CN115645630A - Antibacterial catheter and preparation method thereof - Google Patents
Antibacterial catheter and preparation method thereof Download PDFInfo
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- CN115645630A CN115645630A CN202211377852.3A CN202211377852A CN115645630A CN 115645630 A CN115645630 A CN 115645630A CN 202211377852 A CN202211377852 A CN 202211377852A CN 115645630 A CN115645630 A CN 115645630A
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Images
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The embodiment of the disclosure provides an antibacterial catheter and a preparation method thereof, the antibacterial catheter comprises a catheter body, and an antibacterial coating and a slow-release coating which are sequentially coated on the surface of the catheter body from inside to outside, wherein the antibacterial coating is made of an antibacterial material formed by mixing an antibacterial drug and a first polymer, and the slow-release coating is made of a second polymer. This is disclosed through the antibacterial coating that the surface coating antibacterial medicine and the first polymer mixture of forming at the catheter body to at the slow-release coating that the surface coating second polymer formed, can be on the catheter surface long-term, sustainable, stable release antibacterial medicine, can effective impedance and kill the bacterium, realize long-term antibiotic, and effectively reduce the injury to the patient, improve patient's use comfort.
Description
Technical Field
The disclosure relates to the technical field of medical instruments, in particular to an antibacterial catheter and a preparation method thereof.
Background
Nosocomial infections represent one of the increasingly serious public health problems worldwide, with urinary tract infections accounting for a high percentage of hospital-acquired infections, about 40%, and urinary tract infections due to catheter retention accounting for about 80%. When the catheter is applied to a patient, the catheter is placed into the tissue of the patient for a long time or a short time, the catheter needs to be inserted into or pulled out of the patient, and the patient feels pain to different degrees. Moreover, the catheter and the body tissue have a large friction coefficient, so that the mucous membrane part is easily infected. The current solutions to both of these problems are to apply a drug coating and a hydrophilic coating to the catheter surface to reduce infection during implantation and during the short or long term residence time of the patient. The antibacterial material is mainly divided into a natural antibacterial agent, an inorganic antibacterial agent and an organic antibacterial agent. The natural antibacterial agent mainly refers to materials with effective components extracted from natural animals and plants, such as berberine and chitin, and has the advantages of high safety, long acting, difficult processing and short service life. The inorganic antibacterial material refers to metals such as silver, titanium, copper and the like, has the advantages of wide antibacterial spectrum, good heat resistance and the like, but has the defects of easy discoloration, high cytotoxicity and the like. The organic antibacterial agent refers to some small molecular drugs and some high molecular polymers, such as benzimidazole, polypyridine and the like, and has the advantages of wide sources, low price, good antibacterial performance and the like, but has the defects of easy generation of bacterial drug resistance, poor chemical stability and the like.
The antibiotic has the advantages of high drug effect, wide antibacterial spectrum, easy obtainment and the like, is suitable for various infections, septicemia and other diseases caused by enterobacteriaceae bacteria, streptococcus pneumoniae and hemolytic streptococcus, and has better application prospect in clinic. The antibiotic is directly coated on the catheter, the formation of bacterial biofilm can be effectively prevented by preventing the colonization of bacteria, however, the drug can be quickly released, the long-term antibiosis cannot be realized, and the drug resistance can be generated, so that the antibacterial effect is deteriorated, and obvious side effects (such as chronic infection, pain of patients and the like) are caused.
Disclosure of Invention
An object of the embodiment of the present disclosure is to provide an antibacterial urinary catheter and a preparation method thereof, so as to solve the technical problems of short antibacterial time, poor antibacterial effect and easy pain of patients of urinary catheters in the prior art.
In order to solve the technical problem, the embodiment of the present disclosure adopts the following technical solutions:
the antibacterial catheter comprises a catheter body, and an antibacterial coating and a slow-release coating which are sequentially coated on the surface of the catheter body from inside to outside, wherein the antibacterial coating is made of an antibacterial material formed by mixing an antibacterial drug and a first polymer, and the slow-release coating is made of a second polymer.
In some embodiments, the antibacterial agent is one or more of chitin, levofloxacin, cephamycin, tetracycline, erythromycin, streptomycin, chloramphenicol, cephalexin, norfloxacin.
In some embodiments, the first polymer is one or more of poly n-butyl methacrylate, polyurethane, polyvinylpyrrolidone, polyvinylidene fluoride.
In some embodiments, the second polymer is one or more of polyurethane, polyethylene glycol, polylactic acid, poly (oligo ethylene glycol) methacrylate, polyvinylidene fluoride.
In some embodiments, the slow release coating is further coated with a hydrophilic coating, the material of the hydrophilic coating is a third polymer, and the third polymer is one or more of polyvinylpyrrolidone-vinyl acetate, polyethylene glycol and polyvinylpyrrolidone.
In some embodiments, the mass ratio of the first polymer to the antibacterial agent in the antibacterial material is 2 to 10, and the concentration of the antibacterial agent and the first polymer after mixing in the first solvent is in a range of 0.1 to 2g/mL.
