CN206138577U - Targetable drug delivery device of antitumor nano particles medicine - Google Patents
Targetable drug delivery device of antitumor nano particles medicine Download PDFInfo
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- CN206138577U CN206138577U CN201620663443.3U CN201620663443U CN206138577U CN 206138577 U CN206138577 U CN 206138577U CN 201620663443 U CN201620663443 U CN 201620663443U CN 206138577 U CN206138577 U CN 206138577U
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- magnetic
- interior
- elongation
- magnetostrictor
- medicine
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- 239000003814 drug Substances 0.000 title claims abstract description 35
- 238000012377 drug delivery Methods 0.000 title claims abstract description 29
- 230000000259 anti-tumor effect Effects 0.000 title claims abstract description 22
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 15
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 6
- 239000002122 magnetic nanoparticle Substances 0.000 claims abstract description 4
- 230000005611 electricity Effects 0.000 claims abstract 3
- 230000006698 induction Effects 0.000 claims abstract 2
- 230000008685 targeting Effects 0.000 claims description 10
- 238000005336 cracking Methods 0.000 claims description 7
- 239000002085 irritant Substances 0.000 claims description 3
- 231100000021 irritant Toxicity 0.000 claims description 3
- 230000033228 biological regulation Effects 0.000 abstract 1
- 238000013523 data management Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011982 device technology Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 235000003969 glutathione Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The utility model discloses a targetable drug delivery device of antitumor nano particles medicine, pharmaceutical transfer memory include hard shell, elastic diaphragm, outer magnetic induced shrinkage or elongation layer and the interior magnetic induced shrinkage or elongation body, and the hard shell and the interior magnetic induced shrinkage or elongation body are ellipsoidal structure, are provided with outer magnetic induced shrinkage or elongation layer between hard shell's inner wall and elastic diaphragm's the outer wall, interior magnetic induced shrinkage or elongation physically with be the cavity structure between the outer magnetic induced shrinkage or elongation layer, be used for the antitumor magnetic nanoparticles medicine of splendid attire in this cavity structure, the utility model discloses an outer magnetic induced shrinkage or elongation layer and the interior magnetic induced shrinkage or elongation body receive magnetic field generating device's magnetic field and expand to make the medicine extrude from the medicine mouth, reach the regional live body tissue department of tumour, and can come the speed of the real -time control magnetic induced shrinkage or elongation body through the produced magnetic field intensity of magnetic field generating device, and then the dose rate of control medicine, the biological electricity inductor can realize that speed regulation doses according to biological electricity sensor induction's data management magnetic field intensity.
Description
Technical field
This utility model is related to a kind of targeting drug-delivery system of anti-tumor nano particle medicine, belongs to medical device technology neck
Domain.
Background technology
Target administration improves concentration of the medicine in focus due to drug selectivity can be transferred to target site,
The accumulation in normal tissue cell is reduced simultaneously, is one of most efficient method of reduction drug toxicity and raising curative effect.
In addition, cancerous cell is considered as antitumor class by changing membrane passage and increasing the concentration of glutathion inside cell
The main factor of drug resistant.Target administration is possible to due to changing intake mode of the cell to medicine
Overcome drug resistance of the cancerous cell to antitumor class medicine.In recent years, therefore, the target administration of antitumor class medicine is extensively ground
Study carefully, achieve many progress, wherein having many targeting preparations and compound to have been enter into clinical trial.
Accordingly, it would be desirable to a kind of targeting drug-delivery system is designed, to realize the target administration of anti-tumor nano particle medicine.
The content of the invention
This utility model is directed to existing technical problem, there is provided a kind of target administration dress of anti-tumor nano particle medicine
Put, it is therefore an objective to realize the target administration of anti-tumor nano particle medicine, intend to solve the problem that prior art is present.
For achieving the above object, this utility model provides following technical scheme：A kind of target of anti-tumor nano particle medicine
To doser, it includes drug delivery memorizer, field generator for magnetic and biological electric inductor, it is characterised in that described
Drug delivery memorizer includes hard shell, elastic diaphragm, outer magnetostrictive layer and interior magnetostrictor, wherein, described is hard
Matter shell and the interior magnetostrictor are elliposoidal structure, the outer wall of the inwall of the hard shell and the elastic diaphragm
Between be provided with the outer magnetostrictive layer, the interior magnetostrictor after elastic diaphragm parcel by being arranged on the hard
The center of shell, is cavity structure between the interior magnetostrictor and the outer magnetostrictive layer, in the cavity structure
For containing antitumor magnetic nano-particle medicine, drug delivery port, the drug delivery port and the sky are provided with the hard shell
Cavity configuration is connected, and cracking film is provided with the drug delivery port, and the cracking film ensures to be split automatically in magnetostriction volume expansion,
The field generator for magnetic is arranged on the external of human body, and described biological electric inductor is arranged on tumor region biological tissue and sentences
Just the irritant reaction of biological tissue is sensed, the biological electric inductor and the field generator for magnetic are connected with controller.
