CN105998649A - Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method - Google Patents

Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method Download PDF

Info

Publication number
CN105998649A
CN105998649A CN201610478620.5A CN201610478620A CN105998649A CN 105998649 A CN105998649 A CN 105998649A CN 201610478620 A CN201610478620 A CN 201610478620A CN 105998649 A CN105998649 A CN 105998649A
Authority
CN
China
Prior art keywords
patch
ointment
microneedle
scapulohumeral periarthritis
radix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610478620.5A
Other languages
Chinese (zh)
Inventor
凌云
赵晶晶
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610478620.5A priority Critical patent/CN105998649A/en
Publication of CN105998649A publication Critical patent/CN105998649A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention discloses a compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and a preparation method. The compound traditional Chinese medicine micro needle transdermal patch is prepared from medical materials including poria, manyflower solomonseal rhizomes, cortex eucommiae, cortex cinnamomi, herba schizonepetae, rhizoma chuanxiong, roots or stems of smoothfruit ventilago, Japanese creeper, leaves or roots of dentate wampee, silvery aleuritopteris and radix angelicae pubescentis and auxiliaries including polysorbate-80, granulesten, glycerin monostearate and tacrolimus. The patch is composed of a base plate, medicament, an ointment blank patch body and an ointment back patch body, the front face of the base plate is provided with a plurality of micro needles, micro needle gaps are formed among the micro needles, the medicament is stored in the micro needle gaps and a porous structure of the base plate, the back face of the base plate is pasted to the inner surface of the ointment blank patch body, the inner surface of the ointment back patch body is arranged on the front face of the base plate in a covering mode, and the inner surface of the ointment blank patch body and the inner surface of the ointment back patch body are fixedly connected in a pasting mode. The invention further discloses preparation steps of the micro needle transdermal patch. The micro needle transdermal patch has the advantages of being precise in medicine composition, free of pain, capable of being released slowly, efficient and convenient to apply.