The present disclosure also provides a preparation method of the above antibacterial urinary catheter, including:
pretreating the catheter body;
respectively preparing an antibacterial coating solution and a slow-release coating solution;
coating the surface of the catheter body with the antibacterial coating solution and drying to form an antibacterial coating;
coating the slow-release coating solution on the surface of the antibacterial coating and drying to form a slow-release coating;
the antibacterial coating solution is a mixed solution formed by mixing an antibacterial drug and a first polymer, and the slow-release coating solution is a second polymer solution.
In some embodiments, the catheter body is pretreated, comprising:
soaking the catheter body into an ethanol solution, and carrying out ultrasonic treatment on the catheter body;
drying the catheter body after ultrasonic treatment.
In some embodiments, the method further comprises:
preparing a hydrophilic coating solution;
and coating the hydrophilic coating solution on the surface of the slow release coating, and drying to form the hydrophilic coating.
In some embodiments, the method further comprises:
coating the antibacterial coating solution, the slow-release coating solution and the hydrophilic coating solution in a single or multiple coating mode;
and after the antibacterial coating solution, the slow-release coating solution or the hydrophilic coating solution is coated each time, drying the catheter body coated with the corresponding coating solution.
According to the antibacterial catheter and the preparation method thereof provided by the embodiment of the disclosure, the antibacterial coating formed by mixing the antibacterial medicine and the first polymer is coated on the surface of the catheter body, and the slow-release coating formed by the second polymer is coated on the surface of the antibacterial coating, so that the antibacterial medicine can be continuously and stably released on the surface of the catheter for a long time, the bacteria can be effectively resisted and killed, the long-acting antibacterial effect is realized, the harm to a patient is effectively reduced, and the use comfort of the patient is improved.
Drawings
In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, it is obvious that the drawings in the following description are only some embodiments described in the present disclosure, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic view of an antimicrobial urinary catheter according to an embodiment of the present disclosure;
fig. 2 is a flow chart of a method of making an antimicrobial urinary catheter according to an embodiment of the present disclosure;
fig. 3 is a release profile of a drug in an antimicrobial drug coating of an antimicrobial urinary catheter according to an embodiment of the present disclosure;
fig. 4 is a schematic view of the antibacterial effect of the antibacterial agent coating according to the embodiment of the present disclosure.
Detailed Description
Various aspects and features of the disclosure are described herein with reference to the drawings.
It should be understood that various modifications may be made to the embodiments of the present application. Accordingly, the foregoing description should not be construed as limiting, but merely as exemplifications of embodiments. Other modifications will occur to those skilled in the art within the scope and spirit of the disclosure.
The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate embodiments of the disclosure and, together with a general description of the disclosure given above, and the detailed description of the embodiments given below, serve to explain the principles of the disclosure.
These and other characteristics of the present disclosure will become apparent from the following description of preferred forms of embodiment, given as a non-limiting example, with reference to the attached drawings.
It should also be understood that, although the present disclosure has been described with reference to some specific examples, a person of skill in the art shall certainly be able to achieve many other equivalent forms of the disclosure, having the characteristics as set forth in the claims and hence all coming within the field of protection defined thereby.
The above and other aspects, features and advantages of the present disclosure will become more apparent in view of the following detailed description when taken in conjunction with the accompanying drawings.
Specific embodiments of the present disclosure are described hereinafter with reference to the accompanying drawings; however, it is to be understood that the disclosed embodiments are merely exemplary of the disclosure that may be embodied in various forms. Well-known and/or repeated functions and structures have not been described in detail so as not to obscure the present disclosure with unnecessary or unnecessary detail. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present disclosure in virtually any appropriately detailed structure.
The specification may use the phrases "in one embodiment," "in another embodiment," "in yet another embodiment," or "in other embodiments," which may each refer to one or more of the same or different embodiments in accordance with the disclosure.
Fig. 1 shows a schematic structural diagram of an antibacterial urinary catheter according to an embodiment of the present disclosure, and as shown in fig. 1, the antibacterial urinary catheter provided by the embodiment of the present disclosure includes a urinary catheter body 1, and an antibacterial coating 2 and a slow-release coating 3 which are sequentially coated on the surface of the urinary catheter body 1 from inside to outside, the antibacterial coating 2 is made of an antibacterial material formed by mixing an antibacterial drug and a first polymer, and the slow-release coating 3 is made of a second polymer.
According to the antibacterial catheter provided by the embodiment of the disclosure, the antibacterial coating 2 formed by mixing the antibacterial medicine and the first polymer is coated on the surface of the catheter body 1, and the slow-release coating 3 formed by coating the second polymer is coated on the surface of the antibacterial coating 2, so that the antibacterial medicine can be continuously and stably released on the surface of the catheter for a long time, bacteria can be effectively resisted and killed, long-acting antibacterial is realized, the harm to a patient is effectively reduced, and the use comfort of the patient is improved.
