CN103611089A

CN103611089A - Medicine for treating psoriasis and preparation method thereof

Info

Publication number: CN103611089A
Application number: CN201310653845.6A
Authority: CN
Inventors: 孙凤梅
Original assignee: Individual
Current assignee: Sun Guixia
Priority date: 2013-12-09
Filing date: 2013-12-09
Publication date: 2014-03-05
Anticipated expiration: 2033-12-09
Also published as: CN103611089B

Abstract

The invention discloses a medicine for treating psoriasis and a preparation method thereof. The medicine is mainly prepared from the medicines such as dark plum, rhizoma anemarrhenae, minium, madder, curcuma zedoary, pillis ophidiae, rhizoma alismatis and mountain wood at a certain weight ratio. The medicine disclosed by the invention has the functions of nourishing yin to lessen fire, removing stasis and stimulating the menstrual flow, and clearing heat and removing toxicity, and is fast in effect taking, good in curative effect, and free from psoriasis relapse in case of being used for treating psoriasis.

Description

A kind of psoriatic medicine and preparation method thereof for the treatment of

Technical field

The present invention relates to a kind of psoriatic medicine and preparation method thereof for the treatment of, belong to the field of Chinese medicines.

Technical background

Psoriasis is commonly called as psoriasis, is chronic dermatitis, is a kind of FFI erythroderma desquamativum and psychosomatic disease.According to clinical manifestation, primary disease can be divided into homeliness type, arthropathica, pustule type and erythrodermic, take homeliness type as common.Its cause of disease is not yet completely clear and definite, may be allergy or autoimmune disease.The course of disease is very long, has tendency of recurrence, and some cases almost cannot be cured all one's life.Because Western medicine cannot effectively be treated psoriasis, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the psoriatic Chinese medicine of effective treatment.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the psoriatic medicine of effective treatment, thereby has completed the present invention.

Object of the present invention is just to provide a kind ofly can effectively treat psoriatic composition of medicine.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Fructus Mume, the Rhizoma Anemarrhenae, Plumbum preparatium, Radix Rubiae, Rhizoma Curcumae, Periostracum Serpentis, Rhizoma Alismatis, Asbestus, Radix Arnebiae (Radix Lithospermi), the Fructus Kochiae, Flos Lonicerae, Radix Scrophulariae medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat psoriatic recurrence.Wherein select Fructus Mume to be because its nature and flavor are sour, temperature, enters liver, spleen, and lung, large intestine channel, has convergence to promote the production of body fluid, and the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, dysentery, has blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.Select the Rhizoma Anemarrhenae to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, there is nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Plumbum preparatium to be because its nature and flavor are pungent salty, cold, poisonous, enter the heart, spleen, Liver Channel, there is removing toxic substances, granulation promoting, the function of eliminating phlegm down to arrest convulsion, controls carbuncle, ulcer, incised wound is hemorrhage, aphtha, corneal nebula, the soup fire ， Jing Epilepsy of burning is demented, malaria, dysentery, tells converse stomach.Select Radix Rubiae to be because its nature and flavor are bitter, cold, there is cooling blood for hemostasis, the function that blood stasis dispelling stimulates the menstrual flow, controls haematemesis, epistaxis, metrorrhagia, traumatic hemorrhage, stasis blocking amenorrhea, arthralgia, tumbling and swelling.Select Rhizoma Curcumae to be because its nature and flavor acrid, bitter, warm.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain, treating swelling and pain by traumatic injury, early cervical carcinoma.Select Periostracum Serpentis to be because its property sweet-salty is flat, poisonous, enter Liver Channel, dispel the wind, arresting convulsion, nebula removing, detumescence, the function of parasite killing, controls the frightened Epilepsy of little youngster, acute throat trouble aphtha, swollen and rigid tongue congenital deformity of the tongue, corneal nebula cataract, furuncle, carbuncle, scrofula, parotitis, anal fistula, scabies.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, there is diuretic, eliminating dampness by diuresis, the function expelling the heat-evil, controls dysuria, and edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Asbestus to be because its nature and flavor are sweet, cold, there is heat clearing away, relieving restlessness, the function of diuresis, controls cough due to lung-heat, laryngopharynx swelling and pain, dysphoria with smothery sensation sun is fainted, dysuria, miliaria alba skin ulcer.Select Radix Arnebiae (Radix Lithospermi) to be because its nature and flavor are bitter, cold, enter percardium, Liver Channel, there is removing heat from blood, to invigorate blood circulation, the function of heat-clearing and toxic substances removing, controls warm macule, jaundice due to damp-heat, purpura, tells, nosebleed, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.Select the Fructus Kochiae to be because its nature and flavor sweetness and bitterness is cold, enter kidney, urinary bladder channel, have diuresis, the function of clearing away damp-heat, controls dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Radix Scrophulariae to be because its nature and flavor are bitter, salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, controls calentura excessive thirst, sends out speckle, and hectic fever due to YIN-deficiency consumptive fever, sleeps not peaceful night, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.

