CN103766906B - Peroral composition containing chicory powder and preparation method thereof - Google Patents

Peroral composition containing chicory powder and preparation method thereof Download PDF

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CN103766906B
CN103766906B CN201410054921.6A CN201410054921A CN103766906B CN 103766906 B CN103766906 B CN 103766906B CN 201410054921 A CN201410054921 A CN 201410054921A CN 103766906 B CN103766906 B CN 103766906B
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ratio
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CN103766906A (en
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钮金木
钮立强
钮立卫
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Jin Mu Group Ltd
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ANGUO TONGYUAN BIOLOGICAL TECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a peroral composition containing chicory powder and a preparation method thereof, belonging to the technical field of food processing. The packaged peroral composition in per unit contains the following components in parts by weight: 10 to 30 parts of chicory powder, 2 to 6 parts of rhizoma polygonati powder, 5 to 7 parts of jerusalem artichoke powder, 2 to 4 parts of kalimeris powder, 3 to 7 parts of konjaku powder, 10 to 12 parts of grape seed powder, 2 to 4 parts of lavender powder, 30 to 40 parts of fructo-oligosaccharide and 30 to 42 parts of maltodextrin. The components which are correspondingly matched have synergistic effects, so that the poor quality and psychological imbalance state of the structure degradation and the physiological function decline of a human body can be regulated and even reversed by the peroral composition. In addition, the peroral composition is convenient to take.

Description

A kind of for the oral composition and method of making the same containing witloof powder
Technical field
The present invention relates to a kind of composition and method of making the same, particularly relate to a kind of for the oral composition and method of making the same containing witloof powder, belong to food processing technology field.
Background technology
The environment of the modern life goes from bad to worse, and comprises the forming of anxiety that rhythm of life constantly accelerates to bring and pressure, bad life style and custom, the harmful effect of environmental pollution and the stimulation of bad spirit, at heart factor etc.Research shows, anxiety over a long time and pressure can produce in four health and endanger: one is cause acute and chronic directly to damage cardiovascular system and to unify gastronintestinal system, causes stress ulcer and blood pressure risings, increased heart rate, acceleration vascular sclerosis process and cardiovascular event generation; Two be cause brain stress tired and decrease of cognitive function; Three is destroy biological clock, affects sleep quality; Four is that immunologic function declines, and causes malignant tumour and infection chance to increase.In addition, bad life style and custom are (as high salt, high fat and high caloric diet, a large amount of smoking and to drink and sitting is not moved), the harmful effect of environmental pollution (as water source and air pollution, noise, microwave, electromagnetic wave and other chemistry, physical factor are polluted), bad psychic factor stimulate, what these were all subtle affects the healthy of the mankind, allows people produce disease unconsciously.
The human body sensory caused by above-mentioned factor to uncomfortable state, before not there is some organic disease, there is no clear and definite symptom, that is without clinical symptoms and sign, or have illness feel and without clinical examination evidence, but the information of existing potential morbidity tendency, is in a kind of housing construction is degenerated and physiological function goes down low-quality and psychological unbalance state.This is to the crowd being in this state, and reasonable diet or suitable extra-nutrition then can control the deterioration even reversing this state, thus makes that such crowd lifts one's head, life easy.For current this problem, developing and a kind ofly supplement the nutrients for facilitating oral food or reconcile function of human body, is improve such crowd's quality of life problem demanding prompt solution.
Summary of the invention
Technical problem to be solved by this invention is the defect overcoming prior art, there is provided a kind of for the oral composition containing witloof powder, said composition has the effect such as hypoglycemic, fat-reducing liver-protecting, antibacterial, antiallergy, anti-trioxypurine, and steady quality, absorbs fully; In addition, the present invention further provides this for the oral preparation method containing the composition of witloof powder.
Technical problem of the present invention is realized by following technical scheme.
For the oral composition containing witloof powder, the component containing following weight portion in its per unit packaging:
Witloof powder 10 ~ 30, sealwort powder 2 ~ 6, jerusalem artichoke powder 5 ~ 7, kalimeris head powder 2 ~ 4, konjaku flour 3 ~ 7, grape pip powder 10 ~ 12, lavender powder 2 ~ 4, FOS 30 ~ 40, maltodextrin 30 ~ 42.
Preferably, above-mentioned for the oral composition containing witloof powder, the component containing following weight portion in its per unit packaging: witloof powder 20, sealwort powder 4, jerusalem artichoke powder 6, kalimeris head powder 3, konjaku flour 5, grape pip powder 11, lavender powder 3, FOS 35, maltodextrin 36.
