CN103446328A - Slow-release film for treating glaucoma and preparation method thereof - Google Patents
Slow-release film for treating glaucoma and preparation method thereof Download PDFInfo
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- CN103446328A CN103446328A CN2013104065265A CN201310406526A CN103446328A CN 103446328 A CN103446328 A CN 103446328A CN 2013104065265 A CN2013104065265 A CN 2013104065265A CN 201310406526 A CN201310406526 A CN 201310406526A CN 103446328 A CN103446328 A CN 103446328A
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Abstract
The invention discloses a slow-release film for treating glaucoma and a preparation method thereof. The preparation method is characterized by being a complete set of manufacturing method comprising the steps of extracting traditional Chinese medicine compound Qiangguangan, centrifugal separating, filtering, adding a proper amount of auxiliary material, homogenizing, forming film and sterilizing. The medicine disclosed in the invention is a formulation innovation based on the existing Qiangguangan granules, a novel long-acting film is provided to patients, so as to meet the ever increasing medicine and medical treatment requirements.
Description
Technical field
The present invention relates to a kind of glaucomatous medicine, specifically a kind of glaucomatous slow-release medicine-membrane and preparation method thereof for the treatment of.
Background technology
Furamon granule with benefiting QI for activating blood circulation diuretic effect, by the Radix Astragali, Pheretima, Radix Paeoniae Rubra, Flos Carthami, Poria, Semen Plantaginis, the Rhizoma Atractylodis Macrocephalae, Pheretima eight herbal medicine prescriptions, formed, be used for the treatment of glaucoma and gone through 18 years as preparation in the first institute of Affiliated Hospital of medical drugs university in Hunan, mature and reliable.Due to high, the easy deliquescence of granule cost of manufacture, high to packing method and material requirements, mobility is poor, palatability is slightly poor.
At present, the dosing eyes dosage form is modal is eye drop and Eye ointments, but special anatomical configurations and physiology and biochemistry character due to eyes, make exogenous medicine be difficult to enter wherein, at the bottom of wherein distinct issues are exactly dosing eyes artifact availability, indivedual medicines are because nose eye Tube Drain causes systemic adverse reactions.Traditional eye drop easily flows out from eye in addition, needs multiple dosing, and Eye ointments easily causes that mist looks, thereby causes the patient compliance type poor.
And the sustained release film formulation that the present invention does, by controlling slowly Stable Release medicine of substrate, can the prolong drug eye holdup time, reduce administration number of times, avoid the administration at night, blood drug level is steady, increase the stability of Drug therapy, also can reduce the accumulated dose of medication, thereby improved curative effect.And ocular inserts is little and thin, pliability is high, through ultraviolet radiation sterilization, needn't add antibacterial, to the general nonirritant of eye and sense of discomfort.There is no at present the report of glaucoma slow releasing agent membrane and making thereof both at home and abroad.
Summary of the invention
In order to overcome the deficiency of above-mentioned existing dosage form, the invention provides a kind of glaucomatous slow-release medicine-membrane and preparation method thereof for the treatment of.
Letter out eye slow-release medicine-membrane of the present invention, its raw material forms and weight fraction is: 45-55 parts of filmogens, glycerol 7-10 part, furamon medicinal liquid 15-25 part, Tween 80 1-3 part.
Described filmogen is formulated by 5 to 1 weight by PVAC polyvinylalcohol, chitosan CS.
Described furamon medicinal liquid is that following method makes: the former medicine of furamon is mixed to rear pulverizing by its formula, add the water reflux, extract,,, filtering and concentrating centrifugal extracting solution and get final product.
The preparation method of letter out eye slow-release medicine-membrane of the present invention is: filmogen is added water-soluble swollen, heating for dissolving, add glycerol, furamon medicinal liquid, Tween 80, stirs evenly, and films, and dries, and sterilization, form medicine film finished product after opening film.
Compared with prior art, the invention has the beneficial effects as follows: 1. can reduce medicining times, easy to use, can greatly improve the compliance that patient takes medicine like this; 2. make blood drug level steady, avoid or reduce peak valley phenomenon, be conducive to reduce the toxic and side effects of medicine; 3. can reduce the total amount of medication, therefore the dosage of available minimum reaches maximum effect.And the present invention to have a technological process short, the simple characteristics of method, have good popularizing application prospect.
The step of the specific embodiment 1 is:
1, get Radix Astragali 40-80g, Pheretima 10-30g, Radix Paeoniae Rubra 10-30g, Flos Carthami 10-30g, Poria 10-30g, Semen Plantaginis 10-30g, Rhizoma Atractylodis Macrocephalae 10-30g, Radix Rehmanniae 10-30g mix pulverizing, water reflux, extract, 1-3 hour with 1.8L, pour out extracting solution, with the centrifugal 10-20min of the speed of 30r/min, filtration under diminished pressure again, it is the furamon medicinal liquid that gained is considered liquid.
