CN103271238A - Preparation method of feed additive mono ethanol amine and application - Google Patents
Preparation method of feed additive mono ethanol amine and application Download PDFInfo
- Publication number
- CN103271238A CN103271238A CN2013101700976A CN201310170097A CN103271238A CN 103271238 A CN103271238 A CN 103271238A CN 2013101700976 A CN2013101700976 A CN 2013101700976A CN 201310170097 A CN201310170097 A CN 201310170097A CN 103271238 A CN103271238 A CN 103271238A
- Authority
- CN
- China
- Prior art keywords
- monoethanolamine
- mixture
- livestock
- growth
- pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention discloses a preparation method of a feed additive mono ethanol amine and an application. The method comprises steps of: a, adding 90%-99% stronger ammonia water and liquid ethylene oxide into a reactor according to a ratio, and reacting under a proper temperature and pressure so as to obtain a mixture; b, deaminizing and dehydrating the mixture obtained in the step a under a proper temperature and pressure so as to obtain a mixture consisting of mono ethanol amine, diethanolamine and triethanolamine; c, separating the mixture obtained in the step b under a proper temperature and pressure so as to obtain the mono ethanol amine; and d, processing the liquid mono ethanol amine obtained in the step c in a liquid state so as to form particles in bags, and thus obtaining a feed additive finished product. The feed additive can be applied to promoting livestock intestinal growth, improving young livestock intestinal health and improving the livestock growth performance. The method is simple, convenient to operate, easy in raw material obtaining and low in cost. The feed additive is applied to a livestock feed, can improve the livestock growth performance, promotes the livestock intestinal growth and improves the young livestock intestinal health.
Description
Technical field
The present invention relates to the pig feed additive technical field, the preparation method who more specifically relates to a kind of feed addictive monoethanolamine also relates to this feed addictive simultaneously and is improving the growth of animals or poultry performance, promotes animal and bird intestines to grow and improving application in the animal and bird intestines health.
Background technology
Animal husbandry is the pillar industry of agricultural and rural economy, the whole nation animal husbandry gross output value in the general production value of agriculture shared proportion above four one-tenth, livestock and poultry cultivation activate rural economy, increase farmers' income, aspects such as absorbing rural surplus laborers, the development of drive private enterprise have brought into play the important support effect, have made significant contribution for growth of the national economic and living standards of the people improve.Yet, fast development along with livestock and poultry breeding industry, feed resource is in short supply to have become the bottleneck that restricts China's livestock and poultry breeding industry sustainable development with environmental pollution, and improve the feed resource utilization ratio and then reduce feed resource waste, minimizing environmental pollution, be the needs of aquaculture sustainable development.An important means that improve food utilization efficiency, reduces environmental pollution is to promote animal and bird intestines to grow, so the material that has additional nutrients digest and assimilate efficient.Promoting animal and bird intestines to grow also is the important means that improves its growth performance.The regulation and control animal and bird intestines is grown except providing outside the intestinal growth basic nutrition material (as protein, glucose etc.), and another important method is the functional materials that promotes intestinal growth (as polyamines etc.) of feeding.
The cub fowl stage is the key of its intestinal growth.Studies show that in a large number, breast milk is the key that promotes that the mammal enteron aisle is grown, because contain a large amount of relevant nutrition with intestinal growth and functional materials in the breast milk, be the main energy sources material of intestinal epithelial cell as the glutamine in the milk and glutamic acid etc., hormones such as EGF, HGF and IGF-I are the major hormone of regulation and control epithelial cell proliferation.Separating and identify nutrition and the functional component of regulation and control intestinal growth in the milk, is the classical way of artificial adjustment intestinal growth.Monoethanolamine is present in the milk of rat, people and Niu in a large number, is the important component that constitutes the cell membrane lipid simultaneously, can significantly promote cell proliferations such as liver cell, human oral cavity epithelial cell.Yet animal and bird intestines is grown for it and the influence of growth performance does not have report as yet.The monoethanolamine of this patent preparation is with low cost, and stability is strong.Further test finds that it can significantly improve the growth performance of livestock and poultry, promote animal and bird intestines to grow, improve animal and bird intestines health, has great importance to livestock and poultry cultivation.
