CN103520829B - Ultrasonicly involve static electricity compound transdermal delivery system - Google Patents
Ultrasonicly involve static electricity compound transdermal delivery system Download PDFInfo
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- CN103520829B CN103520829B CN201210580806.3A CN201210580806A CN103520829B CN 103520829 B CN103520829 B CN 103520829B CN 201210580806 A CN201210580806 A CN 201210580806A CN 103520829 B CN103520829 B CN 103520829B
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Abstract
The present invention relates to medical art, be specifically related to a kind of drug-supplying system.Ultrasonicly involve static electricity compound transdermal delivery system, comprise a sealing coat, be arranged on the pastille pressure-sensitive adhesive layer inside sealing coat, it is characterized in that, the outside of sealing coat is provided with the electret layer that an employing electret is made, and the inner side of pastille pressure-sensitive adhesive layer is provided with a controlled release rete; Be placed with electret layer, sealing coat, pastille pressure-sensitive adhesive layer and controlled release rete successively by outer and interior, form a reservoir devices patch; Post a ultrasound wave genetic horizon outside pastille pressure-sensitive adhesive layer, ultrasound wave genetic horizon is connected with a ultrasonic output circuit.The ul-trasonic irradiation that ultrasound wave genetic horizon sends, in pastille pressure-sensitive adhesive layer, can improve pharmaceutically active, improve water activity promotion drug absorption in skin.<!--1-->
Description
Technical field
The present invention relates to medical art, be specifically related to a kind of drug-supplying system.
Background technology
Transdermal drug delivery system refers in skin surface administration, makes medicine enter body circulation with constant rate of speed or close to constant rate of speed by skin, produces the novel form of whole body or local therapeutic effects.Its advantage applies exists: drug absorption does not affect by factors such as PH, food, transhipment times in digestive tract; Liver is avoided to be subject to effect; Overcome because absorbing the too high and untoward reaction caused of too fast generation haemoconcentration; Sustainable control injection speed, flexibly administration etc.
But existing transdermal drug delivery system often exists defects such as drug molecule amount and polarity limit to some extent, also there is drug delivery dosage and is not easy the problems such as control, poor air permeability.
Also there is the shortcomings such as seepage velocity is slow, drug utilization is abundant not in existing transdermal drug delivery system in addition.
Summary of the invention
The object of the invention is to, provide a kind of and ultrasonicly involve static electricity compound transdermal delivery system, solve above technical problem.
Technical problem solved by the invention can realize by the following technical solutions:
Ultrasonicly involve static electricity compound transdermal delivery system, comprise a sealing coat, be arranged on the pastille pressure-sensitive adhesive layer inside described sealing coat, it is characterized in that, the outside of described sealing coat is provided with the electret layer that an employing electret is made, and the inner side of described pastille pressure-sensitive adhesive layer is provided with a controlled release rete;
Be placed with described electret layer, described sealing coat, described pastille pressure-sensitive adhesive layer and described controlled release rete successively by outer and interior, form a reservoir devices patch;
Post a ultrasound wave genetic horizon outside described pastille pressure-sensitive adhesive layer, ultrasound wave genetic horizon is connected with a ultrasonic output circuit.
The ul-trasonic irradiation that ultrasound wave genetic horizon sends, in described pastille pressure-sensitive adhesive layer, can improve pharmaceutically active, improve water activity promotion drug absorption in skin.
The acoustic pressure that ultrasound wave produces simultaneously can act on pastille pressure-sensitive adhesive layer and skin, impels drug absorption by acoustic pressure.
Described ultrasound wave genetic horizon can be arranged between described sealing coat and described pastille pressure-sensitive adhesive layer, also can be arranged between described electret layer and described sealing coat, or also can be arranged on outside described electret layer.
Described ultrasound wave genetic horizon adopts a piezoceramics layer.To simplify structure and to be beneficial to skin-proximal.
The described ultrasonic static electricity compound transdermal delivery system that involves also comprises a flexible substrate, and described reservoir devices patch is arranged on described flexible substrate, and the area of described flexible substrate is greater than described reservoir devices patch area; Described ultrasonic output circuit is arranged on the described flexible substrate of described reservoir devices patch avris.
Flexible substrate adopts cloth, containing 10% ~ 50% apocynum fibre in described cloth.Apocynum fibre can send the far infrared light wave of 8 ~ 15 microns, the radiance of 86%, and far infrared light wave acts on the food such as vegetable and fruit, both non-toxic reaction, and can slow down again the vitamin oxidation of food, the loss of moisture, plays fresh-keeping effect.The present invention containing apocynum fibre, both can not affect the effect of sack itself, have preservation again.
