CN103257070A - 用于平衡同位素稀释质谱样品的方法 - Google Patents
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| CN103837593A (zh) * | 2014-03-18 | 2014-06-04 | 中国计量科学研究院 | 一种人血清蛋白质电泳后同位素稀释质谱定量方法 |
| CN103913534A (zh) * | 2014-02-11 | 2014-07-09 | 中国科学院地质与地球物理研究所兰州油气资源研究中心 | 一种天然气中系列烃类化合物碳同位素分析方法 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5414259A (en) * | 1994-01-05 | 1995-05-09 | Duquesne University Of The Holy Ghost | Method of speciated isotope dilution mass spectrometry |
| CN1292090A (zh) * | 1998-01-29 | 2001-04-18 | 霍利戈斯特杜肯大学 | 活性物质的物种化同位素稀释质谱法及相关方法 |
| EP1256370A2 (en) * | 1996-03-15 | 2002-11-13 | British Nuclear Fuels PLC | Separation of isotopes by ionisation for processing of nuclear fuel materials |
| CN1575195A (zh) * | 2001-01-29 | 2005-02-02 | 美塔莱公司 | 自动在过程同位素和质谱分析 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6113153A (ja) * | 1984-06-29 | 1986-01-21 | Hitachi Ltd | 自動滴定装置 |
| JP2004503780A (ja) * | 2000-06-12 | 2004-02-05 | ユニバーシティ オブ ワシントン | リンペプチドの選択的標識および単離ならびにプロテオーム分析への適用 |
| EP1330532B1 (en) * | 2000-10-03 | 2011-12-14 | Mirari Biosciences, Inc. | Methods and compositions for directed microwave chemistry |
| US7348182B2 (en) * | 2000-10-03 | 2008-03-25 | Mirari Biosciences, Inc. | Directed microwave chemistry |
| JP4062514B2 (ja) * | 2001-01-02 | 2008-03-19 | ザ・クリーブランド・クリニック・ファンデーション | ミエロペルオキシダーゼ、心臓血管疾患についての危険性指示因子 |
| US7183116B2 (en) * | 2001-05-14 | 2007-02-27 | The Institute For Systems Biology | Methods for isolation and labeling of sample molecules |
| US7220383B2 (en) * | 2001-07-13 | 2007-05-22 | Metara, Inc. | Method and instrument for automated analysis of fluid-based processing systems |
| US7531134B1 (en) * | 2002-03-08 | 2009-05-12 | Metara, Inc. | Method and apparatus for automated analysis and characterization of chemical constituents of process solutions |
| FR2883977B1 (fr) * | 2005-04-05 | 2007-06-22 | Centre Nat Rech Scient | Machine laser d'analyse directe |
-
2007
- 2007-12-07 CA CA2671859A patent/CA2671859C/en active Active
- 2007-12-07 AU AU2007349186A patent/AU2007349186B2/en active Active
- 2007-12-07 CN CN2013100318147A patent/CN103257070A/zh active Pending
- 2007-12-07 CN CN2007800509715A patent/CN101600954B/zh active Active
- 2007-12-07 US US11/952,471 patent/US8383420B2/en active Active
- 2007-12-07 DK DK07873961.2T patent/DK2108111T3/da active
- 2007-12-07 WO PCT/US2007/086795 patent/WO2008112032A2/en not_active Ceased
- 2007-12-07 EP EP07873961.2A patent/EP2108111B1/en active Active
- 2007-12-07 JP JP2009540500A patent/JP5412288B2/ja active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5414259A (en) * | 1994-01-05 | 1995-05-09 | Duquesne University Of The Holy Ghost | Method of speciated isotope dilution mass spectrometry |
| EP1256370A2 (en) * | 1996-03-15 | 2002-11-13 | British Nuclear Fuels PLC | Separation of isotopes by ionisation for processing of nuclear fuel materials |
| CN1292090A (zh) * | 1998-01-29 | 2001-04-18 | 霍利戈斯特杜肯大学 | 活性物质的物种化同位素稀释质谱法及相关方法 |
| CN1575195A (zh) * | 2001-01-29 | 2005-02-02 | 美塔莱公司 | 自动在过程同位素和质谱分析 |
Non-Patent Citations (1)
| Title |
|---|
| ROBERT CLOUGH等: "Investigation of equilibration and uncertainty contributions for the determination of inorganic mercury and methylmercury by isotope dilution inductively coupled plasma mass spectrometry", 《ANALYTICA CHIMICA ACTA》 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103913534A (zh) * | 2014-02-11 | 2014-07-09 | 中国科学院地质与地球物理研究所兰州油气资源研究中心 | 一种天然气中系列烃类化合物碳同位素分析方法 |
| CN103913534B (zh) * | 2014-02-11 | 2016-08-17 | 中国科学院地质与地球物理研究所兰州油气资源研究中心 | 一种天然气中系列烃类化合物碳同位素分析方法 |
| CN103837593A (zh) * | 2014-03-18 | 2014-06-04 | 中国计量科学研究院 | 一种人血清蛋白质电泳后同位素稀释质谱定量方法 |
| CN103837593B (zh) * | 2014-03-18 | 2016-11-23 | 中国计量科学研究院 | 一种人血清蛋白质电泳后同位素稀释质谱定量方法 |
| CN104006993A (zh) * | 2014-05-26 | 2014-08-27 | 中国兵器工业集团第五三研究所 | Id-icp-ms法燃油中硫含量的测试样品制备方法 |
| CN104006993B (zh) * | 2014-05-26 | 2016-08-24 | 中国兵器工业集团第五三研究所 | Id-icp-ms法燃油中硫含量的测试样品制备方法 |
| CN108780064A (zh) * | 2016-03-07 | 2018-11-09 | 株式会社日立高新技术 | 分析装置 |
| CN109073658A (zh) * | 2016-04-14 | 2018-12-21 | 豪夫迈·罗氏有限公司 | 用于测定体液样品中的靶分析物的浓度的方法 |
| CN109073658B (zh) * | 2016-04-14 | 2021-07-09 | 豪夫迈·罗氏有限公司 | 用于测定体液样品中的靶分析物的浓度的方法 |
| CN113167802A (zh) * | 2018-12-04 | 2021-07-23 | 百时美施贵宝公司 | 通过多同位素体反应监测使用样品内校准曲线的分析方法 |
| CN110243919A (zh) * | 2019-05-14 | 2019-09-17 | 中国石油天然气股份有限公司 | 一种利用钒同位素对油气成因与来源进行分析的方法 |
Also Published As
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| CA2671859A1 (en) | 2008-09-18 |
| WO2008112032A2 (en) | 2008-09-18 |
| DK2108111T3 (da) | 2019-07-15 |
| JP2010512515A (ja) | 2010-04-22 |
| EP2108111B1 (en) | 2019-04-24 |
| HK1138908A1 (en) | 2010-09-03 |
| CA2671859C (en) | 2016-07-12 |
| EP2108111A2 (en) | 2009-10-14 |
| US8383420B2 (en) | 2013-02-26 |
| CN101600954A (zh) | 2009-12-09 |
| CN101600954B (zh) | 2013-03-13 |
| AU2007349186A1 (en) | 2008-09-18 |
| AU2007349186B2 (en) | 2014-03-06 |
| WO2008112032A3 (en) | 2008-12-31 |
| JP5412288B2 (ja) | 2014-02-12 |
| US20120142545A1 (en) | 2012-06-07 |
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