Specifically, when the surface of the catheter body 1 is directly coated with the antibacterial agent, the antibacterial agent cannot achieve the purpose of effective sterilization due to drug resistance, and the antibacterial agent may not be recognized by the immune system of the body, so that chronic infection and relapse are caused, and high morbidity and mortality are caused. Therefore, in the embodiment, the antibacterial coating 2 formed by mixing the antibacterial drug and the first polymer is coated on the surface of the catheter body 1, so that the drug resistance of bacteria to the antibacterial drug can be reduced, the bacteria can be effectively resisted and killed, the antibacterial effect is improved, and the formed catheter is safer and more reliable due to the fact that the first polymer is low in toxicity, not only can be suitable for short-term retention, but also can be suitable for long-term retention. The slow release coating 3 formed by the second polymer can regularly release the medicine for a long time, can reach the minimum bacteriostatic concentration, and effectively reduces the harm to patients.
In some embodiments, the antibacterial agent is one or more of chitin, levofloxacin, cephamycin, tetracycline, erythromycin, streptomycin, chloramphenicol, cephalexin, norfloxacin.
In this embodiment, the antibacterial agent adopts the above-mentioned broad-spectrum drug that is not commonly used for treating urinary tract infection related to urinary catheter, can effectively avoid the drug resistance of bacteria to the antibacterial agent, improves antibacterial, bactericidal effect.
In this embodiment, when selecting antibacterial agents, can select antibacterial agents of different mechanism of action for use, for example, can select for use tetracycline, erythromycin, chloramphenicol etc. that have antibacterial performance to carry out bacteriostasis, select for use simultaneously cefamycin that has bactericidal performance to carry out the sterilization, the material that specifically chooses for use this disclosure does not specifically limit.
In some embodiments, the first polymer is one or more of poly n-butyl methacrylate (PBMA), polyurethane, polyvinylpyrrolidone (PVP), polyvinylidene fluoride.
Wherein, nontoxic poly n-butyl methacrylate is used as an antibacterial polymer, so that the antibacterial material is safer and more environment-friendly. Fluoropolymers help to resist the spread of bacteria and harmful viruses. The PVP has excellent physiological inertia, does not participate in metabolism of patients, has excellent biocompatibility, does not stimulate skin and the like, and can avoid urethral injury and the like.
In some embodiments, the second polymer is one or more of polyurethane, polyethylene glycol (PEG), polylactic acid, poly (oligo ethylene glycol methacrylate) (POEGMA), polyvinylidene fluoride.
In the embodiment, different drugs can be released according to specific drug release rates by the slow release action of the slow release coating 3 formed by the multiple second polymers, so that the drugs can be released regularly for a long time by adopting different release sequences and different release times according to different pathogenesis.
In some embodiments, the slow release coating 3 is further coated with a hydrophilic coating 4, the material of the hydrophilic coating 4 is a third polymer, and the third polymer is one or more of polyvinylpyrrolidone-vinyl acetate, polyethylene glycol, and polyvinylpyrrolidone (PVP).
The hydrophilic coating 4 formed by the third polymer can effectively improve the lubricity of the surface of the catheter, has excellent biocompatibility, can effectively reduce the risk of urinary tract infection, reduces the pain feeling of a patient when the catheter is inserted or pulled out, effectively reduces the harm to the patient, improves the use comfort of the patient, and has the advantages of difficult falling off of the coating and better lubrication durability.
The first polymer, the second polymer and the third polymer may be the same or different, and the disclosure is not particularly limited.
In some embodiments, the antibacterial material has a mass ratio of the first polymer to the antibacterial agent of 2 to 10, and the concentration of the antibacterial agent and the first polymer after mixing in the first solvent ranges from 0.1 to 2g/mL.
In this embodiment, the first polymer and the antibacterial agent may be mixed with a certain amount of the first solvent to prepare an antibacterial coating solution, and the prepared antibacterial coating solution is coated on the surface of the catheter body 1 to form the antibacterial coating 2.
Similarly, a second polymer may be mixed with a certain amount of a second solvent to prepare a slow-release coating solution, and the prepared slow-release coating solution is coated on the surface of the antibacterial coating 2 to form a slow-release coating 3; the third polymer may be mixed with a certain amount of the third solvent to prepare a hydrophilic coating solution, and the prepared hydrophilic coating solution is coated on the surface of the slow release coating 3 to form the hydrophilic coating 4.
The concentration of the second polymer in the second solvent is preferably in the range of 0.1 to 2g/mL, and the concentration of the third polymer in the third solvent is preferably in the range of 0.1 to 2g/mL.
Optionally, the catheter body 1 is made of a silica gel material, is soft in material, has good elasticity and biocompatibility, and can effectively reduce pain of a patient during intubation. The material of the catheter body 1 can also be latex, polyurethane or polyvinyl chloride and other materials with good elasticity and biocompatibility.
In some embodiments, the total thickness of the antibacterial coating formed by the antibacterial coating 2, the slow release coating 3 and the hydrophilic coating 4 is less than 1um, so that the urinary bladder and urethra can be prevented from being damaged while the catheter is conveniently implanted, pain caused when the catheter is implanted or pulled out is reduced, and the use comfort of a patient is improved.