Description

A kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture and preparation method
Technical field
The present invention relates to tcm field, particularly relate to a kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture and preparation method.
Background technology
Scapulohumeral periarthritis is the chronic aseptic inflammation of the soft tissues such as shoulder joint Surrounding muscles, tendon, synovial bursa and joint capsule.Inflammation causes The outer adhesion of intraarticular, thus affect the activity of shoulder joint.Its lesion characteristic is extensive, i.e. pain is extensive, function limitation extensive, Tenderness is extensive.The full name of scapulohumeral periarthritis is scapulohumeral periarthritis.
In terms of doctor trained in Western medicine, the clinical characters of primary disease, it is more common in the crowd above middle age that shoulder activity gradually decreases, doctor trained in Western medicine is to scapulohumeral periarthritis Mainly expectant treatment.Such as composite treatments such as oral anti-inflammatory analgesic, naturopathy, pain spot partial closure, self-massages.West Although doctor's Therapeutic Method pain relieving instant effect, but can only take stopgap measures, it is impossible to effecting a permanent cure, simply temporary relief of symptoms, after drug withdrawal, majority can be answered Send out.
In Chinese medicine, primary disease claims " scapulohumeral periarthritis ", " scapulohumeral periarthritis " etc., belongs to arthromyodynia category.Many bodies the most with age are empty, wind-cold damp pathogen take advantage of a weak point in opponent's defence and Enter, cause to hinder through BI-syndrome involved the blood vessels;Or tumbling down damage, in blood stasis stays, QI and blood is not all right, and muscles along the regular meridians effect is not normal and causes primary disease.The traditional Chinese medical science at present Main with expelling wind and cold, spasmolytic dredging collateral, activating blood circulation to dissipate blood stasis is Therapeutic Method, is used mostly the treatment means of external application, this treatment hands Although section instant effect, but radical cure difficulty, need the long-term drug of topical application to treat, and easily recur, and external application serves inconvenience to life band.
A kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture that the present invention relates to is that one optimizes existing microneedle transdermal patch Novel formulation.On the least area, with micron-sized porous microneedle keratodermatitis, make to be stored in micropin loose structure Chinese medicine penetrates infiltration epidermal area.Avoid the chemical permeation enhancers overstimulation to skin, simplify percutaneous importing process simultaneously, It is coated filling liquid using solid lipid nanoparticle suspension as the micropin of ingredient, it is possible to achieve ingredient essence in said preparation Really, painless, slow release, efficiently, be advantageously administered.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that a kind of cure scapulohumeral periarthritis herbal mixture is microneedle cutaneous Patch and preparation method, deposit solving common Chinese liniment, liniment, patch and the micropin patch medicine when preparation or actual application The technical problems such as reserves are little, the sustained release time is short and propose.
The present invention is achieved by the following technical solutions:
A kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture disclosed by the invention, including substrate, medicament, ointment blank patch With ointment back of the body patch, substrate is positioned at the centre of ointment blank patch and ointment back of the body patch, and substrate uses the material with loose structure, substrate Front be provided with more than one micropin, the top of micropin is provided with sharp portion, and micropin is vertically fixed on substrate, between micropin have Having micropin gap, medicament is stored among micropin gap and loose structure, and the back side of substrate is plane, and the back side of substrate is pasted onto On the inner surface of ointment blank patch, the inner surface of ointment back of the body patch covers on the front of substrate, the inner surface of ointment blank patch and medicine The inner surface of cream back of the body patch is fixedly connected by the way of pasting.In use, can directly open backing layer will contain patient The adhesive layer of medicament is attached to affected part, thus realizes the purpose for the treatment of.
