrhoea, irregular menstruation, the proliferation of mammary gland, prostatitis, bronchitis, flu, rhinitis, cerebral insufficiency, god The effect of through property headache, chronic gastritis, chronic enteritis and the symptoms such as weakness of the spleen and the stomach.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office It can be combined in any suitable manner in one or more embodiments or example.In addition, without conflicting with each other, the skill of this field Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned Embodiment is changed, changes, replacing and modification.

Claims (9)

1. a kind of Chinese medicine composition, which is characterized in that raw material components include：
Moschus, pangolin, Paris polyphylla, pilose antler, deer horn, deer's sinew, Yak Bone, hippocampus, donkey-hide gelatin, tortoiseshell, saussurea involucrata, agalloch eaglewood, Rhizoma Gastrodiae, white flower Snake, centipede, scorpio, stiff silkworm, leech, kylin dragon's blood, girald daphne bark, the rhizome of davallia, Radix Notoginseng, safflower, Cortex Eucommiae, teasel root, Sargent gloryvine, dark plum, Berba aristolochiae mollissimae, lamiophlomis rotata, radix aconiti agrestis, monkshood, vomiting nut, Herba Lycopi, lycopodium calvatum, lopseed, semen brassicae, SEMEN SINAPIS ALBAE, Spiderflower Seed, Huang A kind of reed mentioned in ancient books, radix tetrastigme, edible tulip, rhizoma atractylodis, the coptis, Radix Isatidis, dandelion, Sculellaria barbata, Hedyotidis Diffusae, Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, folium artemisiae argyi, the stem of noble dendrobium, It is one or more in ganoderma lucidum, wild ginseng, cordyceps sinensis and asafoetide.
2. Chinese medicine composition according to claim 1, which is characterized in that raw material components by weight, including：
5~20 parts by weight of Moschus, 5~20 parts by weight of pangolin, 10~20 parts by weight of Paris polyphylla, 0.5~3 parts by weight of pilose antler, deer horn 2 ~10 parts by weight, 1~5 parts by weight of deer's sinew, 5~10 parts by weight of Yak Bone, 5~10 parts by weight of hippocampus, 5~15 parts by weight of donkey-hide gelatin, 5~10 parts by weight of tortoiseshell, 2~10 parts by weight of saussurea involucrata, 5~10 parts by weight of agalloch eaglewood, 3~9 parts by weight of Rhizoma Gastrodiae, 5~10 weight of long-noded pit viper Measure part, 5~20 parts by weight of centipede, 5~20 parts by weight of scorpio, 5~20 parts by weight of stiff silkworm, 5~20 parts by weight of leech, kylin dragon's blood 5~16 parts by weight, 5~20 parts by weight of the rhizome of davallia, 5~20 parts by weight of Radix Notoginseng, 5~18 parts by weight of safflower, 5~15 weight of Cortex Eucommiae Part, 5~20 parts by weight of teasel root, 5~20 parts by weight of Sargent gloryvine, 5~20 parts by weight of dark plum, 2~10 parts by weight of berba aristolochiae mollissimae, lamiophlomis rotata 5 ~20 parts by weight, 3~8 parts by weight of radix aconiti agrestis, 1~5 parts by weight of monkshood, 5~18 parts by weight of Herba Lycopi, 5~30 parts by weight of lycopodium calvatum, thoroughly 5~18 parts by weight of bone grass, 5~20 parts by weight of semen brassicae, 5~15 parts by weight of Spiderflower Seed, 5~20 parts by weight of radix scutellariae, radix tetrastigme 5 ~20 parts by weight, 5~18 parts by weight of rhizoma atractylodis, 5~10 parts by weight of the coptis, 5~20 parts by weight of Radix Isatidis, 5~20 weight of dandelion Part, 5~20 parts by weight of Sculellaria barbata, 3~15 parts by weight of Hedyotidis Diffusae, 5~20 parts by weight of Rhizoma Atractylodis Macrocephalae, 5~30 parts by weight of Radix Salviae Miltiorrhizae, folium artemisiae argyi 10~30 parts by weight, 5~10 parts by weight of the stem of noble dendrobium, 5~10 weight of 2~10 parts by weight of ganoderma lucidum, 5~20 parts by weight of wild ginseng and cordyceps sinensis Measure part.
3. Chinese medicine composition according to claim 2, which is characterized in that further include：