The specific embodiment

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Fructus Mume 5-15 gram of Rhizoma Anemarrhenae 8-15 gram of Plumbum preparatium 2-3 gram

Radix Rubiae 10-20 gram of Rhizoma Curcumae 10-15 gram of Periostracum Serpentis 8-15 gram

Rhizoma Alismatis 8-15 gram of Asbestus 8-15 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram

Fructus Kochiae 8-15 gram of Flos Lonicerae 10-15 gram of Radix Scrophulariae 8-15 gram

Preferable amount is

2 grams of 10 grams of Plumbum preparatiums of 10 grams of Rhizoma Anemarrhenaes of Fructus Mume

10 grams of 12 grams of Periostracum Serpentiss of 15 grams of Rhizoma Curcumae of Radix Rubiae

15 grams of 10 grams of Radix Arnebiae (Radix Lithospermi)s of 10 grams of Asbestuss of Rhizoma Alismatis

10 grams of 12 grams of Radix Scrophulariaes of 10 grams of Flos Loniceraes of the Fructus Kochiae

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Fructus Mume: choose clean impurity, sieve dedust bits, clean, and dry;

2, the Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, softens, and section is dried;

3, Plumbum preparatium: pure lead is placed in iron pan and is heated, fry and move, utilize air to make it oxidation, be then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drift out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;

4, Radix Rubiae: remove impurity, clean, run through, cut sheet or section, dry, sieve removes chip;

5, Rhizoma Curcumae: get crude drug, remove impurity, big or small stepping, cleans, and slightly soaks, and takes out, runs through, shave, and dry, sieve removes chip;

6, Periostracum Serpentis: with Radix Glycyrrhizae, washed, dried, evener with yellow wine spray, put pot interior micro-stir-fry to yellow, 100 jin of every Periostracum Serpentiss, with 5 jin of wine;

7, Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;

8, Asbestus: get crude drug, choose clean impurity;

9, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;

10, the Fructus Kochiae: get crude drug, remove impurity, sieve removes chip;

11, Flos Lonicerae: sieve removes silt, chooses clean impurity;

12, Radix Scrophulariae: choose clean impurity, except removing LU, clean and run through, section, dries.

Two, preparation

1, the Fructus Mume of described weight, the Rhizoma Anemarrhenae, Plumbum preparatium, Radix Rubiae, Rhizoma Curcumae, Periostracum Serpentis, Rhizoma Alismatis, Asbestus, Radix Arnebiae (Radix Lithospermi), the Fructus Kochiae, Flos Lonicerae, Radix Scrophulariae are decocted with water twice, add for the first time 8 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.

2, will filter for the first time rear medicinal residues and add 4 times of amounts of water, and decoct boiling, then within 20 minutes, obtain decoction liquor for the second time with slow fire boiling.

3, twice decoction liquor mixed, be divided into 3 doses and take.

Medicine of the present invention has nourishing YIN to lower pathogenic fire, and blood stasis dispelling stimulates the menstrual flow, and the function of heat-clearing and toxic substances removing is used for the treatment of psoriasis instant effect, and short treating period, does not recur.

