CN103251054B - Anti-fatigue health protection food composition and preparation method thereof - Google Patents
Anti-fatigue health protection food composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an anti-fatigue health protection food composition and a preparation method thereof. The anti-fatigue health protection food composition comprises the following materials in percentage by weight: 20-35 percent of a rhodiola extract, 10-20 percent of a guarana extract, 10-20 percent of an astragalus extract, 3-5 percent of vitamin C, 3-5 percent of vitamin E, 2-5 percent of nicotinic acid and the balance of edible auxiliary materials. On the basis of a fatigue generation mechanism and with combination of modern pharmacological research results, the rhodiola extract, the guarana extract and the astragalus extract are taken as the main raw materials for timely supplementing the consumption of internal energy substances, quickly resisting fatigue and recovering strength, reliving brain fatigue and improving the durability and the working efficiency in a fatigue state. By the reducing nutritious substances, such as the vitamin C and the vitamin E, the radical level and the oxidization stress reaction in vivo in the fatigue state are reduced and alleviated, the fatigue can be effectively alleviated, and the anti-fatigue health protection effect is enhanced.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, particularly relate to a kind of based on the mechanism of fatigue generation, in conjunction with modern pharmacological research achievement, select the natural products of integration of drinking and medicinal herbs, based on the effective extract of rhodiola root, guarana and the Radix Astragali, harmless to human non-toxic, can be used as the long-term practical fatigue resistant health food composition and method of making the same of health food.
Background technology
Fatigue is a kind of sub-health state having a strong impact on people's quality of life, and fatigue causes disease, tired work capacity, operating efficiency and the study efficacy of reducing is finalized.Since Mosso (Moso) fatigue of studying the mankind in 1880 starts, have the history of more than 100 year both at home and abroad about the physiological Study of organism fatigue (fatigue).Chronic fatigue syndrome (chronic fatigue syndrome, CFS) by CDC of the U.S. (CDC) in definite designation in 1988, be defined as and " a kind ofly show as main syndrome so that fatigue, conscious heating, sore-throat, myalgia, arthralgia, headache, difficult concentrating, poor memory, sleep-disorder and depression etc. are non-specific, and establish CDC diagnostic criteria.Fukuda improved definition in 1994, and defined 1994CDC diagnostic criteria.
About the tired domestic and international scientist of mechanism carried out many research from every subjects field, and set up many hypothesis.Protectiveness as Pavlov suppresses theory to think no matter be physical fatigue or mental fatigue, it is all the result that cerebral cortex protectiveness holds back the development, think that cerebral cortex is in a kind of fever state in high strength or the process that works long hours, brain cell working strength obviously increases time quieter, cerebral cortex cells ability to work is declined, in order to prevent the further consume of brain cell, cerebral cortex transfers suppression to by excitatory state, and this suppression is protectiveness and suppresses; Harvard University's fatigue study homeostasis sexual maladjustment theory think that fatigue is because pH value declines, water and salt metabolic disturbance and the factor such as plasma osmolarity change causes; The energy exhaustion theory of Syed thinks tired generation mainly because energy substance in body in motion process consumes in a large number and can not get supplementing in time, and exercise intensity, time are different, and the energy substance of consumption is not identical yet, produces different exercise induced fatigues; Oxygen radical and the peroxidatic reaction of lipid that causes thereof strengthen theory and think that oxygen radical and the peroxidatic reaction of lipid that causes thereof can the other biological such as attack cells and mitochondria films, cause ion and energetic supersession disorderly, thus cause exercise induced fatigue.Although these viewpoints have limitation, but in modern physiology research, still obtain the support of many experiments and supplement, being considered to the basis of illustrating tired mechanism.
