KR101146645B1 - Feedstuff and manufacturing method thereof - Google Patents

Abstract

 The present invention relates to a propolis having an antimicrobial action, an antioxidant action, an anti-inflammatory action, and a livestock feed provided as a feed for livestock using herbal medicines, and a method of preparing the feed thereof, the composition of which is extracted from propolis coagulum. Propolis 15-25% by weight: baekgulchae, motherwort, bellflower chopped and mixed in an appropriate ratio of 75-85% by weight of the herbal medicine mixture to make an additive;

Vacuum freeze-drying the additives using a vacuum freeze dryer and grinding the dried additives into a powder state using a grinder, and then 5-15% by weight of the powdered additives: powdered feed prepared by a conventional method. Mixing at a rate of 85-95% by weight.

Livestock feed, vacuum freeze drying, propolis, herbal medicine

Description

Livestock feed and its feed manufacturing method

The present invention relates to a propolis having an antibacterial action, an antioxidant action, an anti-inflammatory action, and a livestock feed provided as a feed of a livestock using a herbal medicine, and a method of manufacturing the feed.

Propolis (propolis) is a natural antibiotic made by mixing bees and enzymes with resin-like substances extracted from plants for honeybees to survive and breed. It is also called Russian penicillin or natural penicillin.

Bees apply propolis in the gaps of the honeycomb to disinfect and sterilize the honeycomb to prevent germs and viruses, and to maintain a habitat suitable for spawning and growing, ripening and storing honey.

These propolis are mainly composed of organic matter and minerals (inorganic salts) as well as a variety of more than 100 different components. Among these components, especially minerals, vitamins, amino acids, fats, organic acids, flavonoids and the like play an important role in cellular metabolism and immune system enhancement.

Meanwhile, Propolis is listed in the Korea Food and Drug Administration as a functional food for antimicrobial and antioxidant functions. The main effects include antibacterial, anti-inflammatory and antioxidant effects. And has been proved to have an excellent effect in several parts, such as anesthesia.

Propolis, on the other hand, is known to be aseptic as it can be seen from the fact that the honeycomb, where tens of thousands of bees live, is always sterile, even though its internal temperature is around 34 ° C. And inhibits proliferation. Several studies have demonstrated the effectiveness of propolis in the inhibition of various bacteria, including Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Escherichia coli, Trichomonas, Salmonella, etc. (Korean j. Food Sci. Ani. 2002, Resour Vol. 1 p.66-71), because it is known that propolis inhibits protein synthesis by bacteria.

In addition, propolis has an excellent anti-inflammatory effect by reducing the enzymes that make prostaglandins, which cause inflammation, by half, resulting in radiation disorders, ulcerative inflammation, burns, allergies, atopic dermatitis, skin tumors, warts, and traumatic skin. It is widely used to treat acne, eczema and athlete's foot.

In addition, propolis has the effect of activating the macrophage (macrophage) to strengthen the body's immune function, the flavonoids (Flavonoid), the main active ingredient of propolis has antioxidant activity and inhibits the production of peroxide Excellent for preventing aging and cancer.

Therefore, when using propolis having various effects as a functional feed additive, there are fewer problems such as residual body resistance and resistance compared to general antibacterial and antioxidant agents which are inevitably used in livestock farming and aquaculture. Almost all kinds of bacteria, viruses and fungi can be effectively prevented and treated without the need for other applications.

In addition, it is possible to increase the self-healing power of livestock due to the immunity enhancing effect of propolis, and to prevent the decay of the stored feed due to the antioxidant function of the propolis without the use of additional antioxidants and preservatives, fresh feed (Korean j. Food Sci.Ani. 2002, Resour Vol. 22 No.1 p.77-88).

In other words, the use of propolis as a feed additive enables the supply of differentiated livestock and aquaculture products without preservatives and antibiotics.

