CN101461853B - Chinese medicine granular formulation for relieving cough, dispelling phlegm and calming panting and preparation method thereof - Google Patents
Chinese medicine granular formulation for relieving cough, dispelling phlegm and calming panting and preparation method thereof Download PDFInfo
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- CN101461853B CN101461853B CN2007101605092A CN200710160509A CN101461853B CN 101461853 B CN101461853 B CN 101461853B CN 2007101605092 A CN2007101605092 A CN 2007101605092A CN 200710160509 A CN200710160509 A CN 200710160509A CN 101461853 B CN101461853 B CN 101461853B
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Abstract
The invention provides a traditional Chinese medicine granule for relieving cough, eliminating phlegm and relieving asthma and a preparation method thereof. The traditional Chinese medicine granule is obtained by improving the prior product. The formula and the preparation method adopted by the invention greatly reduce the dosage per time of the traditional Chinese medicine granule. Compared with the prior formula and the prior art, the traditional Chinese medicine granule produced by the formula and the technology not only is convenient for patients to carry and take but also has better antitussive and expectorant effects, and achieves obvious progress and uncontemplated effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine granules that is used for relieving cough and expelling phlegm, relievings asthma and preparation method thereof, be specifically related to cough peaceful granule and preparation method thereof.
Technical background
According to the health ministry statistics, China annual cough patient reaches more than 5,000 ten thousand, and China urban and rural residents cough prevalence is 15.36%.Cough is divided into 3 types by the time usually: acute cough's (＜3 week), subacute cough (3-8 week) and chronic cough (>=8 week).The common cause of chronic cough is: drip syndrome, EC's property bronchitis, chronic bronchitis, bronchiectasis, endobronchial tuberculosis, allergia cough (AC), psychological cough etc. behind cough variant asthma, the nose.
Cough peaceful granule and be used to treat recurrent cough, cough with asthma fullness in the chest just, chronic bronchitis, suffering from cold causes the Chinese medicine of cold cough.Its prescription records in " Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation " the 8th the 116th page with standard, and name is called coughs instant granule for curing, has comprised two kinds of dosage forms of granule and square." Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation " abbreviated ministry standard as when hereinafter was quoted.
The every bag of peaceful granule of coughing originally weighs 10g, and the adjuvant of utilization is a sucrose, and the content of sucrose has accounted for 95% of whole preparation.Sucrose contains high heat, eats to be unfavorable for health more, and is inappropriate for and avoids sugared crowd and take.The also inconvenient patient of each fractional pack 10g carries and takes simultaneously.
Therefore, in order to address the deficiencies of the prior art, improving coughing peaceful particulate prescription and technology, is necessary.
Summary of the invention
The present invention provides a kind of peaceful particulate prescription and preparation technology thereof of coughing, and remedies prior art and is not easy to the shortcoming of carrying and taking.
Of the present inventionly cough peaceful granule and be made up of active component and adjuvant, the weight portion proportioning of its active component and adjuvant is following:
Active ingredient 300～600 diluent 800～1800 binding agents 0.1～0.4
Described diluent is: 6～10: 1 mixture of soluble starch or soluble starch and dextrin;
Described binding agent is: sodium carboxymethyl cellulose.
The weight portion proportioning of coughing preferred active component of peaceful granule and adjuvant of the present invention is following:
Active ingredient 450 diluent 1000 binding agents 0.3
Described diluent is: 9: 1 mixture of soluble starch or soluble starch and dextrin;
Described binding agent is: sodium carboxymethyl cellulose.
Described active component is that the feedstock production by following weight portion forms:
The Strobilus Pini 60～120 Radix Gossypiis 40～70 Folium Eriobotryaes 10～40
The said best proportioning that is used for preparing active component raw material is:
The Strobilus Pini 93 Radix Gossypiis 56 Folium Eriobotryaes 28
Describedly cough peaceful particulate method for preparing and be:
1, with the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical materials, decocte with water 1～3 time, each amount of water is the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical material weight 6～12 times; Each decocting time is 1～3 hour, and collecting decoction filters; Filtrating is concentrated into 0.2～0.5 times that is equivalent to the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical material weight, puts coldly, and adding ethanol is 40%～60% to containing alcoholic acid weight percent concentration; Stir, left standstill 24 hours, filter; It is 1.10～1.30 clear paste that filtrating is concentrated into relative density, promptly obtains active component;
2, sodium carboxymethyl cellulose is added water-solubleization, be mixed with percent weight in volume and be 1% sodium carboxymethyl cellulose solution;
3, with active component and mixing diluents, add percent weight in volume concentration then and be 1% sodium carboxymethyl cellulose solution, process granule, drying promptly obtains coughing peaceful granule.