By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 245 examples for medical treatment.

2, diagnostic criteria

Clinical manifestation

Typical case shows as the erythema that boundary is clear, shape size differs, and slightly infiltrates and thickens.On erythema face, cover silvery white lamination squama.Squama is easy to scrape de-, the common petechial hemorrhage of its basal plane after scraping.Skin lesion is apt to occur in head, sacrum portion and extremity and stretches side, conscious pruritus.

Divide general property and limitation.Generalized pustular psoriasis comprises again Von Zumbusch psoriasis pustulosa, Hallopeau acrodermatitis continua and impetigo herpetiformis.Their common feature is the aseptic pustule that occurs the shallow table of gregariousness in erythema, and oral mucosa can be got involved simultaneously.Acute onset or increase the weight of suddenly often with General Symptomies such as shiver with cold, heating, arthralgia, general malaises.In the catabasis, often there is psoriasis vulgaris.Limitation psoriasis pustulosa comprises " accompanying pustulate psoriasis ", limitation Hallopeau acrodermatitis continua, annular pustular psoriasis and palmoplantar pustulosis.

3, Therapeutic Method

Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 10 days was a course for the treatment of, took continuously 4 courses for the treatment of.

4, efficacy assessment standard

Effective: psoriasis is eliminated, observe after half a year without recurrence;

Take a turn for the better: psoriasis symptom is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

Figure 2013106538456100002DEST_PATH_IMAGE001

In above-mentioned treatment, by Drug therapy psoriatic's 245 examples of the present invention, effective 231 examples of result, obvious effective rate is 94.29%, 11 examples that take a turn for the better, and improvement rate is 4.49%, invalid 3 examples, total effective rate is 98.78%.

Claims

1. treat a psoriatic medicine, it is characterized in that: it is to be made by the crude drug in following weight range:

Fructus Kochiae 8-15 gram of Flos Lonicerae 10-15 gram of Radix Scrophulariae 8-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

10 grams of 12 grams of Radix Scrophulariaes of 10 grams of Flos Loniceraes of the Fructus Kochiae.

3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Fructus Mume: choose clean impurity, sieve dedust bits, clean, and dry;

(2) Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, softens, and section is dried;

(3) Plumbum preparatium: pure lead is placed in iron pan and is heated, fry and move, utilize air to make it oxidation, be then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drift out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;

(4) Radix Rubiae: remove impurity, clean, run through, cut sheet or section, dry, sieve removes chip;

(5) Rhizoma Curcumae: get crude drug, remove impurity, big or small stepping, cleans, and slightly soaks, and takes out, runs through, shave, and dry, sieve removes chip;

(6) Periostracum Serpentis: with Radix Glycyrrhizae, washed, dried, evener with yellow wine spray, put pot interior micro-stir-fry to yellow, 100 jin of every Periostracum Serpentiss, with 5 jin of wine;

(7) Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;

(8) Asbestus: get crude drug, choose clean impurity;

(9) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;

(10) Fructus Kochiae: get crude drug, remove impurity, sieve removes chip;

(11) Flos Lonicerae: sieve removes silt, chooses clean impurity;

(12) Radix Scrophulariae: choose clean impurity, except removing LU, clean and run through, section, dries;

(2) preparation

(1) Fructus Mume of described weight, the Rhizoma Anemarrhenae, Plumbum preparatium, Radix Rubiae, Rhizoma Curcumae, Periostracum Serpentis, Rhizoma Alismatis, Asbestus, Radix Arnebiae (Radix Lithospermi), the Fructus Kochiae, Flos Lonicerae, Radix Scrophulariae are decocted with water twice, add for the first time 8 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time;

(2) will filter for the first time rear medicinal residues and add 4 times of amounts of water, and decoct boiling, then within 20 minutes, obtain decoction liquor for the second time with slow fire boiling;

(3) twice decoction liquor mixed, be divided into 3 doses and take.