However, propolis with this effect should be administered at least the minimum inhibitory concentration (MIC) in order to exert beneficial functions such as antibacterial and antioxidant in the body of the animal. It is known that at least about 1000 ppm of propolis should be administered in order for the propolis to function as desired.

However, since propolis is a natural product and its collection is limited, it is difficult to obtain large quantities and the price is high. Therefore, it is difficult to procure raw materials and economical efficiency to be included in feed additives of livestock at a minimum concentration of 1000 ppm. There was a point.

Therefore, while using a small amount of propolis to ensure economics with smooth supply of raw materials, the various functions that can be obtained from the propolis are fully exhibited so that the production of livestock and aquaculture products without the use of separate antibiotics and antioxidants. There is a need in the art for the development of economically functional feed additives that can improve productivity and quality.

In this regard, the present applicant can significantly reduce the mortality of livestock due to the effects of antibacterial, anticancer, and antibiotic effects by adding propolis to the extract of the herbal medicine in order to satisfy the request. There is a technology registered in advance (patent registration No. 631317) for the preparation method of the natural animal feed additive used.

The technology of the Patent No. 631317 is a Chinese medicine preparation step of washing and drying 100 parts by weight of Baekchulchae, 50 parts by weight motherwort and 20 parts by weight of bellflower; 4500 ~ 5500 parts by weight of ground water and the dried herbal medicines are put into the medicine bath, heating and filtration step of filtering by decoction after 50 to 70 minutes at a temperature of 75 ~ 85 ℃ sufficiently filtered; A aging step in which the extract, subjected to the above steps, is aged in a container of a predetermined size for 72 to 144 hours and stirred at an interval of 7 to 12 hours; 45 to 55 parts by weight of propolis in pure stock solution containing no impurities in the mature extract is mixed and uniformly characterized in that the mixing and packaging step of packaging in a container.

Patent registration No. 631317 having the characteristics described above because the additive itself is produced in the liquid phase, there is a difficulty in use, it is difficult to use a quantitative even in use, even when mixing the feed to a uniform amount There was a problem that can not be mixed constantly.

In addition to the problems described above, the patent registration No. 631317 should go through the heating and filtration step of washing the herbal medicine, that is, baekgulchae, motherwort herb, bellflower, etc., clean and dry it, put it in the medicinal bath with ground water, and then decoct enough to filter and refine. There was a hassle.

The present invention has been invented to solve the above problems, the object of the first is to produce a livestock feed by producing a livestock feed using a propolis and antibacterial action, antioxidant action, anti-inflammatory action, herbal medicine It is possible to raise, as well as to significantly reduce the mortality rate of livestock, and to eat meat of the livestock animal feed and a method of manufacturing the feed that can be indirect intake of the herbal medicine and propolis to promote health In providing.

Secondly, by simply and easily mass-producing the feed having the above-mentioned effects and functions, it is to provide a livestock feed and a method for producing the feed that can reduce the economic burden of the livestock producer and increase productivity.

The problem solving means of the present invention for achieving the above object, 15-25% by weight of propolis extracted from propolis ingot: 75-85% by weight of herbal medicines mixed with the appropriate ratio by cutting the baekgulchae, motherwort, bellflower Mixing the additives to form an additive;
Vacuum freeze-drying the additives using a vacuum freeze dryer and grinding the dried additives into a powder state using a grinder, and then 5-15% by weight of the powdered additives: powdered feed prepared by a conventional method. Mixing at a rate of 85-95% by weight.

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The feed of the present invention as described above is propolis antibacterial, antioxidant, and anti-inflammatory action, and by using the herbal medicine prepared by providing the feed of the livestock can raise the livestock, as well as the mortality of the livestock It is possible to significantly reduce, and the meat eater of the livestock has the indirect intake effect of the herbal medicine and propolis has the effect of promoting health, as well as easy to feed the effects and functions as described above By mass-producing and easily mass-producing, it is possible to reduce the economic burden on the livestock producing farmers and increase productivity.