Summary of the invention
The objective of the invention is to be to provide a kind of preparation method of feed addictive monoethanolamine, method is simple, and easy and simple to handle, raw material is easy to get, and is with low cost.This product is raw material with ammoniacal liquor and oxirane, and raw material is easy to get, and cost is low, the product purity height that obtains, and stability is strong.This additive can promote the propagation of intestinal epithelial cell, the intestinal tract injury that improve because ablactation stress etc. causes.
Another object of the present invention is to be to provide a kind of feed addictive monoethanolamine promoting animal and bird intestines to grow, improve the purposes in the growth performance of newborn animal fowl road health, raising livestock and poultry.
In order to realize above-mentioned purpose, the present invention adopts following technical measures:
A kind of preparation method of feed addictive monoethanolamine the steps include:
A, the concentrated ammonia liquor with 90%～99% and the liquid epoxy ethane ratio of 10:1～50:1 in molar ratio add in the reactor, it is 60～200 ℃ in temperature, pressure is to react under the condition of 6～20MPa, obtains the mixture that monoethanolamine, diethanol amine, triethanolamine and unreacted ammonia and water etc. are formed;
B, the mixture that step a is obtained are 110～150 ℃ in temperature, and pressure is the mixture that the deamination dehydration obtains containing monoethanolamine, diethanol amine and triethanolamine under the condition of 0.1～1MPa;
C, the mixture that step b is obtained are 165～185 ℃ in temperature, and pressure is to separate the monoethanolamine that obtains purity＞99% under the condition of 0.25～0.5Mpa;
The monoethanolamine that d, step c obtain is made graininess (or powdery or micro-capsule) packed (or bottled) with liquid form or after emulsification processing, is the feed addictive finished product.The feed addictive that obtains can add in the livestock and fowl drinking water with the form of liquid state, also can add the livestock and poultry of feeding in the livestock and poultry feed to particle or powdery.
Described livestock and poultry are: newborn piglet, weanling pig, growth pig, boar and broiler chicken or laying hen.
Described growth pig body weight is 20～60kg
A kind of feed addictive monoethanolamine the steps include: promoting animal and bird intestines to grow, improve the application in the growth performance of newborn animal fowl road health, raising livestock and poultry
A. add in the drinking water or the monoethanolamine that is processed into graininess (or powdery or micro-capsule) adds in the complete feed by the addition of 200-500ppm with obtaining the addition of liquid monoethanolamine by 200-500uM, fully mixing;
B. the water that step a is obtained or feed are fed to suckling pig, weanling pig, growth pig, boar and broiler chicken, laying hen.
The present invention compares with present technology, has the following advantages and effect:
1. this product is raw material with ammoniacal liquor and oxirane, and raw material is easy to get, and method is simple, and is easy and simple to handle, with low cost, the product purity height that obtains, and stability is strong.
2. this product is the composition that itself has in animal and human's the milk, and having avoided residual may damage human body, safe.
3. monoethanolamine can promote animal and bird intestines to grow, and improves the nutrient utilization efficient of livestock and poultry, saves feed resource, reduces environmental pollution, is a kind of environment-friendly feed additive that the applications well prospect is arranged.
4. add the monoethanolamine that the present invention of various dose produces by feed and carry out the raising poultry nutritive test, result of the test shows in 5～8kg weanling pig, add in the drinking-water and add 200ppm in 500uM, the feed for best regulation and control dosage, can significantly improve piglet small intestine weight and growth performance.
Description of drawings
Fig. 1 is that monoethanolamine is to the schematic diagram that influences of weanling pig small intestine weight.
The nutritional test that the monoethanolamine of producing by the present invention who adds various dose in the drinking-water carries out in 21-35 age in days weanling pig is seen Fig. 1, test shows, monoethanolamine can effectively promote intestine of young pigs to grow, and the small intestine weight of adding piglet increases, wherein 500uM addition best results.