Fig. 2 shows a flowchart of a method for manufacturing an antimicrobial urinary catheter according to an embodiment of the present disclosure, and as shown in fig. 2, an embodiment of the present disclosure further provides a method for manufacturing an antimicrobial urinary catheter, including:
s1: pretreating the catheter body 1;
s2: respectively preparing an antibacterial coating solution and a slow-release coating solution;
s3: coating the antibacterial coating solution on the surface of the catheter body 1 and drying to form an antibacterial coating 2;
s4: coating the slow release coating solution on the surface of the antibacterial coating 2 and drying to form a slow release coating 3;
the antibacterial coating solution is a mixed solution formed by mixing an antibacterial drug and a first polymer, and the slow-release coating solution is a second polymer solution.
Specifically, carry out preliminary treatment to the outer wall of catheter body 1 earlier, step S1 specifically includes:
s11: soaking the catheter body 1 into an ethanol solution, and carrying out ultrasonic treatment on the catheter body 1;
s12: drying the catheter body 1 after ultrasonic treatment.
In this embodiment, the catheter body 1 is subjected to ultrasonic treatment with 99% ethanol, the catheter body 1 may be first soaked in an ethanol solution for a certain time, which may be 5 to 10min, preferably 5min, at room temperature, then the catheter body 1 is subjected to ultrasonic treatment at a certain ultrasonic temperature and ultrasonic power, and the catheter body 1 after ultrasonic treatment is dried to complete pretreatment of the catheter body 1. The ultrasonic temperature is preferably 35-39 ℃, the ultrasonic power is preferably 40-70w, 220Hz; the ultrasonic time is preferably 10 to 20min.
The catheter body 1 after ultrasonic treatment can be placed into a blast drying oven for drying, and the drying temperature can be 40-60 ℃; meanwhile, the dried catheter body 1 can be placed in a forced air drying oven overnight.
After the catheter body 1 is pretreated in the step S1, the antibacterial agent and the first polymer are dissolved in the first solvent in the step S2 to prepare an antibacterial coating solution. The antimicrobial coating solution is a polymer base solution. Wherein the antibacterial drug can be one or more of chitin, levofloxacin, cefamycin, tetracycline, erythromycin, streptomycin, chloramphenicol, cephalexin, and norfloxacin; the first polymer can be one or more of poly n-butyl methacrylate, polyurethane, polyvinylpyrrolidone and polyvinylidene fluoride. The mass ratio of the first polymer to the antibacterial drug in the antibacterial material is 2-10, and the concentration range of the antibacterial drug and the first polymer after mixing in the first solvent is 0.1-2 g/mL.
Similarly, a second polymer may be dissolved in a second solvent to formulate a slow release coating solution. The second polymer may be one or more of polyurethane, polyethylene glycol (PEG), polylactic acid, poly (oligo ethylene glycol methacrylate) (POEGMA), and polyvinylidene fluoride. The concentration range of the second polymer after mixing in the second solvent is 0.1-2 g/mL.
In some embodiments, the solvent of the antimicrobial coating solution and the sustained release coating solution is N, N-Dimethylformamide (DMF).
N, N-dimethylformamide is used as an excellent organic solvent of a high polymer, can quickly dissolve antibacterial drugs and polymers, can prepare an antibacterial coating solution and a sustained-release coating solution which are uniformly mixed, improves the uniformity of the antibacterial coating 2 and the sustained-release coating 3, and avoids uneven drug release to cause poor local sterilization effect.
The solvent in the antibacterial coating solution and the slow-release coating solution may also be other solvents, and the first solvent and the second solvent respectively used for preparing the antibacterial coating solution, the slow-release coating solution and the hydrophilic coating solution may be the same or different, and the disclosure is not particularly limited thereto.
After the antibacterial coating solution and the slow-release coating solution are prepared, the prepared antibacterial coating solution is coated on the surface of the catheter body 1 through the step S3, and drying treatment is carried out to obtain the antibacterial coating 2. When the antibacterial coating solution is applied, the antibacterial coating layer 2 may be formed by single or multiple applications, and after each application, a drying process is performed. After the antibacterial coating 2 is formed by coating, the surface of the antibacterial coating 2 is coated with the slow-release coating solution and is dried to obtain the slow-release coating 3.
In some embodiments, the method further comprises:
s5: preparing a hydrophilic coating solution;
s6: and coating the hydrophilic coating solution on the surface of the slow release coating, and drying to form a hydrophilic coating 4. And dissolving the third polymer in a third solvent to prepare a hydrophilic coating solution. The third polymer may be one or more of polyvinylpyrrolidone-vinyl acetate, polyethylene glycol, polyvinylpyrrolidone (PVP). The concentration range of the mixed third polymer in the third solvent is 0.1-2 g/mL. The third solvent used to prepare the hydrophilic coating solution may be N, N-Dimethylformamide (DMF) as described above.