Describedly cough peaceful particulate preferred for preparation method and be:
1, with the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical materials, decocte with water 2 times, each amount of water is the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical material weight 10 times, each decocting time is 2 hours; Collecting decoction filters, and filtrating is concentrated into 3 times that are equivalent to the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical material weight; Putting cold rnning ethanol is 50% to containing alcoholic acid weight percent concentration, stirs, and leaves standstill 24 hours; Filter, it is 1.25 clear paste that filtrating is concentrated into relative density, promptly obtains active component;
2, sodium carboxymethyl cellulose is added water-solubleization, be mixed with percent weight in volume and be 1% sodium carboxymethyl cellulose solution;
3, with active component and mixing diluents, add percent weight in volume concentration then and be 1% sodium carboxymethyl cellulose solution, process granule, drying promptly obtains coughing peaceful granule.
The present invention is through being altered to soluble starch, dextrin and sodium carboxymethyl cellulose with particulate adjuvant cane sugar powder; Make the weight of final finished alleviate greatly,, process the peaceful granule of coughing of 20 weight portions by the active component of 1 weight portion of record in the 8th of the original ministry standard; Change becomes the active component of 1 weight portion; Process the peaceful granule of coughing of 2.3～6 weight portions, made things convenient for the patient to carry and take, through the pharmacological evaluation contrast; The better effects if of coughing peaceful granule expelling phlegm for arresting cough after the improvement has obtained obvious improvement and beyond thought effect.
Specific embodiment
Embodiment one
The active raw materials prescription:
Strobilus Pini 930g Radix Gossypii 560g Folium Eriobotryae 280g
Diluent: soluble starch 100g
Adhesive: sodium carboxymethyl cellulose 0.03g
Method for making:
1, with the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical materials, decocte with water 2 times, each amount of water is 17700ml, each decocting time is 2 hours; Collecting decoction filters, and filtrating is concentrated into 600ml, puts cold; Adding ethanol is 50% to containing alcoholic acid weight percent concentration, stirs, and leaves standstill 24 hours; Filter, it is 1.25 clear paste that filtrating is concentrated into relative density, promptly obtains active component 45g;
2, sodium carboxymethyl cellulose is added water-solubleization, be configured to percent weight in volume and be 1% sodium carboxymethyl cellulose solution;
3, active component is mixed with soluble starch, add percent weight in volume then and be 1% sodium carboxymethyl cellulose solution, process granule, drying promptly obtains coughing peaceful granule 140g.
Embodiment two
The active raw materials prescription:
Strobilus Pini 600g Radix Gossypii 400g Folium Eriobotryae 100g
Diluent: soluble starch 80g dextrin 10g
Adhesive: sodium carboxymethyl cellulose 0.01g
Method for making:
1, with the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical materials, decocte with water 1 time, amount of water is 6600ml, decocting time is 1 hour; Decocting liquid filters, and filtrating is concentrated into 220ml, puts cold; Adding ethanol is 40% to containing alcoholic acid weight percent concentration, stirs, and leaves standstill 24 hours; Filter, it is 1.10 clear paste that filtrating is concentrated into relative density, promptly obtains active component 30g;
2, sodium carboxymethyl cellulose is added water-solubleization, be configured to percent weight in volume and be 1% sodium carboxymethyl cellulose solution;
3, active component is mixed with soluble starch, dextrin, add percent weight in volume then and be 1% sodium carboxymethyl cellulose solution, process granule, drying promptly obtains coughing peaceful granule 110g.
Embodiment three
The active raw materials prescription:
Strobilus Pini 1200g Radix Gossypii 700g Folium Eriobotryae 400g
Diluent: soluble starch 180g
Adhesive: sodium carboxymethyl cellulose 0.04g
Method for making:
1, with the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical materials, decocte with water 3 times, each amount of water is 23000ml, each decocting time is 3 hours; Collecting decoction filters, and filtrating is concentrated into 1150ml, puts cold; Adding ethanol is 60% to containing alcoholic acid weight percent concentration, stirs, and leaves standstill 24 hours; Filter, it is 1.30 clear paste that filtrating is concentrated into relative density, promptly obtains active component 63g;
2, sodium carboxymethyl cellulose is added water-solubleization, be configured to percent weight in volume and be 1% sodium carboxymethyl cellulose solution;
3, active component is mixed with soluble starch, add percent weight in volume then and be 1% sodium carboxymethyl cellulose solution, process granule, drying promptly obtains coughing peaceful granule 235g.