Feed production method of the present invention for achieving the above object and effect is 15-25% by weight of propolis extracted from propolis ingot: medicinal herbs 75-85 mixed with the appropriate ratio by cutting baekgulchae, motherwort, bellflower Making an additive by mixing in a ratio of weight percent: vacuum freeze drying the additive using a vacuum freeze dryer; Grinding the vacuum freeze-dried additive into a powder state using a grinder; 5-15% by weight of the additive in the powder state: mixing in a ratio of 85-95% by weight of the powdered feed prepared by a conventional method; consisting of, the feed prepared by the method from the propolis 15-25% by weight of extracted propolis: 5-15% by weight of additives in powder form, mixed with 75-85% by weight of Chinese herbal medicine, chopped white oyster, motherwort, bellflower, and mixed in proper ratio. State feed consists of 85-95% by weight.

Efficacy of the herbal medicine used in the feed of the present invention and the feed production method as described above are as follows.

The white oyster is a perennial herb of the poppy family, the taste is hot and bitter and warm nature. It is effective in abdominal pain, dysentery, jaundice hepatitis due to acute gastroenteritis, gastric ulcer, cholecystitis, and known as the components include keridinine, protopin, etc. It has been demonstrated that the action of inhibiting cancer cells.

The motherwort is a medicinal herb that has a bitter taste, a cold, cold nature, and is a herb that helps the mother as the word means. The motherwort not only activates blood but also removes toxic blood from the body, 즉) In other words, the high blood pressure to control the nervous pulse and detoxification action, so that when the postpartum bleeding blood, dizziness and high fever due to the bleeding blood, severe pain, uterine bleeding, hematuria, bloody stool, hemorrhoids, large ㅇ It is known to be effective in treating urinary incontinence.

The bellflower is a plant of several seaweeds belonging to the Gilyeong family, the root of the bellflower contains abundant calcium, fiber, iron, saponin, minerals, protein, vitamins, etc., sputum, cough, which cuts general cough, asthma, sputum, etc. It has excellent detoxification, diuretic and palliative effects, and is used for the prevention or treatment of diseases such as nephritis, kidney stones, whooping cough, gynecological diseases, postpartum abdominal pain, nervous breakdown, enteritis, headache and sinusitis.

Herbal medicines as described above will be able to achieve the antibiotic effect without using an antibiotic by using the extract of the herbal medicine with an anticancer effect.

In addition, the propolis is already well known as a material made by mixing bees saliva and enzymes with a substance such as resins collected from various plants for their survival and breeding, antibacterial activity, antioxidant Action, anti-inflammatory action, local anesthetic action, antiviral proliferation, immune regulation.

When the propolis is used in the human body, it promotes the resurgence and growth of cells, prevents the damage of cells and the onset of various diseases through the removal of free radicals, maintains health by enhancing immunity and natural healing, and resists disease Increase the In particular, many studies have been published to restore the human body's unique function and balance to increase the ability of the human body to maintain a healthy state, resist disease, and heal the disease.

The components forming the additive as described above is the herbal medicine and propolis, the mixing ratio of the herbal medicine and propolis is 15-25% by weight of propolis: 75-85% by weight of herbal medicine, the reason of using the propolis 15-25% by weight If the propolis is less than 15% by weight, antibacterial, antioxidant, and anti-inflammatory actions are not achieved normally. If it exceeds 25% by weight, antibacterial, antioxidant, and anti-inflammatory actions may be good. This raises the problem of rising feed costs. Therefore, the mixing ratio of the herbal medicine and propolis is preferably 15-25% by weight of propolis: 75-85% by weight of the herbal medicine.