After the slow release layer 3 is obtained in step S4, a prepared hydrophilic coating solution may be coated on the surface of the slow release layer 3, and dried to form the hydrophilic coating 4. The hydrophilic coating 4 formed by the third polymer has very good lubricity, is convenient to implant into a patient body, and can effectively improve the use comfort and safety of the patient.
In some embodiments, the method further comprises:
coating the antibacterial coating solution, the slow-release coating solution and the hydrophilic coating solution in a single or multiple coating mode;
after the antibacterial coating solution, the slow-release coating solution or the hydrophilic coating solution is coated each time, the catheter body 1 coated with the corresponding coating solution is dried.
Specifically, when the sustained-release coating solution is applied, the sustained-release coating layer 3 may be formed by single or multiple applications, and after each application, a drying treatment is performed. After the slow release coating 3 is formed by coating, a hydrophilic coating solution is coated on the surface of the slow release coating 3, and drying treatment is carried out to obtain a hydrophilic coating 4, so that a finished catheter product coated with the antibacterial coating is obtained. When the hydrophilic coating solution is applied, the hydrophilic coating 4 may be formed by single or multiple applications, and after each application, a drying process is performed.
The number of applications of the antibacterial coating solution, the sustained-release coating solution and the hydrophilic coating solution is preferably 2 to 10. The coating times can be predetermined or can be based on the surface flatness during the coating process to ensure uniform coating. In this embodiment, form corresponding coating through the mode coating of single or many times, can guarantee the homogeneity of each coating, and then guarantee that antibacterial agent's in antibacterial coating 2 is stable, evenly released, improves antibiotic effect.
After each coating, drying the coating by using an oven so as to enable the coating to be solidified on the surface of the catheter body 1, wherein the drying temperature can be 80-100 ℃, and is preferably 90 ℃; the drying time is 10 to 20min, preferably 10min.
The drying method adopts a hot drying method to dry the antibacterial coating solution, the slow-release coating solution and the hydrophilic coating solution attached to the surface of the catheter body 1 so as to form corresponding coatings. In other embodiments, drying modes such as ultraviolet radiation drying or microwave drying can be adopted to quickly dry the corresponding coating, so that the diffusion of the medicine is avoided, and the antibacterial effect of the catheter is ensured.
In this embodiment, one or more of brushing, rolling and spraying processes may be used for coating.
It should be noted that, in order to improve the preparation efficiency of the urinary catheter, in the embodiment of the present disclosure, the antibacterial coating solution, the slow release coating solution, and the hydrophilic coating solution may be simultaneously configured in step S2, and when the antibacterial coating solution is coated, the slow release coating solution and the hydrophilic coating solution are left to stand for use. In order to avoid that the quality of the finished catheter product is affected by dilution of the solution concentration due to volatilization and the like caused by the fact that a slow-release coating solution and a hydrophilic coating solution are prepared in advance, in specific implementation, the preparation can also be carried out before the corresponding coating solution is coated, for example, only the antibacterial coating solution can be prepared through the step S2, then the antibacterial coating solution is coated on the surface of the catheter body 1 through the step S3, and the antibacterial coating 2 is obtained through drying; then, preparing a slow-release coating solution, coating the slow-release coating solution on the surface of the antibacterial coating 2 through the step S4, and drying to obtain a slow-release coating 3; and then, preparing a hydrophilic coating solution through step S5, coating the hydrophilic coating solution on the surface of the slow release coating 3 through step S6, and drying to obtain a hydrophilic coating 4, thereby obtaining the finished catheter product coated with the antibacterial coating.
The catheter coated with the antibacterial coating (comprising the antibacterial coating 2, the slow-release coating 3 and the hydrophilic coating 4) prepared by the method in the embodiment of the disclosure has long-term curative effect, has good antibacterial effect (adopts polymers as coating materials and the like), and can realize long-acting antibacterial; meanwhile, the thickness of the prepared antibacterial drug coating is lower than 1um, the surface is smooth, and the use comfort of a patient can be improved; the preparation method of the catheter does not need complex procedures, has low requirements on preparation environment (such as temperature and the like), is easy to operate, convenient to prepare, low in preparation cost, more suitable for industrial production and wide in application range.
To further illustrate the present disclosure, the disclosure will be further described by way of examples.