Witloof (formal name used at school: Cichorium intybus) is a kind of brushy herbaceos perennial, has effect that is clearing heat and detoxicating, inducing diuresis to reduce edema, cures mainly jaundice with damp-heat pathogen, nephritic dropsy, epigastric distending pain, poor appetite.
Sealwort has another name called tendrilleaf solomonseal rhizome, chicken head ginseng.For the dry rhizome of liliaceous plant P. kingianum, sealwort or David's-harp, there is hypotensive, hypoglycemic, reducing blood lipid, atherosclerosis, delay senility and the effect such as antibacterial, cure mainly that deficiency of Yin labor is coughed, xeropulmonary cough, insufficiency of the spleen weak, the few dry of food, quench one's thirst, deficiency of the kidney soreness and weakness of waist and knees, impotence and seminal emission, tinnitus order are dark, poliosis, body void wins thin, wind favus disease.
Jerusalem artichoke (Helianthus tuberosus) has another name called Jerusalem artichoke, is a kind of composite family Helianthus perennial root herbaceous plant, have Li Shui dehumidifying, clearing heat and cooling blood, beneficial stomach and in effect.
Kalimeris head (Kalimeris indica (L.)) belongs to composite family, and herbaceos perennial is the young stem and leaf (seedling) of feverfew kalimeris Kalimeris indica.Its nature and flavor: cool, pungent.Clearing heat and detoxicating, dampness removing helps digestion, have anti-inflammatory and antalgic, anti-aging, anticancer, prevent and reduce the risk of stroke that caused by hypertension to effect.
Konjaku mainly contains mannose and glucose with-1; 4 strong strong to close the high molecular weight non-ionic mannosan (glucomannan) of [mol ratio is 1.6:(1--4) :]; have a small amount of with-1; 4 keys and bond structure; on average have an acetyl group every 9--19 Ge Tang unit along on glucomannans main chain, it contributes to the dissolving of glucomannans.Mean molecule quantity 200,000--2,000,000.Can be promoting blood circulation and removing blood stasis, removing toxicity for detumescence, wide intestines defaecation, resolving phlegm and softening hard masses; Cure mainly scrofula subcutaneous nodule, damage the diseases such as the stasis of blood is swollen, constipation stomachache, abscess of throat, swelling and aching of gum.In addition, konjaku also has and replenishes the calcium, balances the effects such as salinity, clean stomach, whole intestines, toxin expelling.
Grape pip is the seed of vitaceae grape Vitis vinifera L., be rich in linoleic acid, other multiple unrighted acids, vitamin F, mineral matter, protein, linoleic acid, chlorophyll etc., there is reduction Blood Cholesterol, prevent thrombosis, hemangiectasis effect, there is the effect of nourishing brain cell, regulating plant nerve simultaneously, effectively prevent the various diseases that cardiovascula arteriosclerosis causes.
Lavender (formal name used at school: Lavandula angustifolia Mill.) has another name called perfume plant, Lysimachia foenum-graecum, vanilla, yellow vanilla, La Wende.Belong to Labiatae lavender to belong to, originate in Mediterranean, throughout Europe and Oceania archipelago, extensively to be planted in Britain and Yugoslavia afterwards.Effect: treatment whelk, nourishing healthy hair, pain relieving is calm, alleviation is neural, regulate endocrine, skin maintenance, calmness of calming the nerves, and desalinates scar, goes acne to print, improving water flood, improve women's diseases as dysmenorrhoea etc., eliminate dejected.Lavender also has the good reputation of " fragrant medicinal herbs ", is applicable to any skin, can promotes cytothesis, accelerating wound healing, improve acne, abscess, eczema, balance sebum secretion, and scalding to burning sunburn of burning has special effect, can anti-bacteria, reduce scar.
FOS is also known as fructooligosaccharide, it is the mixture being combined ketose, Nystose and the GF4 etc. that generate by 1 ~ 3 fructosyl by the fructosyl of β (2-1) glycosidic bond in sucrose, obviously can improve microbial population ratio in enteron aisle, it is the activation and proliferation factor of Bifidobacterium in intestines, can reduce and suppress the generation of corrupt substance in intestines, suppress the growth of harmful bacteria, regulating intestinal canal inner equilibrium; Absorption and the utilization of trace elements iron, calcium can be promoted, to prevent osteoporosis; Can hepatotoxin be reduced, anticancer organic acid can be generated in intestines, have significant preventing cancer function.