Meanwhile, the medicinal herb is mixed with Baekgulchae, motherwort herb, bellflower, and the mixing ratio of Baekgulchae, motherwort herb, bellflower forming the herbal medicine is 50-70% by weight, 25-35% by weight, bellflower 5-15% by weight. , The white buckwheat is mainly to enjoy the effects of acute chronic gastroenteritis, stomach ulcers, abdominal pain, dysentery, jaundice hepatitis (hereinafter referred to as "enteritis"), the use of less than 50% by weight of the above effect is insufficient , When used in excess of 70% by weight is effective in enteritis, but there is a problem according to the amount of motherwort, bellflower described below is less used.

In addition, the motherwort is not only to activate the blood, but also to clear the body blood and detoxification, bellflower mainly acts to maintain the health of the livestock by acting expectoration, Jinhae, diuretic, the case of the motherwort It is preferable to use 25 to 35% by weight, preferably 5 to 15% by weight of bellflower, and the amount of the motherwort and the bellflower is less than or equal to the amount of the additive used in the present invention. There is a problem of not functioning normally. Therefore, the motherwort 25 to 35% by weight, the bellflower is preferably used 5 to 15% by weight.

In addition, the herbal medicine (baekgulchae, motherwort, bellflower) is preferably finely chopped in order to facilitate the mixing when mixed with each other, the size of the medicinal herbs are slightly different depending on the type of herbal medicine, but the length and diameter It is desirable not to exceed 0.5-4 cm.

In addition, the method of extracting propolis from the propolis ingot is a screening operation to remove impurities and unnecessary substances from the collected propolis ingot, and after adding and stirring a solvent (alcohol, water) to this, aged and stirred again Purification to extract the propolis, which is a known conventional method, a detailed description thereof will be omitted.

However, the aging is done in pottery and the aging conditions in the pottery is 5-6 months at room temperature. The reason why the aging container is Onggi is because the Onggi functions to breathe due to the characteristics of the material, in order to maximize the effect of natural ripening to maximize the efficacy of propolis, and the reason for the temperature at room temperature is also in the atmospheric state This is to maintain the condition of the state.

The reason for the aging period of 5 to 6 months is to turn into a aging vessel, and the temperature is set to room temperature, which is the temperature of the air, so that sufficient aging period must be ensured. If this is not done and exceeds six months, the concentration becomes higher than necessary and it is difficult to maintain a constant quality.

When the mixture of the propolis and the herbal medicine extract is made as described above, it is vacuum-freeze-dried, for the purpose of drying while maintaining the same without destroying the active ingredient described above. However, the vacuum freeze dryer used in the vacuum freeze drying uses a vacuum freeze dryer generally available on the market.

In addition, the moisture content of the mixture during the vacuum freeze drying is preferably maintained to 70 ~ 80%, the vacuum freeze drying temperature is 18-36 hours at -40 ~ -50 ℃ because the vacuum freeze drying temperature And when the time is less than or more than the problem occurs that the vacuum freeze drying time of the mixture takes too long or the nutrients of the mixture is destroyed, and vacuum freeze drying does not occur normally.

On the other hand, the drying time is changed according to the internal pressure of the vacuum freeze dryer, and the drying time is 18 to 36 hours in consideration of that because there is a large moisture content and a small moisture content depending on the type of medicine.

The vacuum freeze-dried additive as described above is pulverized into a powder state using a pulverizer, for the purpose of easily mixing with a powdered feed (excipient) prepared by a conventional method described below. The mixing method mixes using a mixer.

The mixing ratio between the powdered additive and the conventional feed is 5-15% by weight of the additive: 85-95% by weight of the conventional feed. When the additive is used less than 5% by weight, the drug efficacy is insignificant to function as an additive. When used in excess of 15% by weight, the drug efficacy is improved, but the cost of feed is increased, causing the economic burden of livestock farms and aquaculture farms to increase. Therefore, it is preferable that the mixing ratio of the additive and the normal feed is 5-15% by weight: 85-95% by weight.

In addition, the present invention may be used in the form of granules in order to give the feed in the form of powder prepared by the method as described above according to the eating habits of the livestock. Powdered feed and granular feed of the present invention as described above is preferably distributed in a sealed package to the bag in order to prevent distribution and storage and deterioration.

