JPH1147260A - Antibacterial urine guiding catheter - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antibacterial urine guiding catheter which enables keeping of the catheter antibacterial for a long time with excellent antibacterial capability. SOLUTION: The antibacterial urine guiding catheter is formed out of a natural rubber latex which has a silver compound introduced onto the surface thereof by an aqueous solution with the concentration of 0.0001-5 wt.% containing at least one silver compound selected from a group of silver nitrate, silver acetate and perchloric acid while being dispersed together with a compound bondable to silver ions as blended at a rate of 0.001-20 wt.%. The pH of the natural rubber latex dispersed together with the compound bondable to the silver ions is preferably 5 or more.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antimicrobial urinary catheter. More specifically, a urinary catheter molded from a natural rubber latex in which a compound capable of binding to silver ions is dispersed in a natural rubber latex as a base material has an antimicrobial conductivity in which a silver compound is mainly introduced into the surface by ionic bonding. It relates to a urine catheter.

[0002]

2. Description of the Related Art Urinary catheters, which are one of the medical devices to be placed in a living body, have been disinfected, sterilized, and used in some way prior to their use, but are often used for a long time. Therefore, it is often the case that the sterility of the urinary catheter itself is not maintained during use, and thus an improvement is desired. The reason that the sterility cannot be maintained is that bacteria invade from the outside through the inside and outside of the lumen of the catheter. Some of the invading bacteria can be ascending against the urine flow, causing infections such as urethritis, cystitis, and pyelonephritis.

As a countermeasure, chemotherapy for prophylactic administration of antibiotics or the like has been performed. However, in this method, since the antibiotic is administered in a large amount, the problem of side effects cannot be avoided depending on the type of the antibiotic. In addition, once infected, the bacteria are temporarily eliminated by chemotherapy, but there is a problem in easy chemotherapy since re-infection is likely to occur due to the emergence of resistant bacteria thereafter.

As the most effective measure, there is a method of imparting an antibacterial property to the entire urinary catheter or the surface thereof.

[0005] Typical antibacterial substances include gold, silver, copper,
There are heavy metals such as zinc and their metal compounds. These are bacteria, even in very small amounts in the form of metal ions.
It has a broad antibacterial spectrum against fungi. Up to now, attempts have been made to manufacture urinary catheters containing these metal compounds in a matrix to impart antibacterial properties.

A method disclosed in Japanese Patent Publication No. 6-34817 is one in which a silver-based antibacterial substance is applied to a urinary catheter. This document describes a method of forming a urinary catheter coated with a latex containing silver protein.

[0007] In addition to the above-mentioned metal compounds, compounds having antibacterial properties include quaternary ammonium salts, which are one of cationic antibacterial substances. Since these compounds also show strong antibacterial activity against bacteria, attempts have been made to use them in urinary catheters which are contained in a matrix as in metal compounds to impart antibacterial properties.

[0008] Japanese Patent Publication No. 3-64143 discloses a urinary catheter containing a cationic antibacterial substance. In this method, a poorly water-soluble quaternary ammonium salt is contained on the surface of a urinary catheter.

As a method for introducing antibacterial properties, besides a method of processing by dispersing an antibacterial substance in a base material, Japanese Patent Publication No.
341 discloses a method of absorbing a solution of a water-soluble antibacterial substance into a urinary catheter, and then converting the antibacterial substance into a poorly water-soluble compound.

Further, as disclosed in Japanese Patent Application Laid-Open No. 4-502111, there is a method of introducing an antibacterial substance between the leaching step and the curing step in the production of a natural rubber product. Further, as disclosed in Japanese Patent Publication No. 24544/1990, there is a manufacturing method in which a coating having a maleic anhydride group is formed on the surface of a urinary catheter, and the maleic acid group is hydrolyzed to bind an antibacterial substance.