There is the advantage of 5,000 years TCM Cultures in China, utilize in medicine-food two-purpose natural plants richly endowed by nature especially.For mechanism and the nutritional intervention thereof of all kinds of fatigue, foreign study is many, domestic more, all kinds of nutritional agents emerges in an endless stream especially, but the research utilizing different fatigue generation mechanism to carry out the health products of nutritional supplementation targetedly at present still comparatively lacks, if utilize the different angles of tired mechanism, adopt antifatigue product targetedly to carry out combination composite, be then expected to the effect greatly improving antifatigue.
The object of the invention is to utilize domestic and international antifatigue plant to prepare its extract, in conjunction with achievement in research in the past, provide a kind of can the health-care food composition and preparation method thereof of faster fatigue-relieving.
The present invention is directed to the tired Mechanism Study occurred, effective fatigue preparations is made after adopting the natural products with different antifatigue effect composite, point out as Gramiqnano teaches to write articles at " Nutrition " for 2006, effectively can lessen fatigue by reducing response to oxidative stress, and obtain the checking of great many of experiments evidence; Utilize the natural products such as caffeine can improve corticocerebral excitability, in supplementing in time, the consumption of energy substance, removes the generation of physical fatigue and mental fatigue; Some have and improve the natural products of immunocompetence as astragalus polyose, can the effective symptom such as the homeostasis sexual maladjustment that causes of fatigue-relieving.Numerous literature research shows, rhodiola root, the Radix Astragali, ginseng, wilsonii etc. are all the plants with more definite antifatigue effectiveness.We also find that in early-stage Study the nutritional preparation intervention of the combination such as vitamin C, vitamin E, nicotinic acid can improve the working memory level of psychological stress compound sleep-deprived rat, can the walking weight load of prolong rats.
Rhodiola root is the perennial meat herbaceous plant of Crassulaceae rhodiola, mainly originates in the high and cold mountain area on the ground such as Tibet, Xinjiang, Qinghai, Gansu, northeast, is wherein top grade with the rhodiola kirilowii Regel in Tibet.The medicinal extract of Soviet Union's report Rhodida plant has the strong effect of intelligence development, can as antifatigue and the medication for the treatment of nervous function disease.Brekgman school thinks that Rhodida plant has good adaptive significances, has special regulating action to human body, and ill-conditioned index that different pathogeny causes can be made to normal condition conversion.When Kangxu Supreme Being fights west, once took this thing tired to eliminate army.Document is recorded it and can be strengthened the body resistance to consolidate the constitution, can be clearing heat and detoxicating, and detumescence, is used for the treatment of warm disease, lung heat, poisoning and limb edema.Modern biomedical experiment display, rhodiola root has antifatigue, anti anoxia, resisting microwave radiation, raising immunity, regulates the effect of the growth of nervous function, stimulating central nervous system, inhibition tumor cell and prevention and cure of cardiovascular disease, diabetes, and rhodiola root is without any side effects and additive.
Brazil's rain forest plant guarana (Guarana) is a kind of containing the antifatigue plant of natural caffeine compared with horn of plenty, but its effect is not exclusively equal to caffeine, almost caffeine-free additive, is therefore also the favorite antifatigue food of Brazilian.Except containing except natural caffeine, guarana extract is also containing theophylline, theobromine, tannin, Chinese honey locust alkali, multiple catechol and other micro substances.Can be used for the raising of memory, promoting circulation of blood, convergence, prevention Adipogenesis and reduce fat, repair the DNA that caused by nitrite by cell and destroy and antioxidation.To the application domestic still rare report at present of guarana antifatigue.
The Radix Astragali is successive dynasties conventional traditional tonic medicines, be the dry root of legume Astragalus membranacus or astragalus mongolicus, there is tonifying middle-Jiao and Qi, apocenosis of drawing out pus by applying a plaster to the affected part, expelling pus and promoting granulation and raising immunity effect.
