CN104224837A - Traumatic infection treatment preparation and preparation method thereof - Google Patents
Traumatic infection treatment preparation and preparation method thereof Download PDFInfo
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- CN104224837A CN104224837A CN201410490117.2A CN201410490117A CN104224837A CN 104224837 A CN104224837 A CN 104224837A CN 201410490117 A CN201410490117 A CN 201410490117A CN 104224837 A CN104224837 A CN 104224837A
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Abstract
The invention relates to the technical field of medicines for treating traumatic infections, in particular to a traumatic infection treatment preparation and a preparation method thereof. Nano carbon powder, a dispersant, an organic solvent and an inorganic solvent are mixed, and the adding sequence and process parameters of all the raw materials are controlled in the preparation process to enable nano carbon powder to be more uniformly dispersed in a solution, so that the dispersity of nano carbon powder in the preparation is improved, the effect of the preparation on treating traumatic infections is enhanced, and the curing rate and the effective rate of the traumatic infections are both increased.
Description
Technical field
The present invention relates to trauma infection contamination practical technique field, especially one treats trauma infection contamination preparation and preparation method thereof.
Background technology
Trauma infection contamination is after the skin histology of human body sustains damage, because the deterioration of environment, treatment of wounds are incorrect, and then make injured skin histology be in undesirable environment, and then cause a large amount of antibacterials to invade wound, the degree of depth of skin histology is caused to destroy, the lighter, can cause damaged portion to fill with pus, and then cause large-area skin histology to damage; Severe one, then can cause other diseases, and as the generation of high thermal phenomenon, and then cause human body weak, immunity receives the impact of high degree.
For this reason, the process for wound is incorrect, and the infection process even for wound is all inappropriate, all can bring great injury to human body, so, have a large amount of researcheres from then on angle start with, a large amount of research and discoveries is made to the medication after trauma infection contamination, but its effect is all comparatively undesirable.
And from eighties of last century latter stage, nano material obtains multi-disciplinary research focus and forward position in the many-side such as medicine, chemistry, physics.This main cause is, nano material can demonstrate the performance characteristics not identical with macro-scale material, i.e. nano effect.And nano effect comprises skin effect, small size effect, macro quanta tunnel effect; The existence of these effects, makes nano material have special physicochemical properties, and along with the nanoscale of nano material different, its physicochemical properties embodied are also different.
For this reason, the effect of nano material and organism, improves constantly along with nano level, and the effect of its effect is also different, and then makes nano material obtain application in a big way at field of medicaments, and comprises the various aspects such as treatment and diagnosis, spike.
Nano-carbon powder is the one in nano material, and nano-sized carbon has stronger absorption property, be simultaneously disclose nano-carbon powder in CN201110093333.X " a kind of preparation method of nanogate carbon suspension " to apply at field of medicaments as tracer in the such as patent No., also be that CN201010152187.9 " application of nano carbon particle in the external used medicine of preparation treatment hemorrhoid and this medicine " discloses a kind of using the hemorrhoid of nano carbon particle as therapeutical effect in the patent No., it mainly utilizes nano-carbon powder or nano carbon particle to have stronger absorption property.
But, constantly explore through researcher of the present invention, nano-carbon powder is applied to field of medicaments and provides a kind of new technical scheme, expand the range of application of nano-carbon powder at field of medicaments, and improve the action effect of nano-carbon powder at field of medicaments, and then provide a kind of new approaches for the medicine for treatment of trauma infection contamination.
Summary of the invention
In order to solve the above-mentioned technical problem existed in prior art, the invention provides one and treat trauma infection contamination preparation, there is the degree can alleviating trauma infection contamination, stop the expanded range of trauma infection contamination, prevent the feature of the filling pus caused, high thermal phenomenon because human skin tissue damage infects.
Meanwhile, the present invention also provides a kind of preparation method for the treatment of trauma infection contamination preparation.
Be achieved particular by following technical scheme:
One treats trauma infection contamination preparation, and its raw material composition is nano-carbon powder, the dispersant of 1-1.3 part, 23-50 part organic solvent, 40 parts of-50 parts of inorganic solvents of 0.1-0.5 part; Wherein nano-carbon powder be containing >=95% size scope be 0.1-5nm, and the dispersibility in water is 99.57%.
Described dispersant is a kind of or its several mixture in lignosulfonates, oleic acid, fish oil.
Described lignosulfonates are sodium lignin sulfonate, and described oleic acid is glyceric acid.
Described dispersant, when dispersant is mixed with fish oil by lignosulfonates, the mass percentage of lignosulfonates is 1-3%; When dispersant is mixed with oleic acid by lignosulfonates, the mass percentage of lignosulfonates is 0.5-1.7%; When dispersant is mixed with fish oil by oleic acid, the mass percentage of oleic acid is 11-17.3%.