When a compound having a strong antibacterial property against bacteria, such as protein silver or a quaternary ammonium salt, is dispersed in natural rubber latex and processed, a stable dispersion state is maintained in the latex for a long time. It is difficult to carry out, and aggregation of latex particles and sedimentation of antibacterial substances (particularly metal compounds) tend to occur, and the coating layer becomes non-uniform and stable antibacterial properties are hardly obtained. further,
The antibacterial substance is dispersed in latex and exposed to a high temperature in a post-treatment process such as vulcanization after application, and the antibacterial substance is oxidized or thermally decomposed, resulting in darkening due to silver precipitation and decomposition products. There is a fear that the stability is reduced.

Regarding the method of applying the antibacterial substance other than mixing the antibacterial substance into the base material, the method of absorbing the antibacterial substance solution into the urinary catheter has a disadvantage in that the rate of penetration of the antibacterial substance into the base material is slow. It takes many days to complete the process, which is not an economical manufacturing method. In addition, the method of forming a maleic anhydride film on the catheter surface and bonding it to an antibacterial substance requires a large number of processing steps, such as forming a maleic acid film and hydrolyzing it.

[0013]

SUMMARY OF THE INVENTION An object of the present invention is to solve the above-mentioned problems when an antibacterial substance is added to latex, exhibit excellent antibacterial properties, and maintain the antibacterial properties for a long period of time. An object of the present invention is to provide an antimicrobial urinary catheter that maintains its properties.

[0014]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that a silver compound is used as a substance having antibacterial properties against various bacteria after forming a urinary catheter. It has been found that it is useful to impart antibacterial properties by introducing it before or after the heat treatment, that is, it is useful not to mix the above antibacterial substances directly into the substrate prior to processing. The present invention has been reached.

That is, the present invention has the following configuration. (1) An antimicrobial urinary catheter formed from a natural rubber latex in which a silver compound is introduced on the surface and dispersed together with a compound capable of binding to silver ions, the group comprising silver nitrate, silver acetate and silver perchlorate Antibacterial urinary catheter characterized in that a silver compound is introduced on the surface thereof with a 0.0001 to 5% by weight aqueous solution containing at least one silver compound selected from the group consisting of: (2) natural rubber latex Antibacterial urinary catheter containing a compound capable of binding to silver ions in a ratio of 0.001 to 20% by weight (3) The pH of natural rubber latex dispersed with a compound capable of binding to silver ions is 5 or more (4) A heat treatment is performed after molding the urinary catheter, and the silver compound is added before or after the heat treatment. Antibacterial urinary catheter formed by incoming

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION The antibacterial substance used in the antibacterial urinary catheter of the present invention is a silver compound. The silver compound is preferably one of silver nitrate, silver acetate, and silver perchlorate from the viewpoint that the silver compound has good solubility in a solvent and has high reactivity because of its low molecular weight.

The processing conditions of the silver compound to be processed into the antimicrobial urinary catheter vary depending on the kind and combination, but in the present invention, an aqueous solution of the silver compound of 0.0001 to 5% by weight is used. More preferably 0.001 to
A 0.1% by weight aqueous solution is used. In this case 0.00
When the amount is less than 01% by weight, a sufficient amount of the silver compound does not bind to the catheter, and when the amount is more than 5% by weight, the silver compound may not be sufficiently dissolved.

The compound capable of binding to silver ions dispersed in the natural rubber latex which is the base material of the antimicrobial urinary catheter of the present invention includes, for example, amino acid monomers having amino acid residues, amino acid oligomers, amino acid polymers, amino acid derivatives and the like. Is mentioned. Of these, only one type may be used, or several types may be used simultaneously. Here, the amino acid oligomer is defined as having 2 to 10 amino acid residues.
Means Further, the amino acid polymer refers to a polymer having 11 or more amino acid residues, and preferably has 11 to 500 amino acid residues, and more preferably 11 to 200 amino acid residues. Specific examples include sodium poly-L-glutamate and the like. Further, an amino acid derivative is a compound in which a part of an amino acid is bonded to another compound, and examples thereof include sodium stearoyl-L-glutamate and the like.