Summary of the invention
For the problems referred to above, main purpose of the present invention is to provide a kind of based on the mechanism of fatigue generation, in conjunction with modern pharmacological research achievement, select the natural products of integration of drinking and medicinal herbs, based on the effective extract of rhodiola root, guarana and the Radix Astragali, harmless to human non-toxic, can be used as the long-term practical fatigue resistant health food composition and method of making the same of health food.
The present invention solves above-mentioned technical problem by following technical proposals: a kind of fatigue resistant health food composition, and described composition comprises gadol extract, guarana extract, Astragalus Root P.E, vitamin C, vitamin E, nicotinic acid and edible auxiliary materials; Wherein gadol extract, guarana extract, Astragalus Root P.E, vitamin C, vitamin E and the part by weight shared by nicotinic acid are respectively between 20%-35%, 10%-20%, 10-20%, 3%-5%, 3%-5% and 2%-5%, and remaining is edible auxiliary materials.
In specific embodiments of the invention, in described gadol extract, the mass percentage content of rhodioside is more than or equal to 3%, the mass percentage content of caffeine is more than or equal to 8% in guarana extract, the mass percentage content of astragalus polyose and total saposins is more than or equal to 35% in Astragalus Root P.E.
In specific embodiments of the invention, described edible auxiliary materials is one or more combinations in disintegrant, filler, sweetener and the lubricant pharmaceutically commonly used.
A kind of method preparing above-mentioned composition, described method comprises the steps: to adopt water extraction to prepare gadol extract, guarana extract and Astragalus Root P.E respectively, then the gadol extract obtained, guarana extract, Astragalus Root P.E are mixed by formula rate with vitamin C, vitamin E, nicotinic acid and edible auxiliary materials, wet granulation, less than 60 DEG C dry, and conventional method is prepared into solid pharmaceutical preparation.
In specific embodiments of the invention, described gadol extract, guarana extract and Astragalus Root P.E adopt lower noodle producing method:
After block rhodiola root, guarana and astragalus root are cleaned up respectively, dry, pulverize, sieve obtained respective fine powder, often kind of fine powder adds 3 times of dose water at every turn or ethanol water decocts 2-3 time, each 2 hours, filter, slow fire heating evaporation was concentrated into quantitatively, adjust pH value of solution to 4-5 with hydrochloric acid, the method precipitated with the gelatin is settled out tannin from aqueous extract, by the filtrate spraying dry obtained, obtains dry gadol extract, guarana extract and Astragalus Root P.E respectively.
In specific embodiments of the invention, the solid pharmaceutical preparation be prepared into is capsule, electuary or tablet.
Positive progressive effect of the present invention is: the present invention and common fatigue resistant health food compare, the present invention is based on the mechanism of fatigue generation, in conjunction with modern pharmacological research achievement, select the natural products of integration of drinking and medicinal herbs, based on the effective extract of rhodiola root, guarana and the Radix Astragali, the consumption of energy substance in supplementing in time, Fast Anti is tired, regain one's strength rapidly, alleviate mental fatigue, improve the endurance under frazzle and operating efficiency.In conjunction with the reproducibility such as vitamin C, vitamin E thing nutriment, reduce Free Radical Level and response to oxidative stress in fatigue state lower body, effectively lessen fatigue, strengthen anti-fatigue health-caring effect.
Detailed description of the invention
Present pre-ferred embodiments is provided, to describe technical scheme of the present invention in detail below in conjunction with specific embodiment.
Embodiment 1
1, the preparation method of rhodiola root, guarana and Astragalus Root P.E: after block rhodiola root, guarana and astragalus root being cleaned up respectively, dry, pulverize, sieve obtained respective fine powder.Various fine powder adds 3 times of dose soak by water 2-3 time respectively at every turn, each 2 hours, merge the extract through the preliminary natural filtration of 200 order filter cloth, airtight standing 24 hours, incline and supernatant, 400 order filter cloth natural filtration removing precipitations, slow fire heating evaporation is concentrated into quantitatively, adjust pH value of solution to 4-5 with hydrochloric acid, the method precipitated with the gelatin is settled out tannin from aqueous extract, natural filtration removing precipitation.By the filtrate spraying dry obtained, respectively dry gadol extract, guarana extract and Astragalus Root P.E.
