CN106074691A - The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain and preparation method - Google Patents
The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain and preparation method Download PDFInfo
- Publication number
- CN106074691A CN106074691A CN201610476673.3A CN201610476673A CN106074691A CN 106074691 A CN106074691 A CN 106074691A CN 201610476673 A CN201610476673 A CN 201610476673A CN 106074691 A CN106074691 A CN 106074691A
- Authority
- CN
- China
- Prior art keywords
- folium
- radix
- unguentum
- folium pini
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 38
- 150000001875 compounds Chemical class 0.000 title claims abstract description 31
- 239000008280 blood Substances 0.000 title claims abstract description 20
- 210000004369 blood Anatomy 0.000 title claims abstract description 20
- 230000036407 pain Effects 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 230000017531 blood circulation Effects 0.000 title claims abstract description 19
- 230000001737 promoting effect Effects 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 24
- 241000628997 Flos Species 0.000 claims abstract description 10
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 10
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 10
- 210000000582 semen Anatomy 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 11
- 239000003921 oil Substances 0.000 claims description 11
- 239000008346 aqueous phase Substances 0.000 claims description 10
- 239000012071 phase Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 239000000341 volatile oil Substances 0.000 claims description 10
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 9
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 9
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 9
- 239000008347 soybean phospholipid Substances 0.000 claims description 9
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000009413 insulation Methods 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 239000000758 substrate Substances 0.000 claims description 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 239000005864 Sulphur Substances 0.000 claims description 3
- 240000002853 Nelumbo nucifera Species 0.000 claims description 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- -1 ultrasonic disperse Substances 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000009740 moulding (composite fabrication) Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 206010020651 Hyperkinesia Diseases 0.000 description 3
- 208000000269 Hyperkinesis Diseases 0.000 description 3
- 206010050031 Muscle strain Diseases 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000002386 leaching Methods 0.000 description 3
- 210000002097 psoas muscle Anatomy 0.000 description 3
- 238000001256 steam distillation Methods 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 238000002390 rotary evaporation Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000003390 Chinese drug Substances 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010061223 Ligament injury Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 235000020603 homogenised milk Nutrition 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses Folium Pini compound recipe unguentum and the preparation method of a kind of promoting blood circulation, removing blood stasis and relieving pain, include following medicine material: Folium Pini, Flos Carthami, Radix Saposhnikoviae, Radix Notoginseng, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, Folium Artemisiae Argyi, Folium Mahoniae, Semen Impatientis and Herba Menthae；Its preparation method include Organic substance extract, distill, be centrifuged, the step such as dispersing and dissolving, the present invention is with Chinese medicine as base stock, the external application Chinese medicine unguentum of new generation that applicating modern times technology is developed, have dispenser accurately, efficiently, the feature such as convenient.
Description
Technical field
The present invention relates to Folium Pini compound recipe unguentum and the preparation method of a kind of promoting blood circulation, removing blood stasis and relieving pain, belong to the system of herbal mixture unguentum
Standby technical field.
Background technology
At present, market has several treatment because of overworking, lumbar muscle strain that hyperkinesia causes, psoas muscle pull bloodization silt
The Compound Chinese Herbs for Fatigue-Resistance of Animal of pain relieving, its therapeutic effect and preparation method are not quite similar, and differ greatly.But in a word, in the market
The treatment sold because overworking, lumbar muscle strain that hyperkinesia causes, psoas muscle pull the Chinese herbal and crude drugs preparations of blood silt releasing and analgesia
There is also treatment speed compared with slow, the poor weak point of effect, and pharmaceutics of Chinese drugs is as the traditional medicine of China, uses dialectical executing
Control, the difference of the method such as prescription, dosage form, processing technique, Different therapeutical effect is the biggest.And the general side effect for the treatment of of Chinese medicine preparation is compared
Little, the property of medicine is stable, take effect ratio comparatively fast, there is the advantages such as strong, the lasting medicine of effect, and do not have dependency, drug resistance and poison secondary
Effect, the development to Chinese medicine, there is highly important clinical meaning.