Further, in order to ensure the convenience of the microneedle cutaneous patch of herbal mixture and improve therapeutic efficiency, microneedle array is Multiple, the length of microneedle array and width are all for being designed as 0.5cm, and the spacing between microneedle array is adjacent is 0.1cm, in actual production In, it is also possible to according to market demand be designed as all size and shape to plaster.
Further, in order to ensure to store more medicine component and the time of increase medicament sustained release, substrate to plaster The material selected is the one in porous silicon, POROUS TITANIUM or expanded polystyrene or other composites.The selection of substrate is wanted Possess the loose structure skin simultaneously to human body and will not produce the material of secondary injury.
A kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture disclosed by the invention and preparation method, including following preparation process:
1, the preparation of extracting solution liquid
1) Poria 60~80g, Rhizoma Polygonati 50~70g, the Cortex Eucommiae 60~70g, Cortex Cinnamomi 50~60g, Rhizoma Chuanxiong 40~50g, blood are weighed Radix seu Caulis fici Martinii 40~50g, Radix seu Caulis Parthenocissi tricuspidatae 40~50g, Folium seu Radix Clausenae dentatae 30~40g, Aleuritopteris argentea (Gmel.) Fee 20~30g, Radix Angelicae Pubescentis 10~20g, mixing is pulverized After, add the concentration of Ingredients Weight 5~10 times be 50~80% ethanol solution soak at room temperature 3~5 days, cross leaching liquid, then will Extracting solution rotary evaporation is concentrated into the concentrated solution that water content is 5%~10%.
2) weigh Herba Schizonepetae 40~60g and put in there-necked flask, with extraction by steam distillation 1h, distillate is centrifuged, takes Layer fluid, obtains Herba Schizonepetae volatile oil.
2, the preparation of herbal mixture solid lipid nanoparticle:
1) take concentrated solution, dissolve with 200~1000ml purified water and 10~50ml Tween-80s, ultrasonic disperse 30 minutes, It is heated to 65~75 DEG C of insulations standby, prepares aqueous phase.
2) soybean phospholipid and glyceryl monostearate mixture 10~30 grams are weighed in the ratio of 1:1~3:1, with 200~500ml Ratio be the ethanol/dichloromethane mixture of 4:1 (volume ratio) be that solvent dissolves, add Herba Schizonepetae volatile oil and 0.5~1 gram he Ke Mosi crude drug continues stirring, and ultrasonic dissolution disperses 15 minutes, prepares oil phase.
3) oil phase injection is being stirred and in the aqueous phase of water bath heat preservation, mixing speed 1500~2000rpm, forming milky white color contamination Suspension.After continuing insulated and stirred evaporation of organic solvent, ultrasonic disperse 30 minutes, obtain lipid nanoparticle suspension crude product.
4) above-mentioned lipid nanoparticle suspension crude product is injected high pressure homogenizer, to solid in cold water (2~6 DEG C) circulator bath Lipid nanoparticle suspension crude product carries out high pressure homogenize, sets operating pressure as 2000Bar, after the even concentration of homogenized milk, obtains compound recipe Solid lipid nanoparticles loaded with traditional Chinese medicine.
3, the preparation of the microneedle cutaneous patch of herbal mixture:
Use laser-etching method that the one side of porous silicon, POROUS TITANIUM or expanded polystyrene baseplate material is cut into microneedle array, Porous microneedle unit is made with 0.5*0.5cm size;Described microneedle unit is placed on described herbal mixture solid lipid nanoparticle In, through being coated, filling, take out after drying, described microneedle unit is fixed on the inner surface of ointment blank patch, then is covered with medicine The cream back of the body pastes and i.e. obtains the microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture.
Further, microneedle array is the arrangement of square formation formula, and unit interval 0.1cm, scope of structuring the formation 2*2cm to 4*4cm are giving birth to Quantitative flexible selection can be given by different size during product.