The compounds capable of binding to silver ions dispersed in the substrate of the antimicrobial urinary catheter of the present invention include those having a sulfonate in addition to those having an amino acid residue. The sulfonic acid salt is, for example, a compound represented by the formula [1], more specifically, dimethyl-5-sulfoisophthalate sodium salt, diethyl-5-sulfoisophthalate sodium salt, dibutyl-5-sulfoisophthalate sodium salt Dihexyl-5-sulfoisophthalate sodium salt, dioctyl-5-sulfoisophthalate sodium salt, di (6-hydroxyhexamethylene)-
Sulfonates whose safety to living organisms have already been confirmed, such as 5-sulfoisophthalate sodium salt and di (6-hydroxyoctamethylene) -5-sulfoisophthalate sodium salt. Of these, only one type may be used, or two or more types may be used simultaneously.

[0020]

Embedded image

In the above formula [1], R ¹ and R ² are an alkyl group having 1 to 12 carbon atoms or C _n H _{2n + 1} OH
(N is an integer of 1 to 12). Note that R ¹ and R ² may be the same or different.

The compound of the compound capable of binding to silver ions described above may be directly mixed with the natural rubber latex, which is a base material, or may be mixed with a dispersant or the like after being well dispersed in a ball mill. .

The amount of the compound capable of binding to silver ions in the natural rubber latex, which is the base material, varies depending on the type and combination, but is preferably 0.001 to 20% by weight based on the natural rubber latex. And more preferably 0.01 to 5% by weight. In this case, 0.00
When the amount is less than 1% by weight, the amount of the silver compound that can be bound is too small and the antibacterial property cannot be sufficiently exhibited. On the other hand, if it is 20% by weight or more, the physical properties of the substrate may be impaired.

The natural rubber latex dispersed together with a compound capable of binding to silver ions as a base material of the antimicrobial urinary catheter of the present invention has a pH of 5 from the viewpoint of dispersibility of the components.
It is preferable that it is above. More preferably, the pH is 7 or more, and further preferably, the pH is 7 to 12.

The method of introducing a silver compound into an antimicrobial urinary catheter according to the present invention is characterized in that a heat treatment is performed after the urinary catheter is molded and before or after the heat treatment step, the silver compound is immersed in the silver compound solution. I do. Preferred conditions for the heat treatment performed after molding the urinary catheter in the present invention are 50 to 150 ° C. for 10 minutes to 24 hours.

The antimicrobial urinary catheter obtained by the above-mentioned steps does not need to consider the dispersibility of the natural rubber latex as the base material and the silver compound as the antimicrobial substance.
In addition, since the process of imparting antibacterial properties can be performed under mild processing conditions, processing is easy and decomposition of the antibacterial substances by heat can be prevented. Furthermore, since the silver compound is efficiently chemically bonded only to the surface of the urinary catheter that requires antibacterial performance, it is economical because no extra silver compound is required.

The catheter is immersed in a silver compound solution satisfying the above conditions. The conditions are not limited as long as they do not adversely affect the natural rubber latex and the silver compound as the catheter base, but are usually 20 to 100 ° C, and particularly preferably 30 to 80 ° C. In this case, it is preferable to shake. The preferred immersion time varies depending on the immersion temperature. For example, under a temperature condition of 35 ° C., the immersion time is 5 minutes to 1 week, and more preferably 10 minutes to 3 days.

The silver compound bound to the antimicrobial urinary catheter according to the present invention is water-soluble before binding to the compound dispersed in the urinary catheter base material, but is bound to the binding agent contained in the urinary catheter base. By exhibiting a property of lowering water solubility when bound to a possible compound than before binding, the antibacterial component is less likely to be washed away by urine or the like during use, and long-term antibacterial performance is obtained.