Further, preferably, the field generator for magnetic is the field generator for magnetic for exchanging electric forming.
Further, preferably, the drug delivery port is symmetrically arranged two.
Further, preferably, the outer magnetostrictive layer and interior magnetostrictor are interconnected.
Further, preferably, the volume of the interior magnetostrictor is the 1/10 to 1/5 of hard shell volume.
Compared with prior art, the beneficial effects of the utility model are：
This utility model is subject to the magnetic field of field generator for magnetic and expands by outer magnetostrictive layer and interior magnetostrictor,
So that medicine is extruded from medicine mouth, reach at tumor region biological tissue, and can be by produced by field generator for magnetic
Magnetic field intensity controlling the speed of magnetostrictor in real time, and then the injection speed of medicine is controlled, additionally, being also provided with life
Thing electric inductor, can in real time control magnetic field intensity according to the data that biological electric inductor is sensed, and realize what speed was adjusted
Administration.
Description of the drawings
Fig. 1 is a kind of structural representation of the targeting drug-delivery system of anti-tumor nano particle medicine of the present utility model；
Wherein, 1, drug delivery memorizer, 2, field generator for magnetic, 3, biological electric inductor, 4, hard shell, 5, elasticity
Barrier film, 6, outer magnetostrictive layer, 7, interior magnetostrictor, 8, cracking film, 9, drug delivery port.
Specific embodiment
Below in conjunction with the accompanying drawing in this utility model embodiment, the technical scheme in this utility model embodiment is carried out
Clearly and completely describe, it is clear that described embodiment is only a part of embodiment of this utility model, rather than whole
Embodiment.Based on the embodiment in this utility model, those of ordinary skill in the art are not under the premise of creative work is made
The every other embodiment for being obtained, belongs to the scope of this utility model protection.
Fig. 1 is referred to, this utility model provides a kind of technical scheme：A kind of target administration of anti-tumor nano particle medicine
Device, it includes drug delivery memorizer 1, field generator for magnetic 2 and biological electric inductor 3, it is characterised in that described medicine
Delivery reservoir 1 includes hard shell 4, elastic diaphragm 5, outer magnetostrictive layer 6 and interior magnetostrictor 7, wherein, described is hard
Matter shell 4 and the interior magnetostrictor 7 are elliposoidal structure, the inwall of the hard shell 4 and the elastic diaphragm 5
The outer magnetostrictive layer 6 is provided between outer wall, the interior magnetostrictor 7 is arranged on after being wrapped up by the elastic diaphragm 5
The center of the hard shell, is cavity structure between the interior magnetostrictor 7 and the outer magnetostrictive layer 6, should
It is used to contain antitumor magnetic nano-particle medicine in cavity structure, drug delivery port 9, the administration is provided with the hard shell
Mouth 9 is connected with the cavity structure, and cracking film 8 is provided with the drug delivery port, and the cracking film 8 ensures swollen in magnetostrictor
Split automatically when swollen, the field generator for magnetic is arranged on the external of human body, described biological electric inductor is arranged on tumor area
To sense the irritant reaction of biological tissue at the biological tissue of domain, the biological electric inductor and the field generator for magnetic with
Controller connects.
In the present embodiment, the field generator for magnetic is the field generator for magnetic for exchanging electric forming.The drug delivery port 9 is
Symmetrically arranged two.The outer magnetostrictive layer and interior magnetostrictor are interconnected.The volume of the interior magnetostrictor
For the 1/10 to 1/5 of hard shell volume.
This utility model is subject to the magnetic field of field generator for magnetic and expands by outer magnetostrictive layer and interior magnetostrictor,
So that medicine is extruded from medicine mouth, reach at tumor region biological tissue, and can be by produced by field generator for magnetic
Magnetic field intensity controlling the speed of magnetostrictor in real time, and then the injection speed of medicine is controlled, additionally, being also provided with life
Thing electric inductor, can in real time control magnetic field intensity according to the data that biological electric inductor is sensed, and realize what speed was adjusted
Administration.
While there has been shown and described that embodiment of the present utility model, for the ordinary skill in the art,
It is appreciated that these embodiments can be carried out various changes in the case of without departing from principle of the present utility model and spirit, repaiies
Change, replace and modification, scope of the present utility model is defined by the appended claims and the equivalents thereof.