Example 1
1) Putting a catheter body 1 of 40cm into a beaker filled with 100mL of ethanol solution, soaking for 5min at room temperature, carrying out ultrasonic treatment at 37 ℃ for 10min, wherein the ultrasonic power is 60w and 220Hz, after the ultrasonic treatment is finished, putting the catheter body 1 into a blast drying oven, drying at 60 ℃, and standing overnight;
2) Weighing 5g of polyvinylidene fluoride, 5g of polyurethane and 1g of levofloxacin, adding 60mL of N, N-dimethylformamide solution, stirring at room temperature for 24h for dissolution, and preparing an antibacterial coating solution for later use;
3) Brushing the antibacterial coating solution prepared in the step 2) on the surface of the catheter body 1 treated in the step 1) at room temperature, repeating brushing for 6 times, and drying in a 90 ℃ oven for 10min after finishing brushing each time to form an antibacterial coating 2 for later use;
4) Weighing 5g of polyurethane, adding 50mL of N, N-dimethylformamide solution, stirring at room temperature for 30min, and preparing a slow-release coating solution for later use;
5) At room temperature, brushing the prepared slow-release coating solution of the step 4) on the surface of the antibacterial coating 2 formed in the step 3), repeating brushing for 6 times, and drying in a 90 ℃ oven for 10min after each brushing to form a slow-release coating 3 for later use;
6) Weighing 10g of polyvinylpyrrolidone-vinyl acetate, adding 50mL of N, N-dimethylformamide solution, stirring at room temperature for 30min for dissolving, and preparing hydrophilic coating solution for later use;
7) And (3) brushing the hydrophilic coating solution prepared in the step 6) on the surface of the slow-release coating 3 formed in the step 5) at room temperature, repeating brushing for 6 times, and drying in an oven at 90 ℃ for 10min after each brushing is finished to form a hydrophilic coating 4 to obtain a finished catheter product.
The antimicrobial agent of example 1 was levofloxacin, the first polymer was polyurethane and polyvinylidene fluoride, the second polymer was polyurethane, and the third polymer was polyvinylpyrrolidone-vinyl acetate.
Example 2
1) Placing a catheter body 1 of 40cm into a beaker filled with 100mL of ethanol solution, soaking for 5min at room temperature, carrying out ultrasonic treatment for 10min at 37 ℃, wherein the ultrasonic power is 60w and 220Hz, after the ultrasonic treatment is finished, placing the catheter body 1 into a forced air drying oven, drying at 60 ℃, and standing overnight;
2) Weighing 5g of polyvinylidene fluoride and 1g of levofloxacin, adding 60mL of N, N-dimethylformamide solution, stirring at room temperature for 24h for dissolving, and preparing an antibacterial coating solution for later use;
3) At room temperature, brushing the antibacterial coating solution prepared in the step 2) on the surface of the catheter body 1 treated in the step 1), repeatedly brushing for 6 times, and drying in a 90 ℃ drying oven for 10min after finishing brushing each time to form an antibacterial coating 2 for later use;
4) Weighing 5g of polyurethane, adding 50mL of N, N-dimethylformamide solution, stirring at room temperature for 30min, and preparing a slow-release coating solution for later use;
5) At room temperature, brushing the surface of the antibacterial coating 2 formed in the step 3) with the slow-release coating solution prepared in the step 4), repeatedly brushing for 6 times, and drying in a 90 ℃ oven for 10min after each brushing to form a slow-release coating 3 for later use;
6) Weighing 10g of polyvinylpyrrolidone-vinyl acetate, adding 50mL of N, N-dimethylformamide solution, stirring at room temperature for 30min for dissolving, and preparing hydrophilic coating solution for later use;
7) And (3) brushing the hydrophilic coating solution prepared in the step 6) on the surface of the slow-release coating 3 formed in the step 5) at room temperature, repeating brushing for 6 times, and drying in an oven at 90 ℃ for 10min after each brushing is finished to form a hydrophilic coating 4 to obtain a finished catheter product.
Example 2 differs from example 1 in that: polyvinylidene fluoride was used as the first polymer in example 2, and polyurethane and polyvinylidene fluoride were used as the first polymer in example 1.
Example 3
1) Putting a catheter body 1 of 40cm into a beaker filled with 100mL of ethanol solution, soaking for 5min at room temperature, carrying out ultrasonic treatment at 37 ℃ for 10min, wherein the ultrasonic power is 60w and 220Hz, after the ultrasonic treatment is finished, putting the catheter body 1 into a blast drying oven, drying at 60 ℃, and standing overnight;
2) Weighing 5g of polyurethane, 5g of polyvinylidene fluoride and 1g of tetracycline, adding 60mL of N, N-dimethylformamide solution, stirring at room temperature for 24h for dissolving, and preparing an antibacterial coating solution for later use;
3) Brushing the antibacterial coating solution prepared in the step 2) on the surface of the catheter body 1 treated in the step 1) at room temperature, repeating brushing for 6 times, and drying in a 90 ℃ oven for 10min after finishing brushing each time to form an antibacterial coating 2 for later use;
4) Weighing 5g of polyurethane, adding 50mL of N, N-dimethylformamide solution, stirring at room temperature for 30min, and preparing a slow-release coating solution for later use;
5) At room temperature, brushing the surface of the antibacterial coating 2 formed in the step 3) with the slow-release coating solution prepared in the step 4), repeatedly brushing for 6 times, and drying in a 90 ℃ oven for 10min after each brushing to form a slow-release coating 3 for later use;
6) Weighing 10g of polyvinylpyrrolidone-vinyl acetate, adding 50mL of N, N-dimethylformamide solution, stirring at room temperature for 30min for dissolving, and preparing hydrophilic coating solution for later use;
7) And (3) brushing the hydrophilic coating solution prepared in the step (6) on the surface of the slow-release coating 3 formed in the step (5) at room temperature, repeating brushing for 6 times, and drying in an oven at 90 ℃ for 10min after each brushing is finished to form a hydrophilic coating 4 to obtain a finished catheter product.