Embodiment four
The 8th of former ministry standard recorded and coughed the peaceful granule pharmacodynamics contrast test of coughing of the peaceful granule and the embodiment of the invention one:
Laboratory animal: the Kunming kind is a mice;
Body weight: 17～22g;
Sex: male and female half and half
1, to the influence (the phenol red method of trachea section) of mice phlegm-dispelling functions
Choosing the Kunming kind is 20 of mices, and body weight 18～22g is divided into 2 groups at random, 10 every group, and male and female half and half.Give respectively and the peaceful granule of coughing after peaceful granule and the present invention's improvement of coughing by the method preparation in the 8th of the former ministry standard.More than two groups of administrated methods be administration by gavage, once a day, successive administration 5 days.Behind the last medicine 30 minutes, the phenol red 5mg/10g body weight of lumbar injection, inject phenol red 30 minutes after; Put to death animal, peel off the trachea surrounding tissue, cut one section trachea down to the tracheorrhaphy expenditure from first shape flexible pipe; Put into the test tube that fills the 2ml normal saline, add 0.1ml sodium hydroxide (1mol/L) again, use spectrophotometer; Wavelength 546nm surveys the OD value, with the phenol red standard curve of doing, calculates phenol red content.
Cough peaceful granule to the influence of the phenol red excretion amount of mice trachea section (x ± s) for two kinds
| Group | Dosage (g/kg) | The laboratory animal number | The phenol red excretion amount of trachea (μ g) |
| 8 technologies of ministry standard cough peaceful granule | 8.85 | 10 | 0.50±0.17 |
| The embodiment of the invention one technology cough peaceful granule | 1.24 | 10 | 0.62±0.3 |
2, the mice strong aqua ammonia is drawn the influence of coughing
Choosing the Kunming kind is 20 of mices, and body weight 18～22g is divided into 2 groups at random, 10 every group, and male and female half and half.Give respectively and the peaceful granule of coughing after peaceful granule and the present invention's improvement of coughing by the method preparation in the 8th of the former ministry standard.More than two groups of administrated methods be administration by gavage, once a day, successive administration 5 days.Administration was after 1 hour on 1; Put into 500ml wide mouthed bottle (each) to mice; Draw the 0.1ml strong aqua ammonia with syringe and inject the equal and opposite in direction cotton balls, accepting strong aqua ammonia stimulates, and is recorded to cough incubation period (second) (from stimulating beginning to the time that cough occurs) and the number of times of coughing in 3 minutes.
Cough peaceful granule for two kinds the mice strong aqua ammonia is drawn the influence coughed (x ± s)
| Group | Dosage (g/kg) | The laboratory animal number | Latent time | The number of times of coughing in 3 minutes |
| 8 technologies of ministry standard cough peaceful granule | 8.85 | 10 | 71.9023.79 | 10.50±2.95 |
| The embodiment of the invention one technology cough peaceful granule | 1.24 | 10 | 79.20±28.70 | 8.60±3.96 |
Experiment conclusion: the embodiment of the invention one cough the better effects if of coughing peaceful granule expelling phlegm for arresting cough that peaceful granule records in the 8th of the former ministry standard.
Claims (6)
1. a Chinese medicine granules that is used for relieving cough and expelling phlegm, relievings asthma is characterized in that being made up of active component and adjuvant, and the weight portion of its active component and adjuvant is:
Active ingredient 300～600 diluent 800～1800 binding agents 0.1～0.4
Described active component is that the feedstock production by following weight portion forms:
The Strobilus Pini 60～120 Radix Gossypiis 40～70 Folium Eriobotryaes 10～40
Described diluent is: 6～10: 1 mixture of soluble starch and dextrin;
Described binding agent is: sodium carboxymethyl cellulose.
2. Chinese medicine granules according to claim 1 is characterized in that the proportioning of active component and adjuvant is:
Active ingredient 450 diluent 1000 binding agents 0.3
Described active component is that the feedstock production by following weight portion forms:
The Strobilus Pini 93 Radix Gossypiis 56 Folium Eriobotryaes 28
Described diluent is: 9: 1 mixture of soluble starch and dextrin;
Described binding agent is: sodium carboxymethyl cellulose.