Summary of the invention
The invention aims to overcome the deficiencies in the prior art, it is provided that the Folium Pini compound recipe of a kind of promoting blood circulation, removing blood stasis and relieving pain
Unguentum and preparation method, low to solve the ointment drug effect of prior art, take effect slow, inconvenient to carry and propose；
The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain disclosed by the invention and preparation method, including following preparation step
Rapid:
1, the preparation of extracting solution liquid
1) Folium Pini 60～80g, Flos Carthami 50～70g, Radix Saposhnikoviae 40～60g, Radix Notoginseng 50～70g, Radix Angelicae Sinensis 40～60g, the Qin are weighed
Macrophylla 40～60g, Folium Artemisiae Argyi 60～80g, Folium Mahoniae 50～70g and Semen Impatientis 40～60g, after mixing is pulverized, addition quality is composition
Weight 5～10 times, concentration be 50～70% ethanol solution soak at normal temperatures 5～8 days, cross leaching liquid, then extracting solution rotated
Evaporation and concentration is 10%～15% to water content, obtains compound Chinese medicine extract.
2) weigh Herba Menthae 40～60g and put in there-necked flask, with extraction by steam distillation 1h, distillate is centrifuged, from
Calm put, take upper strata fluid and obtain Herba Menthae Haplocalycis volatile oil.
2, the preparation of Folium Pini compound recipe concentration unguentum:
1) the compound Chinese medicine extract mixed liquor of 200～1000ml purified water and 10～50ml Tween-80s is entered
Row dissolves, and ultrasonic disperse 30 minutes is heated to 65～75 DEG C of insulations standby, prepares aqueous phase A；
2) soybean phospholipid and glyceryl monostearate mixture 10～30 grams are weighed for the ratio of 1:1～3:1 in mass ratio,
It is that mixture is dissolved by solvent with the ethanol/dichloromethane mixed liquor that 200～500ml volume ratios are 4:1, adds Chinese medicine thin
Lotus volatile oil continues stirring, and ultrasonic dissolution disperses 15 minutes, prepares oil phase B.
3) oil phase B injection is being stirred and in the aqueous phase A of water bath heat preservation, mixing speed 1500～2000rpm, forming breast
White suspension E.After continuing insulated and stirred evaporation solvent, ultrasonic disperse 30 minutes, obtain the concentration unguentum that water content is 5～10%
F。
3, the preparation of Folium Pini compound recipe unguentum
Above-mentioned concentration unguentum F is in harmonious proportion uniformly with the ratio of 1:0.5～1:1 with sulfur or soft petroleum ointment substrate, makes
The Folium Pini compound recipe unguentum of promoting blood circulation, removing blood stasis and relieving pain.
The invention provides the Folium Pini compound recipe unguentum of a kind of activating blood circulation to dissipate blood stasis pain relieving, it has reducing swelling and alleviating pain, activating blood circulation to dissipate blood stasis
Effect, and lumbar muscle strain can be treated, psoas muscle is pulled, ligament injury, soft tissue injury or overwork, hyperkinesia etc. causes
Damage, trauma.Compared with existing dosage form, have that volume is little, drug loading is high, quick release feature, be invigorating blood circulation of one
The preferable dosage form of silt pain relieving, has notable Development volue, and the present invention is with Chinese medicine as base stock, and applicating modern times technology exploitation makes new advances
Generation external application Chinese medicine unguentum, is the direction of Development of Chinese Medicine.
Detailed description of the invention
Elaborating embodiments of the invention below, the present embodiment is the technical scheme is that to enter under premise
Row is implemented, and gives detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following reality
Execute example.
Embodiment 1
1) Folium Pini 60g, Flos Carthami 50g, Radix Saposhnikoviae 40g, Radix Notoginseng 50g, Radix Angelicae Sinensis 40g, Radix Gentianae Macrophyllae 40g, Folium Artemisiae Argyi 60g, Folium Mahoniae are weighed
50g and Semen Impatientis 40g, mixing pulverize after, add weight be Ingredients Weight 5 times, concentration be 50% ethanol solution at normal temperatures
Soak 8 days, cross leaching liquid, then the concentrated solution being concentrated into by extracting solution rotary evaporation.Pulverizing after mixing, obtaining water content is
The concentrate of 10%, is compound Chinese medicine extract I；
2) weigh Herba Menthae 40g and put in there-necked flask, with extraction by steam distillation 1h, distillate is centrifuged, takes upper strata
Fluid obtains Herba Menthae Haplocalycis volatile oil II.
3) take compound Chinese medicine extract I, dissolve with 200ml purified water and 10ml Tween-80, ultrasonic disperse 30 points
Clock, is heated to 65 DEG C of insulations standby, prepares aqueous phase A.
