CN103282370A - 抗菌氨基糖苷类类似物 - Google Patents

抗菌氨基糖苷类类似物 Download PDF

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Publication number
CN103282370A
CN103282370A CN2011800640360A CN201180064036A CN103282370A CN 103282370 A CN103282370 A CN 103282370A CN 2011800640360 A CN2011800640360 A CN 2011800640360A CN 201180064036 A CN201180064036 A CN 201180064036A CN 103282370 A CN103282370 A CN 103282370A
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CN
China
Prior art keywords
compound
acid
mmol
compounds
rna
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN2011800640360A
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English (en)
Chinese (zh)
Inventor
亚当·亚伦·罗德伯鲁姆
保拉·朵兹欧
蒂莫西·罗伯特·凯恩
詹姆士·布拉德利·阿根
马丁·舍灵汉姆·里恩塞尔
达林·詹姆士·希尔德布兰德
弥迦·詹姆士·格列德特
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Achaogen Inc
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Achaogen Inc
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Application filed by Achaogen Inc filed Critical Achaogen Inc
Publication of CN103282370A publication Critical patent/CN103282370A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN2011800640360A 2010-11-17 2011-11-14 抗菌氨基糖苷类类似物 Pending CN103282370A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41476210P 2010-11-17 2010-11-17
US61/414,762 2010-11-17
US201161505371P 2011-07-07 2011-07-07
US61/505,371 2011-07-07
PCT/US2011/060513 WO2012067978A1 (en) 2010-11-17 2011-11-14 Antibacterial amiinoglycoside analogs

Publications (1)

Publication Number Publication Date
CN103282370A true CN103282370A (zh) 2013-09-04

Family

ID=45099181

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800640360A Pending CN103282370A (zh) 2010-11-17 2011-11-14 抗菌氨基糖苷类类似物

Country Status (7)

Country Link
US (2) US8318685B2 (enExample)
EP (1) EP2640735A1 (enExample)
JP (1) JP2013542992A (enExample)
CN (1) CN103282370A (enExample)
AR (1) AR083879A1 (enExample)
TW (1) TW201304784A (enExample)
WO (1) WO2012067978A1 (enExample)

Families Citing this family (16)

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AU2006320374B2 (en) 2005-12-02 2012-08-30 Isis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
JP2010527913A (ja) * 2007-04-10 2010-08-19 アカオジェン インコーポレイテッド 抗菌性１，４，５置換アミノグリコシド類似体
KR101296099B1 (ko) 2007-11-21 2014-02-26 아카오젠, 인코포레이티드 항균성 아미노글리코사이드 동족체
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
JP2013507391A (ja) 2009-10-09 2013-03-04 アカオジェン インコーポレイテッド 抗ウイルスアミノグリコシド類似体
US8318685B2 (en) 2010-11-17 2012-11-27 Achaogen, Inc. Antibacterial aminoglycoside analogs
GB2584009B (en) * 2017-08-28 2022-03-23 Revagenix Inc Aminoglycosides and uses thereof
WO2019194858A1 (en) 2018-04-03 2019-10-10 Achaogen, Inc. Modular synthesis of aminoglycosides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064954A2 (en) * 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
WO2009067692A1 (en) * 2007-11-21 2009-05-28 Achaogen, Inc. Antibacterial aminoglycoside analogs
CN101715455A (zh) * 2007-04-10 2010-05-26 尔察祯有限公司 抗菌的1,4,5-取代的氨基糖苷类似物

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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2007064954A2 (en) * 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
CN101715455A (zh) * 2007-04-10 2010-05-26 尔察祯有限公司 抗菌的1,4,5-取代的氨基糖苷类似物
WO2009067692A1 (en) * 2007-11-21 2009-05-28 Achaogen, Inc. Antibacterial aminoglycoside analogs

Non-Patent Citations (1)

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Title
I WATANABE等: "SYNTHESES OF 6’-AMINO-6’-DEOXYLIVIDOMYCIN B AND 6’- DEOXY-6’-METHYLAMINO- AND 6’-DEOXY-6’-(2-HYDROXYETHYLAMINO)- LIVIDOMYCIN B", 《THE JOURNAL OF ANTIBIOTICS》 *

Also Published As

Publication number Publication date
EP2640735A1 (en) 2013-09-25
JP2013542992A (ja) 2013-11-28
US8653041B2 (en) 2014-02-18
US20120122809A1 (en) 2012-05-17
WO2012067978A1 (en) 2012-05-24
AR083879A1 (es) 2013-03-27
TW201304784A (zh) 2013-02-01
US20130178438A1 (en) 2013-07-11
US8318685B2 (en) 2012-11-27

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Application publication date: 20130904