Further, the front of substrate forms many micropins after laser-etching method in its surface, and these micropins are on substrate Forming one group of rectangular-shaped microneedle array, microneedle array is more than one, and the length of microneedle array and width are all 0.5cm, adjacent micropin battle array Spacing between row is 0.1cm.
Further, the composite of one or more during baseplate material can be selected for porous silicon, POROUS TITANIUM or expanded polystyrene.
The present invention by solid lipid nanoparticle technology and micropin percutaneous technique R. concomitans in percutaneous administration patch, by by slightly solubility Composition makes solid lipid nanoparticle, improves medicine carrying efficiency, and porous micropin is also equipped with the slow release effect of similar porous microsphere, permissible Avoiding patient's repeat administration, the pain, the congestive edema that cause various arthritis, hyperosteogeny, traumatic injury etc. extend drug effect.With Prior art is compared and is had the advantage that, with Chinese medicine as base stock, applicating modern times technology develops a new generation's external subcutaneous administration Patch, directly acts on subcutaneous by medicine active component, by microneedle cutaneous, has that therapeutic effect is good, its instant effect, right Human body skin is almost without damage, and have no side effect feature, is the direction of Development of Chinese Medicine.
Accompanying drawing explanation
Fig. 1 is substrate back structural representation;
Fig. 2 is microneedle array structural representation;
Fig. 3 is the product structure schematic diagram of the present invention;
Fig. 4 is the scanning electron microscope (SEM) photograph of substrate loose structure.
Detailed description of the invention
Elaborating embodiments of the invention below, the present embodiment is implemented under premised on technical solution of the present invention, Give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.This Bright include: ointment blank patch inner surface 1, substrate 2, ointment back of the body patch 3, medicament, microneedle array gap 4, sharp portion 5, micro- Pin 6 and micropin gap 7;
Embodiment 1
As Figure 1-4, substrate 2 is positioned at the centre of ointment blank patch and ointment back of the body patch, and the front of substrate is through laser-etching method After form many micropins 6 in its surface, these micropins 6 form one group of rectangular-shaped microneedle array on a substrate 2.Substrate 2 is adopted With having the porous silica material of loose structure, the top of micropin 6 is provided with sharp portion 5, and micropin 6 is vertically fixed on substrate 2, Having micropin gap 7 between micropin 6, medicament is stored among micropin gap 7 and loose structure, and the back side of substrate 2 is plane, The back side of substrate 2 is pasted onto on the inner surface 1 of ointment blank patch, and the inner surface of ointment back of the body patch 3 covers on the front of substrate 2, The inner surface 1 of ointment blank patch is fixedly connected by the way of pasting with the inner surface of ointment back of the body patch, sets between microneedle array Having microneedle array gap 4, the spacing of adjacent microneedle array is 0.1cm, and the size of microneedle array is 0.5*0.5cm, scope of structuring the formation 2*2cm。
Embodiment 2
In the present embodiment, the material that substrate 2 uses is expanded polystyrene, and substrate 2 has loose structure, the front warp of substrate Forming many micropins 6 after crossing laser-etching method in its surface, these micropins 6 form one group of rectangular-shaped micropin battle array on a substrate 2 Row, microneedle array is to be arranged in order by multiple micropins 6 to form, and the top of micropin 6 is provided with sharp portion 5, and microneedle array is vertical Fixing have micropin gap 7 on a substrate 2 between micropin 6, medicament is stored among micropin gap 7 and loose structure, base The back side of plate 2 is plane, and the back side of substrate 2 is pasted onto on ointment blank patch inner surface 1, and ointment back of the body patch 3 covering is at substrate 2 Front on, ointment blank patch inner surface 1 and ointment the back of the body patch 3 size and shape adapt and opposing parallel setting, micropin Being provided with microneedle array gap 4 between array, the spacing of adjacent microneedle array is 0.1cm, and the size of microneedle array is 0.5*0.5cm, The scope of structuring the formation is 4*4cm, in order to paste closely by plaster, can leave 1cm size in the surrounding of ointment blank patch inner surface 1 Paste district, so can improve the sealing effectiveness of plaster, prevent because surrounding covered with dust causes stickup property the strongest.