Claims (5)
1. a kind of targeting drug-delivery system of anti-tumor nano particle medicine, it includes drug delivery memorizer, field generator for magnetic
With biological electric inductor, it is characterised in that described drug delivery memorizer includes that hard shell, elastic diaphragm, outer mangneto are stretched
Contracting layer and interior magnetostrictor, wherein, described hard shell and the interior magnetostrictor is elliposoidal structure, described hard
Be provided with the outer magnetostrictive layer between the outer wall of the inwall of matter shell and the elastic diaphragm, the interior magnetostrictor by
The center of the hard shell is arranged on after the elastic diaphragm parcel, the interior magnetostrictor is stretched with the outer mangneto
It is cavity structure between contracting layer, is used to contain antitumor magnetic nano-particle medicine in the cavity structure, on the hard shell
Drug delivery port is provided with, the drug delivery port is connected with the cavity structure, cracking film, the cracking film are provided with the drug delivery port
Ensure to be split automatically in magnetostriction volume expansion, the field generator for magnetic is arranged on the external of human body, described bio electricity
Induction apparatuss are arranged at tumor region biological tissue to sense the irritant reaction of biological tissue, the biological electric inductor and institute
State field generator for magnetic to be connected with controller.
2. the targeting drug-delivery system of a kind of anti-tumor nano particle medicine according to claim 1, it is characterised in that：It is described
Field generator for magnetic is the field generator for magnetic for exchanging electric forming.
3. the targeting drug-delivery system of a kind of anti-tumor nano particle medicine according to claim 1, it is characterised in that：It is described
Drug delivery port is symmetrically arranged two.
4. the targeting drug-delivery system of a kind of anti-tumor nano particle medicine according to claim 1, it is characterised in that：It is described
Outer magnetostrictive layer and interior magnetostrictor are interconnected.
5. the targeting drug-delivery system of a kind of anti-tumor nano particle medicine according to claim 1, it is characterised in that：It is described
The volume of interior magnetostrictor is the 1/10 to 1/5 of hard shell volume.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620663443.3U CN206138577U (en) | 2016-06-29 | 2016-06-29 | Targetable drug delivery device of antitumor nano particles medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620663443.3U CN206138577U (en) | 2016-06-29 | 2016-06-29 | Targetable drug delivery device of antitumor nano particles medicine |
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| Publication Number | Publication Date |
|---|---|
| CN206138577U true CN206138577U (en) | 2017-05-03 |
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| CN201620663443.3U Expired - Fee Related CN206138577U (en) | 2016-06-29 | 2016-06-29 | Targetable drug delivery device of antitumor nano particles medicine |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107497039A (en) * | 2017-10-18 | 2017-12-22 | 河南科技大学第附属医院 | Internal Medicine-Oncology doser |
| CN111921071A (en) * | 2020-07-07 | 2020-11-13 | 杭州电子科技大学 | Targeting grading drug delivery robot containing paper folding art and control method thereof |
| CN112438835A (en) * | 2019-08-28 | 2021-03-05 | 美国发现集团有限公司 | Control device and control system of nano robot |
| CN112439123A (en) * | 2019-08-28 | 2021-03-05 | 美国发现集团有限公司 | Nano robot control system |
-
2016
- 2016-06-29 CN CN201620663443.3U patent/CN206138577U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107497039A (en) * | 2017-10-18 | 2017-12-22 | 河南科技大学第附属医院 | Internal Medicine-Oncology doser |
| CN107497039B (en) * | 2017-10-18 | 2020-04-17 | 河南科技大学第一附属医院 | Medical oncology device of dosing |
| CN112438835A (en) * | 2019-08-28 | 2021-03-05 | 美国发现集团有限公司 | Control device and control system of nano robot |
| CN112439123A (en) * | 2019-08-28 | 2021-03-05 | 美国发现集团有限公司 | Nano robot control system |
| CN112439123B (en) * | 2019-08-28 | 2022-08-09 | 美国发现集团有限公司 | Nano robot control system |
| CN112438835B (en) * | 2019-08-28 | 2023-02-03 | 美国发现集团有限公司 | Control device and control system of nano robot |
| CN111921071A (en) * | 2020-07-07 | 2020-11-13 | 杭州电子科技大学 | Targeting grading drug delivery robot containing paper folding art and control method thereof |
| CN111921071B (en) * | 2020-07-07 | 2022-04-29 | 杭州电子科技大学 | Targeting grading drug delivery robot containing paper folding art and control method thereof |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170523 Address after: Jilin province 130032 City Road No. 677 Changchun Changchun Changchun Jilin Normal University Patentee after: CHANGCHUN NORMAL UNIVERSITY Address before: Jilin province 130032 City Road No. 677 Changchun Changchun Changchun Jilin Normal University Patentee before: Song Kai |
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| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170503 Termination date: 20180629 |
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| CF01 | Termination of patent right due to non-payment of annual fee |