CN103316043B - Containing the medicinal usage of the compositions of carbonaceous material and active particle - Google Patents
Containing the medicinal usage of the compositions of carbonaceous material and active particle Download PDFInfo
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- CN103316043B CN103316043B CN201310225936.XA CN201310225936A CN103316043B CN 103316043 B CN103316043 B CN 103316043B CN 201310225936 A CN201310225936 A CN 201310225936A CN 103316043 B CN103316043 B CN 103316043B
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- carbonaceous material
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Abstract
The present invention proposes the purposes of medicine of a kind of compositions for the preparation for the treatment of or prevention Helicobacter pylori infection, said composition contains a carbonaceous material and an active particle, and active particle is carried on carbonaceous material and its material is silver, gold, aluminum, zinc, copper or titanium dioxide.
Description
Technical field
The present invention relates to a kind of purposes of compositions for the preparation of medicine containing carbonaceous material and active particle.This compositions has the effect suppressing Helicobacter pylori infection, and can be used for the infection treating or prevent helicobacter pylori.
Background technology
Helicobacter pylori (formal name used at school: Helicobacter pylori) is that kind is gram-negative micro-addicted to oxygen bacterium, mainly parasitizes human stomach or ID each region.Since the scientists such as nineteen eighty-two R.Warren and B.Marshall isolate helicobacter pylori from the stomach of patient, existing many reported in literature confirm that the infection of helicobacter pylori can cause gastroenteritis, even more seriously cause the diseases such as gastric ulcer, duodenal ulcer, gastric lymphoma or gastric cancer.World Health Organization (WHO) (World HealthOrganization, WHO) more announces in 1994 that helicobacter pylori is the I class cancerigenic factor of gastric cancer.
At present, the clinical treatment of Helicobacter pylori infection mainly adopts " three-in-one therapy ", the method casts the different antibiotic of sufferer two kinds, such as clarithromycin (Clarithromycin), amoxicillin (Amoxicillin), tetracycline (Tetracycline), Metronidazole (Metronidazole) and a kind of gastric acid secretion inhibitor, such as omeprazole (Omeprazole), Lan Su draw azoles (Lansoprazole).Antibiotic casting must continue one week (when being necessary, can extend to two weeks); Casting of gastric acid secretion inhibitor must continue two months (when being necessary, can extend to four months).But in whole therapeutic process, most sufferer may produce toxic and side effects to medicine, such as: dizziness, bitter taste, tongue fond of gossip, abdominal distention, amblygeustia, nauseating, diarrhoea; And, add that therapeutic process is quite tediously long, so sufferer easily produces Incooperation to treatment, and affect the healing of disease.On the other hand, after sufferer long-term taking antibiotic, helicobacter pylori may be caused to develop immunity to drugs, and drug-fast result not only affects the healing of disease, more affects the medicament selection of disease treatment backward.
In sum, the medicine being used for the treatment of Helicobacter pylori infection also exists toxic and side effects and drug-fast problem, is therefore really necessary to develop multiple different medicine, treats diversified selection to provide Helicobacter pylori infection.
Summary of the invention
The object of the present invention is to provide a kind of medicine being used for the treatment of Helicobacter pylori infection.
For reaching above-mentioned and/or other objects, the present invention proposes a kind of compositions for the preparation for the treatment of or the purposes of preventing Helicobacter pylori infection medicine, and compositions contains a carbonaceous material and an active particle, active particle is carried on carbonaceous material, and the material of active particle is silver, gold, aluminum, zinc, copper or titanium dioxide.
According to the present invention, carbonaceous material can adsorb helicobacter pylori on one's own initiative, and utilizes active particle to kill except to be adsorbed and/or not by the helicobacter pylori adsorbed.By this mechanism, compositions of the present invention can suppress the infection of helicobacter pylori effectively, and can be used as the medicine for the treatment of or prevention Helicobacter pylori infection.
Accompanying drawing explanation
Fig. 1 is that the gastric ulcer sufferer that causes of explanation one helicobacter pylori is in the gastric visor photo taking the treatment situation of the present composition after 7 days.
Fig. 2 is the one scan electron micrograph (X5,000) of the outward appearance of the compositions that preparation example 1 is described.
Fig. 3 is the one scan electron micrograph (X1,000) of the adsorbable helicobacter pylori of activated carbon fiber illustrated in the compositions of preparation example 3.