Containing copper ion in described cloth.Described copper ion good anti-bacterial effect, antibacterial range are wide, and to article non-toxic reaction.The composite antibacterial ability of apocynum fibre and copper ion is stronger, and due to the effect of copper ion, makes described antibiotic layer in blue, also in blue inside the present invention being provided with antibiotic layer, uses elegant in appearance inside described bag body.
Also 5% ~ 30%AB anti-bacterial fibre is contained containing interior in described cloth, described AB anti-bacterial fibre has the effect eliminating 15 kinds of antibacterials such as staphylococcus aureus, Staphylococcus albus, Candida albicans, bacillus subtilis, escherichia coli, gonococcus, halophilic bacteria, bacillus pyocyaneus, Bacillus typhi, group B streptococcus, bactericidal effect is good, safe and reliable.
Described ultrasonic output circuit is provided with a power interface, connects a power supply by described power interface.The present invention does not preferably involve internal battery in static electricity compound transdermal delivery system ultrasonic, to avoid because battery fluid is revealed cause environmental pollution.
A metal electrode layer is also posted outside described electret layer.With improving SNR.
Permanent magnet powder granule is also distributed with in described pastille pressure-sensitive adhesive layer.Permanent magnet powder granule can adopt Ru-Fe-Mn permanent magnet powder granule.Can molecular activity be promoted by magnetic field, the activity of hydrone in human body can be promoted especially.
Tourmaline powder particle is also distributed with in described pastille pressure-sensitive adhesive layer.
Tourmaline is also called tourmaline.Tourmaline powder particle is blended in described pastille pressure-sensitive adhesive layer, there is promotion blood circulation of human body, improve cytoactive, improve electret electric field, human body carried out to the advantages such as mineral supplements.
Reservoir devices patch of the present invention can avoid peroral dosage form to stimulate gastrointestinal, also overcomes the use inconvenience of other short infiltration methods, to defects such as drug molecule amount and polarity limit to some extent; Can systemic blood levels be reduced simultaneously, improve affected part, local drug level; Can dosage be controlled by the adjustment of administration area, medicine with Zero order controlled releasing, 24 hours sustained release drugs, thus make curative effect long lasting and stable; Only need throw off patch gets final product interruption of the administration, easy to use.Electret can standby storage space electric charge and dipole electric charge, the particular/special requirement that its chemical stability is good, moisture resistant performance is good, surface point position is high, charge stability good, driving force meets Transdermal absorption by force, completely.The present invention adopts electret as the physical regulating factor, can be used as ion-drive source and provides electrostatic field and micro-electric current to skin, the electret state of regulation and control skin, electric structure and enhancing ionic drug Transdermal absorption.
Drug-supplying system of the present invention possesses that preparation method is simple, transdermal effect good, dose composition is controlled and the six large features such as slow release, good permeability, convenient operation non-stimulated to skin.
Described electret layer can adopt the electret layer of non-multi cellular type.The electret layer of porous type can be adopted.
The viscosifier, transdermal enhancer and the antioxidant that are dispersed in described substrate is also provided with in described pastille pressure-sensitive adhesive layer.So that better collaborative urging is oozed together.
Accompanying drawing explanation
Fig. 1 is part-structure schematic diagram of the present invention.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, setting forth the present invention further below in conjunction with concrete diagram.
With reference to Fig. 1, ultrasonicly involve static electricity compound transdermal delivery system, comprise a sealing coat 2, be arranged on the pastille pressure-sensitive adhesive layer 4 inside sealing coat 2, the outside of sealing coat 2 is provided with the electret layer 1 that an employing electret is made, and the inner side of pastille pressure-sensitive adhesive layer 4 is provided with a controlled release rete 5.Be placed with electret layer 1, sealing coat 2, pastille pressure-sensitive adhesive layer 4 and controlled release rete 5 successively by outer and interior, form a reservoir devices patch.Post a ultrasound wave genetic horizon outside pastille pressure-sensitive adhesive layer 4, ultrasound wave genetic horizon is connected with a ultrasonic output circuit.
The ul-trasonic irradiation that ultrasound wave genetic horizon sends, in pastille pressure-sensitive adhesive layer 4, can improve pharmaceutically active, improve water activity promotion drug absorption in skin.The acoustic pressure that ultrasound wave produces simultaneously can act on pastille pressure-sensitive adhesive layer 4 and skin, impels drug absorption by acoustic pressure.