Example 3 differs from example 1 in that: the antibacterial agent in example 3 is tetracycline, and the antibacterial agent in example 1 is levofloxacin.
Example 4
1) Putting a catheter body 1 of 40cm into a beaker filled with 100mL of ethanol solution, soaking for 5min at room temperature, carrying out ultrasonic treatment at 37 ℃ for 10min, wherein the ultrasonic power is 60w and 220Hz, after the ultrasonic treatment is finished, putting the catheter body 1 into a blast drying oven, drying at 60 ℃, and standing overnight;
2) Weighing 5g of polyvinylidene fluoride, 5g of polyurethane and 1g of levofloxacin, adding 60mL of N, N-dimethylformamide solution, stirring at room temperature for 24h for dissolution, and preparing an antibacterial coating solution for later use;
3) Brushing the antibacterial coating solution prepared in the step 2) on the surface of the catheter body 1 treated in the step 1) at room temperature, repeating brushing for 6 times, and drying in a 90 ℃ oven for 10min after finishing brushing each time to form an antibacterial coating 2 for later use;
4) Weighing 5g of polyvinylidene fluoride, adding 50mL of N, N-dimethylformamide solution, stirring at room temperature for 30min, and preparing a slow-release coating solution for later use;
5) At room temperature, brushing the prepared slow-release coating solution of the step 4) on the surface of the antibacterial coating 2 formed in the step 3), repeating brushing for 6 times, and drying in a 90 ℃ oven for 10min after each brushing to form a slow-release coating 3 for later use;
6) Weighing 10g of polyvinylpyrrolidone-vinyl acetate, adding 50mL of N, N-dimethylformamide solution, stirring at room temperature for 30min for dissolving, and preparing hydrophilic coating solution for later use;
7) And (3) brushing the hydrophilic coating solution prepared in the step 6) on the surface of the slow-release coating 3 formed in the step 5) at room temperature, repeating brushing for 6 times, and drying in an oven at 90 ℃ for 10min after each brushing is finished to form a hydrophilic coating 4 to obtain a finished catheter product.
Example 4 differs from example 1 in that: the second polymer in example 4 is polyvinylidene fluoride; the second polymer in example 1 was selected to be polyurethane.
Comparative example 1
Compared with the embodiment 1, the difference is that the surface of the catheter body 1 is not coated with the antibacterial agent coating (the catheter is a bare tube).
After drug release experiments are performed on the catheters prepared in the embodiments 1 to 4, the release curve of the drug shown in fig. 3 is obtained, in fig. 3, the horizontal axis represents the release days (D), the vertical axis represents the cumulative release amount (cumulative release percentage (%), the curve a represents the release curve of the drug which is not sterilized in the catheter prepared in the embodiment 1, and the curves B, C, D, and E represent the release curves of the drug which is sterilized in the catheters prepared in the embodiments 1 to 3, and it can be seen from the curves a and B in fig. 3 that the catheter prepared in the embodiments of the present disclosure can have a good long-term drug release effect without being sterilized, still has an antibacterial effect after 90 days, and has stable and uniform drug release (the curves are substantially smooth), i.e., the sterilization has no influence on the drug release. As can be seen from curves B and C in fig. 3, when the drug carrier is a mixed polymer of polyurethane and polyvinylidene fluoride, the drug is nearly completely released (the cumulative release percentage is 99.21%), and long-term release of the drug can be achieved; when the drug carrier is polyvinylidene fluoride, part of the drug is not completely released (the cumulative release percentage is 90.12%), and the drug cannot be released continuously after being rapidly released in a short period, and the long-term release effect cannot be realized. That is, the drug release effect of the drug carrier formed by the mixed polymer is better than that of the drug carrier formed by the single polymer. As can be seen from the curves B and D in FIG. 3, the drug release effect of the catheter 10 using levofloxacin as the antibacterial agent is better than that of the catheter 10 using tetracycline as the antibacterial agent. Tetracycline cannot be completely released (cumulative release percentage is 95.61%) and long-term drug release cannot be achieved. It can be seen from the curves B and E in fig. 3 that the drug is almost completely released (cumulative release percentage is 99.21%) when the carrier of the sustained release layer is polyurethane, and the drug is rapidly released in a short period and cannot be released in a later period when the carrier of the sustained release layer is vinylidene fluoride.
