CN103203062A - Catheter with super-lubricity antibacterial coatings and manufacturing method for catheter - Google Patents
Catheter with super-lubricity antibacterial coatings and manufacturing method for catheter Download PDFInfo
- Publication number
- CN103203062A CN103203062A CN 201210008850 CN201210008850A CN103203062A CN 103203062 A CN103203062 A CN 103203062A CN 201210008850 CN201210008850 CN 201210008850 CN 201210008850 A CN201210008850 A CN 201210008850A CN 103203062 A CN103203062 A CN 103203062A
- Authority
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- China
- Prior art keywords
- catheter
- layer
- solution
- superslide
- release layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
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- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a catheter with super-lubricity antibacterial coatings and a manufacturing method for the catheter. The catheter comprises a body part, an outer wall coating and an inner wall coating, wherein the body part is inserted into a human body; the outer wall coating attaches to the outer wall of the body part; and the inner wall coating attaches to the inner wall of the body part. The outer wall coating comprises an outer antibacterial layer, an outer controlled-release layer and an outer lubricating layer in sequence from inside to outside, wherein the outer antibacterial layer attaches to the surface of the outer wall of the body part, the outer controlled-release layer attaches to the outer antibacterial layer, and the outer lubricating layer attaches to the outer controlled-release layer. The inner wall coating comprises an inner antibacterial layer, an inner controlled-release layer and an inner lubricating layer in sequence from inside to outside, wherein the inner antibacterial layer attaches to the surface of the inner wall of the body part, the inner controlled-release layer attaches to the inner antibacterial layer, and the inner lubricating layer attaches to the inner controlled-release layer. The outer antibacterial layer and the inner antibacterial layer respectively comprise inorganic salt containing Ag<+>, Zn<2+> or Cu<2+> ions; the outer controlled-release layer and the inner controlled-release layer respectively comprise an organic chelate of inert metal; and the outer lubricating layer and the inner lubricating layer respectively comprise hydrophilic gel. After the technical scheme is adopted, the catheter has a sustainable and stable antibacterial function, and the coatings can firmly attach to the surface of the catheter.
Description
Technical field
The present invention relates to a kind of catheter with superslide antimicrobial coating with and manufacture method.
Background technology
Catheter is a kind of medical apparatus and instruments of using always, is mainly used in suffering from the patient of urinary incontinence or paraplegia, quad people with disability, and this class sufferer is inserted catheter and can be helped them to stay urine in the emptying intravesical storage safely and effectively owing to can't Autonomous Control urinate.
Catheter in use should be in strict accordance with the sterile working, but because the physiological structure of urethra self, even the sterile working still can't stop urinary tract infection.The use of remain-type catheter is the one of the main reasons that causes urinary tract infection, and at present clinical data shows: in the common infection of hospital, have 40%-50% to be caused by urinary tract infection.Wherein be again that use by catheter causes more than 80%.In the treatment clinical course, use the patient of catheter, generally take antibiosis simultaneously and usually resist infection.But, the life-time service antibiotic, antibacterial can develop immunity to drugs, and antibiotic effectiveness can reduce even lose efficacy, and in the time of patient infection, also is difficult to treat by antibiotic again.
Therefore, use the catheter that has antibacterial functions to have very big advantage clinically.In existing antibiotic catheters, have plenty of the material that will contain the Ag ion and be sprayed on the catheter outer surface, though have antibacterial effect advantage rapidly, but toxic and side effects is bigger, be difficult to form continual and steady antibacterial action, and the coating of spraying is easy to come off or oxidation in vivo from the catheter surface; Also have plenty of antibacterial is evenly distributed on the catheter, though the harmony of antibacterial action strengthens to some extent, but the antibacterial competence exertion antibacterial action that has only the catheter surface, the most of antibacterial that adds in the catheter material all can not play a role, and therefore also is difficult to realize continual and steady antibacterial effect.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of superslide antimicrobial coating catheter, and this catheter has continual and steady antibacterial functions, and the coating on this catheter surface can be attached to the catheter surface securely.
A kind of superslide antimicrobial coating catheter of the present invention, comprise for the body that inserts human body, be attached to outer wall coating and the inside coating that is attached on this body inwall on this body outer wall, be characterized in, the outer wall coating comprises the outer antibiotic layer that is attached to the body outer wall surface from the inside to the outside successively, be attached to outer slow release layer and the outer lubricating layer that is attached on the outer slow release layer on the outer antibiotic layer, inside coating comprises the interior antibiotic layer that is attached to the body inner wall surface from the inside to the outside successively, interior slow release layer in being attached on the antibiotic layer and the interior lubricating layer that is attached on the interior slow release layer; The composition of outer antibiotic layer and interior antibiotic layer is for containing Ag
+, Zn
2+Or Cu
2+The inorganic salt of ion; The composition of outer slow release layer and interior slow release layer is the organic chelate of inert metal; The composition of outer lubricating layer and interior lubricating layer is hydrophilic gel.