Maltodextrin is the starch hydrolysate that DE value is less than 20, have that sugariness is low, dissolubility good, not easily the moisture absorption, good stability, be difficult to the characteristic that goes bad.Maltodextrin also have thickening property strong, carrier-mediated good, Fermented is little, filling effect good, nonhygroscopic, free from extraneous odour, easy to digest, the feature such as low-heat, low sugariness.Maltodextrin contains a large amount of polysaccharides, in addition also containing calcium, iron etc. to the useful trace element of human body and mineral matter, and the metabolism of human normal can be promoted.
Above-mentioned substance has synergy by corresponding proportioning, can regulate and even reverse the low-quality and psychological unbalance state that housing construction is degenerated and physiological function goes down, and drink conveniently.
Above-mentioned for the oral composition containing witloof powder in order to make, play better effect in vivo, the particle diameter of described witloof powder, sealwort powder, jerusalem artichoke powder, kalimeris head powder, konjaku flour, grape pip powder, lavender powder is 420 ~ 590 μm.This particle diameter can make active ingredient comparatively be easy to stripping from powder, is beneficial to its absorption in human body.
The invention provides and a kind ofly prepare the above-mentioned method for the oral composition containing witloof powder, comprise the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, each 1 hour, collecting decoction, filter, filtrate is condensed into the medicinal extract that relative density is 1.20 at 60 DEG C, vacuum drying at 80 DEG C, pulverizes the former medicinal extract after vacuum drying as powder, for subsequent use;
(2) supplementary material mixing
The FOS of step (1) gained raw material and formula ratio, maltodextrin are mixed 5 minutes, loads packaging bag and get final product.
Above-mentionedly, just can directly to drink after dissolved in boiled water for the oral composition containing witloof powder, easy to use.
In order to strengthen the above-mentioned stability for the oral composition containing witloof powder, extend its shelf life, also in order to improve above-mentioned speed of dissolving in water for the oral composition containing witloof powder, and referring to can in the inner fully absorption of stomach and intestine in human body, component 80 ~ 120 weight portion also containing formula III structural formula in said composition per unit packaging:
Wherein, the structure of R such as formula IV,
The molecular weight of the component of formula III structural formula is 600 to 4422.
Preferably, above-mentioned for the oral composition containing witloof powder, component 100 weight portion also containing formula III structural formula in said composition per unit packaging.
Above-mentioned for the oral composition containing witloof powder, the preparation method of the component of described formula III structure, comprises the steps:
(1) compound of deionized water, dispersant, structure shown in formula I is fully disperseed, make solution, for subsequent use;
(2) solution that step (1) is obtained is stirred under logical condition of nitrogen gas, control certain rotating speed, add the compound of formula II structure, the weight of the compound of formula II structure and the ratio of structure shown in formula I compound by weight are 3 ~ 4:1, are warming up to 25 DEG C ~ 30 DEG C, after stirring 0.5h, add the first catalyst and start to clock, and dripped the second catalyst wherein in 10 minutes, the second catalyst drops adds rear insulation reaction 1h, question response liquid cooling is final vacuum suction filtration but, obtains filter cake for subsequent use;
(3) filter cake obtained to step (2) drips ethanol washing, obtains the component of formula III structure.
Above-mentioned for the oral composition containing witloof powder, the compound deacetylation of described structure shown in formula I is 99.8%, and viscosity average molecular weigh is 740,000; The volume ml of described deionized water and the ratio of structure shown in formula I compound by weight g are 20 ~ 40:1, and preferably, the volume ml of deionized water and the ratio of structure shown in formula I compound by weight g are 30:1;
Described dispersant is selected from polycarboxylic acids sodium, sodium metasilicate, calgon or polyethylene glycol, and the weight g of dispersant and the ratio of structure shown in formula I compound by weight g are 0.2 ~ 0.4:1;
Preferably, described dispersant is polyethylene glycol, and the ratio of its weight and structure shown in formula I compound by weight is 0.3:1;
Described first catalyst is selected from azo-bis-isobutyrate hydrochloride, azo two isobutyl imidazoline hydrochloride, potassium peroxydisulfate or ammonium persulfate, and the weight g of the first catalyst and the ratio of structure shown in formula I compound by weight g are 0.5 ~ 1:1;
Preferably, described first catalyst is ammonium persulfate, and the ratio of its weight and structure shown in formula I compound by weight is 0.7:1;
Described second catalyst is selected from acrylamide, dimethyl diallyl ammonium chloride, acrylyl oxy-ethyl-trimethyl salmiac, MethacryloyloxyethylTrimethyl Trimethyl Ammonium Chloride, NIPA or N-n-pro-pyl acrylamide, and the weight g of the second catalyst and the ratio of structure shown in formula I compound by weight g are 2 ~ 3:1;
Preferably, described second catalyst is acrylyl oxy-ethyl-trimethyl salmiac, and the ratio of its weight and structure shown in formula I compound by weight is 2.5:1.