Described organic solvent is ethanol.
Described inorganic solvent is sodium dihydrogen phosphate, sodium hydroxide, phosphoric acid.
Described preparation is powder, unguentum, suspension.
The preparation method of this treatment trauma infection contamination preparation, comprises the following steps:
(1) according to said ratio, by nano-carbon powder and dispersant evenly after, again it is mixed with organic solvent, and adopt mixing speed to be after the stirring 0.5-1.1h of 150-200r/min, be placed on again in ultrasonic processor, after carrying out supersound process 20-30min, add inorganic solvent wherein again, and when to adjust its pH value be 6.8-7.3, after adding Polyethylene Glycol 0.1-0.5 part, continue stir process 30-40min, after making it be uniformly dispersed, after being carried out spraying dry again, obtain powder, stand-by;
(2) adjuvant that the powder after above-mentioned spraying dry is conventional with pharmaceutics is carried out being mixed with into powder, unguentum, suspension, treatment trauma infection contamination preparation can be obtained.
Inlet temperature during described spraying dry is 200-250 DEG C, and outlet temperature is 30-40 DEG C, and the temperature of wherein import and outlet at a distance of be 7m, and is reduced to outlet temperature in the mode of progressively successively decreasing to outlet from import.
During the preparation of described powder, it is PEG400 that the pharmaceutics of interpolation commonly uses adjuvant; During the preparation of described unguentum, it is vaseline that the pharmaceutics of interpolation commonly uses adjuvant; During the preparation of described suspension, it is PEG600 that the pharmaceutics of interpolation commonly uses adjuvant.
The permeability that the present invention passes through the higher nano-carbon powder of employing nanoscale is strong, the inside at the deep enough trauma infection contamination position of energy, the local dynamic effect state of blood vessel is significantly improved, improve the blood flow state of skin histology medium vessels, and then the histogenic immunity power of human body is improved largely, reduce cell to external world and invade the probability of damaged tissue, improve the environment of trauma tissue.
Compared with prior art, technique effect of the present invention is embodied in:
1. by the mixing of nano-carbon powder, dispersant, organic solvent, inorganic solvent, and in preparation process, the addition sequence of each raw material and technological parameter are controlled, and then make nano-carbon powder degree of scatter in the solution comparatively even, and then improve the degree of scatter of nano-carbon powder in preparation, enhance the effect that preparation is treated trauma infection contamination, improve cure rate and the effective percentage of trauma infection contamination.
2. by carrying out Exploration & stu dy to the nanoscale of nano-carbon powder, be 0.1-5nm at the nanoscale of nano-carbon powder, and when the dispersibility in water is 99.57%, cure rate (infecting the healing area of part) for treatment trauma infection contamination can reach more than 99.12%, and effective percentage reaches 100%.
3. by the supersound process in formulation process, nano-carbon powder is disperseed in the formulation more even, further facilitate the treatment of preparation to trauma infection contamination place, improve the therapeutic effect of preparation to trauma infection contamination; After processing mice leg incised wound, adopt medicine powder of the present invention to spray 2 times every day, after three days, leg wound is in healing substantially, then adopts paste medicine of the present invention to apply 2, and apply 1 every day, leg wound heals completely; The preparation of this invention can promote the blood circulation of damaged tissue, strengthens blood circulation, promotes the healing of cell tissue.
Detailed description of the invention
Below in conjunction with concrete embodiment, further restriction is done to technical scheme of the present invention, but claimed scope is not only confined to done description.
Embodiment 1
One treats trauma infection contamination preparation, and its raw material is nano-carbon powder, the dispersant of 1kg, 23kg organic solvent, the 40kg inorganic solvent of 0.1kg;
Wherein nano-carbon powder be containing 95% size scope be 0.1nm, and the dispersibility in water is 99.57%.
Dispersant is sodium lignin sulfonate.
Organic solvent is ethanol.
Inorganic solvent is sodium dihydrogen phosphate.
Its preparation method, comprises the following steps:
(1) according to said ratio, by nano-carbon powder and dispersant evenly after, then it to be mixed with organic solvent, and adopt mixing speed to be after the stirring 0.5h of 150r/min, then be placed in ultrasonic processor, after carrying out supersound process 20min, add inorganic solvent wherein again, and when to adjust its pH value be 6.8, after adding Polyethylene Glycol 0.1kg, continue stir process 30min, after making it be uniformly dispersed, after being carried out spraying dry again, obtain powder, stand-by;
(2) adjuvant that the powder after above-mentioned spraying dry is conventional with pharmaceutics is carried out being mixed with into powder, treatment trauma infection contamination preparation can be obtained.
Inlet temperature during spraying dry is 200 DEG C, and outlet temperature is 30 DEG C, and the temperature of wherein import and outlet is apart 7m, and is reduced to outlet temperature in from import to exporting the mode of progressively successively decreasing.