Embodiment 3
In embodiment 3, the material that substrate 2 uses is porous titanium material, and substrate 2 has loose structure, and the front of substrate 2 sets Having microneedle array, microneedle array is to be arranged in order by multiple micropins 6 to form, and the top of micropin 6 is provided with sharp portion 5, spine The big I in portion 5 adjusts the precision of laser-etching according to actual needs and is realized, and microneedle array is vertically fixed on substrate 2, micro- Having micropin gap 7 between pin 6, medicament is stored among micropin gap 7 and loose structure, and the back side of substrate 2 is plane, The back side of substrate 2 is pasted onto on the inner surface 1 of ointment blank patch, and the inner surface of ointment back of the body patch 3 covers on the front of substrate 2, The inner surface 1 of ointment blank patch is fixedly connected by the way of pasting with the inner surface of ointment back of the body patch, sets between microneedle array Having microneedle array gap 4, the spacing of adjacent microneedle array is 0.1cm, and the size of microneedle array is 0.5*0.5cm, scope of structuring the formation For 4*4cm.
Embodiment 4
1) weigh Poria 60g, Rhizoma Polygonati 50g, Cortex Eucommiae 60g, Cortex Cinnamomi 50g, Rhizoma Chuanxiong 40g, Radix seu Caulis Verntilaginis Leiocarpae 40g, Radix seu Caulis Parthenocissi tricuspidatae 40g, Folium seu Radix Clausenae dentatae 30g, Aleuritopteris argentea (Gmel.) Fee 20g, Radix Angelicae Pubescentis 10g, after mixing is pulverized, add 50% ethanol solvent of Ingredients Weight 5 times at room temperature Soak 5 days, cross leaching liquid, then extracting solution rotary evaporation is concentrated into the concentrated solution that water content is 5%.
2) weigh Herba Schizonepetae 40g, with extraction by steam distillation 1h, distillate is centrifuged, takes upper strata fluid and obtain Herba Schizonepetae volatile oil.
3) take concentrated solution, dissolve with 500ml purified water and 20ml Tween-80, ultrasonic disperse 30 minutes, be heated to 65 DEG C It is incubated standby, prepares aqueous phase.
4) soybean phospholipid and 20 grams of glyceryl monostearate the mixture, (body with 300ml ratio as 4:1 are weighed in the ratio of 1:1 Long-pending than) ethanol/dichloromethane mixture be that solvent dissolves, add Herba Schizonepetae volatile oil and 0.5 gram of tacrolimus continue stirring, super Sound dissolves dispersion 15 minutes, prepares oil phase.
5) oil phase injection is being stirred and in the aqueous phase of water bath heat preservation, mixing speed 1500rpm, forming milky suspension. After continuing insulated and stirred evaporation of organic solvent, ultrasonic disperse 30 minutes, obtain lipid nanoparticle suspension crude product.
6) above-mentioned lipid nanoparticle suspension crude product is injected high pressure homogenizer, to lipid nanoparticle in 2 DEG C of circulating chilled water water-baths Suspension crude product carries out high pressure homogenize, sets operating pressure as 2000Bar, after the even concentration of homogenized milk, obtains herbal mixture solid fat Matter nanoparticle.
7) use laser-etching method that the one side of porous silicon-base panel material is cut into microneedle array, make many with 0.5*0.5cm size Hole microneedle unit;Described microneedle unit is placed in described herbal mixture solid lipid nanoparticle, through being coated, filling, takes Go out after drying, described microneedle unit is fixed on described adhesive layer, then be covered with described backing layer and i.e. obtain cure scapulohumeral periarthritis herbal mixture Microneedle cutaneous patch.
Embodiment 5
1) weigh Poria 80g, Rhizoma Polygonati 70g, Cortex Eucommiae 70g, Cortex Cinnamomi 60g, Rhizoma Chuanxiong 50g, Radix seu Caulis Verntilaginis Leiocarpae 50g, Radix seu Caulis Parthenocissi tricuspidatae 50g, Folium seu Radix Clausenae dentatae 40g, Aleuritopteris argentea (Gmel.) Fee 30g, Radix Angelicae Pubescentis 20g, after mixing is pulverized, the concentration adding Ingredients Weight 10 times is that 80% ethanol is molten Matchmaker, soak at room temperature 3 days, crosses leaching liquid, then extracting solution rotary evaporation is concentrated into the concentrated solution that water content is 10%.