Realize improving the speed of dissolving in water, and to drink in human body can stomach and intestine inner fully absorb above-mentioned for the oral composition method containing witloof powder, also namely a kind ofly prepare the above-mentioned method for the oral composition containing witloof powder, comprise the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, each 1 hour, collecting decoction, filter, gained filtrate is for subsequent use;
(2) supplementary material mixing
The FOS of formula ratio, maltodextrin are added in the filtrate of step (1) gained, be uniformly mixed 5 minutes, gained mixture material solution is for subsequent use;
(3) finished product preparation
The component of getting formula III structural formula of formula ratio add pH value be 6.8 containing stirring and dissolving in the phosphate buffer of pancreatin, the volume ml of phosphate buffer and the weight g of the component of formula III structural formula are than being 5:1, add step (2) gained mixed material solution & stir again and disperse to obtain solution, by this solution freeze drying, obtain powder and load packaging bag and get final product.
The component of formula III structural formula can improve the effects such as immunity, activating cell, pre-anti-cancer, reducing blood lipid, hypotensive, anti-ageing, anti-inflammation, pain relieving, adjustment body environment, with compatibilities such as witloof powder, sealwort powder, jerusalem artichoke powder, konjaku flour, kalimeris head powder, grape pip powder, lavender powder, FOS, maltodextrins, not only can play the effectiveness of himself, absorption and the utilization of the active ingredients such as witloof powder can also be promoted.
In addition, of the present invention for oral containing in the composition of witloof powder due to the component containing formula III structural formula, can disperse rapidly with during dissolved in boiled water, in addition, active ingredient is wrapped up by the component of formula III structural formula, active ingredient can be changed in the middle part of small intestine and the situation of the not obvious absorption in bottom, the absorption window of obvious increase active ingredient, extend active ingredient at GI soak time, simultaneously, avoid active ingredient on the gastrointestinal tract the prominent of portion release and build up, add the burst size of active ingredient at effective uptake zone small intestine, further raising bioavilability, the component that the application is used for oral composition Chinese style III structural formula containing witloof powder is key factor, and it can regulate the corrosion speed of composition in gastrointestinal tract environment, makes active ingredient from upper part of small intestine until bottom can continue at the uniform velocity to discharge, another key technology of the present invention is, the component of formula III structural formula can make active ingredient increase in the permeability of small bowel, makes it to be easier to be absorbed, the proportioning of the component of formula III structural formula and the component of unclassified stores, release is steady, had good sustained release effect.
Accompanying drawing explanation
Fig. 1 is the effective content comparison diagram of ambroxol hydrochloride in local organization
Detailed description of the invention
Below in conjunction with detailed description of the invention and accompanying drawing, the present invention is described in further detail.
Embodiment 1 the application is used for the preparation of the oral composition containing witloof powder
Formula: witloof powder 100g, sealwort powder 20g, jerusalem artichoke powder 50g, konjaku flour 30g, kalimeris head powder 20g, grape pip powder 100g, lavender powder 20, FOS 300g, maltodextrin 300g.
Preparation method, comprises the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, each 1 hour, collecting decoction, filter, filtrate is condensed into the medicinal extract that relative density is 1.20 at 60 DEG C, vacuum drying at 80 DEG C, pulverizes the former medicinal extract after vacuum drying as powder, for subsequent use;
(2) supplementary material mixing
The FOS of step (1) gained raw material and formula ratio, maltodextrin are mixed 5 minutes, loads packaging bag and get final product.
Embodiment 2 the application is used for the preparation of the oral composition containing witloof powder
Formula: witloof powder 300g, sealwort powder 60g, jerusalem artichoke powder 70g, konjaku flour 70g, kalimeris head powder 40g, grape pip powder 120g, lavender powder 40g, FOS 400g, maltodextrin 420g.
Preparation method, comprises the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, each 1 hour, collecting decoction, filter, filtrate is condensed into the medicinal extract that relative density is 1.20 at 60 DEG C, vacuum drying at 80 DEG C, pulverizes the former medicinal extract after vacuum drying as powder, for subsequent use;
(2) supplementary material mixing
The FOS of step (1) gained raw material and formula ratio, maltodextrin are mixed 5 minutes, loads packaging bag and get final product.