The specific embodiment
Embodiment 1:
A kind of preparation method of feed addictive monoethanolamine the steps include:
A. get concentrated ammonia liquor 17L, oxirane 2L adds in the reactor, is 65 or 75 or 80 or 85 or 125 ℃ in temperature, pressure be 78 or 11 18 or the condition of 20MPa under react, obtain the mixture that monoethanolamine, diethanol amine, triethanolamine and unreacted ammonia and water etc. are formed;
B. the mixture that step a is obtained is 110 or 115 or 125 or 135 or 145 ℃ in temperature, pressure be 0.1 0.4 or the condition of 08MPa under the deamination dehydration obtain containing the mixture of monoethanolamine, diethanol amine and triethanolamine;
C. the mixture that step b is obtained is 165 or 170 or 175 or 182 ℃ in temperature, pressure be 0.25 0.3 or the condition of 0.4MPa under separate and obtain monoethanolamine.
Embodiment 2:
A kind of preparation method of feed addictive monoethanolamine the steps include:
A. concentrated ammonia liquor 20L, oxirane 1L adds in the reactor, is 100 or 110 ℃ in temperature, pressure be 10 14 or the condition of 9MPa under react, obtain the mixture that monoethanolamine, diethanol amine, triethanolamine and unreacted ammonia and water etc. are formed;
B. the mixture that step a is obtained is 120 or 128 or 134 or 142 ℃ in temperature, pressure be 0.5 0.6 or the condition of 0.7MPa under the deamination dehydration obtain containing the mixture of monoethanolamine, diethanol amine and triethanolamine;
C. the mixture that step b is obtained is 168 or 170 or 177 or 184 ℃ in temperature, pressure be 0.3 0.35 or the condition of 0.45MPa under separate and obtain monoethanolamine.
Embodiment 3:
A kind of preparation method of feed addictive monoethanolamine the steps include:
A. concentrated ammonia liquor 34L, oxirane 2L adds in the reactor, is 150 ℃ in temperature, and pressure is to react under the condition of 12MPa, obtains the mixture that monoethanolamine, diethanol amine, triethanolamine and unreacted ammonia and water etc. are formed;
B. the mixture that step a is obtained is 120 ℃ in temperature, and pressure is the mixture that the deamination dehydration obtains containing monoethanolamine, diethanol amine and triethanolamine under the condition of 0.8MPa;
C. the mixture that step b is obtained is 180 ℃ in temperature, and pressure is to separate under the condition of 0.3MPa to obtain monoethanolamine.
Embodiment 4:
A kind of preparation method of feed addictive monoethanolamine the steps include:
A. concentrated ammonia liquor 32L, oxirane 1L adds in the reactor, is 120 ℃ in temperature, and pressure is to react under the condition of 12MPa, obtains the mixture that monoethanolamine, diethanol amine, triethanolamine and unreacted ammonia and water etc. are formed;
B. the mixture that step a is obtained is 150 ℃ in temperature, and pressure is the mixture that the deamination dehydration obtains containing monoethanolamine, diethanol amine and triethanolamine under the condition of 0.6MPa;
C. the mixture that step b is obtained is 175 ℃ in temperature, and pressure is to separate under the condition of 0.4MPa to obtain monoethanolamine.
Embodiment 5:
A kind of preparation method of feed additive N-carbamylglutamic acid the steps include:
A. concentrated ammonia liquor 40L, oxirane 1L adds in the reactor, is 180 ℃ in temperature, and pressure is to react under the condition of 16MPa, obtains the mixture that monoethanolamine, diethanol amine, triethanolamine and unreacted ammonia and water etc. are formed;
B. the mixture that step a is obtained is 135 ℃ in temperature, and pressure is the mixture that the deamination dehydration obtains containing monoethanolamine, diethanol amine and triethanolamine under the condition of 0.5MPa;
C. the mixture that step b is obtained is 175 ℃ in temperature, and pressure is to separate under the condition of 0.35MPa to obtain monoethanolamine.