FIG. 4 is a graph showing the antimicrobial effect of the catheter 10 prepared by the disclosed embodiment and the bare tube 20 of comparative example 1, and FIG. 4 (a) is a schematic diagram of the catheter structure without drug release; FIG. 4 (b) is a schematic diagram showing the structure of the catheter after three months of drug release without sterilization treatment; fig. 4 (c) is a schematic diagram showing the structure of the catheter after three months of drug release after the catheter is sterilized. As shown in fig. 4 (a) and (b), the diameter of the catheter 10 coated with the antibacterial agent coating prepared by the embodiment of the present disclosure is still approximately the same as that before the release, bacteria do not invade into the catheter body 1, the antibacterial agent coating can effectively protect the catheter body 1, and the circumference of the bare tube 20 is full of bacteria; as shown in fig. 4 (b) and (c), the diameter of the catheter 10 coated with the antibacterial agent coating prepared by the embodiment of the present disclosure is reduced after the sterilization process, compared with the diameter of the catheter 10 coated with the antibacterial agent coating before the release, and a part of bacteria may invade into the catheter, that is, the embodiment of the present disclosure provides the prepared catheter 10 coated with the antibacterial agent coating with good long-term antibacterial effect without sterilization.
While the present disclosure has been described in detail with reference to the embodiments, the present disclosure is not limited to the specific embodiments, and those skilled in the art can make various modifications and alterations based on the concept of the present disclosure, and the modifications and alterations should fall within the scope of the present disclosure as claimed.
Claims (10)
1. The antibacterial catheter is characterized by comprising a catheter body, an antibacterial coating and a slow-release coating, wherein the antibacterial coating and the slow-release coating are sequentially coated on the surface of the catheter body from inside to outside, the antibacterial coating is made of an antibacterial material formed by mixing an antibacterial drug and a first polymer, and the slow-release coating is made of a second polymer.
2. The antimicrobial urinary catheter according to claim 1, wherein the antimicrobial drug is one or more of chitin, levofloxacin, cefamycin, tetracycline, erythromycin, streptomycin, chloramphenicol, cephalexin, and norfloxacin.
3. The antimicrobial urinary catheter according to claim 1 wherein the first polymer is one or more of poly n-butyl methacrylate, polyurethane, polyvinylpyrrolidone, polyvinylidene fluoride.
4. The antimicrobial urinary catheter of claim 1 wherein the second polymer is one or more of polyurethane, polyethylene glycol, polylactic acid, poly (oligo ethylene glycol) methacrylate, polyvinylidene fluoride.
5. The antimicrobial urinary catheter according to claim 1, wherein the slow release coating layer is further coated with a hydrophilic coating layer, the hydrophilic coating layer is made of a third polymer, and the third polymer is one or more of polyvinylpyrrolidone-vinyl acetate, polyethylene glycol and polyvinylpyrrolidone.
6. The antimicrobial urinary catheter according to claim 1, wherein the mass ratio of the first polymer to the antimicrobial drug in the antimicrobial material is 2 to 10, and the concentration range of the antimicrobial drug and the first polymer after mixing in the first solvent is 0.1 to 2g/mL.
7. A preparation method of an antibacterial catheter is characterized by comprising the following steps:
pretreating the catheter body;
respectively preparing an antibacterial coating solution and a slow-release coating solution;
coating the surface of the catheter body with the antibacterial coating solution and drying to form an antibacterial coating;
coating the slow-release coating solution on the surface of the antibacterial coating and drying to form a slow-release coating;
the antibacterial coating solution is a mixed solution formed by mixing an antibacterial drug and a first polymer, and the slow-release coating solution is a second polymer solution.
8. The method for preparing the antibacterial urinary catheter according to claim 7, wherein the pretreatment of the urinary catheter body comprises the following steps:
soaking the catheter body into an ethanol solution, and carrying out ultrasonic treatment on the catheter body;
drying the catheter body after ultrasonic treatment.
9. The method of making an antimicrobial urinary catheter according to claim 7, further comprising:
preparing a hydrophilic coating solution;
and coating the hydrophilic coating solution on the surface of the slow release coating, and drying to form the hydrophilic coating.
10. The method of making an antimicrobial urinary catheter according to claim 9, further comprising:
coating the antibacterial coating solution, the slow-release coating solution and the hydrophilic coating solution in a single or multiple coating mode;
and after the antibacterial coating solution, the slow-release coating solution or the hydrophilic coating solution is coated each time, drying the catheter body coated with the corresponding coating solution.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116712616A (en) * | 2023-06-21 | 2023-09-08 | 眉山尤博瑞新材料有限公司 | Ultrathin durable lubricating polyurethane coating material, and preparation method and application of coating |
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| CN103203062A (en) * | 2012-01-12 | 2013-07-17 | 美昕医疗器械（上海）有限公司 | Catheter with super-lubricity antibacterial coatings and manufacturing method for catheter |
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| US20090202609A1 (en) * | 2008-01-06 | 2009-08-13 | Keough Steven J | Medical device with coating composition |
| CN101711710A (en) * | 2009-11-25 | 2010-05-26 | 深圳市信立泰生物医疗工程有限公司 | Medicament eluting stent and preparation method thereof |
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| CN116712616A (en) * | 2023-06-21 | 2023-09-08 | 眉山尤博瑞新材料有限公司 | Ultrathin durable lubricating polyurethane coating material, and preparation method and application of coating |
| CN116712616B (en) * | 2023-06-21 | 2024-05-31 | 眉山尤博瑞新材料有限公司 | Ultrathin durable lubricating polyurethane coating material, and preparation method and application of coating |
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