CN104225762A - Antibacterial urethral catheter - Google Patents

Antibacterial urethral catheter Download PDF

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Publication number
CN104225762A
CN104225762A CN201410445819.9A CN201410445819A CN104225762A CN 104225762 A CN104225762 A CN 104225762A CN 201410445819 A CN201410445819 A CN 201410445819A CN 104225762 A CN104225762 A CN 104225762A
Authority
CN
China
Prior art keywords
antibacterial
carbon material
urethral catheterization
antibacterial carbon
passage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410445819.9A
Other languages
Chinese (zh)
Inventor
柯泽豪
洪铭谦
林瑞祥
苏彦儒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KEYUN SHENGYI TECHNOLOGY Co Ltd
BIO MEDICAL CARBON Tech CO Ltd
Original Assignee
KEYUN SHENGYI TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KEYUN SHENGYI TECHNOLOGY Co Ltd filed Critical KEYUN SHENGYI TECHNOLOGY Co Ltd
Priority to CN201410445819.9A priority Critical patent/CN104225762A/en
Publication of CN104225762A publication Critical patent/CN104225762A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0017Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/02Inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/146Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104Silver, e.g. silver sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/108Elemental carbon, e.g. charcoal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M2025/0056Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02Holding devices, e.g. on the body
    • A61M25/04Holding devices, e.g. on the body in the body, e.g. expansible

Abstract

The invention provides an antibacterial urethral catheter, which comprises a body and an antibacterial carbon material, wherein a urethral passage is arranged in the body, the antibacterial carbon material is arranged in the urethral passage, the BET specific surface area of the antibacterial carbon material is between 500m<2>/g and 1800m<2>/g, and in addition, the proportion of the micro pore volume of micro pores with the pore diameter being smaller than 2 nanometers in the antibacterial carbon material in the total pore volume is between 30 percent to 50 percent. Through the arrangement of the antibacterial carbon material with the antibacterial function in the urethral passage of the urethral catheter, so bacteria outside a human body cannot enter the bladder, meanwhile, the bacteria in the bladder can also be eliminated, and the bacterium infection in a urinary system can be effectively prevented.

Description

Antibiotic catheters
Technical field
The present invention relates to a kind of catheter, particularly a kind of antibiotic catheters, effectively can prevent the bacteriological infection of urinary system.
Background technology
Catheter common on the market mainly installs a sacculus additional on rubber catheter at present, makes catheter be fixed on intravesical by the sacculus expanded because of water-filling.This kind of catheter, because can life-time service, be also called retained type catheter.
According to statistical data display, have the hospital sufferer of 25% can use retained type catheter, and about have every day the sufferer of 3-10% urinary tract infection can occur, severe patient even can cause septicemia and dead.Separately according to Taiwan statistics, the third quarter from 2003 to 2012, the ratio of sufferer generation urinary tract infection is on average up to 36.5% over 10 years, and rank the first in each medical center name, therefore uses catheter obviously can increase the risk of Exogenous bacteria infection.
Summary of the invention
The object of this invention is to provide a kind of antibiotic catheters, can effective bacteria growing inhibiting, to avoid the bacteriological infection problem of urinary system.
Object is taken off before reaching, antibiotic catheters provided by the present invention includes a body and an antibacterial carbon material, this body has the other end that one is formed at this intrinsic urethral catheterization passage, an introducing port is positioned at this urethral catheterization passage one end and an export mouth are positioned at this urethral catheterization passage, and this urethral catheterization passage is connected with this introducing port and this export mouth respectively; This antibacterial carbon material is located in this urethral catheterization passage, and the BET specific surface area of this antibacterial carbon material is between 500m 2/ g and 1800m 2between/g, and the micropore volume that this antibacterial carbon material mesoporous is less than 2 nanometers accounts for the volume fraction of total hole between 30% and 50%.
By arranging the antibacterial carbon material with antibacterial functions in the urethral catheterization passage of catheter, the antibacterial of human external not only can be made cannot to enter bladder via urethral catheterization passage, also can be killed being positioned at intravesical antibacterial and being removed, effectively to prevent the bacteriological infection of urinary system, improve the bladder bacteriological infection problem that existing catheter causes.
Describe the present invention below in conjunction with the drawings and specific embodiments, but not as a limitation of the invention.
Accompanying drawing explanation
Fig. 1 is the sectional view of the first preferred embodiment of antibiotic catheters of the present invention;
Fig. 2 is ultramicroscope (SEM) photo of the antibacterial carbon material absorption escherichia coli original state of test case 1 of the present invention;
Fig. 3 is the antibacterial carbon material absorption escherichia coli ultramicroscope after 24 hours (SEM) photo of test case 1 of the present invention;
Fig. 4 is ultramicroscope (SEM) photo of the antibacterial carbon material absorption escherichia coli original state of test case 2 of the present invention;
Fig. 5 is the antibacterial carbon material absorption escherichia coli ultramicroscope after 24 hours (SEM) photo of test case 2 of the present invention;
Fig. 6 is the sectional view of the second preferred embodiment of antibiotic catheters of the present invention;
Fig. 7 is the sectional view of the 3rd preferred embodiment of antibiotic catheters of the present invention.
Wherein, Reference numeral
1 body
11 introducing ports
12 urethral catheterization passages
13 drainage channels
14 export mouths
15 injection ports
2 antibacterial carbon materials
21 antibacterial passages
22 extensions
23 Fixed Divisions
3 sacculus
Detailed description of the invention
Below in conjunction with accompanying drawing, structural principle of the present invention and operation principle are described in detail:
As shown in Figure 1, the first preferred embodiment of antibiotic catheters of the present invention comprises a body 1 and and is located at antibacterial carbon material 2 in this body 1.This antibiotic catheters is applicable to the bladder being placed into a sufferer, and wherein, the leading portion of this body 1 is be placed in this intravesical together with this antibacterial carbon material 2, and the posterior segment of this body 1 is then positioned at outside human body.
This body 1 for flexible material is made by silica gel or polrvinyl chloride, and comprises introducing port 11, urethral catheterization passage 12, export mouth 14, sacculus 3, drainage channel 13, and an injection port 15.Urethral catheterization passage 12 is formed in this body 1, this introducing port 11 is positioned at the front end of this urethral catheterization passage 12, for importing this urethral catheterization passage 12 for this intravesical urine, this export mouth 14 is positioned at the rear end of this urethral catheterization passage 12, this urethral catheterization passage 12 is connected with this introducing port 11 and this export mouth 14 respectively, this export mouth 14 is positioned at outside human body, the urine of this urethral catheterization passage can be exported in a urine collecting bag.This sacculus 3 is located at outer and this introducing port 11 contiguous of this urethral catheterization passage 12, this drainage channel 13 and this urethral catheterization passage 12 are side by side and not connected, this injection port 15, this drainage channel 13 and this sacculus 3 three are connected, and this injection port 15 connects for a syringe, so that medical personnel inject normal saline solution and are full of by this sacculus 3 and make it expand, by this leading portion of this sacculus 3 and this body 1 being fixed on the intravesical of sufferer, making this antibiotic catheters can not because of being pullled or other factors and coming off.
This antibacterial carbon material 2 is located at this urethral catheterization passage 12 foremost and close to this introducing port 11 place, and has an antibacterial passage 21 be connected with this introducing port 11 and this urethral catheterization passage 12.When urine enters in this body 1 from this introducing port 11, first can flow through this antibacterial passage 21, then be flowed out by this export mouth 14 via this urethral catheterization passage 12.Therefore, when the antibacterial of outside is for entering bladder via urine or urethral catheterization passage 12, just can be adsorbed by this antibacterial carbon material 2 and go out and removing.It should be noted that this antibacterial carbon material 2 can be polyacrylonitrile (PAN) activated carbon, bamboo charcoal or Graphene, and this antibacterial carbon material can be textile-like, non-woven shape or Powdered.If this antibacterial carbon material is Powdered, then the length of single powder is 10-300 μm, and diameter is 5-15 μm.The BET specific surface area of this antibacterial carbon material 2 is between 500m 2/ g and 1800m 2between/g, and the micropore volume that this activated carbon material mesoporous is less than 2 nanometers accounts for the volume fraction of total hole between 30% and 50%.
For understanding the antibacterial characteristics of antibacterial carbon material 2 of the present invention, following apparatus and method for is hereby adopted to carry out measuring and observing:
Carbon material surface observation instrument is cold field emission sweep electron microscope and energy dissipation spectrogrph (Cold Field Emission Scanning Electron Microscope and Energy Dispersive Spectrometer), HITACHI company of Japan manufactures, and model is S-4800.Method of testing is, with carbon paste band, the carbon material of suitable size is fixed on (diameter 2.5 centimeters) on microscope carrier, is positioned on 80 DEG C of heating plates and dries 1 hour.Use the accelerating potential of 10 to 15kv, the enlargement ratio of 5000 times carries out the surface observation of carbon material.
Specific surface area (BET) analytical equipment is the Micromeritics ASAP2020 that Micromeritics company manufactures, side method for testing is first via after high temperature (360 DEG C) evacuation by sample, insert adsorbed gas (nitrogen), experimental temperature and pressure fixing are at 77K and 760mm-Hg.
Sample cut-off footpath 4.8 ± 0.1cm circular sample 6 will be tested before antibacterial assay, then with 121 DEG C and 103kPa (1.05kg/m2) sterilizing 20 minutes, and test according to AATCC 100-1998 antibacterial test standard criterion.
Test case 1 uses oxidized polyacrylonitrile fiber cloth to carry out activation processing, under nitrogen protection, with the heating rate of 4 DEG C/min, after rising to 1000 DEG C by room temperature, carries out steam activation and lasts 10 minutes, then be down to room temperature with the rate of temperature fall of 10 DEG C/min.Finally make polyacrylonitrile based activated carbon fiber cloth, its BET specific surface area value is 1050m2/g, and the volume fraction that the micropore volume that aperture is less than 2 nanometers accounts for total hole is 45%, above-mentioned activated carbon fiber cloth is made antibacterial carbon material 2, to carry out follow-up antibacterial test.
Test case 2 is impregnated in 0.01M silver nitrate aqueous solution by the activated carbon fiber cloth made by test case 1; carry out stirring 0.5 hour with 50rpm rotating speed simultaneously; dewater afterwards; and at 120 DEG C, carry out oven dry removing moisture; then under nitrogen protection, with the heating rate of 4 DEG C/min, after rising to 600 DEG C by room temperature; carry out thermal cracking and last 1 minute, then be down to room temperature with the rate of temperature fall of 10 DEG C/min.Then carry out washing 2 hours, then at 120 DEG C, carry out oven dry 2 hours, and obtained last finished product.Wherein silver accounts for the 0.06wt% of gross weight, and the Argent grain size on activated carbon fiber is nanoscale, and its particle diameter is about 10 to 50nm.The activated carbon fiber cloth of Ag-bearing granule, its true density is 2.06g/cm 3, carbon content is 85.5wt%, and oxygen content is 10.4wt%, and BET specific surface area is 1030m 2/ g, the volume fraction that the micropore volume that aperture is less than 2 nanometers accounts for total hole is 44%, and the activated carbon fiber cloth of above-mentioned Ag-bearing granule is made antibacterial carbon material 2, and to carry out follow-up antibacterial test, its result as shown in Table 1.
Table 1 anti-bacteria test result table
According to the antibacterial ability of AATCC 100 normative testing test case 1 and test case 2, wherein the antibiotic rate of test case 1 pair of staphylococcus aureus is 99.3%, is 99.0% to the antibiotic rate of bacillus pyocyaneus.Fig. 2 is the electron micrograph of the antibacterial carbon material absorption escherichia coli original state of test case 1, and Fig. 3 is the electron micrograph of antibacterial carbon material absorption escherichia coli after 24 hours of test case 1, and two compare, and colibacillary quantity obviously reduces.After activated carbon fiber cloth is carried the silver of upper 0.06wt% by test case 2, whole anti-microbial property can rise to more than 99.99%, the electron micrograph of the antibacterial carbon material absorption escherichia coli original state of Fig. 4 test case of the present invention 2, Fig. 5 is then the electron micrograph of antibacterial carbon material absorption escherichia coli after 24 hours of test case 2, show original escherichia coli dead on this antibacterial carbon material successively, represent that silver can assist PAN activated carbon fiber to sterilize, improve antibiotic rate.
For understanding the specific surface area size of antibacterial carbon material to the impact of anti-microbial property, oxidized polyacrylonitrile fiber cloth is made polyacrylonitrile (PAN) activated carbon fiber respectively under 600 DEG C, 800 DEG C with the activation temperature of 1200 DEG C and makes antibacterial carbon material, according to activation temperature low to high called after matched group, test case 3 and test case 4 respectively, its activation processing condition is as test case 1, only changing activation temperature, being respectively 380m through measuring its BET specific surface area 2/ g, 650m 2/ g and 1800m 2/ g, and the volume fraction that the micropore volume that aperture is less than 2 nanometers accounts for total hole is respectively 27%, 41% and 48%.
According to the antibacterial ability of the method for testing test comparison group of AATCC 100 specifications, test case 3 and test case 4, result is as the anti-microbial property table with test results of following table 2, low and the micropore volume of the BET specific surface area of matched group is shown than low, the test case 3 that its antibacterial ability is obviously high not as BET specific surface area and test case 4 by table 2.
Table 2 anti-bacteria test result table
Conclude above experimental results, the BET specific surface area of antibacterial carbon material can be obtained between 500m 2/ g and 1800m 2between/g, and the micropore volume that this antibacterial carbon material mesoporous is less than 2 nanometers accounts for the volume fraction of total hole between 30% and 50%, time its antibacterial ability better, wherein with the BET specific surface area of antibacterial carbon material between 650m 2/ g and 1800m 2between/g, its antibacterial ability is better.
For strengthening the antibacterial ability of this antibacterial carbon material 2 further, organic or inorganic antimicrobial treatment can be bestowed.In organic anti-bacterial process, can impregnation or smear amino sugae glycoside (aminoglycoside) material, such as gentamycin (gentamicin), tobramycin (tobramycin), amikacin (amikacin) etc., this antibacterial carbon material 2 is combined with above-mentioned organic substance, finally forms the material with high antibacterial ability.Therefore, the antibacterial carbon material 2 through organic anti-bacterial process is applied to the bacteriological infection that effectively can prevent urinary system in this catheter.Wherein, gentamycin is used to carry out the effect of organic anti-bacterial process for better.
In inorganic antibacterial process, can by this antibacterial carbon material 2 with technology such as impregnation, coating, plating, evaporation, chemical vapour deposition (CVD), electroless platings, the inorganic antibiotic metals such as gold, silver, copper or zinc are combined on this antibacterial carbon material 2, finally form the material with high antibacterial ability.In this antibacterial carbon material, the content of gold, silver, copper or zinc is 0.01 ~ 0.1wt%.Therefore, the antibacterial carbon material 2 through inorganic antibacterial process is applied to the bacteriological infection that effectively can prevent urinary system in this catheter.Wherein, silver or copper is used to carry out the effect of inorganic antibacterial process for better.
Concrete structure about this antibacterial carbon material 2 implements aspect, one activated carbon fiber cloth can be rolled into column to form this antibacterial carbon material 2, or be stained with the glutinous powder ground by above-mentioned activated carbon fiber to form this antibacterial carbon material 2 in the inwall of this body 1, also can add above-mentioned activated carbon fiber to form bar-shaped antibacterial carbon material 2 in the foaming process of PU expanded material.
As shown in Figure 6, second preferred embodiment of antibiotic catheters of the present invention, it is roughly identical with the first preferred embodiment, its difference is: this antibacterial carbon material 2 is porous and plug is located at close to this export mouth 14 place, and the urine entered in this body 1 is sequentially outwards flowed out through this antibacterial carbon material 2 and this export mouth 14 from this urethral catheterization passage 12.Therefore, when the antibacterial of outside is for entering bladder with urine or catheter for medium, this antibacterial carbon material 2 just can be adsorbed in, and dead after absorption a period of time, make this antibacterial carbon material 2 play its antibacterial effect with blocking.
As shown in Figure 7,3rd preferred embodiment of antibiotic catheters of the present invention, it is roughly identical with the first preferred embodiment, its difference is: this antibacterial carbon material 2 one end has a Fixed Division 23 and is located at this urethral catheterization passage 12 foremost close to this introducing port 11 place, and has one from this Fixed Division 23 along the extension 22 that this urethral catheterization passage 12 length direction extends.In the present embodiment, this extension 22 is in column or bar-shaped.Therefore, when the antibacterial of outside is for entering bladder with urine or catheter for medium, the extension 22 of this antibacterial carbon material 2 just can be adsorbed in, and dead after absorption a period of time, make this antibacterial carbon material 2 play its antibacterial effect with blocking.
In sum, the invention has the advantages that: by arranging the antibacterial carbon material 2 with antibacterial functions in the urethral catheterization passage 12 of catheter, namely energetically the bang path of antibacterial is blocked, make the antibacterial of human external cannot with urine or this catheter for medium enters bladder, effectively can prevent the bacteriological infection of urinary system, the problems such as the bacterial cystitis avoiding existing Preserving time type catheter to cause.
Certainly; the present invention also can have other various embodiments; when not deviating from the present invention's spirit and essence thereof; those of ordinary skill in the art are when making various corresponding change and distortion according to the present invention, but these change accordingly and are out of shape the protection domain that all should belong to the claim appended by the present invention.