2, method of granulating: gadol extract 25g, guarana extract 15g, Astragalus Root P.E 15g, vitamin C 5g, nicotinic acid 2g and pharmaceutic adjuvant filler microcrystalline cellulose 22g, disintegrant PVPP 10g, mix by above-mentioned formula rate respectively, medical surfaces is sprayed on after the vitamin E of 5g oily is dissolved in 95% ethanol, wet granulation, less than 60 DEG C dry
3, by above granulation desciccate capsule charge in conventional manner.
Embodiment 2
1, the preparation method of rhodiola root, guarana and Astragalus Root P.E: after block rhodiola root, guarana and astragalus root being cleaned up respectively, dry, pulverize, sieve obtained respective fine powder.Various fine powder adds 3 times of dose soak by water 2-3 time respectively at every turn, each 2 hours, merge the extract through the preliminary natural filtration of 200 order filter cloth, airtight standing 24 hours, incline and supernatant, 400 order filter cloth natural filtration removing precipitations, slow fire heating evaporation is concentrated into quantitatively, adjust pH value of solution to 4-5 with hydrochloric acid, the method precipitated with the gelatin is settled out tannin from aqueous extract, natural filtration removing precipitation.By the filtrate spraying dry obtained, respectively dry gadol extract, guarana extract and Astragalus Root P.E.
2, method of granulating: gadol extract 25g, guarana extract 15g, Astragalus Root P.E 15g, vitamin C 5g, nicotinic acid 2g and pharmaceutic adjuvant filler microcrystalline cellulose 15g, disintegrant PVPP 8g, magnesium stearate lubricant 10g, mix by above-mentioned formula rate respectively, medical surfaces is sprayed on after the vitamin E of 5g oily is dissolved in 95% ethanol, wet granulation, less than 60 DEG C dry
3, above granulation desciccate is pressed into tablet with tablet press machine.
Embodiment 3
1, the preparation method of rhodiola root, guarana and Astragalus Root P.E: after block rhodiola root, guarana and astragalus root being cleaned up respectively, dry, pulverize, sieve obtained respective fine powder.Various fine powder adds 3 times of dose soak by water 2-3 time respectively at every turn, each 2 hours, merge the extract through the preliminary natural filtration of 200 order filter cloth, airtight standing 24 hours, incline and supernatant, 400 order filter cloth natural filtration removing precipitations, slow fire heating evaporation is concentrated into quantitatively, adjust pH value of solution to 4-5 with hydrochloric acid, the method precipitated with the gelatin is settled out tannin from aqueous extract, natural filtration removing precipitation.By the filtrate spraying dry obtained, respectively dry gadol extract, guarana extract and Astragalus Root P.E.
2, method of granulating: gadol extract 30g, guarana extract 15g, Astragalus Root P.E 15g, vitamin C 5g, nicotinic acid 2g and filler microcrystalline cellulose 22g, disintegrant PVPP 10g, mix by above-mentioned formula rate respectively, medical surfaces is sprayed on after the vitamin E of 5g oily is dissolved in 95% ethanol, wet granulation, less than 60 DEG C dry.
3, by the suitable damp-prrof packing of above granulation desciccate, electuary is.
Embodiment 4
1, the preparation method of rhodiola root, guarana and Astragalus Root P.E: after block rhodiola root, guarana and astragalus root being cleaned up respectively, dry, pulverize, sieve obtained respective fine powder.Various fine powder adds 3 times of dose 60% ethanol respectively at every turn and decocts 2-3 time, each 2 hours, merge the extract through the preliminary natural filtration of 200 order filter cloth, airtight standing 24 hours, incline and supernatant, 400 order filter cloth natural filtration removing precipitations, slow fire heating evaporation is concentrated into quantitatively, adjust pH value of solution to 4-5 with hydrochloric acid, the method precipitated with the gelatin is settled out tannin from extract, natural filtration removing precipitation.By the filtrate spraying dry obtained, respectively dry gadol extract, guarana extract and Astragalus Root P.E.