As described above, the antibacterial urinary catheter of the present invention can bind a silver compound to the inner and outer surfaces of the catheter lumen under mild conditions as compared with the conventional antibacterial urinary catheter. Also, unlike the coating method, it is easy to finish the inner diameter and outer diameter of the urinary catheter according to a predetermined standard.

Hereinafter, the present invention will be described with reference to examples.
The present invention is not particularly limited by the examples.

Example 1 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
1.2 parts of stearic acid and 0.5 parts of dimethyl-5-sulfoisophthalate sodium were added to prepare a natural rubber latex solution. The pH of the natural rubber latex was 10.0.

Next, the dip mold for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (at 80 ° C. for 10 minutes) until the thickness became 1.6 mm. Finally, at 70 ° C, 12
After drying for 1 hour, then washing in running water for 1 week and drying, a urinary catheter was prepared. 0.05% by weight of the above catheter
And then shaken at 30 ° C. for 12 hours. Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain an antibacterial urinary catheter.

The above antibacterial urinary catheter is 5 cm long.
And sterilized with ethylene oxide gas. A Pseudomonas aeruginosa suspension having a bacterial count of about 1 × 10 ⁵ cells / ml was prepared with a broth solution (diluted 50-fold with physiological saline), and the catheter was immersed in this suspension for 24 hours at 37 ° C. The cells were cultured with shaking. The number of bacteria in the liquid after the culture was measured by a smear method to evaluate the antibacterial property. The same evaluation was performed for Escherichia coli and Staphylococcus aureus.
The results are shown in Table 1.

Example 2 0.5 parts of 2-mercaptobenzothiazole zinc salt, 1.5 parts of colloidal sulfur, and 1 part of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
0 part, stearic acid 1.0 part, and taurine 0.1 part were added to prepare a natural rubber latex solution. The pH of the natural rubber latex solution was 10.0. Next, the immersion mold for urinary catheter is immersed in the above-mentioned natural rubber latex solution and dried (8).
(0 ° C., 10 minutes) to a thickness of 1.6 mm. Finally, dry at 70 ° C for 12 hours and then run in running water for 1 hour.
After washing and drying for a week, a urinary catheter was prepared.

The urinary catheter was immersed in a 0.005% by weight aqueous solution of silver perchlorate and shaken at 30 ° C. for 24 hours. After that, the urinary catheter was washed with water,
After drying at ℃, an antibacterial urinary catheter was obtained. Evaluation of antibacterial properties was performed in the same manner as in Example 1. The results are shown in Table 1.

Example 3 0.5 part of 2-mercaptobenzothiazole zinc salt, 1.5 parts of colloidal sulfur, and 1 part of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
0 parts, 1.0 part of stearic acid and 0.1 part of disodium lauroyl-L-glutamate were added to prepare a natural rubber latex solution. The pH of the natural rubber latex liquid is 10.
It was 0. Next, the immersion mold for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes).
Repeated to a thickness of 6 mm. Lastly, drying was performed at 70 ° C. for 12 hours, followed by washing in running water for one week and drying to prepare a urinary catheter.

The urinary catheter was immersed in a 0.01% by weight aqueous solution of silver acetate and shaken at 35 ° C. for 24 hours. Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain an antibacterial urinary catheter. Evaluation of antibacterial properties was performed in the same manner as in Example 1. The results are shown in Table 1.

<Example 4> 100 parts of natural rubber latex having a solid content of 60% was added to 0.5 parts of butyl hydroperoxide.
Part, tetraethylenepentamine 0.5 part, polyoxyethylene lauryl ether 0.075 part, stearoyl-
0.5 parts of disodium L-glutamate was added to prepare a natural rubber latex solution. Natural rubber latex liquid p
H was 10.0. Next, the immersion type for urinary catheter is immersed in the above-mentioned natural rubber latex solution and dried (60 ° C., 1 ° C.).
0 min) was repeated to a thickness of 1.6 mm. Last is 90
After drying at 4 ° C. for 4 hours, the plate was washed and dried in a water bath at 70 ° C. for 3 minutes to prepare a urinary catheter.