Detailed description of the invention
The present inventor, in U.S. patent Nos publication number 2007/0122463, has disclosed a kind of antimicrobial compositions, and more points out that this antimicrobial compositions initiatively can kill microorganism, but it only illustrates the purposes for the treatment of skin injury.On the other hand, the activated carbon in antimicrobial compositions for the gastric lavage of toxic medicament poisoning patient, with in patient's stomach internal adsorption toxic medicament.And, the silver in antimicrobial compositions by European Union legally as the additive of numbering E174 food coloring.That is, no matter be that activated carbon or silver are edible in our daily life.If the present inventor it is believed that the compositions that activated carbon and silver combine can be killed except helicobacter pylori effectively, this compositions should can be used for the infection for the treatment of helicobacter pylori.Further, have edible characteristic based on the component out of the ordinary in this compositions, the present inventor more it is believed that this constituent should have no side effect and drug-fast problem.
Can effectively kill except helicobacter pylori based on the activated carbon fiber carrying Argent grain, the present invention proposes a kind of compositions for the preparation for the treatment of or the purposes of preventing Helicobacter pylori infection medicine, and compositions contains a carbonaceous material and an active particle, active particle to be carried on carbonaceous material and its material is silver, gold, aluminum, zinc, copper or titanium dioxide.Term used herein " treatment " one word or its derivative words, mean the individuality casting compositions to tool Helicobacter pylori infection, to reach reduction, slow down or to stop the increase infected or the object spreading or reduce infection or healing infection; " prevention " used herein word or its derivative words, means the individuality casting the non-tool Helicobacter pylori infection of compositions to, takes precautions against the increase infected or reduce or slow down infection or the object spread to reach.
Cast compositions of the present invention to individual for suitable with oral form, and compositions of the present invention can present for the individual food form of directly eating or drinking, such as but not limited to, health food or health drink; Also can present for the individual medicine type directly taken, such as but not limited to, capsule, lozenge, powder, suspension or emulsifying agent.
According to embodiment hereafter, compositions of the present invention utilizes carbonaceous material to adsorb helicobacter pylori, and recycling active particle kills except to be adsorbed and/or all the other are not by the helicobacter pylori adsorbed.Therefore, compositions of the present invention can remove helicobacter pylori effectively, and can be used as the medicine being used for the treatment of or preventing Helicobacter pylori infection.As shown in Figure 1, compositions of the present invention also can be used for the intestines and stomach disease for the treatment of or prevention Helicobacter pylori infection causes, such as but not limited to, the gastric ulcer that Helicobacter pylori infection causes, gastroenteritis or duodenal ulcer.
According to the data do not proposed, the 30th day after feeding rat (rat) compositions of the present invention, do not find in the liver of rat, kidney and blood that the composition of any active particle exists, but find the active particle composition of trace in the feces of only discharging rat.This phenomenon illustrates, the active particle in compositions of the present invention can not residue in rat body.
Carbonaceous material in compositions of the present invention is not limited to any kind, as long as can helicobacter pylori be adsorbed, and the example can be but be not limited to, the carbon dust that activated carbon fiber, activated carbon powder, Linesless charcoal, bamboo charcoal grain, carbon black, graphite powder, expanded graphite powder or phenolic resins or artificial resin are made, and the specific surface area of carbonaceous material is preferably 400 to 2,500m
2/ g.Active particle in compositions of the present invention is not limited to any apparent size, as long as can kill except helicobacter pylori, and its particle diameter is preferably 1nm to 500 μm, is more preferably 5nm to 10 μm.
For promoting the effect of carbonaceous material absorption helicobacter pylori, carbonaceous material can have hole.In general, carbonaceous material is except adsorbable helicobacter pylori, also may adsorb other materials intraindividual (as: various vitamin) or probiotic bacteria, and occur in order to avoid this phenomenon, the radius of hole is preferably greater than 0nm and more than 2.5nm, is more preferably 0.5 to 2.3nm.
Cast compositions of the present invention to individuality for convenience of per os ground, when carbonaceous material is activated carbon fiber, the feature of carbonaceous material is as follows: length is for being greater than 0mm and more than 0.1mm, diameter for being greater than 0 μm and more than 10 μm.
Cause the injury of individuality for avoiding active particle to come off from carbonaceous material in individual, with the weight of carbonaceous material for benchmark, the percentage by weight of active particle is preferably 0.001 to 15wt%, and the amount of precipitation of active particle in water is preferably greater than 0ppm and more than 100ppm.