Embodiment 6:
The application of a kind of feed addictive monoethanolamine in Production of Livestock and Poultry the steps include:
A. add in the drinking water obtaining the addition of liquid monoethanolamine by 300uM, fully mixing;
B. the water that step a is obtained is fed to suckling pig, weanling pig, growth pig, boar and broiler chicken, laying hen;
Embodiment 7:
The application of a kind of feed addictive monoethanolamine in Production of Livestock and Poultry the steps include:
A. with after the monoethanolamine emulsification processing, make powder;
B. the monoethanolamine powder that step a is obtained is invested in the premix feed in the ratio of 200ppm, puts in the mixer then and stirs, and makes abundant mixing, makes the powdery pack;
C. the premix that step b is obtained makes an addition to feed and feeds to suckling pig, weanling pig, growth pig, boar and broiler chicken, laying hen.
Embodiment 8:
The application of a kind of monoethanolamine feed addictive in improving the growth of animals or poultry performance the steps include:
A. with after the monoethanolamine emulsification processing, make granular substance;
B. the monoethanolamine powder that step a is obtained is invested in the premix feed in the ratio of 300ppm, puts in the mixer then and stirs, and makes abundant mixing, makes the powdery pack;
C. the premix that step b is obtained makes an addition to feed and feeds to suckling pig, weanling pig, growth pig, boar and broiler chicken, laying hen.
Embodiment 9:
A kind of monoethanolamine feed addictive the steps include: promoting the developmental application of animal and bird intestines
A. add in the drinking water obtaining the addition of liquid monoethanolamine by 500uM, fully mixing;
B. the water that step a is obtained is fed to suckling pig, weanling pig, growth pig, boar and broiler chicken, laying hen;
Embodiment 10:
The application of a kind of monoethanolamine feed addictive in improving animal and bird intestines health the steps include:
A. with after the monoethanolamine emulsification processing, make the microencapsulated form thing;
B. the monoethanolamine powder that step a is obtained is invested in the premix feed in the ratio of 400ppm, puts in the mixer then and stirs, and makes abundant mixing, makes the powdery pack;
C. the premix that step b is obtained makes an addition to feed and feeds to suckling pig, weanling pig, growth pig, boar and broiler chicken, laying hen.
Add the nutritional test that monoethanolamine that the present invention of various dose produces carries out by feed in the piglet of 21-35 age in days and see Table 1, test shows that monoethanolamine can effectively improve the production performance of piglet; The best results of 200ppm monoethanolamine wherein.
Table 1 varying level monoethanolamine effect in the piglet of 21-35 age in days
Claims (4)
1. the preparation method of a feed addictive monoethanolamine the steps include:
A, the concentrated ammonia liquor with 90% ~ 99% and the liquid epoxy ethane ratio of 10:1 ~ 50:1 in molar ratio add in the reactor, it is 60 ~ 200 ℃ in temperature, pressure is to react under the condition of 6 ~ 20MPa, obtains the mixture that monoethanolamine, diethanol amine, triethanolamine and unreacted ammonia and water are formed;
B, the mixture that step a is obtained are 110 ~ 150 ℃ in temperature, and pressure is the mixture that the deamination dehydration obtains containing monoethanolamine, diethanol amine and triethanolamine under the condition of 0.1 ~ 1MPa;
C, the mixture that step b is obtained are 165 ~ 185 ℃ in temperature, and pressure is to separate the monoethanolamine that obtains purity＞99% under the condition of 0.25 ~ 0.5Mpa;
The monoethanolamine that d, step c obtain makes graininess with liquid form or after emulsification processing or powdery is packed, is the feed addictive finished product.
2. the application of the described a kind of monoethanolamine feed addictive of claim 1 in improving the growth of animals or poultry performance;
Described livestock and poultry are: newborn piglet, weanling pig, growth pig, boar and broiler chicken or laying hen.