Embodiment 3 the application is used for the preparation of the oral composition containing witloof powder
Formula: witloof powder 200g, sealwort powder 40g, jerusalem artichoke powder 60g, konjaku flour 50g, kalimeris head powder 30g, grape pip powder 110g, lavender powder 30g, FOS 350g, maltodextrin 360g.
Preparation method, comprises the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, each 1 hour, collecting decoction, filter, filtrate is condensed into the medicinal extract that relative density is 1.20 at 60 DEG C, vacuum drying at 80 DEG C, pulverizes the former medicinal extract after vacuum drying as powder, for subsequent use;
(2) supplementary material mixing
The FOS of step (1) gained raw material and formula ratio, maltodextrin are mixed 5 minutes, loads packaging bag and get final product.
The preparation of the component of embodiment 4 formula III structural formula
(1) compound of deionized water 3000ml, polyethylene glycol 30g, structure shown in formula I (deacetylation be 99.8%, viscosity average molecular weigh 740,000) 100g is fully disperseed, make solution, for subsequent use;
(2) solution that step (1) is obtained is stirred under logical condition of nitrogen gas, control rotating speed 20 ~ 30 revs/min, add the compound 350g of formula II structure, be warming up to 28 DEG C, after stirring 0.5h, add ammonium persulfate 70g and start to clock, and acrylyl oxy-ethyl-trimethyl salmiac 250g was dripped wherein in 10 minutes, acrylyl oxy-ethyl-trimethyl salmiac drips rear insulation reaction 1h, and question response liquid cooling is final vacuum suction filtration but, obtains filter cake for subsequent use;
(3) filter cake obtained to step (2) drips ethanol washing, obtains the component of formula III structure.
The structural identification of the component of formula III structure:
1. elementary analysis
Measured value compares with calculated value, all in allowable error.
2. ultra-violet absorption spectrum
Get this product, accurately weighed, make the solution of 2% with watery hydrochloric acid dilution, at 200-400nm wavelength, place is scanned, and result without absorbing, proves that compound is without conjugated system at more than 230nm.
3. mass spectrum (MS)
(1) BIFLEX type III MALDI TOF mass spectrograph (Bruker company) is adopted; Nitrogen laser, wavelength 337nm, adopt ion to postpone to draw the working method of (delayed extraction) and reflection (reflectorn), cation detects; With DHB (DHB) for matrix, second-crystallized method is adopted to carry out sample preparation.
Known: sample is made up of from the molecule that about 600 to 4400 have various different polymerization degree molecular weight, the maximum molecular weight that can detect is 4422.4, and quasi-molecular ions presents more regular normal distribution, peak value increases progressively with 313Da, matches with this product monomer mass number 313.The maximum peak of relative abundance is the fragment ion peak of 1292, [M+Na]+peak when it is N=4; Near this external m/z 1292, m/z is [the M+K]+peak of 1318 in addition.
(2) get this product, add dilute sulfuric acid, add hot reflux 5 hours, gained hydrolysate adopts triple level Four bar mass spectrograph to analyze, and cation detects.Known:
M/Z=332, is [M+H] +quasi-molecular ions;
M/Z=313, for compound sloughs-H 2o fragment ion;
M/Z=160, is [M+H] +-H is sloughed at peak 2o and R side chain fragment ion
M/Z=155 is the R side chain fragment ion sloughed.
4. proton nmr spectra ( 1hNMR)
Adopt high resolution NMR instrument, with deuterated acetic acid for solvent, measure this product and Glucosamine reference substance and positive borneol reference substance 1hNMR composes, by comparison this product and reference substance 1hNMR spectrogram, finds that the ownership at each peak is almost consistent.
5. carbon-13 nmr spectra ( 13cNMR)
Adopt high resolution NMR instrument, with deuterated acetic acid for solvent, measure this product and Glucosamine reference substance and positive borneol reference substance 13cNMR composes, by comparison this product and reference substance 13cNMR spectrogram, finds that the ownership at each peak is almost consistent.
The preparation of the component of embodiment 5 formula III structural formula
(1) compound of deionized water 2000ml, polycarboxylic acids sodium 20g, structure shown in formula I (deacetylation be 99.8%, viscosity average molecular weigh 740,000) 100g is fully disperseed, make solution, for subsequent use;
(2) solution that step (1) is obtained is stirred under logical condition of nitrogen gas, control rotating speed 20 ~ 30 revs/min, add the compound 300g of formula II structure, be warming up to 25 DEG C, after stirring 0.5h, add azo-bis-isobutyrate hydrochloride 50g and start to clock, and acrylamide 200g was dripped wherein in 10 minutes, acrylamide drips rear insulation reaction 1h, and question response liquid cooling is final vacuum suction filtration but, obtains filter cake for subsequent use;
(3) filter cake obtained to step (2) drips ethanol washing, obtains the component of formula III structure.