Special instruction, active particle is carried on carbonaceous material by impregnation, sprinkling or plating mode that compositions of the present invention is familiar with by the art, or by the present inventor in U.S. patent Nos notification number 7,687,433 methods disclosed.And, when carbonaceous material is activated carbon fiber, can first utilize polyacrylonitrile (Polyacrylonitrile, PAN) series fiber, pitch fibers, phenolic fibre, lignin fibre or staple fibre (Rayon) are its raw material, and the processing mode that recycling the art is familiar with is by Viability for feedstock conversion carbon fiber.The detailed manufacturing process of compositions for the present invention will propose to illustrate in embodiment hereinafter.
Hereby with following embodiment, to illustrate the present invention further.
< preparation example 1>
There is provided a polyacrylonitrile based activated carbon fiber cloth, its character is as follows: cloth is heavily 70g/m
2, weft density is 16/in, BET specific surface area is 1,630m
2/ g, density are 2.09g/m
3, carbon content is 85wt%, silver content is 0wt%.
Under vacuum environment, fiber cloth to be immersed in the silver nitrate aqueous solution (pH3.8) of concentration 0.1M 5 hours, with the silver bullion allowing silver ion reduction become to be attached in fiber cloth.The dry fiber cloth with silver bullion, to remove its residual moisture.
By dried fibre placement in temperature 400 DEG C and in the high temperature furnace being full of nitrogen 90 minutes, be cracked into the Argent grain disperseing to be attached in fiber cloth to allow silver bullion.
Fiber cloth with Argent grain is ground, pulverizes and sieved, and obtains the activated carbon fiber (as shown in Figure 2, the unitary construction of Argent grain and activated carbon fiber is referred to as " compositions ") that carries Argent grain.
The compositions of this preparation example has following characteristics: BET specific surface area is about 1,200m
2/ g, density are about 2.13g/m
3, carbon content is about 64wt%, silver content is about 12.5wt%; Activated carbon fiber in compositions has following characteristics: length is about 0.1mm, diameter is about 6.0 μm, hole diameter is about 2.41nm; Argent grain in compositions has following characteristics: the amount of precipitation in water is about 15.75ppm.
< preparation example 2>
Under vacuum environment, the polyacrylonitrile based activated carbon fiber cloth used to be immersed in the silver nitrate aqueous solution (pH3.8) of concentration 0.1M 5 hours, with the silver bullion allowing silver ion reduction become to be attached in fiber cloth just like preparation example 1.The dry fiber cloth with silver bullion, to remove its residual moisture.
By dried fibre placement in temperature 400 DEG C and in the high temperature furnace being full of nitrogen 90 minutes, be cracked into the Argent grain disperseing to be attached in fiber cloth to allow silver bullion.
With the fiber cloth 120 hour of the water cleaning of public liter/min of flow velocity 4.5 with Argent grain, to remove the Argent grain be not attached in fiber cloth.Fiber cloth after dry cleaning.
By dried fiber cloth grinding, pulverize and sieve, and obtaining the activated carbon fiber (unitary construction of Argent grain and activated carbon fiber is referred to as " compositions ") that carries Argent grain.
The compositions of this preparation example has following characteristics: BET specific surface area is about 1,220m
2/ g, density are about 2.13g/m
3, silver content is about 0.03wt%; Activated carbon fiber in compositions has following characteristics: length is about 0.1mm, diameter is about 6.0 μm, hole diameter is about 2.41nm; Argent grain in compositions has following characteristics: the amount of precipitation in water is about 10.04ppm.
< preparation example 3>
There is provided a phenolic aldehyde system active carbon fiber felt, its character is as follows: felt is heavily 100g/m
2, BET specific surface area is Isosorbide-5-Nitrae 20m
2/ g, density are 2.032g/m
3, carbon content is 85wt%, silver content is 0wt%.
Under vacuum environment, fiber felt to be immersed in the silver nitrate aqueous solution (pH6.4) of concentration 0.001M 5 hours, with the silver bullion allowing silver ion reduction become to be attached on fiber felt.The dry fiber felt with silver bullion, to remove its residual moisture.
Dried fiber felt is placed in temperature 400 DEG C and in the high temperature furnace being full of nitrogen 90 minutes, is cracked into the Argent grain disperseing to be attached on fiber felt to allow silver bullion.
Fiber felt with Argent grain is ground, pulverizes and sieves, and obtains the activated carbon fiber (unitary construction of Argent grain and activated carbon fiber is referred to as " compositions ") that carries Argent grain.
The compositions of this preparation example has following characteristics: BET specific surface area is about 1,380m
2/ g, density are about 2.0425g/m
3, carbon content is about 75wt%, silver content is about 0.072wt%; Activated carbon fiber in compositions has following characteristics: length is about 0.1mm, diameter is about 6.0 μm, hole diameter is about 2.23nm; Argent grain in compositions has following characteristics: the amount of precipitation in water is about 13.52ppm.