3. the described a kind of monoethanolamine feed addictive of claim 1 is promoting the developmental application of animal and bird intestines;
Described livestock and poultry are: newborn piglet, weanling pig, growth pig, boar and broiler chicken or laying hen.
4. the described a kind of monoethanolamine feed addictive of claim 1, the application in improving animal and bird intestines health;
Described livestock and poultry are: newborn piglet, weanling pig, growth pig, boar and broiler chicken or laying hen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310170097.6A CN103271238B (en) | 2013-05-10 | 2013-05-10 | Preparation method of feed additive mono ethanol amine and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310170097.6A CN103271238B (en) | 2013-05-10 | 2013-05-10 | Preparation method of feed additive mono ethanol amine and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103271238A true CN103271238A (en) | 2013-09-04 |
| CN103271238B CN103271238B (en) | 2014-04-02 |
Family
ID=49053482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310170097.6A Active CN103271238B (en) | 2013-05-10 | 2013-05-10 | Preparation method of feed additive mono ethanol amine and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103271238B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753470A (en) * | 2017-10-09 | 2018-03-06 | 武汉大学 | A kind of micromolecular inhibitor of polymyxins drug-resistant protein and its application |
| CN109349432A (en) * | 2018-12-14 | 2019-02-19 | 北京中农华正兽药有限责任公司 | For promoting the medical stone composition of food source growth of animal |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049653A (en) * | 1990-07-02 | 1991-03-06 | 浙江大学 | The process for liquid-liquid tube reaction that thanomin is produced |
| CN1139101A (en) * | 1996-04-19 | 1997-01-01 | 浙江大学 | Waterless tubular reaction process for ethanolamine production |
| CN1329588A (en) * | 1998-12-01 | 2002-01-02 | 巴斯福股份公司 | Method for purifying triethanolamine |
| CN1081461C (en) * | 1994-07-09 | 2002-03-27 | 奴布卢克实验室有限公司 | Long-acting oxytetracycline composition |
| US20030065224A1 (en) * | 2001-09-05 | 2003-04-03 | Werner Peschel | Continuous preparation of monoethanolamine, diethanolamine and triethanolamine |
| US20030149305A1 (en) * | 2000-06-09 | 2003-08-07 | Matthias Frauenkron | Method for producing alkanolamines |
| CN1863761A (en) * | 2003-10-08 | 2006-11-15 | 巴斯福股份公司 | Method for separating triethanolamin from a mixture obtainable by ammonia and ethylene oxide reaction |
| CN101139296A (en) * | 2007-09-29 | 2008-03-12 | 吴兆立 | Ethanolamine distilling process added with gas purification topping section |
| CN101434551A (en) * | 2008-12-13 | 2009-05-20 | 江苏远洋化学有限公司 | Method for synthesizing monoethanolamine |
| CN101613289A (en) * | 2009-05-12 | 2009-12-30 | 嘉兴金燕化工有限公司 | The abbreviated system that thanomin is produced |
-
2013
- 2013-05-10 CN CN201310170097.6A patent/CN103271238B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049653A (en) * | 1990-07-02 | 1991-03-06 | 浙江大学 | The process for liquid-liquid tube reaction that thanomin is produced |
| CN1081461C (en) * | 1994-07-09 | 2002-03-27 | 奴布卢克实验室有限公司 | Long-acting oxytetracycline composition |
| CN1139101A (en) * | 1996-04-19 | 1997-01-01 | 浙江大学 | Waterless tubular reaction process for ethanolamine production |
| CN1329588A (en) * | 1998-12-01 | 2002-01-02 | 巴斯福股份公司 | Method for purifying triethanolamine |
| US20030149305A1 (en) * | 2000-06-09 | 2003-08-07 | Matthias Frauenkron | Method for producing alkanolamines |
| US20030065224A1 (en) * | 2001-09-05 | 2003-04-03 | Werner Peschel | Continuous preparation of monoethanolamine, diethanolamine and triethanolamine |