The catheter was immersed in a 0.01% by weight aqueous solution of silver acetate and shaken at 30 ° C. for 12 hours. Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain an antibacterial urinary catheter. Evaluation of antibacterial properties was performed in the same manner as in Example 1. The results are shown in Table 1.

Example 5 0.5 part of 2-mercaptobenzothiazole sodium salt, 1.5 parts of colloidal sulfur, 1.0 part of active zinc and 1.0 part of stearic acid were added to 100 parts of natural rubber latex having a solid content of 60%. 0 parts, stearoyl-L
-After adding 0.5 part of sodium glutamate, the natural rubber latex solution was adjusted to pH 6.0 with hydrochloric acid. At this time, the dispersion state of the natural rubber latex liquid did not change. Next, the immersion type for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes) at 1.6 mm.
To the thickness of Finally, drying was performed at 70 ° C. for 12 hours, followed by washing with running water for one week and drying to prepare a urinary catheter.

The above catheter was immersed in an aqueous solution of silver nitrate adjusted to 0.01% by weight and permeated at 30 ° C. for 12 hours.
Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain an antibacterial urinary catheter. Evaluation of antibacterial properties was performed in the same manner as in Example 1. The results are shown in Table 1.

Example 6 0.5 part of 2-mercaptobenzothiazole sodium salt, 1.5 parts of colloidal sulfur, 1.0 part of active zinc and 1.0 part of stearic acid were added to 100 parts of natural rubber latex having a solid content of 60%. 0 parts, stearoyl-L
After adding 0.5 parts of sodium glutamate, the natural rubber latex solution was adjusted to pH 8.0 with hydrochloric acid. At this time, the dispersion state of the natural rubber latex liquid did not change. Next, the immersion type for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes) at 1.6 mm.
To the thickness of Finally, drying was performed at 70 ° C. for 12 hours, followed by washing with running water for one week and drying to prepare a urinary catheter.

The above catheter was immersed in an aqueous solution of silver nitrate adjusted to 0.01% by weight and permeated at 30 ° C. for 12 hours.
Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain an antibacterial urinary catheter. Evaluation of antibacterial properties was performed in the same manner as in Example 1. The results are shown in Table 1.

Example 7 0.5 part of 2-mercaptobenzothiazole zinc salt, 1.5 parts of colloidal sulfur, and 1 part of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
0 parts, 1.0 part of stearic acid and 0.1 part of disodium stearoyl-L-glutamate were added to prepare a natural rubber latex solution. The pH of the above natural rubber latex solution was 10.0. Next, the immersion type for urinary catheter is immersed in the above-mentioned natural rubber latex solution and dried (at 80 ° C., 10 ° C.).
Min) was repeated to a thickness of 1.6 mm. The last is 70 ° C
For 12 hours, and then washed with running water for one week and dried to prepare a urinary catheter.

The above catheter was immersed in an aqueous silver nitrate solution adjusted to 5.0% by weight and permeated at 30 ° C. for 2 hours. Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain an antibacterial urinary catheter. Evaluation of antibacterial properties was performed in the same manner as in Example 1. The results are shown in Table 1.

Example 8 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 50%.
1.2 parts of stearic acid and 20.0 parts of sodium dimethyl-5-sulfoisophthalate were added to prepare a natural rubber latex solution. The pH of the above natural rubber latex liquid is 1
0.0. Next, the immersion type for urinary catheter is immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes).
Was repeated to a thickness of 1.6 mm. Finally at 70 ° C 1
It was dried for 2 hours, washed with running water for 1 week, and dried to prepare a urinary catheter.