The method of superslide antimicrobial coating catheter of the present invention comprises the following steps:
The body of catheter is immersed in the alcoholic solution;
Body from alcoholic solution taking-up catheter cleans, and is immersed in then and contains Ag
+, Zn
2+Or Cu
2+In the inorganic salt solution of ion;
Body from inorganic salt solution taking-up catheter cleans, and the body with catheter is immersed in the organic chelate solution of inert metal again;
Take out the body of catheter from the organic chelate solution of inert metal, clean, the body with catheter is immersed in the hydrophilic gel again;
The body of catheter is taken out from hydrophilic gel, clean then, dry, pack and sterilize.
The present invention has the following advantages:
When 1, slow release layer of the present invention and antibiotic layer run into electrolyte (for example body fluid), produce positive and negative electrode, form potential difference, the obstruction microorganism is adhered to the catheter surface, thereby can suppress the formation of bacterial biof iotalm.Slow release layer is conducive to the stable of antibiotic layer, slowly stably discharges antibiotic ion, thereby reaches bacteriostasis efficacy steady in a long-term, has prolonged the time in the urinary catheter in body, and has reduced the sense of discomfort in the sufferer use;
2, antibiotic layer of the present invention, slow release layer and lubricating layer can stably combine, and can form firm adhering to the catheter surface, thus the safety that has improved catheter.
Description of drawings
Fig. 1 is the structural representation of an embodiment of superslide antimicrobial coating catheter of the present invention.
Fig. 2 is the partial enlarged drawing of the P part of Fig. 1.
Fig. 3 is the flow chart of an embodiment of the manufacture method of superslide antimicrobial coating catheter of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is made further instructions.
As shown in Figure 1.Superslide antimicrobial coating catheter comprises for the body 1 that inserts human body, is exposed to the outer connecting portion 2 of human body, is attached to the outer wall coating 3 on the outer wall of body 1 and is attached to inside coating 4 on the inwall of body 1 according to an embodiment of the invention.
As shown in Figure 2.Outer wall coating 3 comprise successively from the inside to the outside the outer wall surface that is attached to body 1 outer antibiotic layer 31, be attached to the outer slow release layer 32 on the outer antibiotic layer and be attached to outer lubricating layer 33 on the outer slow release layer 32; Inside coating 4 comprise successively from the inside to the outside the inner wall surface that is attached to body 1 interior antibiotic layer 41, be attached on the antibiotic layer 41 interior slow release layer 42 and be attached in interior lubricating layer 43 on the slow release layer 42.
The material of body 1 can be latex, silica gel, silicone rubber or rubber.
The composition of outer antibiotic layer 31 and interior antibiotic layer 41 is and contains Ag
+, Zn
2+Or Cu
2+The inorganic salt of ion.This contains Ag
+, Zn
2+Or Cu
2+The inorganic salt of ion preferably contains Ag
+, Zn
2+Or Cu
2+The hydrochlorate of ion, or contain Ag
+, Zn
2+Or Cu
2+The acetate of ion.This contains Ag
+, Zn
2+Or Cu
2+The hydrochlorate of ion for example is hydrochloric acid silver, hydrochloric acid zinc or hydrochloric acid copper etc., and this contains Ag
+, Zn
2+Or Cu
2+The acetate of ion for example is silver acetate, zinc acetate or Schweinfurt green etc.
The composition of outer slow release layer 32 and interior slow release layer 42 is the organic chelate of inert metal.β-the ketoamine of the organic chelate preferred inert metal of this inert metal or the dipivaloylmethane of inert metal.β-the ketoamine of inert metal for example is palladium (Pd) metal β-ketoamine or gold (Au) metal β-ketoamine, and the dipivaloylmethane of inert metal for example is palladium (Pd) metal dipivaloylmethane or gold (Au) metal dipivaloylmethane.
The composition of outer lubricating layer 33 and interior lubricating layer 43 is hydrophilic gel.This hydrophilic gel is preferably Polyethylene Glycol (PEG) or polyvinyl pyrrolidone (NVP).