| CN1863761A (en) * | 2003-10-08 | 2006-11-15 | 巴斯福股份公司 | Method for separating triethanolamin from a mixture obtainable by ammonia and ethylene oxide reaction |
| CN101139296A (en) * | 2007-09-29 | 2008-03-12 | 吴兆立 | Ethanolamine distilling process added with gas purification topping section |
| CN101434551A (en) * | 2008-12-13 | 2009-05-20 | 江苏远洋化学有限公司 | Method for synthesizing monoethanolamine |
| CN101613289A (en) * | 2009-05-12 | 2009-12-30 | 嘉兴金燕化工有限公司 | The abbreviated system that thanomin is produced |
Non-Patent Citations (5)
| Title |
|---|
| 《化工科技市场》 20031031 赵光辉 等 乙醇胺的生产现状及应用分析 第5-7，10页 1-4 , 第10期 * |
| 冯汝明 等: "环氧乙烷胺化制乙醇胺", 《化学进展》 * |
| 孙英杰: "乙醇胺生产技术和应用", 《精细与专用化学品》 * |
| 文曜: "乙醇胺", 《化工之友》 * |
| 赵光辉 等: "乙醇胺的生产现状及应用分析", 《化工科技市场》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753470A (en) * | 2017-10-09 | 2018-03-06 | 武汉大学 | A kind of micromolecular inhibitor of polymyxins drug-resistant protein and its application |
| CN109349432A (en) * | 2018-12-14 | 2019-02-19 | 北京中农华正兽药有限责任公司 | For promoting the medical stone composition of food source growth of animal |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103271238B (en) | 2014-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103931946B (en) | A kind of Fattening Sheep high protein mineral matter nutritional lick block contained and preparation method thereof | |
| CN101411388B (en) | Ecological bait for mixed culture of Litopenaeus vannamei and Portunus trituberculatus and preparation method thereof | |
| CN104012779B (en) | A kind of preparation method and application strengthening the immune formulation of fish shrimp crab immunocompetence | |
| RU2551160C1 (en) | Method of increasing productivity of young cattle | |
| CN103181364B (en) | Dynamic feeding method for increasing utilization rate of pig feed | |
| CN102150745A (en) | Pork rich in organic selenium and production method thereof | |
| CN104814328A (en) | Organic freshwater shrimp bait | |
| CN102318768A (en) | A kind of Tibetan is sheep ewe gestational period supplementary feeding feed and preparation method thereof and supplementary feeding method | |
| CN103340329A (en) | Aquatic seedling bait and preparation process thereof | |
| CN103478406A (en) | Fermented mineral feed and preparation method thereof | |
| CN103931950B (en) | Special abalone sheet feed stuff of a kind of cage and preparation method thereof | |
| CN109463296B (en) | Multi-vitamin and multi-mineral licking brick for cattle and sheep and preparation method thereof | |
| CN103271238B (en) | Preparation method of feed additive mono ethanol amine and application | |
| CN102028102A (en) | Natural and safe growth-type feed additive | |
| CN104206822A (en) | Efficient compound attractant growth promoting additive and preparation and application thereof | |
| CN104082839B (en) | A kind of feed manufacturing is produced Collocation cultivation and to be fed system | |
| CN103783292B (en) | Feed for promoting galactopoiesis and stress resistance of minks and foxes and application method thereof | |
| CN104705257A (en) | Rapid fattening method for pork pigs | |
| CN103340328A (en) | Aquatic feed protein source | |
| CN103734544B (en) | A kind of Chinese herbal medicine food attractant for Liza haematocheila | |
| CN104206915B (en) | Promote production method and the application thereof of the additive of piglet growth | |
| CN103719618B (en) | A kind of full price coordinates pig feed and preparation method and application | |
| CN108967719A (en) | A kind of laying hen special feed | |
| CN103125750A (en) | Nutrition additive of young bird livestock and poultry feed | |
| CN102894211B (en) | Shelling and growth-promoting Chinese herbal medicine composite feedstuff additive used for penaeus vannamei |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |