JP2013542992A - 抗菌性アミノグリコシド類似体 - Google Patents

抗菌性アミノグリコシド類似体 Download PDF

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Publication number
JP2013542992A
JP2013542992A JP2013539922A JP2013539922A JP2013542992A JP 2013542992 A JP2013542992 A JP 2013542992A JP 2013539922 A JP2013539922 A JP 2013539922A JP 2013539922 A JP2013539922 A JP 2013539922A JP 2013542992 A JP2013542992 A JP 2013542992A
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Prior art keywords
compound
acid
mmol
pharmaceutically acceptable
compounds
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Japanese (ja)
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JP2013542992A5 (enExample
Inventor
アダム アーロン ゴールドブルーム,
パオラ ドッゾ,
ティモシー ロバート ケイン,
ジェイムズ ブラッドリー アッゲン,
マーティン シェリングハム リンゼル,
ダリン ジェイムズ ヒルデブランド,
ミカ ジェイムズ グリード,
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アカオジェン インコーポレイテッド
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Publication of JP2013542992A publication Critical patent/JP2013542992A/ja
Publication of JP2013542992A5 publication Critical patent/JP2013542992A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/22Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/232Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2013539922A 2010-11-17 2011-11-14 抗菌性アミノグリコシド類似体 Pending JP2013542992A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41476210P 2010-11-17 2010-11-17
US61/414,762 2010-11-17
US201161505371P 2011-07-07 2011-07-07
US61/505,371 2011-07-07
PCT/US2011/060513 WO2012067978A1 (en) 2010-11-17 2011-11-14 Antibacterial amiinoglycoside analogs

Publications (2)

Publication Number Publication Date
JP2013542992A true JP2013542992A (ja) 2013-11-28
JP2013542992A5 JP2013542992A5 (enExample) 2015-01-08

Family

ID=45099181

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013539922A Pending JP2013542992A (ja) 2010-11-17 2011-11-14 抗菌性アミノグリコシド類似体

Country Status (7)

Country Link
US (2) US8318685B2 (enExample)
EP (1) EP2640735A1 (enExample)
JP (1) JP2013542992A (enExample)
CN (1) CN103282370A (enExample)
AR (1) AR083879A1 (enExample)
TW (1) TW201304784A (enExample)
WO (1) WO2012067978A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1957507B1 (en) 2005-12-02 2018-10-24 Ionis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
WO2008124821A1 (en) * 2007-04-10 2008-10-16 Achaogen Inc. Antibacterial 1,4,5-substituted aminoglycoside analogs
HRP20170154T1 (hr) 2007-11-21 2017-03-24 Achaogen, Inc. Analozi antibakterijskog aminoglikozida
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
JP2013507391A (ja) 2009-10-09 2013-03-04 アカオジェン インコーポレイテッド 抗ウイルスアミノグリコシド類似体
JP2013542992A (ja) 2010-11-17 2013-11-28 アカオジェン インコーポレイテッド 抗菌性アミノグリコシド類似体
GB2584009B (en) * 2017-08-28 2022-03-23 Revagenix Inc Aminoglycosides and uses thereof
US11673907B2 (en) 2018-04-03 2023-06-13 Revagenix, Inc. Modular synthesis of aminoglycosides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010042850A1 (en) * 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
JP2010527913A (ja) * 2007-04-10 2010-08-19 アカオジェン インコーポレイテッド 抗菌性1,4,5置換アミノグリコシド類似体

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Also Published As

Publication number Publication date
WO2012067978A1 (en) 2012-05-24
US20120122809A1 (en) 2012-05-17
US20130178438A1 (en) 2013-07-11
US8318685B2 (en) 2012-11-27
US8653041B2 (en) 2014-02-18
AR083879A1 (es) 2013-03-27
CN103282370A (zh) 2013-09-04
TW201304784A (zh) 2013-02-01
EP2640735A1 (en) 2013-09-25

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