With reference to figure 3.The manufacture method of superslide antimicrobial coating catheter comprises the following steps: according to an embodiment of the invention
Step S11 is immersed in the body 1 of catheter in the alcoholic solution, generally soaks 5-20 minute, with the removals such as oils and fats with the catheter surface, plays the effect on cleaning catheter surface.This alcoholic solution is preferably alcoholic solution, aqueous isopropanol, butanol solution or methyl butanol solution;
Step S12, the body 1 from alcoholic solution taking-up catheter cleans with purified water, and the body 1 after will cleaning then is immersed in and contains Ag
+, Zn
2+Or Cu
2+In the inorganic salt solution of ion.This contains Ag
+, Zn
2+Or Cu
2+The inorganic salt solution of ion is preferably and contains Ag
+, Zn
2+Or Cu
2+The hydrochlorate solution of ion, for example hydrochloric acid silver solution, hydrochloric acid zinc solution or hydrochloric acid copper solution etc., or contain Ag
+, Zn
2+Or Cu
2+The acetate solution of ion, for example silver acetate solution, zinc acetate solution or Schweinfurt green solution etc.;
Step S13, the body 1 from inorganic salt solution taking-up catheter cleans with purified water, and the body 1 with catheter is immersed in the organic chelate solution of inert metal again; The organic chelate solution of this inert metal is preferably the β-ketoamine solution of inert metal, for example palladium (Pd) metal β-ketoamine solution or gold (Au) metal β-ketoamine solution etc., or the dipivaloylmethane solution of inert metal, for example be palladium (Pd) metal dipivaloylmethane solution or gold (Au) metal dipivaloylmethane solution etc.;
Step S14, the body 1 of taking-up catheter cleans with purified water from the organic chelate solution of inert metal, and the body 1 with catheter is immersed in the hydrophilic gel again; This hydrophilic gel is Polyethylene Glycol (PEG) or polyvinyl pyrrolidone (NVP);
Step S15 takes out the body 1 of catheter from hydrophilic gel, clean then, dry, pack and sterilize.
As required, the step of all right repeating step S11-S14 is with the coating that obtains to meet the demands.
Superslide antimicrobial coating catheter of the present invention has lasting, stable antibacterial functions, can effectively suppress common bacteria in the clinical use, thereby has prolonged the time in the urinary catheter in body, and has reduced the sense of discomfort in the sufferer use.
Claims (10)
1. superslide antimicrobial coating catheter, comprise for the body that inserts human body, be attached to outer wall coating and the inside coating that is attached on this body inwall on this body outer wall, it is characterized in that, described outer wall coating comprises the outer antibiotic layer that is attached to described body outer wall surface from the inside to the outside successively, be attached to outer slow release layer and the outer lubricating layer that is attached on the described outer slow release layer on the described outer antibiotic layer, described inside coating comprises the interior antibiotic layer that is attached to described body inner wall surface from the inside to the outside successively, be attached to interior slow release layer and the interior lubricating layer that is attached on the described interior slow release layer on the described interior antibiotic layer;
The composition of described outer antibiotic layer and interior antibiotic layer is for containing Ag
+, Zn
2+Or Cu
2+The inorganic salt of ion; The composition of described outer slow release layer and interior slow release layer is the organic chelate of inert metal; The composition of described outer lubricating layer and interior lubricating layer is hydrophilic gel.
2. superslide antimicrobial coating catheter as claimed in claim 1 is characterized in that, the described Ag that contains
+, Zn
2+Or Cu
2+The inorganic salt of ion is for containing Ag
+, Zn
2+Or Cu
2+The hydrochlorate of ion or contain Ag
+, Zn
2+Or Cu
2+The acetate of ion.
3. superslide antimicrobial coating catheter as claimed in claim 1 is characterized in that, the organic chelate of described inert metal is the β-ketoamine of inert metal or the dipivaloylmethane of inert metal.
4. superslide antimicrobial coating catheter as claimed in claim 1 is characterized in that, described hydrophilic gel is Polyethylene Glycol or polyvinyl pyrrolidone.
5. superslide antimicrobial coating catheter as claimed in claim 1 is characterized in that, the material of described body is latex, silica gel, silicone rubber or rubber.
6. a method of making superslide antimicrobial coating catheter as claimed in claim 1 is characterized in that: comprise the following steps:
The body of catheter is immersed in the alcoholic solution;
Body from alcoholic solution taking-up catheter cleans, and is immersed in then and contains Ag
+, Zn
2+Or Cu
2+In the inorganic salt solution of ion;
Body from inorganic salt solution taking-up catheter cleans, and the body with catheter is immersed in the organic chelate solution of inert metal again;
Take out the body of catheter from the organic chelate solution of inert metal, clean, the body with catheter is immersed in the hydrophilic gel again;
The body of catheter is taken out from hydrophilic gel, clean then, dry, pack and sterilize.
7. the production method of superslide antimicrobial coating catheter as claimed in claim 6 is characterized in that, described alcoholic solution is alcoholic solution, aqueous isopropanol, butanol solution or methyl butanol solution.
8. the production method of superslide antimicrobial coating catheter as claimed in claim 6 is characterized in that, the described Ag that contains
+, Zn
2+Or Cu
2+The inorganic salt solution of ion is for containing Ag
+, Zn
2+Or Cu
2+The hydrochlorate solution of ion or contain Ag
+, Zn
2+Or Cu
2+The acetate solution of ion.
9. the production method of superslide antimicrobial coating catheter as claimed in claim 6 is characterized in that, the organic chelate solution of described inert metal is the dipivaloylmethane solution of the β of inert metal-ketoamine solution or inert metal.
10. the production method of superslide antimicrobial coating catheter as claimed in claim 6 is characterized in that, described hydrophilic gel is Polyethylene Glycol or polyvinyl pyrrolidone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210008850 CN103203062A (en) | 2012-01-12 | 2012-01-12 | Catheter with super-lubricity antibacterial coatings and manufacturing method for catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210008850 CN103203062A (en) | 2012-01-12 | 2012-01-12 | Catheter with super-lubricity antibacterial coatings and manufacturing method for catheter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103203062A true CN103203062A (en) | 2013-07-17 |
Family
ID=48750603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210008850 Pending CN103203062A (en) | 2012-01-12 | 2012-01-12 | Catheter with super-lubricity antibacterial coatings and manufacturing method for catheter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103203062A (en) |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225762A (en) * | 2014-09-03 | 2014-12-24 | 科云生医科技股份有限公司 | Antibacterial urethral catheter |
| CN104740690A (en) * | 2015-04-03 | 2015-07-01 | 青岛明药堂医疗股份有限公司 | Medicine-carrying nano antibacterial super-smooth coating for marine organisms |
| CN104857571A (en) * | 2014-12-03 | 2015-08-26 | 美昕医疗器械（上海）有限公司 | Hydrophilic lubrication silicone rubber catheter and preparation method for hydrophilic lubrication coating layer |
| CN105218810A (en) * | 2015-11-17 | 2016-01-06 | 中国科学院长春应用化学研究所 | A kind of antibacterial super slippery medical material and preparation method thereof and antibacterial super slippery urethral catheter |
| CN105251095A (en) * | 2015-10-22 | 2016-01-20 | 江苏康诺医疗器械有限公司 | PVC ultra-lubricating catheter and preparation method for same |
| CN106139360A (en) * | 2015-03-24 | 2016-11-23 | 上海千山医疗科技有限公司 | Antibiotic medical catheter |
| CN106422027A (en) * | 2016-11-29 | 2017-02-22 | 刘锋 | Coating method applied to silica gel catheter |
| CN109107021A (en) * | 2018-06-22 | 2019-01-01 | 江南大学附属医院 | A kind of catheter preventing urinary tract infections |
| CN109200334A (en) * | 2018-09-26 | 2019-01-15 | 湖北大学 | A kind of composite hydrogel dressing of optical dynamic therapy wound infection and preparation method thereof |
| CN111249537A (en) * | 2020-01-16 | 2020-06-09 | 兰州大学 | Antibacterial catheter and preparation method thereof |
| CN111514432A (en) * | 2019-02-02 | 2020-08-11 | 江苏百赛飞生物科技有限公司 | Microcatheter, method of making the same and medical device comprising the same |
| CN113382756A (en) * | 2018-11-30 | 2021-09-10 | 斯特拉塔卡系统有限公司 | Coated and/or impregnated ureteral catheter or stent and method of making same |
| US11420014B2 (en) | 2015-07-20 | 2022-08-23 | Roivios Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
| US11471583B2 (en) | 2015-07-20 | 2022-10-18 | Roivios Limited | Method of removing excess fluid from a patient with hemodilution |
| US11541205B2 (en) | 2015-07-20 | 2023-01-03 | Roivios Limited | Coated urinary catheter or ureteral stent and method |
| CN115645630A (en) * | 2022-11-04 | 2023-01-31 | 湖南埃普特医疗器械有限公司 | Antibacterial catheter and preparation method thereof |
| US11612714B2 (en) | 2015-07-20 | 2023-03-28 | Roivios Limited | Systems and methods for inducing negative pressure in a portion of a urinary tract of a patient |
| US11752300B2 (en) | 2015-07-20 | 2023-09-12 | Roivios Limited | Catheter device and method for inducing negative pressure in a patient's bladder |
| US11896785B2 (en) | 2015-07-20 | 2024-02-13 | Roivios Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
| US11918754B2 (en) | 2015-07-20 | 2024-03-05 | Roivios Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
-
2012
- 2012-01-12 CN CN 201210008850 patent/CN103203062A/en active Pending
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225762A (en) * | 2014-09-03 | 2014-12-24 | 科云生医科技股份有限公司 | Antibacterial urethral catheter |
| CN104857571A (en) * | 2014-12-03 | 2015-08-26 | 美昕医疗器械（上海）有限公司 | Hydrophilic lubrication silicone rubber catheter and preparation method for hydrophilic lubrication coating layer |
| CN106139360A (en) * | 2015-03-24 | 2016-11-23 | 上海千山医疗科技有限公司 | Antibiotic medical catheter |
| CN104740690A (en) * | 2015-04-03 | 2015-07-01 | 青岛明药堂医疗股份有限公司 | Medicine-carrying nano antibacterial super-smooth coating for marine organisms |
| US11420014B2 (en) | 2015-07-20 | 2022-08-23 | Roivios Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
| US11471583B2 (en) | 2015-07-20 | 2022-10-18 | Roivios Limited | Method of removing excess fluid from a patient with hemodilution |
| US11752300B2 (en) | 2015-07-20 | 2023-09-12 | Roivios Limited | Catheter device and method for inducing negative pressure in a patient's bladder |
| US11541205B2 (en) | 2015-07-20 | 2023-01-03 | Roivios Limited | Coated urinary catheter or ureteral stent and method |
| US11612714B2 (en) | 2015-07-20 | 2023-03-28 | Roivios Limited | Systems and methods for inducing negative pressure in a portion of a urinary tract of a patient |
| US11918754B2 (en) | 2015-07-20 | 2024-03-05 | Roivios Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
| US11904113B2 (en) | 2015-07-20 | 2024-02-20 | Roivios Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
| US11904121B2 (en) | 2015-07-20 | 2024-02-20 | Roivios Limited | Negative pressure therapy system |
| US11896785B2 (en) | 2015-07-20 | 2024-02-13 | Roivios Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
| CN105251095A (en) * | 2015-10-22 | 2016-01-20 | 江苏康诺医疗器械有限公司 | PVC ultra-lubricating catheter and preparation method for same |
| CN105251095B (en) * | 2015-10-22 | 2018-05-15 | 江苏康诺医疗器械有限公司 | PVC ultra-smooth urinary catheters and preparation method thereof |
| CN105218810B (en) * | 2015-11-17 | 2017-12-19 | 中国科学院长春应用化学研究所 | A kind of antibacterial super slippery medical material and preparation method thereof and antibacterial super slippery urethral catheter |
| CN105218810A (en) * | 2015-11-17 | 2016-01-06 | 中国科学院长春应用化学研究所 | A kind of antibacterial super slippery medical material and preparation method thereof and antibacterial super slippery urethral catheter |
| CN106422027A (en) * | 2016-11-29 | 2017-02-22 | 刘锋 | Coating method applied to silica gel catheter |
| CN109107021A (en) * | 2018-06-22 | 2019-01-01 | 江南大学附属医院 | A kind of catheter preventing urinary tract infections |
| CN109200334B (en) * | 2018-09-26 | 2021-04-09 | 湖北大学 | Composite hydrogel dressing for photodynamic therapy of wound infection and preparation method thereof |
| CN109200334A (en) * | 2018-09-26 | 2019-01-15 | 湖北大学 | A kind of composite hydrogel dressing of optical dynamic therapy wound infection and preparation method thereof |
| CN113382756A (en) * | 2018-11-30 | 2021-09-10 | 斯特拉塔卡系统有限公司 | Coated and/or impregnated ureteral catheter or stent and method of making same |
| CN111514432B (en) * | 2019-02-02 | 2021-06-08 | 江苏百赛飞生物科技有限公司 | Microcatheter, method of making the same and medical device comprising the same |
| CN111514432A (en) * | 2019-02-02 | 2020-08-11 | 江苏百赛飞生物科技有限公司 | Microcatheter, method of making the same and medical device comprising the same |
| CN111249537A (en) * | 2020-01-16 | 2020-06-09 | 兰州大学 | Antibacterial catheter and preparation method thereof |
| CN115645630A (en) * | 2022-11-04 | 2023-01-31 | 湖南埃普特医疗器械有限公司 | Antibacterial catheter and preparation method thereof |
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Application publication date: 20130717 |