The above catheter was immersed in an aqueous solution of silver nitrate adjusted to 0.01% by weight and permeated at 30 ° C. for 8 hours. Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain an antibacterial urinary catheter. Evaluation of antibacterial property was conducted in Example 1.
Was performed in the same manner as described above. The results are shown in Table 1.

Example 9 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 50%.
A natural rubber latex solution was prepared by adding 1.2 parts of stearic acid and 0.001 part of disodium stearoyl-L-glutamate. The pH of the natural rubber latex liquid is 10.
It was 0. Next, the immersion mold for urinary catheter was immersed in the above-mentioned natural rubber latex liquid and dried (80 ° C., 10 minutes) to a thickness of 1.6 mm. Finally, at 70 ° C, 12
After drying for an hour, it was washed with running water for one week and dried to prepare a urinary catheter.

The above catheter was immersed in an aqueous solution of silver nitrate adjusted to 0.05% by weight and permeated at 35 ° C. for 24 hours.
Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain an antibacterial urinary catheter. Evaluation of antibacterial properties was performed in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 1 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
1.2 parts of stearic acid was added to prepare a natural rubber latex solution. The pH of the natural rubber latex solution was 10.0.

Next, the immersion mold for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes) until the thickness became 1.6 mm. Finally, at 70 ° C, 12
After drying for 1 hour, then washing in running water for 1 week and drying, a urinary catheter was prepared. Evaluation of antibacterial properties was performed in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 2 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
1.2 parts of stearic acid and 0.5 parts of dimethyl-5-sulfoisophthalate sodium were added to prepare a natural rubber latex solution. PH of natural rubber latex liquid is 10.0
Met. Next, the immersion type for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes).
Repeated to a thickness of 6 mm. Finally, it was dried at 70 ° C. for 12 hours, then washed in running water for one week, and dried to prepare a urinary catheter. The antibacterial property was evaluated in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 3 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
1.2 parts of stearic acid was added to prepare a natural rubber latex solution. The pH of the natural rubber latex solution was 10.0. Next, the immersion type for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes) at 1.6 mm.
To the thickness of Lastly, drying was performed at 70 ° C. for 12 hours, followed by washing in running water for one week and drying to prepare a urinary catheter.

The urinary catheter was immersed in an aqueous solution of silver nitrate adjusted to 0.01% by weight and shaken at 30 ° C. for 12 hours. Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain a urinary catheter. Antibacterial properties were evaluated in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 4 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
1.2 parts of stearic acid and 0.5 parts of dimethyl-5-sulfoisophthalate sodium were added to prepare a natural rubber latex solution. The pH of the natural rubber latex was 10.0. Next, the immersion type for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes) at 1.6.
Repeated to a thickness of mm. Lastly, drying was performed at 70 ° C. for 12 hours, followed by washing in running water for one week and drying to prepare a urinary catheter.

The above catheter was immersed in an aqueous silver nitrate solution adjusted to 1 × 10 ^-5 % by weight and shaken at 30 ° C. for 12 hours. Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain a urinary catheter. The antibacterial evaluation was performed in the same manner as in Example 1, and the results are shown in Table 1.

Comparative Example 5 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
A natural rubber latex solution was prepared by adding 1.2 parts of stearic acid and 1.0 part of sodium dimethyl-5-sulfoisophthalate. The pH of the natural rubber latex was 10.0. Next, the immersion type for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes) at 1.6.
Repeated to a thickness of mm. Lastly, drying was performed at 70 ° C. for 12 hours, followed by washing in running water for one week and drying to prepare a urinary catheter.

The catheter was immersed in an aqueous solution of silver nitrate adjusted to 6.0% by weight and shaken at 30 ° C. for 12 hours.
After that, the urinary catheter was washed with water and dried at 70 ° C., and the surface of the urinary catheter was found to have silver compounds deposited thereon, and the surface became non-uniform, making it unsuitable for use.

