CN103271238B - Preparation method of feed additive mono ethanol amine and application - Google Patents
Preparation method of feed additive mono ethanol amine and application Download PDFInfo
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- CN103271238B CN103271238B CN201310170097.6A CN201310170097A CN103271238B CN 103271238 B CN103271238 B CN 103271238B CN 201310170097 A CN201310170097 A CN 201310170097A CN 103271238 B CN103271238 B CN 103271238B
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- mea basf
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Abstract
The invention discloses a preparation method of a feed additive mono ethanol amine and an application. The method comprises steps of: a, adding 90%-99% stronger ammonia water and liquid ethylene oxide into a reactor according to a ratio, and reacting under a proper temperature and pressure so as to obtain a mixture; b, deaminizing and dehydrating the mixture obtained in the step a under a proper temperature and pressure so as to obtain a mixture consisting of mono ethanol amine, diethanolamine and triethanolamine; c, separating the mixture obtained in the step b under a proper temperature and pressure so as to obtain the mono ethanol amine; and d, processing the liquid mono ethanol amine obtained in the step c in a liquid state so as to form particles in bags, and thus obtaining a feed additive finished product. The feed additive can be applied to promoting livestock intestinal growth, improving young livestock intestinal health and improving the livestock growth performance. The method is simple, convenient to operate, easy in raw material obtaining and low in cost. The feed additive is applied to a livestock feed, can improve the livestock growth performance, promotes the livestock intestinal growth and improves the young livestock intestinal health.
Description
Technical field
The present invention relates to pig feed addictive technical field, the preparation method who more specifically relates to a kind of fodder additives Monoethanolamine MEA BASF, also relates to this fodder additives simultaneously and is improving growth of animals or poultry performance, promoting animal and bird intestines growth and improve the application in animal and bird intestines health.
Background technology
Livestock industry is the mainstay industry of agricultural and rural economy, the whole nation livestock industry gross output value in the general production value of agriculture shared proportion over four one-tenth, livestock and poultry cultivation activating rural economy, increase farmers' income, the aspect such as absorbing rural surplus laborers, drive Citizen-owned Enterprise Development brought into play important support effect, for growth of the national economic and living standards of the people improve, made significant contribution.Yet, fast development along with livestock and poultry breeding industry, feed resource is in short supply has become with environmental pollution the bottleneck that restricts China's livestock and poultry breeding industry Sustainable development, and improve feed resource utilising efficiency and then reduce feed resource waste, minimizing environmental pollution, be the needs of aquaculture Sustainable development.An important means that improve food utilization efficiency, reduces environmental pollution is to promote animal and bird intestines to grow, so the material that has additional nutrients digest and assimilate efficiency.Promoting animal and bird intestines to grow is also the important means that improves its growth performance.Regulation and control animal and bird intestines is grown except providing outside intestinal growth basic nutrition material (as protein, glucose etc.), and another important method is to feed to promote the functional substance (as polyamines etc.) of intestinal growth.
The cub fowl stage is the key of its intestinal growth.Large quantity research shows, breast milk is the key that promotes that Mammals enteron aisle is grown, because contain a large amount of nutrition relevant to intestinal growth and functional substance in breast milk, if the glutamine in milk and L-glutamic acid etc. are the main energy sources materials of intestinal epithelial cell, the hormones such as EGF, HGF and IGF-I are the major hormone of regulation and control epithelial cell proliferation.The nutrition and the functional component that in separation and evaluation milk, regulate and control intestinal growth are the classical ways of artificial adjustment intestinal growth.Monoethanolamine MEA BASF is present in the milk of rat, people and Niu in a large number, is the important component that forms Cell membrane lipids simultaneously, can significantly promote the cell proliferations such as liver cell, human oral epithelial cells.Yet its impact on animal and bird intestines development and growth performance not yet has report.Monoethanolamine MEA BASF prepared by this patent is with low cost, and stability is strong.Further test finds that it can significantly improve the growth performance of livestock and poultry, promote animal and bird intestines to grow, improve animal and bird intestines health, has great importance to livestock and poultry cultivation.
