CN103349764A - Medicine for treating breast cancer and preparation method thereof - Google Patents
Medicine for treating breast cancer and preparation method thereof Download PDFInfo
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- CN103349764A CN103349764A CN2013102842705A CN201310284270A CN103349764A CN 103349764 A CN103349764 A CN 103349764A CN 2013102842705 A CN2013102842705 A CN 2013102842705A CN 201310284270 A CN201310284270 A CN 201310284270A CN 103349764 A CN103349764 A CN 103349764A
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Abstract
The invention discloses a medicine for treating breast cancer and a preparation method thereof. The medicine is mainly prepared from prepared rehmannia root, semen brassicae, antler gum, rhizoma zingiberis and ephedra according to a certain weight ratio. The medicine has the effects of clearing heat and detoxifying, promoting the circulation of qi and removing stasis, warming spleen and stomach for dispelling cold as well as subsiding swelling and dissipating stasis, and takes effect quickly and has a good curative effect and high cure rate when being used for treating breast cancer.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of breast carcinoma and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Breast carcinoma is the common cancer that the women ranks the first.The age distribution of pathogenesis of breast carcinoma is different in country between east and west, in countries such as district occurred frequently such as Northern Europe, North Americas, breast carcinoma was since appearance in about 20 years old, before being 45-50 year menopause, keep the fast rise impetus, approximately the sickness rate rising of every growths 10-20 of age year is 1 times, rise after menopause relatively slow, 75-85 year reaches the highest.And in the Asia etc. the low area of sending out, the sickness rate of breast carcinoma can slightly descend after menopause, the onset peak of general breast carcinoma is between 45-55 year.At present, because Western medicine can't rapid, effective treatment breast carcinoma, and have a lot of side effect, therefore, there is very large demand in people to the Chinese medicine of rapid, effective treatment breast carcinoma.
Summary of the invention
The inventor has finally found the medicine of effective treatment breast carcinoma, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of composition of medicine that can effectively treat breast carcinoma.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Rehmanniae Preparata, Semen Sinapis Albae, Colla cornus cervi, Rhizoma Zingiberis, Herba Ephedrae, Cortex Cinnamomi, Radix Glycyrrhizae, Pseudobulbus cremastrae seu pleiones medicine to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby can effectively treat the recurrence of breast carcinoma.Wherein select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor enters liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Select Semen Sinapis Albae to be because its nature and flavor are hot, temperature enters lung, stomach warp, and the promoting the circulation of QI eliminating phlegm is arranged, warming spleen and stomach for dispelling cold, and the function of removing obstruction in the collateral to relieve pain is controlled the phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, the regurgitation vomiting, aphasia due to apoplexy, the limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Selecting Colla cornus cervi is that temperature enters liver, kidney channel because of its property sweet-salty, enriches blood, and the function of benefit essence is controlled deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, uterus cold caused by deficiency, metrorrhagia, leukorrhagia.Select Rhizoma Zingiberis to be because its nature and flavor are hot, heat enters spleen, stomach, lung meridian, has warming middle-JIAO to pursue cold, and the function that recuperating depleted YANG is promoted blood circulation is controlled trusted subordinate's cold type of pain, vomit and diarrhoea, and the cold extremities faint pulse, cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, yang deficiency is told, nosebleed, hematochezia.Select Herba Ephedrae to be because its nature and flavor are worked hard, temperature enters lung, urinary bladder channel, and diaphoresis is arranged, relieving asthma, and the function of diuretic, curing the wound cold table is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia; Cough and asthma, edema due to wind pathogen edema, dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Selecting Cortex Cinnamomi is that heat enters kidney, spleen, urinary bladder channel because of its property acrid-sweet flavor, the complement sun is arranged, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation is controlled decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select Pseudobulbus cremastrae seu pleiones to be because the sweet little suffering of its nature and flavor is cold, enter liver, spleen channel, detumescence is arranged, eliminating stagnation is reduced phlegm, and the function of detoxifcation is controlled the carbuncle furuncle swollen, scrofula, and sore throat swells and ache, and Serpentis, worm, mad dog hinder.