It is PEG400 that the pharmaceutics added commonly uses adjuvant.
Adopt the powder treatment of wounds that mice leg is hurt that said method obtains, according to spraying powder twice every day, each consumption for be covered to wound complete till, spray treatment is after 3 days, and the leg wound of mice heals substantially.
Embodiment 2
One treats trauma infection contamination preparation, and its raw material composition is nano-carbon powder, the dispersant of 1.3kg, 50kg organic solvent, the 50kg inorganic solvent of 0.5kg; Wherein nano-carbon powder be containing 98% size scope be 5nm, and the dispersibility in water is 99.57%.
Dispersant is the mixture of lignosulfonates, oleic acid.
Wherein lignosulfonates are sodium lignin sulfonate, and oleic acid is glyceric acid.
Further, lignosulfonates mass percentage is in the mixture 0.5.
Organic solvent is ethanol.
Inorganic solvent is sodium hydroxide.
Its preparation method, comprises the following steps:
(1) according to said ratio, by nano-carbon powder and dispersant evenly after, then it to be mixed with organic solvent, and adopt mixing speed to be after the stirring 1.1h of 200r/min, then be placed in ultrasonic processor, after carrying out supersound process 30min, add inorganic solvent wherein again, and when to adjust its pH value be 7.3, after adding Polyethylene Glycol 0.5kg, continue stir process 40min, after making it be uniformly dispersed, after being carried out spraying dry again, obtain powder, stand-by;
(2) adjuvant that the powder after above-mentioned spraying dry and pharmaceutics are commonly used is carried out being mixed with paste making agent, treatment trauma infection contamination preparation can be obtained.
Inlet temperature during spraying dry is 250 DEG C, and outlet temperature is 40 DEG C, and the temperature of wherein import and outlet is apart 7m, and is reduced to outlet temperature in from import to exporting the mode of progressively successively decreasing.It is vaseline that the pharmaceutics added commonly uses adjuvant.
Adopt above-mentioned paste application in mice leg wound, according to coating every day once, apply after 2 days, the movable number of times of mice increases, and its leg wound has healed 99.12%, and continue coating 1-3 day, the leg wound of mice is healed.
Embodiment 3
One treats trauma infection contamination preparation, and its raw material is nano-carbon powder, the dispersant of 1.1kg, 40kg organic solvent, the 41kg inorganic solvent of 0.3kg; Wherein nano-carbon powder be containing 99% size scope be 2nm, and the dispersibility in water is 99.57%.
Dispersant is the mixture of oleic acid, fish oil.
Oleic acid is glyceric acid.
Wherein oleic acid mass percentage is in the mixture 11%.
Organic solvent is ethanol.
Inorganic solvent is phosphoric acid.
Its preparation method, comprises the following steps:
(1) according to said ratio, by nano-carbon powder and dispersant evenly after, then it to be mixed with organic solvent, and adopt mixing speed to be after the stirring 0.9h of 180r/min, then be placed in ultrasonic processor, after carrying out supersound process 25min, add inorganic solvent wherein again, and when to adjust its pH value be 7.1, after adding Polyethylene Glycol 0.3kg, continue stir process 35min, after making it be uniformly dispersed, after being carried out spraying dry again, obtain powder, stand-by;
(2) adjuvant that the powder after above-mentioned spraying dry is conventional with pharmaceutics is carried out being mixed with into suspension, treatment trauma infection contamination preparation can be obtained.
Inlet temperature during spraying dry is 230 DEG C, and outlet temperature is 35 DEG C, and the temperature of wherein import and outlet is apart 7m, and is reduced to outlet temperature in from import to exporting the mode of progressively successively decreasing.It is PEG600 that the pharmaceutics added commonly uses adjuvant.
And when preparing suspension, specifically by step 1) spraying dry after after the conventional adjuvant of powder and pharmaceutics mixs homogeneously, adopted again and mixed mutually with human body isosmotic solution, and again carry out the suspension of supersound process 10min acquisition, wherein human body isosmotic solution is the mixed liquor containing 5.1g sodium chloride, 0.43g potassium bicarbonate, 5g Glucose Liquid in 1000ml water.
Embodiment 4
On the basis of embodiment 1, dispersant wherein can also be mixed with fish oil by sodium lignin sulfonate, and sodium lignin sulfonate mass percentage is in the mixture 1% or 3%, 2%; Also can be when being mixed with oleic acid by sodium lignin sulfonate, and sodium lignin sulfonate mass percentage be in the mixture 1.7% or 1.5%; Also can be when being mixed with fish oil by oleic acid, oleic acid mass percentage be in the mixture 17.3% or 16.1%.