Summary of the invention
The preparation method who the object of the invention is to be to provide a kind of fodder additives Monoethanolamine MEA BASF, method is simple, and easy and simple to handle, raw material is easy to get, with low cost.It is raw material that this product be take ammoniacal liquor and oxyethane, and raw material is easy to get, and cost is low, and the product purity obtaining is high, and stability is strong.This additive can promote the propagation of intestinal epithelial cell, the intestinal tract injury that improve because ablactation stress etc. causes.
Another object of the present invention is to be to provide a kind of fodder additives Monoethanolamine MEA BASF promoting animal and bird intestines to grow, improve the purposes in the growth performance of newborn animal fowl road health, raising livestock and poultry.
In order to realize above-mentioned object, the present invention adopts following technical measures:
A preparation method for fodder additives Monoethanolamine MEA BASF, the steps include:
A, by 90%～99% strong aqua and liquid epoxy ethane in molar ratio the ratio of 10:1～50:1 add in reactor, in temperature, it is 60～200 ℃, pressure is to react under the condition of 6～20MPa, obtains the mixture that Monoethanolamine MEA BASF, diethanolamine, trolamine and unreacted ammonia and water etc. form;
B, the mixture that step a is obtained are 110～150 ℃ in temperature, and under the condition that pressure is 0.1～1MPa, deamination dehydration obtains the mixture containing Monoethanolamine MEA BASF, diethanolamine and trolamine;
C, the mixture that step b is obtained are 165～185 ℃ in temperature, the separated Monoethanolamine MEA BASF that obtains purity > 99% under the condition that pressure is 0.25～0.5Mpa;
The Monoethanolamine MEA BASF that d, step c obtain with liquid form or after emulsification processing granulation shape (or powdery or micro-capsule) packed (or bottled), be fodder additives finished product.The fodder additives obtaining can add in livestock and fowl drinking water with liquid form, also can add the livestock and poultry of feeding in the feeds of livestock and poultry to particle or powdery.
Described livestock and poultry are: suckling piglet, weanling pig, growing swine, boar and broiler chicken or laying hen.
Described growing swine body weight is 20～60kg
Fodder additives Monoethanolamine MEA BASF, promoting animal and bird intestines to grow, improve the application in the growth performance of newborn animal fowl road health, raising livestock and poultry, the steps include:
A. by obtaining liquid Monoethanolamine MEA BASF, by the addition of 200-500uM, add in tap water or the Monoethanolamine MEA BASF that is processed into particulate state (or powdery or micro-capsule) adds in complete feed by the addition of 200-500ppm, fully mix;
B. water step a being obtained or feed are fed to sucking piglets, weanling pig, growing swine, boar and broiler chicken, laying hen.
The present invention compares with present technology, has the following advantages and effect:
1. to take ammoniacal liquor and oxyethane be raw material to this product, and raw material is easy to get, and method is simple, easy and simple to handle, with low cost, and the product purity obtaining is high, and stability is strong.
2. this product is the composition itself having in animal and human's milk, and having avoided residual may damage human body, safe.
3. Monoethanolamine MEA BASF can promote animal and bird intestines to grow, and improves the nutrient utilization efficiency of livestock and poultry, saves feed resource, reduces environmental pollution, is a kind of environment-friendly feed additive that has applications well prospect.
4. by feed, add the Monoethanolamine MEA BASF that the present invention of various dose produces and carry out raising poultry nutritive test, in 5～8kg weanling pig, test-results shows, in drinking-water, adding and adding 200ppm in 500uM, feed is the best adjustment dosage, can significantly improve Small Intestine of Piglets weight and growth performance.
Accompanying drawing explanation
Fig. 1 is the affect schematic diagram of Monoethanolamine MEA BASF on weanling pig small intestine weight.
By adding the nutritional test that Monoethanolamine MEA BASF that the present invention of various dose produces carries out in 21-35 age in days weanling pig in drinking-water, see Fig. 1, test shows, Monoethanolamine MEA BASF can effectively promote intestine of young pigs to grow, and the small intestine weight of adding piglet increases, wherein 500uM addition best results.
Embodiment
Embodiment 1:
A preparation method for fodder additives Monoethanolamine MEA BASF, the steps include:
A. get strong aqua 17L, oxyethane 2L, adds in reactor, in temperature, is 65 or 75 or 80 or 85 or 125 ℃, pressure be 78 or 11 18 or the condition of 20MPa under react, obtain the mixture that Monoethanolamine MEA BASF, diethanolamine, trolamine and unreacted ammonia and water etc. form;
B. mixture step a being obtained is 110 or 115 or 125 or 135 or 145 ℃ in temperature, pressure be 0.1 0.4 or the condition of 08MPa under deamination dehydration obtain the mixture containing Monoethanolamine MEA BASF, diethanolamine and trolamine;
C. mixture step b being obtained is 165 or 170 or 175 or 182 ℃ in temperature, pressure be 0.25 0.3 or the condition of 0.4MPa under separation obtain Monoethanolamine MEA BASF.
Embodiment 2:
A preparation method for fodder additives Monoethanolamine MEA BASF, the steps include:
A. strong aqua 20L, oxyethane 1L, adds in reactor, in temperature, is 100 or 110 ℃, pressure be 10 14 or the condition of 9MPa under react, obtain the mixture that Monoethanolamine MEA BASF, diethanolamine, trolamine and unreacted ammonia and water etc. form;
B. mixture step a being obtained is 120 or 128 or 134 or 142 ℃ in temperature, pressure be 0.5 0.6 or the condition of 0.7MPa under deamination dehydration obtain the mixture containing Monoethanolamine MEA BASF, diethanolamine and trolamine;
C. mixture step b being obtained is 168 or 170 or 177 or 184 ℃ in temperature, pressure be 0.3 0.35 or the condition of 0.45MPa under separation obtain Monoethanolamine MEA BASF.
Embodiment 3:
A preparation method for fodder additives Monoethanolamine MEA BASF, the steps include:
A. strong aqua 34L, oxyethane 2L, adds in reactor, in temperature, is 150 ℃, under the condition that pressure is 12MPa, reacts, and obtains the mixture that Monoethanolamine MEA BASF, diethanolamine, trolamine and unreacted ammonia and water etc. form;
B. mixture step a being obtained is 120 ℃ in temperature, and under the condition that pressure is 0.8MPa, deamination dehydration obtains the mixture containing Monoethanolamine MEA BASF, diethanolamine and trolamine;
C. mixture step b being obtained is 180 ℃ in temperature, and under the condition that pressure is 0.3MPa, separation obtains Monoethanolamine MEA BASF.
Embodiment 4:
A preparation method for fodder additives Monoethanolamine MEA BASF, the steps include:
A. strong aqua 32L, oxyethane 1L, adds in reactor, in temperature, is 120 ℃, under the condition that pressure is 12MPa, reacts, and obtains the mixture that Monoethanolamine MEA BASF, diethanolamine, trolamine and unreacted ammonia and water etc. form;
B. mixture step a being obtained is 150 ℃ in temperature, and under the condition that pressure is 0.6MPa, deamination dehydration obtains the mixture containing Monoethanolamine MEA BASF, diethanolamine and trolamine;
C. mixture step b being obtained is 175 ℃ in temperature, and under the condition that pressure is 0.4MPa, separation obtains Monoethanolamine MEA BASF.
Embodiment 5:
A preparation method for feed additive N-carbamylglutamic acid, the steps include:
A. strong aqua 40L, oxyethane 1L, adds in reactor, in temperature, is 180 ℃, under the condition that pressure is 16MPa, reacts, and obtains the mixture that Monoethanolamine MEA BASF, diethanolamine, trolamine and unreacted ammonia and water etc. form;
B. mixture step a being obtained is 135 ℃ in temperature, and under the condition that pressure is 0.5MPa, deamination dehydration obtains the mixture containing Monoethanolamine MEA BASF, diethanolamine and trolamine;
C. mixture step b being obtained is 175 ℃ in temperature, and under the condition that pressure is 0.35MPa, separation obtains Monoethanolamine MEA BASF.