The specific embodiment
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope
Radix Rehmanniae Preparata 290-310 gram Semen Sinapis Albaes 50-70 gram Colla cornus cervis 85-95 grams
Rhizoma Zingiberis 10-20 gram Herba Ephedraes 10-20 gram Cortex Cinnamomis 25-35 grams
Radix Glycyrrhizae 25-35 Keshan Rhizoma sagittariae sagittifoliaes 55-65 grams
Preferable amount is
Radix Rehmanniae Preparata 300 gram Semen Sinapis Albaes 60 gram Colla cornus cervis 90 grams
Rhizoma Zingiberis 15 gram Herba Ephedraes 15 gram Cortex Cinnamomis 30 grams
Radix Glycyrrhizae 30 Keshan Rhizoma sagittariae sagittifoliaes 60 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, when solarization is done to eighty per cant, section, drying;
2, Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance and get final product;
3, Colla cornus cervi: get crude drug, remove impurity, the time spent smashs to pieces or levigation;
4, Rhizoma Zingiberis: get Rhizoma Zingiberis and put into pot, fry to surface black, take out, section;
5, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after little profit is drying to obtain;
6, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, infiltrates a moment with warm water, and section is dried;
7, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;
8, Pseudobulbus cremastrae seu pleiones: eliminate fibrous root, clean, clear water soaked 2-4 hour, and taking-up runs through, and section is dried.
Two, preparation
1, Radix Rehmanniae Preparata, Semen Sinapis Albae, Colla cornus cervi, Rhizoma Zingiberis, Herba Ephedrae, Cortex Cinnamomi, Radix Glycyrrhizae, the Pseudobulbus cremastrae seu pleiones with described weight decocts with water twice, each amount of water was with till soaking powder, merge decoction liquor twice, filter to get filtrate, be condensed into proportion and be 1.35 extractum, add 90%-95% ethanol, stir, the precipitation Recycled ethanol is also concentrated, 45-50 ℃ of lower drying, makes dry extract.
2, dry extract is broken into fine powder and makes pill take the Mel of refining as binding agent, every ball 1 restrains.
Medicine of the present invention has heat-clearing and toxic substances removing, regulating qi to disperse stagnation, and warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain, detumescence, the effect of eliminating stagnation, the side effect for the treatment of breast carcinoma is little, and instant effect, short treating period do not recur.
Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 20 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 10 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is balls every days 4, and normal amount is balls every days 2, and administering mode is the administration by gavage administration, serve on 30 days, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 180 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation
1. lump in breast: be the modal performance of breast carcinoma.
2. nipple changes: nipple discharge mostly are optimum change, but to more than 50 years old, have one-sided nipple discharge person should watch out for the probability that breast carcinoma occurs; Crater nipple; It often is the clinical manifestation of mammary gland Paget (Paget is sick) that the eczema samples such as nipple pruritus, desquamation, erosion, ulcer, incrustation change.
3. skin of breast and profile change: the Cooper ligament of tumor invading skin can form " dimple sign "; Tumor cell stops up subcutaneous lymphatic capillary, causes hydroderma, and the hair follicle place is recessed to form " Pericarpium Citri tangerinae is levied "; When skin is extensively invaded, can form most hard lesser tubercle or little rope at epidermis, even merge in flakes, extend to the back and the offside thoracic wall can limit breathing such as pathological changes, form corset cancer; Inflammatory breast cancer breast can occur and obviously increase, and dermathemia is red and swollen, local skin temperature increases; In addition, skin ulceration formation cancer ulcer can appear in advanced breast cancer.
4. lymphadenectasis: but the enlargement of homonymy axillary gland, and advanced breast cancer can cause enlargement to the offside axillary lymphatic metastasis; Also can contact in some cases in addition homonymy and or the offside clavicle on enlarged lymph node.
3, Therapeutic Method
Select above-mentioned pill, take to the patient, each serving using 6 balls, every day early, middle and late respectively the clothes 1 time, 20 days is a course for the treatment of, takes continuously 4 courses for the treatment of.
4, efficacy assessment standard
Produce effects: symptoms of breast cancer disappears, and it is normal that body constitution is recovered, and observes 1 year without the recidivist;
Take a turn for the better: breast carcinoma is clearly better.