2) weigh Herba Schizonepetae 60g and put in there-necked flask, with extraction by steam distillation 1h, distillate is centrifuged, take upper strata oil Liquid obtains Herba Schizonepetae volatile oil.
3) take concentrated solution, dissolve with 1000ml purified water and 50ml Tween-80, ultrasonic disperse 30 minutes, be heated to 75 DEG C of insulations are standby, prepare aqueous phase.
4) soybean phospholipid and 30 grams of glyceryl monostearate the mixture, (body with 500ml ratio as 4:1 are weighed in the ratio of 3:1 Long-pending than) ethanol/dichloromethane mixture be that solvent dissolves, add Herba Schizonepetae volatile oil and 1 gram of tacrolimus continue stirring, ultrasonic Dissolve dispersion 15 minutes, prepare oil phase.
5) oil phase injection is being stirred and in the aqueous phase of water bath heat preservation, mixing speed 2000rpm, forming milky suspension. After continuing insulated and stirred evaporation of organic solvent, ultrasonic disperse 30 minutes, obtain lipid nanoparticle suspension crude product.
6) above-mentioned lipid nanoparticle suspension crude product is injected high pressure homogenizer, to lipid nanoparticle in 6 DEG C of circulating chilled water water-baths Suspension crude product carries out high pressure homogenize, sets operating pressure as 2000Bar, after the even concentration of homogenized milk, obtains herbal mixture solid fat Matter nanoparticle.
7) use laser-etching method that the one side of expanded polystyrene is cut into microneedle array, make porous with 0.5*0.5cm size Microneedle unit;Described microneedle unit is placed in described herbal mixture solid lipid nanoparticle, through being coated, filling, takes out After drying, described microneedle unit is fixed on described adhesive layer, then being covered with described backing layer, i.e. to obtain cure scapulohumeral periarthritis herbal mixture micro- Pin transdermal administration pastes.
Embodiment 6
1) weigh Poria 70g, Rhizoma Polygonati 60g, Cortex Eucommiae 65g, Cortex Cinnamomi 55g, Rhizoma Chuanxiong 50g, Radix seu Caulis Verntilaginis Leiocarpae 45g, Radix seu Caulis Parthenocissi tricuspidatae 45g, Folium seu Radix Clausenae dentatae 35g, Aleuritopteris argentea (Gmel.) Fee 25g, Radix Angelicae Pubescentis 15g, after mixing is pulverized, the concentration adding Ingredients Weight 10 times is that 75% ethanol is molten Matchmaker, soak at room temperature 3 days, crosses leaching liquid, then extracting solution rotary evaporation is concentrated into the concentrated solution that water content is 10%.
2) weigh Herba Schizonepetae 50g, with extraction by steam distillation 1h, distillate is centrifuged, takes upper strata fluid and obtain Herba Schizonepetae volatile oil.
3) take concentrated solution, dissolve with 1000ml purified water and 50ml Tween-80, ultrasonic disperse 30 minutes, be heated to 75 DEG C of insulations are standby, prepare aqueous phase.
4) soybean phospholipid and 30 grams of glyceryl monostearate the mixture, (body with 500ml ratio as 4:1 are weighed in the ratio of 2:1 Long-pending than) ethanol/dichloromethane mixture be that solvent dissolves, add Herba Schizonepetae volatile oil and 1 gram of tacrolimus continue stirring, ultrasonic Dissolve dispersion 15 minutes, prepare oil phase.
5) oil phase injection is being stirred and in the aqueous phase of water bath heat preservation, mixing speed 2000rpm, forming milky suspension. After continuing insulated and stirred evaporation of organic solvent, ultrasonic disperse 30 minutes, obtain lipid nanoparticle suspension crude product.
6) above-mentioned lipid nanoparticle suspension crude product is injected high pressure homogenizer, to lipid nanoparticle in 4 DEG C of circulating chilled water water-baths Suspension crude product carries out high pressure homogenize, sets operating pressure as 2000Bar, after the even concentration of homogenized milk, obtains herbal mixture solid fat Matter nanoparticle.
7) use laser-etching method that the one side of POROUS TITANIUM is cut into microneedle array, make porous micropin list with 0.5*0.5cm size Unit;Described microneedle unit is placed in described herbal mixture solid lipid nanoparticle, through being coated, filling, takes out after drying, Described microneedle unit is fixed on described adhesive layer, then be covered with described backing layer i.e. obtain cure scapulohumeral periarthritis herbal mixture micropin transdermal to Plaster.