Ultrasound wave genetic horizon can be arranged between sealing coat 2 and pastille pressure-sensitive adhesive layer 4, also can be arranged between electret layer 1 and sealing coat 2, or also can be arranged on outside electret layer 1.Ultrasound wave genetic horizon adopts a piezoceramics layer 3.To simplify structure and to be beneficial to skin-proximal.
The ultrasonic static electricity compound transdermal delivery system that involves also comprises a flexible substrate, and reservoir devices patch is arranged on flexible substrate, and the area of flexible substrate is greater than reservoir devices patch area.Ultrasonic output circuit is arranged on the flexible substrate of reservoir devices patch avris.
Flexible substrate adopts cloth, containing 10% ~ 50% apocynum fibre in cloth.Apocynum fibre can send the far infrared light wave of 8 ~ 15 microns, the radiance of 86%, and far infrared light wave acts on the food such as vegetable and fruit, both non-toxic reaction, and can slow down again the vitamin oxidation of food, the loss of moisture, plays fresh-keeping effect.The present invention containing apocynum fibre, both can not affect the effect of sack itself, have preservation again.
Containing copper ion in cloth.Copper ion good anti-bacterial effect, antibacterial range are wide, and to article non-toxic reaction.The composite antibacterial ability of apocynum fibre and copper ion is stronger, and due to the effect of copper ion, makes antibiotic layer be blue, also in blue inside the present invention being provided with antibiotic layer, uses elegant in appearance inside bag body.
Also 5% ~ 30%AB anti-bacterial fibre is contained containing interior in cloth, AB anti-bacterial fibre has the effect eliminating 15 kinds of antibacterials such as staphylococcus aureus, Staphylococcus albus, Candida albicans, bacillus subtilis, escherichia coli, gonococcus, halophilic bacteria, bacillus pyocyaneus, Bacillus typhi, group B streptococcus, bactericidal effect is good, safe and reliable.
Ultrasonic output circuit is provided with a power interface, connects a power supply by power interface.The present invention does not preferably involve internal battery in static electricity compound transdermal delivery system ultrasonic, to avoid because battery fluid is revealed cause environmental pollution.A metal electrode layer is also posted outside electret layer 1.With improving SNR.
Permanent magnet powder granule 6 is also distributed with in pastille pressure-sensitive adhesive layer 4.Permanent magnet powder granule 6 can adopt Ru-Fe-Mn permanent magnet powder granule 6.Can molecular activity be promoted by magnetic field, the activity of hydrone in human body can be promoted especially.Tourmaline powder particle is also distributed with in pastille pressure-sensitive adhesive layer 4.
Tourmaline is also called tourmaline.Tourmaline powder particle is blended in pastille pressure-sensitive adhesive layer 4, there is promotion blood circulation of human body, improve cytoactive, improve electret electric field, human body carried out to the advantages such as mineral supplements.
Reservoir devices patch of the present invention can avoid peroral dosage form to stimulate gastrointestinal, also overcomes the use inconvenience of other short infiltration methods, to defects such as drug molecule amount and polarity limit to some extent; Can systemic blood levels be reduced simultaneously, improve affected part, local drug level; Can dosage be controlled by the adjustment of administration area, medicine with Zero order controlled releasing, 24 hours sustained release drugs, thus make curative effect long lasting and stable; Only need throw off patch gets final product interruption of the administration, easy to use.Electret can standby storage space electric charge and dipole electric charge, the particular/special requirement that its chemical stability is good, moisture resistant performance is good, surface point position is high, charge stability good, driving force meets Transdermal absorption by force, completely.The present invention adopts electret as the physical regulating factor, can be used as ion-drive source and provides electrostatic field and micro-electric current to skin, the electret state of regulation and control skin, electric structure and enhancing ionic drug Transdermal absorption.
Drug-supplying system of the present invention possesses that preparation method is simple, transdermal effect good, dose composition is controlled and the six large features such as slow release, good permeability, convenient operation non-stimulated to skin.Electret layer 1 can adopt the electret layer 1 of non-multi cellular type.The electret layer 1 of porous type can be adopted.