Invalid: as not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, with Drug therapy patient with breast cancer's 180 examples of the present invention, produce effects 109 examples as a result, obvious effective rate is 60.56%; 11 examples that take a turn for the better, improvement rate is 6.11%; Invalid 60 examples, improvement rate are 33.33%, and total effective rate is 66.67%.
Claims (3)
1. medicine for the treatment of breast carcinoma, it is characterized in that: it is to be made by the crude drug in the following weight range:
Radix Rehmanniae Preparata 290-310 gram Semen Sinapis Albaes 50-70 gram Colla cornus cervis 85-95 grams
Rhizoma Zingiberis 10-20 gram Herba Ephedraes 10-20 gram Cortex Cinnamomis 25-35 grams
Radix Glycyrrhizae 25-35 Keshan Rhizoma sagittariae sagittifoliaes 55-65 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Rehmanniae Preparata 300 gram Semen Sinapis Albaes 60 gram Colla cornus cervis 90 grams
Rhizoma Zingiberis 15 gram Herba Ephedraes 15 gram Cortex Cinnamomis 30 grams
Radix Glycyrrhizae 30 Keshan Rhizoma sagittariae sagittifoliaes 60 grams.
3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:
(1) gets the raw materials ready
(1) Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, when solarization is done to eighty per cant, section, drying;
(2) Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance and get final product;
(3) Colla cornus cervi: get crude drug, remove impurity, the time spent smashs to pieces or levigation;
(4) Rhizoma Zingiberis: get Rhizoma Zingiberis and put into pot, fry to surface black, take out, section;
(5) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after little profit is drying to obtain;
(6) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, infiltrates a moment with warm water, and section is dried;
(7) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;
(8) Pseudobulbus cremastrae seu pleiones: eliminate fibrous root, clean, clear water soaked 2-4 hour, and taking-up runs through, and section is dried;
(2) preparation
(1) Radix Rehmanniae Preparata, Semen Sinapis Albae, Colla cornus cervi, Rhizoma Zingiberis, Herba Ephedrae, Cortex Cinnamomi, Radix Glycyrrhizae, the Pseudobulbus cremastrae seu pleiones with described weight decocts with water twice, each amount of water was with till soaking powder, merge decoction liquor twice, filter to get filtrate, be condensed into proportion and be 1.35 extractum, add 90%-95% ethanol, stir, the precipitation Recycled ethanol is also concentrated, 45-50 ℃ of lower drying, makes dry extract;
(2) dry extract is broken into fine powder and makes pill take the Mel of refining as binding agent, every ball 1 restrains.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103893518A (en) * | 2014-04-28 | 2014-07-02 | 房良华 | Anti-tumor traditional Chinese medicine composition |
CN114028531A (en) * | 2021-12-21 | 2022-02-11 | 黑龙江中医药大学 | Medicine for treating breast cancer and preparation method and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101371890A (en) * | 2007-08-23 | 2009-02-25 | 北京亚东生物制药有限公司 | Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof |
CN101537153A (en) * | 2008-03-21 | 2009-09-23 | 北京汉潮联创中药科技有限公司 | Chinese traditional medicine preparation for curing breast cancer |
CN101966255A (en) * | 2007-08-23 | 2011-02-09 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating mammary gland hyperplasia and breast cancer and preparation method thereof |
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2013
- 2013-07-09 CN CN2013102842705A patent/CN103349764A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101371890A (en) * | 2007-08-23 | 2009-02-25 | 北京亚东生物制药有限公司 | Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof |
CN101966255A (en) * | 2007-08-23 | 2011-02-09 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating mammary gland hyperplasia and breast cancer and preparation method thereof |
CN101537153A (en) * | 2008-03-21 | 2009-09-23 | 北京汉潮联创中药科技有限公司 | Chinese traditional medicine preparation for curing breast cancer |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103893518A (en) * | 2014-04-28 | 2014-07-02 | 房良华 | Anti-tumor traditional Chinese medicine composition |
CN114028531A (en) * | 2021-12-21 | 2022-02-11 | 黑龙江中医药大学 | Medicine for treating breast cancer and preparation method and application thereof |
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Application publication date: 20131016 |