Claims (10)

1. an antibiotic catheters, is characterized in that, includes:
One body, have the other end that one is formed at this intrinsic urethral catheterization passage, an introducing port is positioned at this urethral catheterization passage one end and an export mouth are positioned at this urethral catheterization passage, this urethral catheterization passage is connected with this introducing port and this export mouth respectively; And
One is located at the antibacterial carbon material in this urethral catheterization passage, and the BET specific surface area of this antibacterial carbon material is between 500m 2/ g and 1800m 2between/g, and the micropore volume that this antibacterial carbon material mesoporous is less than 2 nanometers accounts for the volume fraction of total hole between 30% and 50%.
2. antibiotic catheters according to claim 1, is characterized in that, the material of this antibacterial carbon material is PAN activated carbon, bamboo charcoal or Graphene.
3. antibiotic catheters according to claim 2, is characterized in that, this antibacterial carbon material is textile-like, non-woven shape or Powdered.
4. antibiotic catheters according to claim 1, is characterized in that, the BET specific surface area of this antibacterial carbon material is between 650m 2/ g and 1800m 2between/g.
5. antibiotic catheters according to claim 1, it is characterized in that, this body has more a sacculus and is located at this urethral catheterization passage outer and contiguous this introducing port, a drainage channel and an injection port, side by side and not connected, this injection port, this drainage channel and this sacculus three are connected for this drainage channel and this urethral catheterization passage.
6. antibiotic catheters according to claim 1, is characterized in that, this antibacterial carbon material is located at close to this introducing port place.
7. antibiotic catheters according to claim 6, is characterized in that, this antibacterial carbon material has an antibacterial passage be connected with this introducing port and this urethral catheterization passage.
8. antibiotic catheters according to claim 1, is characterized in that, this antibacterial carbon material is located at close to this export mouth place.
9. antibiotic catheters according to claim 1, is characterized in that, this antibacterial carbon material has a Fixed Division and is located at this body and close to this introducing port, and one from this Fixed Division along the extension that this urethral catheterization channel-length direction extends.
10. antibiotic catheters according to claim 1, is characterized in that, this antibacterial carbon material contains the gold, silver of 0.01 ~ 0.1wt%, copper or zinc.
CN201410445819.9A 2014-09-03 2014-09-03 Antibacterial urethral catheter Pending CN104225762A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018028613A1 (en) * 2016-08-11 2018-02-15 胡绍勤 Drainage device
CN108463489A (en) * 2016-02-11 2018-08-28 阿波罗恩有限公司 Effective composition of urethral catheterization and preparation method thereof
CN109485919A (en) * 2018-11-17 2019-03-19 广西中医药大学 A kind of anti-biotic material and catheter and preparation method thereof

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CN103203062A (en) * 2012-01-12 2013-07-17 美昕医疗器械(上海)有限公司 Catheter with super-lubricity antibacterial coatings and manufacturing method for catheter
CN103316043A (en) * 2013-06-07 2013-09-25 逢甲大学 Medical application of composition comprising carbon material and active particles
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504015A1 (en) * 1981-04-16 1982-10-22 Glassman Jacob Permanently fitted urinary catheter with external wall grooved - to spread soln. of antiseptic or antibiotic to prevent infection of urethra, bladder etc.
JPH1147260A (en) * 1997-08-06 1999-02-23 Toyobo Co Ltd Antibacterial urine guiding catheter
CN2408878Y (en) * 2000-03-02 2000-12-06 霍新明 Urinary catheter
CN2873167Y (en) * 2006-03-10 2007-02-28 范炳岐 Active carbon nano silver absorptive suppository
CN201375746Y (en) * 2009-02-20 2010-01-06 彭福华 Medical antibiosis catheter
CN103203062A (en) * 2012-01-12 2013-07-17 美昕医疗器械(上海)有限公司 Catheter with super-lubricity antibacterial coatings and manufacturing method for catheter
CN103316043A (en) * 2013-06-07 2013-09-25 逢甲大学 Medical application of composition comprising carbon material and active particles
CN204092807U (en) * 2014-09-03 2015-01-14 科云生医科技股份有限公司 Antibiotic catheters

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CN108463489B (en) * 2016-02-11 2022-01-04 阿波罗恩有限公司 Composition for catheter and method for producing the same
WO2018028613A1 (en) * 2016-08-11 2018-02-15 胡绍勤 Drainage device
CN109485919A (en) * 2018-11-17 2019-03-19 广西中医药大学 A kind of anti-biotic material and catheter and preparation method thereof

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