2, method of granulating: gadol extract 30g, guarana extract 18g, Astragalus Root P.E 20g, vitamin C 5g, nicotinic acid 2g and pharmaceutic adjuvant filler microcrystalline cellulose 10g, disintegrant PVPP 10g, mix by above-mentioned formula rate respectively, medical surfaces is sprayed on after the vitamin E of 5g oily is dissolved in 95% ethanol, wet granulation, less than 60 DEG C dry.
3, by above granulation desciccate capsule charge in conventional manner.
In order to better verify anti-fatigue effect of the present invention, the present inventor has done following test, is below specific experiment process and experiment effect.
To composition prepared by the present invention, the checking of mice burden swimming test and pole-jump test through carrying out antifatigue effect, result is as follows:
1, mice burden swimming experiment
Kun Ming mice, cleaning grade, male, body weight 19-21g, is divided into administration group and negative control group at random, often organizes 10.Administration group mouse is by per kilogram of body weight gavage present composition 0.3g every day, and control group control-animal gives distilled water, 0.5ml/1 times/day, continuous gavage 30 days.After last gavage 30min, the sheet lead of mouse tail load 5% body weight, puts into depth of water 30cm, in the swimming trunk of water temperature (25 ± 1) DEG C, record mouse exhausts the time of (not emerging in 10 seconds) to swimming beginning to power, as mouse swimming time.All data input SPSS10.0 statistical softwares, compare between group and use T-test.Result shows, the walking weight load giving health composition group mouse is significantly longer than control group, compares that there were significant differences (P < 0.05) between the two.Illustrate that the application of the present composition can extend the walking weight load of mouse.
2, mouse pole-climbing time test
Kun Ming mice, cleaning grade, male, body weight 19-21g, is divided into administration group and negative control group at random, often organizes 10.Administration group mouse is by per kilogram of body weight gavage present composition 0.3g every day, and control group control-animal gives distilled water, 0.5ml/1 times/day, continuous gavage 30 days.Grasping clubglass test equipment used is pole-climbing frame, and pole-climbing frame specification is: diameter (0.8 ~ 1.0) cm, and be about the lucite pole into 25cm, upper end is fixed on plank, and lower end is unsettled, is about 20cm apart from ground.After last gavage 30min, mouse is placed on the perspex bar of pole-climbing frame, makes its muscle be in static(al) tense situation, record the time fallen from rod because mouse muscle is tired, stop experiment when third time drops down, the experiment of accumulative three times is as the pole-climbing time.All data input SPSS10.0 statistical softwares, compare between group and use T-test.Result shows, the pole-climbing time giving health composition gavage group mouse is significantly longer than control group, compares that there were significant differences (P < 0.05) between the two.Illustrate that the application of the present composition can extend the pole-climbing time of mouse.
The present invention and common fatigue resistant health food compare, the present invention is based on the mechanism of fatigue generation, in conjunction with modern pharmacological research achievement, select the natural products of integration of drinking and medicinal herbs, with rhodiola root, the effective extract of guarana and the Radix Astragali is main, the consumption of energy substance in supplementing in time, Fast Anti is tired, regain one's strength rapidly, alleviate mental fatigue, improve the endurance under frazzle and operating efficiency, in conjunction with vitamin C, the reproducibility thing nutriments such as vitamin E, reduce Free Radical Level and response to oxidative stress in fatigue state lower body, effectively lessen fatigue, strengthen anti-fatigue health-caring effect.
More than show and describe general principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications; these changes and improvements all fall in the claimed scope of the invention, and application claims protection domain is defined by appending claims and equivalent thereof.