1~5 parts by weight of vomiting nut, 5~20 parts by weight of girald daphne bark, 5~20 parts by weight of SEMEN SINAPIS ALBAE, 5~20 parts by weight of edible tulip and 5~20 parts by weight of asafoetide.
4. Chinese medicine composition according to claim 3, it is characterised in that：
The Chinese medicine composition is in solution, patch, vina, tincture, gelling agent, liniment, aerosol, spray, ointment, bolt Agent or plastics.
5. a kind of pulling out wet plaster for treating rheumatism, osteoproliferation and anti-inflammatory, it is characterised in that：
Including Claims 1 to 4 any one of them Chinese medicine composition and plaster substrate；
Wherein, the plaster substrate includes honey plaster substrate, medicine puree plaster substrate, medical pressure sensitive adhesive, the old plaster of alseodaphne hainanensis, magnetic moxibustion It is one or more in powder packet plaster and gel-type vehicle plaster.
6. for treating the preparation method that wet plaster is pulled out in rheumatism, osteoproliferation and anti-inflammatory described in claim 5, feature exists In：
Including immersion, refinement, distillation, oil refining, it is lower it is red, release fire-toxin, dryness evil, unpacking and booth gone to apply；And specifically comprise the following steps：
It impregnates：It is soaked in sesame oil after each raw material component of Chinese medicine composition is crushed；
It refines：Product after the immersion is boiled with slow boiling to medicine is withered and yellow and floats on pasta, the removal dregs of a decoction are filtered from fire；
Distillation：Medicine oil after the refinement is continued to refine using slow boiling, the filtering removal dregs of a decoction；
Oil refining：Medicine oil after the distillation is tempered into medicine oil to dropping into a bead shape with slow boiling；
Lower pellet：Product after the oil refining is heated to lower pellet with high heat, slow boiling is used instead when dense smoke emits most and continues stirring tanning extremely Lotion color and luster darkly light tone, obtains boiled plaster；
It releases fire-toxin：The boiled plaster is soaked in water；
Go dryness evil and unpacking：The plaster being soaked in water is dried in the shade, sealing preservation, unpacking is for use later；
Beach：After the plaster block water-bath that unpacking obtains is melted and stirred evenly, uniformly it is applied on plaster substrate, obtains the use Wet plaster is pulled out in treatment rheumatism, osteoproliferation and anti-inflammatory.
7. being used to treat the preparation method that wet plaster is pulled out in rheumatism, osteoproliferation and anti-inflammatory described in claim 6, feature exists In：
In the soaking step, soaking time is spring and summer five, seven days autumn and winter；
It in the refining step, is stirred using five, and described five include peach, mulberry, Chinese scholartree, willow and elm branch.
8. Claims 1 to 4 any one of them Chinese medicine composition is in prevention various diseases drug caused by wind, cold, wet numbness In application.
9. application according to claim 8, it is characterised in that：
The disease specifically includes：Acute and chronic rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, sciatica, lumbar muscle strain, vertebra Spondylosis, heavy tired, numb, the movable unfavorable, neck rigidity of the pain caused by osteoproliferation, limbs and gout, trident god Dysmenorrhoea, facial paralysis, dysmenorrhoea, irregular menstruation, the proliferation of mammary gland, prostatitis, bronchitis, flu, rhinitis, cerebral insufficiency, nerve Property headache, chronic gastritis, chronic enteritis and weakness of the spleen and the stomach.
CN201810284262.3A 2018-04-02 2018-04-02 Plaster and preparation method thereof for treating rheumatism, osteoproliferation and the miscellaneous disease of internal medicine Pending CN108355065A (en)

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CN111956740A (en) * 2020-05-22 2020-11-20 刘世兴 Traditional Chinese medicine health-preserving medicinal mud and preparation method thereof
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Application publication date: 20180803