Claims (8)

1. the preparation method of the microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture, it is characterised in that include following preparation process:
1) Poria, Rhizoma Polygonati, the Cortex Eucommiae, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix seu Caulis Verntilaginis Leiocarpae, Radix seu Caulis Parthenocissi tricuspidatae, Folium seu Radix Clausenae dentatae, Aleuritopteris argentea (Gmel.) Fee and Radix Angelicae Pubescentis are weighed, pulverize after mixing, with concentration be 50~80% ethanol solution to mixture soak 3~5 days, filter, after collecting filtrate and described filtrate being evaporated solvent, obtain compound Chinese medicine extract I;
2) weigh Herba Schizonepetae and put in there-necked flask, distillation, to distillate centrifugal treating, stand after being centrifuged, take upper strata fluid, obtain active Chinese drug component thing Herba Schizonepetae volatile oil II;
3) compound Chinese medicine extract I mixed liquor of purified water and Tween-80 is dissolved, ultrasonic disperse 30 minutes, be heated to 65~75 DEG C of insulations, prepare aqueous phase A;
4) by after soybean phospholipid that mass ratio is 1:1~3:1 and glyceryl monostearate mixing, obtain mixture B, with the ethanol/dichloromethane mixed liquor that volume ratio is 4:1, described mixture B is dissolved, obtain solution C, by step 2) in the Herba Schizonepetae volatile oil II of gained and tacrolimus crude drug mix with described solution C three, after ultrasonic disperse, prepare oil phase D;
5) oil phase D injection is being stirred and in the described aqueous phase A of water bath heat preservation, stirring, forming milky suspension E, after insulated and stirred evaporation of organic solvent, ultrasonic disperse, obtain lipid nanoparticle suspension crude product F;
6) by described lipid nanoparticle suspension crude product F injection high pressure homogenizer carries out high pressure homogenize, after concentration, herbal mixture solid lipid nanoparticle G is obtained;
7) use laser-etching method that the front of substrate cuts into the microneedle unit of 0.5*0.5cm size, described microneedle unit is placed in described herbal mixture solid lipid nanoparticle, after being coated, fill and drying, the back side of the substrate after etch processes is pasted on ointment blank patch and has the sticking side, described microneedle unit ointment back of the body exchange premium row covers, it is middle with described ointment back of the body patch that described substrate is positioned at described ointment blank patch, three is fixedly connected by the way of pasting, and obtains the microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture.
The preparation method of a kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture the most as claimed in claim 1, it is characterized in that, the component content of described Poria, Rhizoma Polygonati, the Cortex Eucommiae, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix seu Caulis Verntilaginis Leiocarpae, Radix seu Caulis Parthenocissi tricuspidatae, Folium seu Radix Clausenae dentatae, Aleuritopteris argentea (Gmel.) Fee, Radix Angelicae Pubescentis, Herba Schizonepetae, soybean phospholipid/glyceryl monostearate mixture, Tween-80 and tacrolimus is:
Poria 60~80g
Rhizoma Polygonati 50~70g
The Cortex Eucommiae 60~70g
Cortex Cinnamomi 50~60g
Rhizoma Chuanxiong 40~50g
Radix seu Caulis Verntilaginis Leiocarpae 40~50g
Radix seu Caulis Parthenocissi tricuspidatae 40~50g
Folium seu Radix Clausenae dentatae 30~40g
Aleuritopteris argentea (Gmel.) Fee 20~30g
Radix Angelicae Pubescentis 10~20g
Herba Schizonepetae 40~60g
Soybean phospholipid/glyceryl monostearate mixture 10~30g
Tween-80 10~50ml
Tacrolimus 0.5~1g.
The preparation method of a kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture the most as claimed in claim 1, it is characterized in that, the component content of described Poria, Rhizoma Polygonati, the Cortex Eucommiae, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix seu Caulis Verntilaginis Leiocarpae, Radix seu Caulis Parthenocissi tricuspidatae, Folium seu Radix Clausenae dentatae, Aleuritopteris argentea (Gmel.) Fee, Radix Angelicae Pubescentis, Herba Schizonepetae, soybean phospholipid/glyceryl monostearate mixture, Tween-80 and tacrolimus is:
Poria 80g
Rhizoma Polygonati 70g
Cortex Eucommiae 70g
Cortex Cinnamomi 60g
Rhizoma Chuanxiong 50g
Radix seu Caulis Verntilaginis Leiocarpae 50g
Radix seu Caulis Parthenocissi tricuspidatae 50g
Folium seu Radix Clausenae dentatae 40g
Aleuritopteris argentea (Gmel.) Fee 30g
Radix Angelicae Pubescentis 20g
Herba Schizonepetae 60g
Soybean phospholipid/glyceryl monostearate mixture 10g
Tween-80 50ml
Tacrolimus 1g.
The preparation method of a kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture the most as claimed in claim 2, it is characterized in that, step 2) described in distill the method used be steam distillation, step 3) described in purified water consumption be 200~1000ml.
5. the microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture, it is characterized in that, the described microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture is to be made by either method in the preparation method of a kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture described in Claims 1 to 4.
null6. a kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture as claimed in claim 5,It is characterized in that,Including substrate、Medicament、Ointment blank patch and ointment back of the body patch,Described substrate is positioned at the centre of described ointment blank patch and described ointment back of the body patch,Described substrate uses the material with loose structure,The front of described substrate is provided with more than one micropin,The top of described micropin is provided with sharp portion,Described micropin is vertically fixed on described substrate,There is between described micropin micropin gap,Described medicament is stored among described micropin gap and described loose structure,The back side of described substrate is plane,The back side of described substrate is pasted onto on the inner surface of described ointment blank patch,The inner surface of described ointment back of the body patch covers on the front of described substrate,The inner surface of described ointment blank patch is fixedly connected by the way of pasting with the inner surface of described ointment back of the body patch.
7. a kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture as claimed in claim 5, it is characterised in that the material that described substrate is selected is the one in porous silicon, POROUS TITANIUM or expanded polystyrene.
8. a kind of microneedle cutaneous patch of cure scapulohumeral periarthritis herbal mixture as claimed in claim 6, it is characterized in that, the arrangement of described micropin forms a rectangular-shaped microneedle array, described microneedle array is more than one, the length of described microneedle array and width are all 0.5cm, and the spacing between adjacent described microneedle array is 0.1cm.
CN201610478620.5A 2016-06-24 2016-06-24 Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method Pending CN105998649A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610478620.5A CN105998649A (en) 2016-06-24 2016-06-24 Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610478620.5A CN105998649A (en) 2016-06-24 2016-06-24 Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method