4) ratio of 1:1 in mass ratio weighs soybean phospholipid and 10 grams of glyceryl monostearate mixture, with 200ml volume
Being that solvent dissolves than the ethanol/dichloromethane mixture for 4:1, add Chinese medicine Herba Menthae Haplocalycis volatile oil and continue stirring, ultrasonic dissolution divides
Dissipate 15 minutes, prepare oil phase B.
5) oil phase B injection is being stirred and in the aqueous phase A of water bath heat preservation, mixing speed 1500rpm, forming milky white color contamination
Suspension E.After continuing insulated and stirred evaporation solvent, ultrasonic disperse 30 minutes, obtain the concentration unguentum F that water content is 5%.
6) above-mentioned concentration unguentum F and the sulphur ointment substrate ratio with mass ratio as 1:0.5 is in harmonious proportion uniformly, makes invigorating blood circulation
The Folium Pini compound recipe unguentum of stasis of blood pain relieving.
Embodiment 2
1) Folium Pini 80g, Flos Carthami 70g, Radix Saposhnikoviae 60g, Radix Notoginseng 70g, Radix Angelicae Sinensis 60g, Radix Gentianae Macrophyllae 60g, Folium Artemisiae Argyi 80g, Folium Mahoniae are taken
70g, Semen Impatientis 60g, after mixing is pulverized, add 70% ethanol solution of Ingredients Weight 10 times soak at room temperature 5 days, cross leaching
Liquid, then extracting solution rotary evaporation is concentrated into the concentrated solution that water content is 5%.
2) weigh Herba Menthae 60g and put in there-necked flask, with extraction by steam distillation 1h, distillate is centrifuged, takes upper strata
Fluid obtains Herba Menthae Haplocalycis volatile oil.
3) concentrated solution dissolves with 1000ml purified water and 50ml Tween-80, and ultrasonic disperse 30 minutes is heated to 75 DEG C
It is incubated standby, prepares aqueous phase.
4) soybean phospholipid and 30 grams of glyceryl monostearate mixture are weighed, with 500ml ratio for the ratio of 3:1 in mass ratio
Example be the ethanol/dichloromethane mixed liquor of 4:1 (volume ratio) be that solvent dissolves, add Chinese medicine Herba Menthae Haplocalycis volatile oil and continue stirring, super
Sound dissolves dispersion 15 minutes, prepares oil phase.
5) oil phase injects and is stirring and in the aqueous phase of water bath heat preservation, and mixing speed 2000rpm forms milky suspendible
Liquid.After continuing insulated and stirred evaporation solvent, ultrasonic disperse 30 minutes, obtain the concentration unguentum that the even water content of homogenized milk is 10%.
6) state concentration unguentum soft petroleum ointment substrate to be in harmonious proportion uniformly with the ratio of 1:1, make the Folium Pini of promoting blood circulation, removing blood stasis and relieving pain
Compound recipe unguentum.
Embodiment 3
1) Folium Pini 70g, Flos Carthami 6g, Radix Saposhnikoviae 40g, Radix Notoginseng 60g, Radix Angelicae Sinensis 50g, Radix Gentianae Macrophyllae 60g, Folium Artemisiae Argyi 70g, Folium Mahoniae are weighed
70g and Semen Impatientis 60g, pulverizes after mixing, soaks mixture 7 days with the ethanol solution that concentration is 65%, filters, collects
Filtrate and to described filtrate evaporation solvent after, obtain compound Chinese medicine extract I；
2) weigh Herba Menthae 50g and put in there-necked flask, distillation, to distillate centrifugal treating, stand after being centrifuged, take upper strata oil
Liquid, obtains Herba Menthae Haplocalycis volatile oil II；
3) compound Chinese medicine extract I mixed liquor of 800ml purified water and 30ml Tween-80 is dissolved, super
Sound disperses 30 minutes, is heated to 75 DEG C of insulations standby, prepares aqueous phase A；
4) by after soybean phospholipid that mass ratio is 2:1 and glyceryl monostearate mixing, obtain 30g mixture B, use
500ml volume ratio is that described mixture B is dissolved by the ethanol/dichloromethane mixed liquor of 4:1, obtains solution C, by step 2)
Herba Menthae Haplocalycis volatile oil II and the described solution C mix and blend of middle gained, after ultrasonic disperse, prepares oil phase D；
5) oil phase D injection is being stirred and in the described aqueous phase A of water bath heat preservation, stirring, is forming milky suspension E,
After insulated and stirred evaporation solvent, ultrasonic disperse, unguentum F must be concentrated；
6) the concentration unguentum F of gained is in harmonious proportion uniformly with the sulphur ointment substrate ratio with mass ratio as 1:0.5, obtains work
The Folium Pini compound recipe unguentum of blood blood-activating analgetic.