Comparative Example 6 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
1.2 parts of stearic acid and 0.0001 parts of sodium stearoyl-L-glutamate were added to prepare a natural rubber latex solution. PH of natural rubber latex is 10.0
Met. Next, the immersion type for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes).
Repeated to a thickness of 6 mm. Lastly, drying was performed at 70 ° C. for 12 hours, followed by washing in running water for one week and drying to prepare a urinary catheter.

The above catheter was immersed in an aqueous solution of silver nitrate adjusted to 0.01% by weight and shaken at 30 ° C. for 12 hours.
Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain a urinary catheter. The antibacterial activity was evaluated in the same manner as in Example 1, and the results are shown in Table 1.

Comparative Example 7 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
A natural rubber latex solution was prepared by adding 1.2 parts of stearic acid and 25 parts of sodium stearoyl-L-glutamate. The pH of the natural rubber latex was 10.0. Next, the immersion type for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes) at 1.6 mm.
However, the amount of the additive was too large to obtain a uniform rubber.

Comparative Example 8 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
After adding 1.2 parts of stearic acid and 0.5 parts of dimethyl-5-sulfoisophthalate sodium, the mixture was adjusted to pH 4.0 with hydrochloric acid.
As a result, the latex liquid aggregated, and a catheter having a uniform surface could not be produced.

Comparative Example 9 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 50%.
1.2 parts of stearic acid and 0.0008 parts of sodium dimethyl-5-sulfoisophthalate were added to prepare a natural rubber latex solution. The pH of the natural rubber latex solution was 10.0. Next, the immersion type for urinary catheter is immersed in the above-mentioned natural rubber latex solution and dried (at 80 ° C., 10 ° C.).
Min) was repeated to a thickness of 1.6 mm. The last is 70 ° C
For 12 hours, then wash in running water for 1 week,
After drying, a urinary catheter was prepared.

The above catheter was immersed in an aqueous solution of silver nitrate adjusted to 0.01% by weight and shaken at 30 ° C. for 12 hours.
Thereafter, the urinary catheter was washed with water and dried at 70 ° C. to obtain a urinary catheter. The antibacterial activity was evaluated in the same manner as in Example 1, and the results are shown in Table 1.

[0065]

[Table 1]

[0066]

According to the antimicrobial urinary catheter of the present invention, the antibacterial performance is excellent immediately after use because the antibacterial silver compound is present on the catheter surface. Its antibacterial properties are maintained over a long period of time because it is bound and hardly soluble in water.
Furthermore, since the inner diameter and outer diameter of the urinary catheter are not changed by ion-bonding the silver compound as described above, an antibacterial urinary catheter according to the standard can be manufactured.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Masakazu Tanaka, Inventor 2-1-1 Katata, Otsu-shi, Shiga Inside Toyobo Co., Ltd. (72) Inventor Sou Arimori 2-1-1 Katata, Otsu-shi, Shiga No. Toyobo Co., Ltd.

Claims (4)

[Claims] 1. An antibacterial urinary catheter molded from a natural rubber latex having a silver compound introduced on its surface and dispersed together with a compound capable of binding to silver ions, comprising silver nitrate, silver acetate and silver perchlorate. 0.000 containing at least one silver compound selected from the group consisting of
An antibacterial urinary catheter, wherein a silver compound is introduced into the surface with an aqueous solution having a concentration of 1 to 5% by weight. 2. The antimicrobial urinary catheter according to claim 1, wherein a compound capable of binding to silver ions is blended with the natural rubber latex at a ratio of 0.001 to 20% by weight. 3. The antimicrobial urinary catheter according to claim 1, wherein the pH of the natural rubber latex dispersed together with the compound capable of binding to silver ions is 5 or more. 4. A heat treatment is performed after molding the urinary catheter.
The antibacterial urinary catheter according to any one of claims 1 to 3, wherein a silver compound is introduced before or after the heat treatment.