And 15-25% by weight of propolis extracted from the propolis ingot: baekgulchae, motherwort, bellflower finely chopped and mixed in a ratio of 75-85% by weight of the herbal medicine made by mixing in an appropriate ratio to make an additive, the additive Vacuum freeze drying using a vacuum freeze dryer, and the dried additives are pulverized into a powder state using a pulverizer, and then 5-15% by weight of the powdered additives: aquaculture meat feed prepared by a conventional method 85 It can also be blended at a rate of -95% by weight to form a feed for farmed fish. It is more preferable to use the granulated fish feed prepared in this way as well.

The following experimental example was raised by applying the livestock feed prepared by the method of the present invention to chickens and pigs are shown in the following table.

Experimental Example 1

20% by weight of propolis extracted from the propolis ingot and 10% by weight of additives mixed in the ratio of 80% by weight of Chinese herbal medicine (60% by weight, motherwort herb 30%, bellflower 10%). Livestock feed mixed with the weight% was applied to broiler (chicken) and raised and the results are shown in Table 1.2.

Table 1

division
Harvest
Shipment Upbringing rate
(%) Average weight
(kg) Feed allowance (kg) Antibiotic use
per kg / ton of feed Breeding period
(month) Control 500 485 97 1.37 2.74 One One Test 500 498 99.6 1.53 2.37 0 One

As shown in Table 1, the results of the specification test of the breeding system showed that the test intake of the feed of the present invention was better in growth rate, average weight, and allowance feed intake than the control intake of antibiotics. These results indicate that even though the experimental groups did not separately feed antibiotics artificially combined, the growth rate, average weight, and feed intake were satisfactory. Therefore, the feed of the present invention can increase the effect of increasing the growth rate through rapid growth as well as the disease prevention treatment. This means that there is.

[Table 2]

end. Test history of antibiotic- fed chicken

Inspection items Test result (ppm) Reference (ppm) Remarks Oxytracycline (mg / kg) 0.815 0.1 or less Chlortetracycline (mg / kg) Not detected 0.1 or less Tetracycline (mg / kg) Not detected 0.25 or less Enlofloxacin (mg / kg) Not detected 0.1 or less

I. Inspection History of Chicken Feeding the Feed of the Present Invention

Inspection items Test result (ppm) Reference (ppm) Remarks Oxytracycline (mg / kg) Not detected 0.1 or less Chlortetracycline (mg / kg) Not detected 0.1 or less Tetracycline (mg / kg) Not detected 0.25 or less Enlofloxacin (mg / kg) Not detected 0.1 or less

Table 2 is a test of harmful residues remaining in the body of the chicken ingested antibiotics and the chicken ingested the feed of the present invention, in the case of oxytetracycline among the representative antibiotics was detected in the chicken intake of antibiotics of the present invention It can be seen that it is harmless because it is not detected in the chicken fed the feed.

Experimental Example 2

20% by weight of propolis extracted from the propolis ingot and 10% by weight of additives mixed in the ratio of 80% by weight of Chinese herbal medicine (60% by weight, motherwort herb 30%, bellflower 10%). The livestock feed mixed with the weight% was applied to pigs for breeding and the results are shown in Table 3.4 below.

[Table 3]

division Harvest Shipment Upbringing rate
(%) Average weight
(kg) Feed allowance (kg) Antibiotic use
per kg / ton of feed Breeding period
(month) Control 50 43 86 103 270.5 One 6 Test 50 49 98 109 260.7 0 6

As shown in Table 3, the test results of breeding pigs showed better growth rate, average weight, and allowance feed intake compared to the control group fed the feed of the present invention. These results indicate that the growth rate, average body weight, and feed intake were good even though the experimental groups did not separately feed antibiotics artificially combined, and thus, the feed of the present invention can increase the effect of increasing the growth rate as well as preventing disease treatment. This means that there is.