The preparation of the component of embodiment 6 formula III structural formula
(1) compound of deionized water 4000ml, sodium metasilicate 40g, structure shown in formula I (deacetylation be 99.8%, viscosity average molecular weigh 740,000) 100g is fully disperseed, make solution, for subsequent use;
(2) solution that step (1) is obtained is stirred under logical condition of nitrogen gas, control rotating speed 20 ~ 30 revs/min, add the compound 400g of formula II structure, be warming up to 30 DEG C, after stirring 0.5h, add azo two isobutyl imidazoline hydrochloride 100g and start to clock, and dimethyl diallyl ammonium chloride 300g was dripped wherein in 10 minutes, dimethyl diallyl ammonium chloride drips rear insulation reaction 1h, and question response liquid cooling is final vacuum suction filtration but, obtains filter cake for subsequent use;
(3) filter cake obtained to step (2) drips ethanol washing, obtains the component of formula III structure.
The preparation of the component of embodiment 7 formula III structural formula
(1) compound of deionized water 2500ml, calgon 25g, structure shown in formula I (deacetylation be 99.8%, viscosity average molecular weigh 740,000) 100g is fully disperseed, make solution, for subsequent use;
(2) solution that step (1) is obtained is stirred under logical condition of nitrogen gas, control rotating speed 20 ~ 30 revs/min, add the compound 380g of formula II structure, be warming up to 27 DEG C, after stirring 0.5h, add potassium peroxydisulfate 80g and start to clock, and NIPA 250g was dripped wherein in 10 minutes, NIPA drips rear insulation reaction 1h, and question response liquid cooling is final vacuum suction filtration but, obtains filter cake for subsequent use;
(3) filter cake obtained to step (2) drips ethanol washing, obtains the component of formula III structure.
The sustained release performance test of the component of embodiment 8 formula III structural formula
(1) medicine carrying formula:
The component 300mg of formula III structural formula that embodiment 4 is obtained
Ambroxol hydrochloride 200mg
Purified water 100ml;
(2) preparation method:
The component of formula III structural formula obtained for embodiment 4 is added in purified water, is stirred well to dissolving, then adds ambroxol hydrochloride, be stirred to dissolving, filter, for subsequent use;
(3) test animal:
Big white mouse 72 (body weight 250-260g/ only);
(4) method of testing:
1, big white mouse is divided into two groups, often organize 36, A group gives oral above-mentioned medicine carrying formula, ambroxol hydrochloride content 2mg/ml; B group gives oral commercially available ambroxol hydrochloride solution, ambroxol hydrochloride content 30mg/5ml, is made into ambroxol hydrochloride content 2mg/ml with physiological saline;
2, (every 1mg) in the right rear leg muscle of two groups of rats is injected respectively by by test product;
3, ambroxol hydrochloride content is measured respectively in oral rear 1h, 2h, 4h, 8h, 16h, 1d, 2d, 3d, 5d, 8d, 11d, 15d.
(5) result:
1, organize the fragment of the still component of visible III structural formula in organizing for 15 days after oral administration, within 15 days, topical remedy's content still reaches 21 ~ 24ug/g;
2, B group does not detect ambroxol hydrochloride in tissue in oral latter 3 days;
Fig. 1 shows ambroxol hydrochloride in local organization and can reach effective content and keep more than 15 days.
Result shows, the component of formula III structural formula that the present invention obtains can make active ingredient controllably be discharged.
Embodiment 9 the application is used for the preparation of the oral composition containing witloof powder
Formula: the component 800g of witloof powder 100g, sealwort powder 20g, jerusalem artichoke powder 50g, konjaku flour 30g, kalimeris head powder 20g, grape pip powder 100g, lavender powder 20g, FOS 300g, maltodextrin 300g, formula III structural formula obtained by embodiment 6.
Preparation method, comprises the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, collecting decoction, filter, gained filtrate is for subsequent use;
(2) supplementary material mixing
The FOS of formula ratio, maltodextrin are added in the filtrate of step (1) gained, be uniformly mixed 5 minutes, gained mixture material solution is for subsequent use;
(3) finished product preparation
The component of getting formula III structural formula of formula ratio add pH value be 6.8 containing stirring and dissolving in the phosphate buffer 4000ml of pancreatin, add step (2) gained mixed material solution & stir again and disperse to obtain solution, by this solution freeze drying, obtain powder and load packaging bag and get final product.