Claims (4)
1. the preparation method of the Folium Pini compound recipe unguentum of a promoting blood circulation, removing blood stasis and relieving pain, it is characterised in that include following preparation process:
1) weigh Folium Pini, Flos Carthami, Radix Saposhnikoviae, Radix Notoginseng, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, Folium Artemisiae Argyi, Folium Mahoniae and Semen Impatientis, pulverize after mixing, with
Concentration be 50～70% ethanol solution mixture is soaked 5～8 days, filter, collect filtrate and also described filtrate is evaporated solvent
After, obtain compound Chinese medicine extract I；
2) weigh Herba Menthae and put in there-necked flask, distillation, to distillate centrifugal treating, stand after being centrifuged, take upper strata fluid, to obtain final product
Herba Menthae Haplocalycis volatile oil II；
3) compound Chinese medicine extract I mixed liquor of purified water and Tween-80 is dissolved, ultrasonic disperse 30 minutes,
It is heated to 65～75 DEG C of insulations standby, prepares aqueous phase A；
4) by after soybean phospholipid that mass ratio is 1:1～3:1 and glyceryl monostearate mixing, obtain mixture B, use volume ratio
Described mixture B is dissolved by the ethanol/dichloromethane mixed liquor for 4:1, obtains solution C, by step 2) in gained thin
Lotus volatile oil II and described solution C mix and blend, after ultrasonic disperse, prepare oil phase D；
5) oil phase D injection is being stirred and in the described aqueous phase A of water bath heat preservation, stirring, forming milky suspension E, insulation
After stirring evaporation solvent, ultrasonic disperse, unguentum F must be concentrated；
6) by the concentration unguentum F of gained and sulphur ointment substrate, with mass ratio as 1:0.5～the ratio of 1:1 is in harmonious proportion uniformly, to obtain final product
The Folium Pini compound recipe unguentum of promoting blood circulation, removing blood stasis and relieving pain.
The preparation method of the Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain the most as claimed in claim 1, it is characterised in that institute
State Folium Pini, Flos Carthami, Radix Saposhnikoviae, Radix Notoginseng, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, Folium Artemisiae Argyi, Folium Mahoniae, Semen Impatientis, soybean phospholipid/glyceryl monostearate mix
The component content of compound, Tween-80 and Herba Menthae is:
Folium Pini 60～80g
Flos Carthami 50～70g
Radix Saposhnikoviae 40～60g
Radix Notoginseng 50～70g
Radix Angelicae Sinensis 40～60g
Radix Gentianae Macrophyllae 40～60g
Folium Artemisiae Argyi 60～80g
Folium Mahoniae 50～70g
Semen Impatientis 40～60g
Soybean phospholipid/glyceryl monostearate mixture 10～30g
Tween-80 10～50ml
Herba Menthae 40～60g.
The preparation method of the Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain the most as claimed in claim 1, it is characterised in that institute
State Folium Pini, Flos Carthami, Radix Saposhnikoviae, Radix Notoginseng, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, Folium Artemisiae Argyi, Folium Mahoniae, Semen Impatientis, soybean phospholipid/glyceryl monostearate mix
The component content of compound, Tween-80 and Herba Menthae is:
Folium Pini 60g
Flos Carthami 50g
Radix Saposhnikoviae 40g
Radix Notoginseng 50g
Radix Angelicae Sinensis 40g
Radix Gentianae Macrophyllae 40g
Folium Artemisiae Argyi 60g
Folium Mahoniae 50g
Semen Impatientis 40g
Soybean phospholipid/glyceryl monostearate mixture 10g
Tween-80 10ml
Herba Menthae 40g.