Test example:
Get mice 50, be divided into 10 groups, label is 1,2,3,4,5,6,7,8,9,10 respectively, and to the process of 10 groups of mices employing incised wound shanks, and will wherein No. 1 group only hurt as a control group and not do other process; After No. 2 group incised wounds, adopt normal saline spray treatment every day 2 times; No. 3 groups adopt tetanus treatment of pharmaceutical products to process, and process 2 every day; No. 4 groups adopt the powder process of embodiments of the invention 1, process 2 every day; No. 5 groups adopt the unguentum process of embodiments of the invention 2, process 1 every day; No. 6 groups adopt the suspension process of embodiments of the invention 3, process 1 every day; 7,8,9, No. 10 groups first adopt tetanolysin to infect process, again it is adopted successively normal saline, tetanus treatment medicine, embodiments of the invention 1 and 2 combine, embodiments of the invention 2 and 3 combine process, process 2 every day, and observe wound situation of change and the record healing time of mice, cure number of elements, it the results are shown in Table shown in 1:
Table 1
Shown by the result of upper table 1, the wound tissue that treatment trauma infection contamination preparation of the present invention hurts for mice leg has regenerative healing effect, can accelerate the restore funcitons to damaged tissue, have significant progress.
Claims (10)
1. treat a trauma infection contamination preparation, it is characterized in that, its raw material composition is nano-carbon powder, the dispersant of 1-1.3 part, 23-50 part organic solvent, 40 parts of-50 parts of inorganic solvents of 0.1-0.5 part; Wherein nano-carbon powder be containing >=95% size scope be 0.1-5nm, and the dispersibility in water is 99.57%.
2. treatment trauma infection contamination preparation as claimed in claim 1, it is characterized in that, described dispersant is a kind of or its several mixture in lignosulfonates, oleic acid, fish oil.
3. treatment trauma infection contamination preparation as claimed in claim 2, it is characterized in that, described lignosulfonates are sodium lignin sulfonate, and described oleic acid is glyceric acid.
4. treatment trauma infection contamination preparation as claimed in claim 2, it is characterized in that, described dispersant, when dispersant is mixed with fish oil by lignosulfonates, the mass percentage of lignosulfonates is 1-3%; When dispersant is mixed with oleic acid by lignosulfonates, the mass percentage of lignosulfonates is 0.5-1.7%; When dispersant is mixed with fish oil by oleic acid, the mass percentage of oleic acid is 11-17.3%.
5. treatment trauma infection contamination preparation as claimed in claim 1, it is characterized in that, described organic solvent is ethanol.
6. treatment trauma infection contamination preparation as claimed in claim 1, it is characterized in that, described inorganic solvent is sodium dihydrogen phosphate, sodium hydroxide, phosphoric acid.
7. treatment trauma infection contamination preparation as claimed in claim 1, it is characterized in that, described preparation is powder, unguentum, suspension.
8. the preparation method of the treatment trauma infection contamination preparation as described in any one of claim 1-7, is characterized in that, comprise the following steps:
(1) according to said ratio, by nano-carbon powder and dispersant evenly after, again it is mixed with organic solvent, and adopt mixing speed to be after the stirring 0.5-1.1h of 150-200r/min, be placed on again in ultrasonic processor, after carrying out supersound process 20-30min, add inorganic solvent wherein again, and when to adjust its pH value be 6.8-7.3, after adding Polyethylene Glycol 0.1-0.5 part, continue stir process 30-40min, after making it be uniformly dispersed, after being carried out spraying dry again, obtain powder, stand-by;
(2) adjuvant that the powder after above-mentioned spraying dry is conventional with pharmaceutics is carried out being mixed with into powder, unguentum, suspension, treatment trauma infection contamination preparation can be obtained.
9. the preparation method for the treatment of trauma infection contamination preparation as claimed in claim 8, it is characterized in that, inlet temperature during described spraying dry is 200-250 DEG C, outlet temperature is 30-40 DEG C, wherein the temperature of import and outlet is apart 7m, and is reduced to outlet temperature in from import to exporting the mode of progressively successively decreasing.
10. the preparation method for the treatment of trauma infection contamination preparation as claimed in claim 8, is characterized in that, during the preparation of described powder, it is PEG400 that the pharmaceutics of interpolation commonly uses adjuvant; During the preparation of described unguentum, it is vaseline that the pharmaceutics of interpolation commonly uses adjuvant; During the preparation of described suspension, it is PEG600 that the pharmaceutics of interpolation commonly uses adjuvant.
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| CN110917213A (en) * | 2019-12-30 | 2020-03-27 | 温州激光与光电子协同创新中心 | Nano carbon powder medicine for external use for treating skin inflammation, preparation and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105998063A (en) * | 2016-06-20 | 2016-10-12 | 李璐 | Application of nano activated carbon to bacteria inhibition |
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Application publication date: 20141224 |