Embodiment 10 the application is used for the preparation of the oral composition containing witloof powder
Formula: the component 1200g of witloof powder 300g, sealwort powder 60g, jerusalem artichoke powder 70g, konjaku flour 70g, kalimeris head powder 40g, grape pip powder 120g, lavender powder 40g, FOS 400g, maltodextrin 420g, formula III structural formula obtained by embodiment 5.
Preparation method, comprises the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, collecting decoction, filter, gained filtrate is for subsequent use;
(2) supplementary material mixing
The FOS of formula ratio, maltodextrin are added in the filtrate of step (1) gained, be uniformly mixed 5 minutes, gained mixture material solution is for subsequent use;
(3) finished product preparation
The component of getting formula III structural formula of formula ratio add pH value be 6.8 containing stirring and dissolving in the phosphate buffer 6000ml of pancreatin, add step (2) gained mixed material solution & stir again and disperse to obtain solution, by this solution freeze drying, obtain powder and load packaging bag and get final product.
Embodiment 11 the application is used for the preparation of the oral composition containing witloof powder
Formula: the component 1000g of witloof powder 200g, sealwort powder 40g, jerusalem artichoke powder 60g, konjaku flour 50g, kalimeris head powder 30g, grape pip powder 110g, lavender powder 30g, FOS 350g, maltodextrin 360g, formula III structural formula obtained by embodiment 4.
Preparation method, comprises the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, collecting decoction, filter, gained filtrate is for subsequent use;
(2) supplementary material mixing
The FOS of formula ratio, maltodextrin are added in the filtrate of step (1) gained, be uniformly mixed 5 minutes, gained mixture material solution is for subsequent use;
(3) finished product preparation
The component of getting formula III structural formula of formula ratio add pH value be 6.8 containing stirring and dissolving in the phosphate buffer 5000ml of pancreatin, add step (2) gained mixed material solution & stir again and disperse to obtain solution, by this solution freeze drying, obtain powder and load packaging bag and get final product.
Embodiment 12 typical case
(1) Zhao, man, 37 years old, fasting blood-glucose 7.2mmol/L, long-term constipation, often has a sleepless night, the state of mind is not good, ignorant, and easily catches a cold, has a fever, and throat swells and ache, canker sore, often eat antibiotic medicine and solve slight illness, take composition prepared by the embodiment of the present invention 3, every day 2 times, each 1 bag, the transference cures such as blood sugar reduces to 6.1mmol/L after two months, constipation, sleep quality improves, and catches a cold, throat swells and ache, the frequency of canker sore obviously reduces.
(2) poplar, man, 31 years old, like a Trojan, often work overtime, even to the late into the night, in the course of time, he feels whole body fatigue and weak gradually, and muscle arthrosis is ached, poor appetite, after comprehensive inspection has been done by hospital, has not found positive sign and assay, take composition prepared by the embodiment of the present invention 11, every day 1 time, each 1 bag, after one month, the whole body easily energetically, and muscle arthrosis is ached disappearances, appetite enhancing.
(3) Wang, 40 years old, because of traffic accident before 2 years, injured scaring and induced insomnia, nervous, every afternoon low-heat, all between 37.5-38 degree, but never greater than 38 degree.Though through recuperating in hospital, symptom does not have and alleviates, and can not adhere to work, takes composition prepared by the embodiment of the present invention 11, every day 1 time, each 1 bag, and various transference cure or alleviate after three months, work of can going to work after half a year, as ordinary person.
