CN103611089B - Medicine for treating psoriasis and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating psoriasis and a preparation method thereof. The medicine is mainly prepared from the medicines such as dark plum, rhizoma anemarrhenae, minium, madder, curcuma zedoary, pillis ophidiae, rhizoma alismatis and mountain wood at a certain weight ratio. The medicine disclosed by the invention has the functions of nourishing yin to lessen fire, removing stasis and stimulating the menstrual flow, and clearing heat and removing toxicity, and is fast in effect taking, good in curative effect, and free from psoriasis relapse in case of being used for treating psoriasis.

Description

One treats psoriatic medicine and preparation method thereof

Technical field

The present invention relates to one and treat psoriatic medicine and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Psoriasis is commonly called as psoriasis, is chronic dermatitis, is a kind of FFI erythroderma desquamativum and psychosomatic disease.According to clinical manifestation, primary disease can be divided into homeliness type, arthropathica, pustule type and erythrodermic, is common with homeliness type.Its cause of disease is not yet completely clear and definite, may be allergy or autoimmune disease.The course of disease is very long, has tendency of recurrence, and some cases almost cannot be cured all one's life.Because Western medicine effectively cannot treat psoriasis, and long-term taking Western medicine has more side effect, therefore, and the demand that people are very large to effectively treatment psoriatic Chinese medicine existence.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the effectively psoriatic medicine for the treatment of, thus completes the present invention.

Object of the present invention is just to provide one can effectively treat psoriatic composition of medicine.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Fructus Mume, the Rhizoma Anemarrhenae, Plumbum preparatium, Radix Rubiae, Rhizoma Curcumae, Periostracum Serpentis, Rhizoma Alismatis, Asbestus, Radix Arnebiae (Radix Lithospermi), the Fructus Kochiae, Flos Lonicerae, Radix Scrophulariae medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus can effectively treat psoriatic recurrence.Fructus Mume is wherein selected to be that temperature, enter liver, spleen, lung, large intestine channel, have convergence to promote the production of body fluid, the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, and dysentery, has blood in stool, hematuria, metrorrhagia, and the ascariasis of biliary tract is suffered from abdominal pain, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp because its nature and flavor acid.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Plumbum preparatium to be because its nature and flavor are pungent salty, cold, poisonous, enter the heart, spleen, Liver Channel, have removing toxic substances, granulation promoting, the function of eliminating phlegm down to arrest convulsion, controls carbuncle, ulcer, and incised wound is hemorrhage, aphtha, corneal nebula, and soup fire ， Jing Epilepsy of burning is demented, and malaria, dysentery, tells converse stomach.Radix Rubiae is selected to be because its nature and flavor are bitter, cold, there is cooling blood for hemostasis, the function that blood stasis dispelling stimulates the menstrual flow, control haematemesis, epistaxis, metrorrhagia, traumatic hemorrhage, stasis blocking amenorrhea, arthralgia, tumbling and swelling.Rhizoma Curcumae is selected to be because its nature and flavor acrid, bitter, warm.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain, treating swelling and pain by traumatic injury, early cervical carcinoma.Select Periostracum Serpentis to be because its property sweet-salty, flat, poisonous, enter Liver Channel, dispel the wind, arresting convulsion, nebula removing, detumescence, the function of parasite killing, controls little youngster and shies Epilepsy, acute throat trouble aphtha, swollen and rigid tongue congenital deformity of the tongue, corneal nebula cataract, furuncle, carbuncle, scrofula, parotitis, anal fistula, scabies.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Asbestus is selected to be that cold, have heat clearing away, relieving restlessness, the function of diuresis, controls cough due to lung-heat, laryngopharynx swelling and pain, and dysphoria with smothery sensation sun is fainted, dysuria, miliaria alba skin ulcer because its nature and flavor are sweet.Radix Arnebiae (Radix Lithospermi) is selected to be because its nature and flavor are bitter, cold, enter percardium, Liver Channel, have removing heat from blood, invigorate blood circulation, the function of heat-clearing and toxic substances removing, control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.Select the Fructus Kochiae to be because its nature and flavor sweetness and bitterness, cold, enter kidney, urinary bladder channel, have diuresis, the function of clearing away damp-heat, controls dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Radix Scrophulariae to be because its nature and flavor are bitter, salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, control calentura excessive thirst, send out speckle, hectic fever due to YIN-deficiency consumptive fever, sleep night not peaceful, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.

Detailed description of the invention

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Fructus Mume 5-15 gram of Rhizoma Anemarrhenae 8-15 gram of Plumbum preparatium 2-3 gram

Radix Rubiae 10-20 gram of Rhizoma Curcumae 10-15 gram of Periostracum Serpentis 8-15 gram

Rhizoma Alismatis 8-15 gram of Asbestus 8-15 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram

Fructus Kochiae 8-15 gram of Flos Lonicerae 10-15 gram of Radix Scrophulariae 8-15 gram

Preferable amount is

2 grams, Fructus Mume 10 grams of Rhizoma Anemarrhenaes 10 grams of Plumbum preparatiums

Radix Rubiae 15 grams of Rhizoma Curcumae 12 grams of Periostracum Serpentiss 10 grams

Rhizoma Alismatis 10 grams of Asbestuss 10 grams of Radix Arnebiae (Radix Lithospermi)s 15 grams

The Fructus Kochiae 10 grams of Flos Loniceraes 12 grams of Radix Scrophulariaes 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;

2, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

3, Plumbum preparatium: be placed in iron pan by pure lead and heat, fries dynamic, utilizes air to make it oxidation, is then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drifts out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;

4, Radix Rubiae: removing impurity, cleans, runs through, cut sheet or section, and dry, sieve removes chip;

5, Rhizoma Curcumae: get crude drug, removing impurity, size stepping, cleans, and slightly soaks, and takes out, runs through, shave, dry, and sieve removes chip;

6, Periostracum Serpentis: washed with liquorice beverage, dries, evener with yellow wine spray, and put micro-stir-fry extremely yellow in pot, every Periostracum Serpentis 100 jin, with wine 5 jin;

7, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;

8, Asbestus: get crude drug, picks clean impurity;

9, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;

10, the Fructus Kochiae: get crude drug, removing impurity, sieve removes chip;

11, Flos Lonicerae: sieve removes silt, picks clean impurity;

12, Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries.