Claims (5)
1. a fatigue resistant health food composition, is characterized in that: described composition comprises gadol extract, guarana extract, Astragalus Root P.E, vitamin C, vitamin E, nicotinic acid and edible auxiliary materials; Wherein gadol extract, guarana extract, Astragalus Root P.E, vitamin C, vitamin E and the part by weight shared by nicotinic acid are respectively between 20%-35%, 10%-20%, 10-20%, 3%-5%, 3%-5% and 2%-5%, remaining is edible auxiliary materials, and in described gadol extract, the mass percentage content of rhodioside is more than or equal to 3%, the mass percentage content of caffeine is more than or equal to 8% in guarana extract, the mass percentage content of astragalus polyose and total saposins is more than or equal to 35% in Astragalus Root P.E.
2. fatigue resistant health food composition according to claim 1, is characterized in that: described edible auxiliary materials is one or more combinations in disintegrant, filler, sweetener and the lubricant pharmaceutically commonly used.
3. prepare the method for the composition of one of claim 1-2 for one kind, it is characterized in that: described method comprises the steps: to adopt water extraction to prepare gadol extract, guarana extract and Astragalus Root P.E respectively, then the gadol extract obtained, guarana extract, Astragalus Root P.E are mixed by formula rate with vitamin C, vitamin E, nicotinic acid and edible auxiliary materials, wet granulation, less than 60 DEG C dry, and conventional method is prepared into solid pharmaceutical preparation.
4. method according to claim 3, is characterized in that: described gadol extract, guarana extract and Astragalus Root P.E adopt lower noodle producing method:
After block rhodiola root, guarana and astragalus root are cleaned up respectively, dry, pulverize, sieve obtained respective fine powder, often kind of fine powder adds 3 times of dose water at every turn or ethanol water decocts 2-3 time, each 2 hours, filter, slow fire heating evaporation was concentrated into quantitatively, adjust pH value of solution to 4-5 with hydrochloric acid, the method precipitated with the gelatin is settled out tannin from aqueous extract, by the filtrate spraying dry obtained, obtains dry gadol extract, guarana extract and Astragalus Root P.E respectively.
5. method according to claim 3, is characterized in that: the solid pharmaceutical preparation be prepared into is capsule, electuary or tablet.
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| CN104799270A (en) * | 2014-01-26 | 2015-07-29 | 天津中瑞药业股份有限公司 | Capsule containing Radix Astragali and inositol nicotinate food nutritive fortifier |
| CN104799299A (en) * | 2014-01-26 | 2015-07-29 | 天津中瑞药业股份有限公司 | Preparation method of food nutritive fortifier containing Radix Astragali and inositol nicotinate |
| CN103977056A (en) * | 2014-05-14 | 2014-08-13 | 凌春生 | Compound rhodiola rosea chewing tablet and preparing method thereof |
| CN105360798B (en) * | 2015-01-29 | 2018-11-16 | 华中科技大学 | A kind of enhancing endurance and the maca prescription of explosive force and preparation method thereof |
| CN105918718A (en) * | 2016-04-27 | 2016-09-07 | 青海华实科技投资管理有限公司 | Chinese wolfberry fruit-rhodiola rosea oral liquid and preparation method thereof |
| CN106954854A (en) * | 2017-04-05 | 2017-07-18 | 大连丹特生物技术有限公司 | It is a kind of that there is composition of protection eyesight fatigue-relieving function and its preparation method and application |
| CN108056461B (en) * | 2017-12-10 | 2021-04-30 | 牡丹江师范学院 | Black fungus chewable tablet with intestine moistening function and preparation method thereof |
| CN108541912A (en) * | 2018-04-13 | 2018-09-18 | 浙江依思味生物科技有限公司 | A kind of anti-oxidant blood-fat reducing composition and its preparation method and application |
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