Embodiment 6:
The application of fodder additives Monoethanolamine MEA BASF in Production of Livestock and Poultry, the steps include:
A. by obtaining liquid Monoethanolamine MEA BASF, by the addition of 300uM, add in tap water, fully mix;
B. water step a being obtained is fed to sucking piglets, weanling pig, growing swine, boar and broiler chicken, laying hen;
Embodiment 7:
The application of fodder additives Monoethanolamine MEA BASF in Production of Livestock and Poultry, the steps include:
A. by after Monoethanolamine MEA BASF emulsification processing, make meal;
B. Monoethanolamine MEA BASF meal step a being obtained is invested in Preblend feed in the ratio of 200ppm, then puts in stirrer and stirs, and makes abundant mixing, makes powdery pack;
C. Preblend step b being obtained makes an addition to feed and feeds to sucking piglets, weanling pig, growing swine, boar and broiler chicken, laying hen.
Embodiment 8:
The application of Monoethanolamine MEA BASF fodder additives in improving growth of animals or poultry performance, the steps include:
A. after Monoethanolamine MEA BASF emulsification being processed, granulation shape thing;
B. Monoethanolamine MEA BASF meal step a being obtained is invested in Preblend feed in the ratio of 300ppm, then puts in stirrer and stirs, and makes abundant mixing, makes powdery pack;
C. Preblend step b being obtained makes an addition to feed and feeds to sucking piglets, weanling pig, growing swine, boar and broiler chicken, laying hen.
Embodiment 9:
Monoethanolamine MEA BASF fodder additives, promoting the developmental application of animal and bird intestines, the steps include:
A. by obtaining liquid Monoethanolamine MEA BASF, by the addition of 500uM, add in tap water, fully mix;
B. water step a being obtained is fed to sucking piglets, weanling pig, growing swine, boar and broiler chicken, laying hen;
Embodiment 10:
The application of Monoethanolamine MEA BASF fodder additives in improving animal and bird intestines health, the steps include:
A. by after Monoethanolamine MEA BASF emulsification processing, make microencapsulated form thing;
B. Monoethanolamine MEA BASF meal step a being obtained is invested in Preblend feed in the ratio of 400ppm, then puts in stirrer and stirs, and makes abundant mixing, makes powdery pack;
C. Preblend step b being obtained makes an addition to feed and feeds to sucking piglets, weanling pig, growing swine, boar and broiler chicken, laying hen.
By feed, add nutritional test that Monoethanolamine MEA BASF that the present invention of various dose produces carries out in the piglet of 21-35 age in days in Table 1, test shows, Monoethanolamine MEA BASF can effectively improve the production performance of piglet; The best results of 200ppm Monoethanolamine MEA BASF wherein.
Table 1 different levels Monoethanolamine MEA BASF effect in the piglet of 21-35 age in days
Claims (3)
1. Monoethanolamine MEA BASF application in improving growth of animals or poultry performance as fodder additives;
Described livestock and poultry are: suckling piglet, weanling pig, growing swine, boar and broiler chicken or laying hen.
2. Monoethanolamine MEA BASF is promoting the developmental application of animal and bird intestines as fodder additives;
Described livestock and poultry are: suckling piglet, weanling pig, growing swine, boar and broiler chicken or laying hen.
3. Monoethanolamine MEA BASF is as fodder additives, the application in improving animal and bird intestines health;
Described livestock and poultry are: suckling piglet, weanling pig, growing swine, boar and broiler chicken or laying hen.
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| CN107753470B (en) * | 2017-10-09 | 2021-04-27 | 武汉大学 | Small molecule inhibitor of polymyxin drug-resistant protein and application thereof |
| CN109349432A (en) * | 2018-12-14 | 2019-02-19 | 北京中农华正兽药有限责任公司 | For promoting the medical stone composition of food source growth of animal |
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