< preparation example 4>
Under vacuum environment, the active carbon particle made is immersed in the silver nitrate aqueous solution of concentration 0.008M with plant, and under 50rpm rotating speed, rotates mixing 2 hours, with the silver bullion allowing silver ion reduction become to be attached on active carbon particle.The dry active carbon particle with silver bullion, to remove its residual moisture.
Under the atmosphere being full of nitrogen, with the active carbon particle to 600 DEG C after the programming rate heat drying of 4 DEG C/min, keep this temperature about 60 minutes, last with the active carbon particle after the cooling rate cool drying of 10 DEG C/min to room temperature, be cracked into the Argent grain disperseing to be attached on active carbon particle to allow silver bullion.
After washing has the active carbon particle of Argent grain, the active carbon particle at 120 DEG C after dry washing.
By dried active carbon particle grinding, pulverize and sieve, and obtaining the activated carbon powder (unitary construction of Argent grain and activated carbon powder is referred to as " compositions ") that carries Argent grain.
The compositions of this preparation example has following characteristics: BET specific surface area is about 1,024m
2/ g, carbon content are about 73.54wt%, silver content is about 0.22wt%; Activated carbon powder in compositions has following characteristics: particle diameter is about below 0.1mm, hole diameter is about 2.48nm; Argent grain in compositions has following characteristics: particle diameter is about 100 to 300nm, amount of precipitation in water is about 30.49ppm.
< comparative example 1>
The polyacrylonitrile based activated carbon fiber cloth used just like preparation example 1 is ground, pulverizes and sieve, and obtains the activated carbon fiber that a length is about 0.1mm.
< comparative example 2>
There is one the polyacrylonitrile based active carbon fiber felt grinding of following character, pulverize and sieve, and obtain the activated carbon fiber that a length is about 0.1mm: felt is heavily 100g/m
2, BET specific surface area is 600m
2/ g, hole diameter are 2.07nm, density is 1.932g/m
3, carbon content is 86wt%, silver content is 0wt%.
< comparative example 3>
The active carbon particle used just like preparation example 4 is ground, pulverizes and sieve, and obtains the activated carbon powder that has following characteristics: particle diameter is about below 0.1mm, BET specific surface area is about 1,135m
2/ g, carbon content are about 84.24wt%, hole diameter is about 2.49nm.
< analyzes routine >
Refer to table 1, illustrate the activated carbon powder of the compositions of preparation example 1 to 4, the activated carbon fiber of comparative example 1 and 2 and comparative example 3 to the sterilization effect of different strain." sterilization rate " that represent sterilization effect in table makes NAB National Association 0f Broadcasters (American Association ofTextile Chemists and Colorists, ATCC) 100-1998 method of testing according to Textiles in USA dye chemical industry to record.
The activated carbon powder of the compositions of table 1. preparation example 1 to 4, the activated carbon fiber of comparative example 1 and 2 and comparative example 3 is to the sterilization effect of different strain
Can find out from upper table, though the activated carbon fiber source in the compositions of preparation example 1 is originated identical with the activated carbon fiber of comparative example 1, but because the compositions of preparation example 1 also has Argent grain, therefore the sterilization effect of compositions to escherichia coli, helicobacter pylori, staphylococcus aureus and pneumobacillus of preparation example 1 is obviously better than the activated carbon fiber of comparative example 1.
Separately can find out from upper table, though the activated carbon powder source in the compositions of preparation example 4 is originated identical with the activated carbon powder of comparative example 3, but because the compositions of preparation example 4 also has Argent grain, therefore the sterilization effect of compositions to escherichia coli, bacillus pyocyaneus, staphylococcus aureus, helicobacter pylori and pneumobacillus of preparation example 4 is obviously better than the activated carbon powder of comparative example 3.
As shown in Figure 3, the adsorbable helicobacter pylori of activated carbon fiber in the compositions of preparation example 3 is observed significantly.And Argent grain can discharge silver ion, particularly in water, silver ion like this can combine with the mercapto (-SH) in the ferment of the helicobacter pylori being adsorbed and/or do not adsorb, and allows ferment inactivation also effectively suppress helicobacter pylori.
The explanation of comprehensive above-described embodiment, confirms that compositions of the present invention can suppress helicobacter pylori, and has the potentiality of medicine as treatment or prevention Helicobacter pylori infection.On the other hand, carbonaceous material and active particle are edible, therefore during the medicine of compositions of the present invention as treatment or prevention Helicobacter pylori infection, can not produce toxic and side effects and Drug resistance to the individuality casting this medicine.