Two, prepare

1, the Fructus Mume of described weight, the Rhizoma Anemarrhenae, Plumbum preparatium, Radix Rubiae, Rhizoma Curcumae, Periostracum Serpentis, Rhizoma Alismatis, Asbestus, Radix Arnebiae (Radix Lithospermi), the Fructus Kochiae, Flos Lonicerae, Radix Scrophulariae are decocted with water twice, add water 8 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.

2, add water medicinal residues after first time filtration 4 times amount, decocts boiling, then within 20 minutes, namely obtain second time decoction liquor with slow fire boiling.

3, by twice decoction liquor mixing, 3 doses are divided into take.

Medicine of the present invention has nourishing YIN to lower pathogenic fire, and blood stasis dispelling stimulates the menstrual flow, the function of heat-clearing and toxic substances removing, is used for the treatment of psoriasis instant effect, short treating period, does not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 245 example for medical treatment.

2, diagnostic criteria

Clinical manifestation

Typical performance is the erythema that boundary is clear, shape size differs, and slightly infiltrates and thickens.Erythema face covers silvery white lamination squama.Squama is easy to scrape de-, the common petechial hemorrhage of its basal plane after scraping.Skin lesion is apt to occur in head, sacrum portion and extremity and stretches side, conscious pruritus.

Divide general property and limitation.Generalized pustular psoriasis comprises again Von Zumbusch psoriasis pustulosa, Hallopeau acrodermatitis continua and impetigo herpetiformis.Their common feature is the aseptic pustule occurring the shallow table of gregariousness in erythema, and oral mucosa can be got involved simultaneously.Acute onset or increase the weight of suddenly often with General Symptomies such as shiver with cold, heating, arthralgia, general malaises.Often psoriasis vulgaris is there is in the catabasis.Limitation psoriasis pustulosa comprises " accompanying pustulate psoriasis ", limitation Hallopeau acrodermatitis continua, annular pustular psoriasis and palmoplantar pustulosis.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: psoriasis is eliminated, without recurring after observing half a year;

Take a turn for the better: psoriasis symptom is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy psoriatic 245 example of the present invention, effective 231 examples of result, obvious effective rate is 94.29%, and take a turn for the better 11 examples, and improvement rate is 4.49%, and invalid 3 examples, total effective rate is 98.78%.

Claims (3)

1. treat a psoriatic medicine, it is characterized in that: it is made up of the crude drug in following weight range:

Fructus Mume 5-15 gram of Rhizoma Anemarrhenae 8-15 gram of Plumbum preparatium 2-3 gram

Radix Rubiae 10-20 gram of Rhizoma Curcumae 10-15 gram of Periostracum Serpentis 8-15 gram

Rhizoma Alismatis 8-15 gram of Asbestus 8-15 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram

Fructus Kochiae 8-15 gram of Flos Lonicerae 10-15 gram of Radix Scrophulariae 8-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

2 grams, Fructus Mume 10 grams of Rhizoma Anemarrhenaes 10 grams of Plumbum preparatiums

Radix Rubiae 15 grams of Rhizoma Curcumae 12 grams of Periostracum Serpentiss 10 grams

Rhizoma Alismatis 10 grams of Asbestuss 10 grams of Radix Arnebiae (Radix Lithospermi)s 15 grams

The Fructus Kochiae 10 grams of Flos Loniceraes 12 grams of Radix Scrophulariaes 10 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;

(2) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

(3) Plumbum preparatium: be placed in iron pan by pure lead and heat, fries dynamic, utilizes air to make it oxidation, is then placed on pulverize in stone mortar, with water rinse, by thickness powder separately, drifts out fine powder, then through being oxidized 24 hours, being ground into fine powder and sieving and get final product;

(4) Radix Rubiae: removing impurity, cleans, runs through, cut sheet or section, and dry, sieve removes chip;

(5) Rhizoma Curcumae: get crude drug, removing impurity, size stepping, cleans, and slightly soaks, and takes out, runs through, shave, dry, and sieve removes chip;

(6) Periostracum Serpentis: washed with liquorice beverage, dries, evener with yellow wine spray, and put micro-stir-fry extremely yellow in pot, every Periostracum Serpentis 100 jin, with wine 5 jin;

(7) Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;

(8) Asbestus: get crude drug, picks clean impurity;

(9) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;

(10) Fructus Kochiae: get crude drug, removing impurity, sieve removes chip;

(11) Flos Lonicerae: sieve removes silt, picks clean impurity;

(12) Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;

(2) prepare

(1) Fructus Mume of described weight, the Rhizoma Anemarrhenae, Plumbum preparatium, Radix Rubiae, Rhizoma Curcumae, Periostracum Serpentis, Rhizoma Alismatis, Asbestus, Radix Arnebiae (Radix Lithospermi), the Fructus Kochiae, Flos Lonicerae, Radix Scrophulariae are decocted with water twice, add water 8 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;

(2) add water medicinal residues after first time filtration 4 times amount, decocts boiling, then within 20 minutes, namely obtain second time decoction liquor with slow fire boiling;

(3) by twice decoction liquor mixing, 3 doses are divided into take.