Publications (1)

Publication Number Publication Date
CN105998649A true CN105998649A (en) 2016-10-12

Family

ID=57083752

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610478620.5A Pending CN105998649A (en) 2016-06-24 2016-06-24 Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method

Country Status (1)

Country Link
CN (1) CN105998649A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111433001A (en) * 2017-12-05 2020-07-17 古河电气工业株式会社 Functional member and method for manufacturing same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104367940A (en) * 2014-10-28 2015-02-25 无锡济民可信山禾药业股份有限公司 Microneedle transdermal drug delivery system of Chinese herbal medicine compound preparation
CN104740304A (en) * 2015-04-02 2015-07-01 霍明昌 Traditional Chinese medicine pills for treating scapulohumeral periarthritis and preparation method thereof
CN104825701A (en) * 2015-04-24 2015-08-12 繁昌县智融中药材专业合作社 External application traditional Chinese medicine for treating scapulohumeral periarthritis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104367940A (en) * 2014-10-28 2015-02-25 无锡济民可信山禾药业股份有限公司 Microneedle transdermal drug delivery system of Chinese herbal medicine compound preparation
CN104740304A (en) * 2015-04-02 2015-07-01 霍明昌 Traditional Chinese medicine pills for treating scapulohumeral periarthritis and preparation method thereof
CN104825701A (en) * 2015-04-24 2015-08-12 繁昌县智融中药材专业合作社 External application traditional Chinese medicine for treating scapulohumeral periarthritis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
魏太星等: "《医生专用药物手册》", 31 January 2015, 河南科学技术出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111433001A (en) * 2017-12-05 2020-07-17 古河电气工业株式会社 Functional member and method for manufacturing same

Similar Documents

Publication Publication Date Title
CN103169928B (en) Externally applied traditional Chinese medicine composition for treating dysmenorrhea, as well as preparation method and application thereof
CN102631513B (en) Medicinal plaster for removing stasis, eliminating stagnation and relieving swelling and preparation method thereof
CN102406794A (en) Transdermal administered gel ointment containing rhizoma ligustici wallichii and nutgrass galingale rhizome
CN105055768A (en) Traditional Chinese medicine compound external-application preparation for treating cicatrix and preparation method and application thereof
CN101669986A (en) Compound gel preparation containing sophora alopecuroide oil
CN106109792A (en) One treats the fracture microneedle cutaneous patch of soft tissue injury Chinese medicine and preparation method
CN1806823B (en) Externally applied wind-expelling Chinese medicinal composition plaster
CN101919941B (en) External traditional Chinese medicine composition used for renal function curing and health care and application thereof in preparing traditional Chinese medicine cataplasma for renal function curing and health care
WO2015018124A1 (en) Traditional chinese medicine preparation for reducing blood pressure and preparation method thereof
CN101181531A (en) Externally used medicament for curing rheumatism cold ache disease
CN105998693A (en) Compound traditional Chinese medicine micro needle transdermal patch for treating psoriasis and preparation method
CN105998649A (en) Compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and preparation method
CN102784244B (en) Externally applied traditional Chinese medicine for treating breast lumps
CN107617083A (en) Treat the patch of the proliferation of mammary gland
CN105998463A (en) Micro needle transdermal patch for treating osteoarthritis and preparation method thereof
CN100443110C (en) Tiantan prepn for treating kidney-yang deficiency diseases and its production process
CN105943765A (en) Complex traditional Chinese medicine microneedle transdermal-delivery patch for relieving swelling and pain and preparation method thereof
CN101658592B (en) Patch for treating hypertension
CN105943595A (en) Medicine for treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions and preparation method thereof
CN107184928A (en) A kind of traumatic injury and rheumatism emplastrum and preparation method thereof
CN105998183A (en) Compound traditional Chinese medicine micro needle transdermal patch for treating leucoderma and preparation method thereof
CN105998184A (en) Compound traditional Chinese medicine microneedle transdermal delivery patch capable of relaxing muscles and tendons and activating blood circulation and preparation method
CN106074691A (en) The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain and preparation method
CN103330919A (en) Traditional Chinese medicine compound cream for curing hyperplasia of mammary glands and preparation method thereof
CN106038957A (en) Compound traditional Chinese medicine microneedle transdermal delivery plaster for strain of lumbar muscles and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20161012