Above-described embodiment is only and illustrates principle of the present invention and effect, and unrestricted the present invention.Any those skilled in the art all when without prejudice to the technology of the present invention principle and spirit, can modify and change to above-described embodiment.Therefore, the scope of the present invention should be defined by the following claims.
Claims (10)
1. a compositions for the preparation of oral to individual with the purposes of the medicine for the treatment of or prevention Helicobacter pylori infection, said composition is made up of a carbonaceous material and an active particle, this active particle is carried on this carbonaceous material, and the material of this active particle is selected from the group be made up of silver, gold, aluminum, zinc, copper and titanium dioxide, with the weight of this carbonaceous material for benchmark, the percentage by weight of this active particle is 0.001 to 15wt%;
Wherein, this carbonaceous material has hole, and the radius of this hole is for being greater than 0nm and more than 2.5nm.
2. purposes as claimed in claim 1, wherein this carbonaceous material is selected from the group that the carbon dust be made up of activated carbon fiber, activated carbon powder, Linesless charcoal, bamboo charcoal grain, carbon black, graphite powder and phenolic resins or artificial resin forms.
3. purposes as claimed in claim 1, wherein the specific surface area of this carbonaceous material is 400 to 2,500m
2/ g.
4. purposes as claimed in claim 1, when wherein this carbonaceous material is activated carbon fiber, its length is for being greater than 0mm and more than 0.1mm.
5. purposes as claimed in claim 1, when wherein this carbonaceous material is activated carbon fiber, its diameter is for being greater than 0 μm and more than 10 μm.
6. purposes as claimed in claim 1, wherein the particle diameter of this active particle is 1nm to 500 μm.
7. purposes as claimed in claim 1, wherein the amount of precipitation of this active particle in water is for being greater than 0ppm and more than 100ppm.
8. purposes as claimed in claim 1, wherein said composition is the form of capsule, lozenge, powder, suspension or emulsifying agent.
9. purposes as claimed in claim 1, wherein said composition is the form of health food or health drink.
10. purposes as claimed in claim 1, wherein the said composition gastric ulcer, gastroenteritis or the duodenal ulcer that are used for the treatment of or prevent Helicobacter pylori infection to cause.
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225762A (en) * | 2014-09-03 | 2014-12-24 | 科云生医科技股份有限公司 | Antibacterial urethral catheter |
| CN104224837A (en) * | 2014-09-23 | 2014-12-24 | 贵州特力达纳米碳素科技有限公司 | Traumatic infection treatment preparation and preparation method thereof |
| CN104306978B (en) * | 2014-09-23 | 2017-03-29 | 贵州特力达纳米碳素科技有限公司 | A kind of gastric ulcer therapeutic agent and preparation method thereof |
| CN105325826A (en) * | 2015-12-09 | 2016-02-17 | 四川百草通科新材料科技有限公司 | Multifunctional nanometer carbon drink and preparing method thereof |
| CN105998065B (en) * | 2016-06-30 | 2019-01-15 | 成都本珍纳米生物科技有限公司 | A kind of Nano carbon balls grain preparation and preparation method thereof and Helicobacter pylori Infection experimental method |
| CN107260759A (en) * | 2017-05-17 | 2017-10-20 | 柯泽豪 | A kind of manufacture method of bactericidal composition and a kind of dressing |
| CN107281492B (en) * | 2017-08-17 | 2021-09-24 | 柯泽豪 | Application of composition |
| CN107375327A (en) * | 2017-08-17 | 2017-11-24 | 柯泽豪 | A kind of purposes of composition |
| CN113274404A (en) * | 2020-06-28 | 2021-08-20 | 天翊生物医药科技(天津)有限公司 | New application of medical adsorption resin and helicobacter pylori eliminating medicine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370989A (en) * | 2010-08-19 | 2012-03-14 | 逢甲大学 | Medicinal composition for treating urinary system diseases |
| CN102695516A (en) * | 2009-09-16 | 2012-09-26 | 医疗保健蛋白质组学生物技术株式会社 | Eradicating agent and eradication method for helicobacter pylori |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102695516A (en) * | 2009-09-16 | 2012-09-26 | 医疗保健蛋白质组学生物技术株式会社 | Eradicating agent and eradication method for helicobacter pylori |
| CN102370989A (en) * | 2010-08-19 | 2012-03-14 | 逢甲大学 | Medicinal composition for treating urinary system diseases |
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