The explanation of above embodiment just understands the present invention for helping; professional and technical personnel in the field are realized or uses the present invention; be not limited to the present invention; within the spirit and principles in the present invention all; any amendment of doing, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (5)

1. for the oral composition containing witloof powder, it is characterized in that, said composition per unit packaging is prepared from by the component of following weight portion:
Component 80 ~ 120 weight portion of witloof powder 10 ~ 30, sealwort powder 2 ~ 6, jerusalem artichoke powder 5 ~ 7, kalimeris head powder 2 ~ 4, konjaku flour 3 ~ 7, grape pip powder 10 ~ 12, lavender powder 2 ~ 4, FOS 30 ~ 40, maltodextrin 30 ~ 42, formula III structural formula:
Wherein, the structure of R such as formula IV,
The molecular weight of the component of formula III structural formula is 600 to 4422;
The preparation method of the component of described formula III structure, comprises the steps:
(1) compound of deionized water, dispersant, structure shown in formula I is fully disperseed, make solution, for subsequent use;
(2) solution that step (1) is obtained is stirred under logical condition of nitrogen gas, control rotating speed 20 ~ 30 revs/min, add the compound of formula II structure, the weight of the compound of formula II structure and the ratio of structure shown in formula I compound by weight are 3 ~ 4:1, be warming up to 25 DEG C ~ 30 DEG C, after stirring 0.5h, add the first catalyst and start to clock, and the second catalyst was dripped wherein in 10 minutes, second catalyst drops adds rear insulation reaction 1h, question response liquid cooling is final vacuum suction filtration but, obtains filter cake for subsequent use;
(3) filter cake obtained to step (2) drips ethanol washing, obtains the component of formula III structure;
Wherein, the compound deacetylation of described structure shown in formula I is 99.8%, and viscosity average molecular weigh is 740,000;
The volume ml of described deionized water and the ratio of structure shown in formula I compound by weight g are 20 ~ 40:1;
Described dispersant is selected from polycarboxylic acids sodium, sodium metasilicate, calgon or polyethylene glycol, and the weight of dispersant and the ratio of structure shown in formula I compound by weight are 0.2 ~ 0.4:1;
Described first catalyst is selected from azo-bis-isobutyrate hydrochloride, azo two isobutyl imidazoline hydrochloride, potassium peroxydisulfate or ammonium persulfate, the first catalyst weight and the ratio of structure shown in formula I compound by weight be 0.5 ~ 1:1;
Described second catalyst is selected from acrylamide, dimethyl diallyl ammonium chloride, acrylyl oxy-ethyl-trimethyl salmiac, MethacryloyloxyethylTrimethyl Trimethyl Ammonium Chloride, NIPA or N-n-pro-pyl acrylamide, and the weight of the second catalyst and the ratio of structure shown in formula I compound by weight are 2 ~ 3:1.
2. according to claim 1ly it is characterized in that for the oral composition containing witloof powder, said composition per unit packaging is prepared from by the component of following weight portion:
Component 100 weight portion of witloof powder 20, sealwort powder 4, jerusalem artichoke powder 6, kalimeris head powder 3, konjaku flour 5, grape pip powder 11, lavender powder 3, FOS 35, maltodextrin 36, formula III structural formula.
3. according to claim 2 for the oral composition containing witloof powder, it is characterized in that, the particle diameter of described witloof powder, sealwort powder, jerusalem artichoke powder, konjaku flour, kalimeris head powder, grape pip powder, lavender powder is 420 ~ 590 μm.
4. according to claim 1 for the oral composition containing witloof powder, it is characterized in that, the volume ml of described deionized water and the ratio of structure shown in formula I compound by weight g are 30:1; Described dispersant polyethylene glycol, the weight of dispersant and the ratio of structure shown in formula I compound by weight are 0.3:1; Described first catalyst is ammonium persulfate, and the weight of the first catalyst and the ratio of structure shown in formula I compound by weight are 0.7:1; Described second catalyst is acrylyl oxy-ethyl-trimethyl salmiac, and the weight of the second catalyst and the ratio of structure shown in formula I compound by weight are 2.5:1.
5. prepare as claimed in claim 1 or 2 for a method for the oral composition containing witloof powder, it is characterized in that, comprise the steps:
(1) pretreatment of raw material
By the witloof powder of the complete formula ratio of cleaning, jerusalem artichoke powder, konjaku flour, sealwort powder, kalimeris head powder, grape pip powder, lavender powder boiling three times, each 1 hour, collecting decoction, filter, gained filtrate is for subsequent use;
(2) supplementary material mixing
The FOS of formula ratio, maltodextrin are added in the filtrate of step (1) gained, be uniformly mixed 5 minutes, gained mixture material solution is for subsequent use;
(3) finished product preparation
The component of getting formula III structural formula of formula ratio add pH value be 6.8 containing stirring and dissolving in the phosphate buffer of pancreatin, the weight ratio of the volume of phosphate buffer and the component of formula III structural formula is 5:1, add step (2) gained mixed material solution & stir again and disperse to obtain solution, by this solution freeze drying, obtain powder and load packaging bag and get final product.
CN201410054921.6A 2014-02-18 2014-02-18 Peroral composition containing chicory powder and preparation method thereof Active CN103766906B (en)

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CN1530101A (en) * 2003-03-13 2004-09-22 侯玉庆 Healthy food composition for purifying blood, improving immunity and regulating blood fat
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