4. the Folium Pini compound recipe unguentum of a promoting blood circulation, removing blood stasis and relieving pain, it is characterised in that the Folium Pini compound recipe cream of described promoting blood circulation, removing blood stasis and relieving pain
Agent is by either method in the preparation method of the Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain described in claims 1 to 3
Preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610476673.3A CN106074691A (en) | 2016-06-24 | 2016-06-24 | The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610476673.3A CN106074691A (en) | 2016-06-24 | 2016-06-24 | The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106074691A true CN106074691A (en) | 2016-11-09 |
Family
ID=57253951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610476673.3A Pending CN106074691A (en) | 2016-06-24 | 2016-06-24 | The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106074691A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403763A (en) * | 2018-05-28 | 2018-08-17 | 陈雨薇 | A kind of lumbar muscle strain drug paste and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066290A (en) * | 2007-06-12 | 2007-11-07 | 白岩 | Hongyao ointment and its prepn |
| CN101455706A (en) * | 2009-01-05 | 2009-06-17 | 杨再亮 | Pain-alleviation ointment for treating rheumatism and hyperosteogeny |
| CN102579583A (en) * | 2012-03-07 | 2012-07-18 | 河南省医药科学研究院 | External patch for treating injury of tendons and muscles |
-
2016
- 2016-06-24 CN CN201610476673.3A patent/CN106074691A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066290A (en) * | 2007-06-12 | 2007-11-07 | 白岩 | Hongyao ointment and its prepn |
| CN101455706A (en) * | 2009-01-05 | 2009-06-17 | 杨再亮 | Pain-alleviation ointment for treating rheumatism and hyperosteogeny |
| CN102579583A (en) * | 2012-03-07 | 2012-07-18 | 河南省医药科学研究院 | External patch for treating injury of tendons and muscles |
Non-Patent Citations (3)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 王锦鸿等: "《临床实用中药辞典》", 30 November 2003, 金盾出版社 * |
| 胡郁坤等: "《中医单方全书珍藏本超值版》", 30 June 2012, 湖南科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403763A (en) * | 2018-05-28 | 2018-08-17 | 陈雨薇 | A kind of lumbar muscle strain drug paste and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1931353A (en) | Curcuma extract and its prepn process, medicine composition and use | |
| CN107308234A (en) | A kind of preparation method of guizhi fuling pill | |
| CN106109792A (en) | One treats the fracture microneedle cutaneous patch of soft tissue injury Chinese medicine and preparation method | |
| CN106074691A (en) | The Folium Pini compound recipe unguentum of a kind of promoting blood circulation, removing blood stasis and relieving pain and preparation method | |
| CN106535912B (en) | Control pharmaceutical composition and its application of human body blood fat and body weight | |
| CN105998463A (en) | Micro needle transdermal patch for treating osteoarthritis and preparation method thereof | |
| CN107617083A (en) | Treat the patch of the proliferation of mammary gland | |
| CN101269201B (en) | Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof | |
| CN109528917B (en) | Korean medicinal composition for treating rheumatoid arthritis and preparation method of cream thereof | |
| CN106075183A (en) | A kind of Folium Pini compound recipe unguentum for treating eczema and preparation method | |
| CN106943354B (en) | A kind of preparation method of novel biochemical particles | |
| CN105998693A (en) | Compound traditional Chinese medicine micro needle transdermal patch for treating psoriasis and preparation method | |
| CN104922247A (en) | Extraction method and application of ethyl acetate extract of Prismatomeris tetrandra | |
| CN101721456A (en) | Antiatherosclerotic Chinese traditional medicine for treating cardiovascular and cerebrovascular diseases and method for preparing phospholipid complex formulation thereof | |
| CN103893105A (en) | Traditional Chinese medicine compound whitening and freckle-removing cream | |
| CN108403932A (en) | A kind of Chinese medicine compound prescription external preparation and its preparation method and application for treating steroid dependent dermatitis | |
| CN105963480A (en) | Pine needle compound ointment capable of relieving swelling and pain and preparation method | |
| CN104324081A (en) | Corydalis tuber superfine powder and preparation method and application thereof | |
| CN105998405A (en) | Pine needle compound ointment for treating seborrheic dermatitis and preparation method | |
| CN107095912A (en) | A kind of Ultramicro-powder ointment of Repercusion analgesia and preparation method thereof | |
| CN105998406A (en) | Compound traditional Chinese medicine paste for treating seborrheic dermatitis and preparation method thereof | |
| CN103330919B (en) | Traditional Chinese medicine compound cream for curing hyperplasia of mammary glands and preparation method thereof | |
| CN107961320A (en) | Pharmaceutical composition for treating acute pancreatitis and preparation method thereof | |
| CN100348170C (en) | Yitongshu drop pill for treating pain and its preparation method | |
| CN105943595A (en) | Medicine for treating chemotherapy induced hand-foot syndromes and targeted therapy induced hand-foot skin reactions and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161109 |
|
| RJ01 | Rejection of invention patent application after publication |