3. Chinese medicine granules according to claim 1 and 2 is characterized in that active component is prepared from order to the below method:
With the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical materials, decocte with water 1～3 time, each amount of water is the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical material weight 6～12 times; Each decocting time is 1～3 hour, and collecting decoction filters; Filtrating is concentrated into 0.2～0.5 times that is equivalent to the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical material weight, puts coldly, and adding ethanol is 40%～60% to containing alcoholic acid weight percent concentration; Stir, left standstill 24 hours, filter; It is 1.10～1.30 clear paste that filtrating is concentrated into relative density, promptly obtains active component.
4. Chinese medicine granules according to claim 1 and 2 is characterized in that the method for preparing of active component is:
With the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical materials, decocte with water 2 times, each amount of water is the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical material weight 10 times, each decocting time is 2 hours; Collecting decoction filters, and filtrating is concentrated into 3 times that are equivalent to the Strobilus Pini, Radix Gossypii, Folium Eriobotryae 3 flavor medical material weight; Putting cold rnning ethanol is 50% to containing alcoholic acid weight percent concentration, stirs, and leaves standstill 24 hours; Filter, it is 1.25 clear paste that filtrating is concentrated into relative density, promptly obtains active component.
5. Chinese medicine granules according to claim 3 is characterized in that its preparation method has comprised following steps:
Sodium carboxymethyl cellulose is added water-solubleization, be mixed with percent weight in volume and be 1% sodium carboxymethyl cellulose solution; Active component is mixed with soluble starch, dextrin, add percent weight in volume then and be 1% sodium carboxymethyl cellulose solution, process granule, drying promptly obtains this Chinese medicine granules.
6. Chinese medicine granules according to claim 4 is characterized in that its preparation method has comprised following steps:
Sodium carboxymethyl cellulose is added water-solubleization, be mixed with percent weight in volume and be 1% sodium carboxymethyl cellulose solution; Active component is mixed with soluble starch, dextrin, add the weight percent by volume then and be 1% sodium carboxymethyl cellulose solution, process granule, drying promptly obtains this Chinese medicine granules.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101605092A CN101461853B (en) | 2007-12-20 | 2007-12-20 | Chinese medicine granular formulation for relieving cough, dispelling phlegm and calming panting and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101605092A CN101461853B (en) | 2007-12-20 | 2007-12-20 | Chinese medicine granular formulation for relieving cough, dispelling phlegm and calming panting and preparation method thereof |
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| CN101461853B true CN101461853B (en) | 2012-11-07 |
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| CN102462754B (en) * | 2010-10-28 | 2014-04-16 | 广西壮族自治区花红药业股份有限公司 | Detection method for Chinese medicine preparation for cough relief, phlegm elimination and asthma relief |
| CN106343339A (en) * | 2016-08-26 | 2017-01-25 | 北京徳弘东方健康科技有限公司 | Nutrient composition and making method and application thereof |
| CN109432193B (en) * | 2018-12-13 | 2021-07-27 | 贵州大隆药业有限责任公司 | Pharmaceutical composition for treating cough and preparation method thereof |
| CN115181607A (en) * | 2022-06-21 | 2022-10-14 | 王刚 | Production process for preparing pinecone essential oil by distillation method |
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Non-Patent Citations (3)
| Title |
|---|
| 中华人民共和国卫生部药典委员会.咳宁冲剂.《药品标准 中药成方制剂第八册》.1993,116. * |
| 罗友华等.中药颗粒剂辅料的研究进展.《海峡药学》.2002,第14卷(第1期),1. * |
| 罗明生等.粘合剂与润湿剂.《药剂辅料大全》.1993,73、75. * |
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Address after: 545100 no.529 Liubao Road, Liujiang District, Liuzhou City, Guangxi Zhuang Autonomous Region Patentee after: Huahong Pharmaceutical Group Co.,Ltd. of Guangxi Zhuang Autonomous Region Address before: 545100 the Guangxi Zhuang Autonomous Region the Liujiang River County Liu Bao Liuzhou City Road No. 529 Patentee before: HUAHONG PHARMACEUTICAL Co.,Ltd. GUANGXI ZHUANG AUTONOMOUS REGION |
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