2, be mixed with membrane material: PVAC polyvinylalcohol, chitosan CS(ratio are 5 to 1).
3, the preparation of sustained release film formulation: filmogen 6g is added to suitable quantity of water and soak, heating for dissolving, add glycerol 0.5ml, furamon medicinal liquid 20ml, and 3 of tween 80s, stir evenly, and dries, and the 30min ultraviolet radiation disinfection, open film.
The step of the specific embodiment 2 is:
1, get Radix Astragali 60g, Pheretima 20g, Radix Paeoniae Rubra 20g, Flos Carthami 20g, Poria 20g, Semen Plantaginis 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Rehmanniae 20g mix pulverizing, by the water reflux, extract, of 1.8L 3 hours, pour out extracting solution, with the centrifugal 10min of the speed of 30r/min, filtration under diminished pressure again, obtaining 340ml, to consider liquid be the furamon medicinal liquid.
2, be mixed with membrane material: PVAC polyvinylalcohol, chitosan CS(ratio are 5 to 1).
3, the preparation of sustained release film formulation: filmogen 6g is added to suitable quantity of water and soak, heating for dissolving, add glycerol 0.5ml, furamon medicinal liquid 20ml, and 3 of tween 80s, stir evenly, and dries, and the 30min ultraviolet radiation disinfection, open film.
Claims (5)
1. treat glaucomatous slow-release medicine-membrane for one kind, it is characterized in that: its raw material forms and weight fraction is: 45-55 parts of filmogens, glycerol 7-10 part, furamon medicinal liquid 15-25 part, Tween 80 1-3 part.
2. a kind of medicine film for the treatment of the glaucoma slow release according to claim 1 is characterized in that: described filmogen is formulated by 5 to 1 weight by PVAC polyvinylalcohol, chitosan CS.
3. a kind of medicine film for the treatment of the glaucoma slow release according to claim 1, it is characterized in that: described furamon medicinal liquid is that following method makes: the former medicine of furamon is mixed to rear pulverizing by its formula, add the water reflux, extract,,, filtering and concentrating centrifugal extracting solution and get final product.
4. a kind of medicine film for the treatment of the glaucoma slow release according to claim 1 is characterized in that: described furamon medicinal liquid is to be extracted and formed by following composition: get Radix Astragali 40-80g, Pheretima 10-30g, Radix Paeoniae Rubra 10-30g, Flos Carthami 10-30g, Poria 10-30g, Semen Plantaginis 10-30g, Rhizoma Atractylodis Macrocephalae 10-30g, Radix Rehmanniae 10-30g.
5. the preparation method of an a kind of glaucoma sustained release film formulation as claimed in claim 1 is: filmogen is added water-soluble swollen, heating for dissolving, add glycerol, furamon medicinal liquid, Tween 80, stirs evenly, and films, and dries, and sterilization, form medicine film finished product after opening film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013104065265A CN103446328A (en) | 2013-09-10 | 2013-09-10 | Slow-release film for treating glaucoma and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013104065265A CN103446328A (en) | 2013-09-10 | 2013-09-10 | Slow-release film for treating glaucoma and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103446328A true CN103446328A (en) | 2013-12-18 |
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| CN2013104065265A Pending CN103446328A (en) | 2013-09-10 | 2013-09-10 | Slow-release film for treating glaucoma and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825425A (en) * | 2014-09-28 | 2015-08-12 | 青岛大学附属医院 | Natamycin-cyclodextrin inclusion compound containing ophthalmic sustained-release medicine membrane and application thereof |
| CN108743566A (en) * | 2018-05-23 | 2018-11-06 | 中南大学湘雅二医院 | A kind of preparation method and application of PHBV/ rosiglitazone slow-releases film |
-
2013
- 2013-09-10 CN CN2013104065265A patent/CN103446328A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 曾红艳: "青光安颗粒剂对体外培养小梁细胞凋亡相关基因产物和细胞外基质作用的研究", 《中国博士学位论文全文数据库 医药卫生科技辑》 * |
| 李范珠: "《药剂学》", 28 February 2011, 中国中医药出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825425A (en) * | 2014-09-28 | 2015-08-12 | 青岛大学附属医院 | Natamycin-cyclodextrin inclusion compound containing ophthalmic sustained-release medicine membrane and application thereof |
| CN108743566A (en) * | 2018-05-23 | 2018-11-06 | 中南大学湘雅二医院 | A kind of preparation method and application of PHBV/ rosiglitazone slow-releases film |
| CN108743566B (en) * | 2018-05-23 | 2021-02-02 | 中南大学湘雅二医院 | Preparation method and application of PHBV/rosiglitazone sustained-release membrane |
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Application publication date: 20131218 |
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