The viscosifier be dispersed in substrate, transdermal enhancer and antioxidant is also provided with in pastille pressure-sensitive adhesive layer 4.So that better collaborative urging is oozed together.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (5)
1. ultrasonicly involve static electricity compound transdermal delivery system, comprise a sealing coat, be arranged on the pastille pressure-sensitive adhesive layer inside described sealing coat, it is characterized in that, the outside of described sealing coat is provided with the electret layer that an employing electret is made, and the inner side of described pastille pressure-sensitive adhesive layer is provided with a controlled release rete;
Be placed with described electret layer, described sealing coat, described pastille pressure-sensitive adhesive layer and described controlled release rete successively by outer and interior, form a reservoir devices patch;
Post a ultrasound wave genetic horizon outside described pastille pressure-sensitive adhesive layer, ultrasound wave genetic horizon is connected with a ultrasonic output circuit;
Also be distributed with permanent magnet powder granule in described pastille pressure-sensitive adhesive layer, permanent magnet powder granule adopts Ru-Fe-Mn permanent magnet powder granule;
Tourmaline powder particle is also distributed with in described pastille pressure-sensitive adhesive layer;
A metal electrode layer is also posted outside described electret layer, the described ultrasonic static electricity compound transdermal delivery system that involves also comprises a flexible substrate, described reservoir devices patch is arranged on described flexible substrate, and the area of described flexible substrate is greater than described reservoir devices patch area; Described ultrasonic output circuit is arranged on the described flexible substrate of described reservoir devices patch avris;
Described flexible substrate adopts cloth, containing 10% ~ 50% apocynum fibre in cloth; Containing copper ion in cloth; Also 5% ~ 30%AB anti-bacterial fibre is contained containing interior in going back in cloth.
2. according to claim 1ly ultrasonicly involve static electricity compound transdermal delivery system, it is characterized in that, described ultrasound wave genetic horizon adopts a piezoceramics layer.
3. according to claim 2ly ultrasonicly involve static electricity compound transdermal delivery system, it is characterized in that, described ultrasound wave genetic horizon is arranged between described sealing coat and described pastille pressure-sensitive adhesive layer.
4. according to claim 2ly ultrasonicly involve static electricity compound transdermal delivery system, it is characterized in that, described ultrasound wave genetic horizon is arranged between described electret layer and described sealing coat.
5. according to claim 2ly ultrasonicly involve static electricity compound transdermal delivery system, it is characterized in that, described ultrasound wave genetic horizon is arranged on outside described electret layer.
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| CN201210580806.3A CN103520829B (en) | 2012-12-27 | 2012-12-27 | Ultrasonicly involve static electricity compound transdermal delivery system |
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| CN201210580806.3A CN103520829B (en) | 2012-12-27 | 2012-12-27 | Ultrasonicly involve static electricity compound transdermal delivery system |
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| CN103520829B true CN103520829B (en) | 2016-03-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105816443A (en) * | 2016-01-05 | 2016-08-03 | 中国人民解放军第二军医大学 | GLP-1 sustained-release electret transdermal drug delivery system for treating diabetes |
| CN105816442A (en) * | 2016-01-05 | 2016-08-03 | 中国人民解放军第二军医大学 | 5-fluorouracil nanoparticle transdermal drug delivery electret preparation for treating hypertrophic scars based on action of electric field |
| CN106074460A (en) * | 2016-07-12 | 2016-11-09 | 中国人民解放军第二军医大学 | A kind of electret and the Percutaneously administrable preparation of 5 fluorouracil associating Inhibiting proliferation cicatrix growth |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734090A (en) * | 1986-07-18 | 1988-03-29 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator |
| CN101460214A (en) * | 2006-06-24 | 2009-06-17 | Lts勒曼治疗系统股份公司 | Transdermal therapeutic system reinforced by ultrasounds |
| CN202314980U (en) * | 2011-11-02 | 2012-07-11 | 四川康贝斯消毒药剂有限公司 | Heat release static physiotherapy patch |
| CN202397971U (en) * | 2011-11-18 | 2012-08-29 | 中国人民解放军第二军医大学 | Electret and microneedle transdermal delivery system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7635488B2 (en) * | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
| CN101090012A (en) * | 2007-04-27 | 2007-12-19 | 新康电脑科技（苏州）有限公司 | Far infrared/strong magnetic fied function material |
| CN100560157C (en) * | 2007-11-13 | 2009-11-18 | 重庆市生力医疗设备有限公司 | Ultrasonic medicine plaster |
| CN102015025A (en) * | 2008-02-15 | 2011-04-13 | 压电共振概念有限公司 | Transdermal micro-patch |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734090A (en) * | 1986-07-18 | 1988-03-29 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator |
| CN101460214A (en) * | 2006-06-24 | 2009-06-17 | Lts勒曼治疗系统股份公司 | Transdermal therapeutic system reinforced by ultrasounds |
| CN202314980U (en) * | 2011-11-02 | 2012-07-11 | 四川康贝斯消毒药剂有限公司 | Heat release static physiotherapy patch |
| CN202397971U (en) * | 2011-11-18 | 2012-08-29 | 中国人民解放军第二军医大学 | Electret and microneedle transdermal delivery system |
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