Table 4

end. Test history of antibiotic- fed chicken

Inspection items Test result (ppm) Reference (ppm) Remarks Oxytracycline (mg / kg) 0.981 0.1 or less Chlortetracycline (mg / kg) Not detected 0.1 or less Tetracycline (mg / kg) Not detected 0.25 or less Enlofloxacin (mg / kg) Not detected 0.1 or less

I. Inspection History of Chicken Feeding the Feed of the Present Invention

Inspection items Test result (ppm) Reference (ppm) Remarks Oxytracycline (mg / kg) Not detected 0.1 or less Chlortetracycline (mg / kg) Not detected 0.1 or less Tetracycline (mg / kg) Not detected 0.25 or less Enlofloxacin (mg / kg) Not detected 0.1 or less

Table 4 shows the harmful residues remaining in the body of the pigs ingested antibiotics and the pigs fed the feed of the present invention. It can be seen that it is harmless since it is not detected in pigs fed the feed of the invention.

Experimental Example 3

Experimental Example 3 of the present invention is the same conditions as in Experimental Example 1 above 15% by weight of propolis extracted from propolis and herbal medicine (60% by weight baekjachae, 30% by weight motherwort, bellflower 10% by weight) 85% by weight As a result of applying the livestock feed mixed with 85% by weight of the conventional powdered feed to the broiler (chicken), the same result as in Example 1 was obtained.

Experimental Example 4

Example 4 of the present invention is the same conditions as in Example 2 25% by weight of propolis extracted from propolis ingot and herbal medicine (60% by weight baekjachae, 30% by weight motherwort, bellflower 10% by weight) 75% by weight 5% by weight of the additives mixed at a ratio of 95% by weight of a conventional powdered feed was applied to a livestock feed obtained in pigs and the same result as in Example 2.

1 is a process chart for explaining the feed manufacturing process of the present invention,

Figure 2 is a process chart for explaining a method of extracting propolis in the feed manufacturing process of the present invention,

Figure 3 is a process diagram illustrating the process of producing a granular feed of the present invention.

Claims (6)

Propolis 15-25% by weight extracted from the propolis ingot: chopped baekgulchae, motherwort, bellflower and mixed in an appropriate ratio of the herbal medicine 75-85% by weight to make an additive; Vacuum freeze-drying the additives using a vacuum freeze dryer and grinding the dried additives into a powder state using a grinder, and then 5-15% by weight of the powdered additives: powdered feed prepared by a conventional method. Mixing at a ratio of 85 to 95% by weight; livestock feed manufacturing method characterized in that it comprises a configuration. 15-25% by weight of propolis extracted from propolis ingot: 5-15% by weight of powdered additives mixed with 75-85% by weight of Chinese herbal medicine, which is mixed with a proper ratio by cutting baekgulchae, motherwort and bellflower. %, And 5-15% by weight of the additive in the form of powder: livestock feed, characterized in that the mixture in the proportion of 85-95% by weight of ordinary powdered feed. The method of claim 1, wherein the extraction method of propolis from the propolis ingot is a conventional method of going through the process of propolis ingot → screening → solvent injection → stirring → ripening → stirring → purification → propolis extraction, The maturation is made in the pottery, and the aging conditions in the pottery is a livestock feed manufacturing method characterized in that 5 to 6 months at room temperature. The livestock feed of claim 2, wherein the mixing ratio of Baekgulchae, motherwort herb and bellflower forming the herbal medicine is 50-70% by weight, motherwort herb 25-35% by weight, bellflower 5-15% by weight. [Claim 3] The livestock feed of claim 2, wherein the feed prepared in a powder state is prepared in a granular state. The method of claim 1, wherein the vacuum freeze drying conditions of the additive is a livestock feed manufacturing method, characterized in that 18 to 36 hours at -40 ~ -50 ℃.

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