CN107296279A - Black ginseng oral liquid and preparation method rich in the fatigue-relieving of ginsenoside Rg 5 - Google Patents
Black ginseng oral liquid and preparation method rich in the fatigue-relieving of ginsenoside Rg 5 Download PDFInfo
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- CN107296279A CN107296279A CN201710563344.7A CN201710563344A CN107296279A CN 107296279 A CN107296279 A CN 107296279A CN 201710563344 A CN201710563344 A CN 201710563344A CN 107296279 A CN107296279 A CN 107296279A
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- ginseng
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- 229910052742 iron Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000012866 low blood pressure Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
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- 210000005036 nerve Anatomy 0.000 description 1
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- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000005195 poor health Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229910052702 rhenium Inorganic materials 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 235000021228 wine soup Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a kind of black ginseng oral liquid of the fatigue-relieving rich in ginsenoside Rg 5, by 60 200 parts of ginseng by weight, 5 15 parts of gadol extract, 5 15 parts of prepared rehmannia root extract, 5 15 parts of yam extract, 5 15 parts of wolfberry fruit extract, 20 30 parts of white granulated sugar, 5 10 parts of steviol glycoside, 15 parts of sodium acid carbonate, 0.1 0.5 parts of potassium sorbate, 0.2 1 parts of sodium benzoate, 250 1000 parts of purified water are made.The present invention is using the black ginseng through the treated processing of Panax ginseng of citric acid solution as primary raw material, together with the collocation of several natural drug extracts, the Chinese medicine of synergy can be played, and various composition compatibility is reasonable, play effect of mutual help, combine alleviate physical fatigue in terms of effect significantly, and also have regain one's strength of body, energy, improve sleep, regulation endocrine etc. is acted on.And raw material is natural, and edible safety, stability is good, and mouthfeel is soft, effect is notable, with the healthcare function for alleviating physical fatigue and strengthen immunity.Present invention also offers a kind of preparation method of above-mentioned black ginseng oral liquid.
Description
Technical field
The present invention relates to health food manufacture field, a kind of black ginseng rich in the fatigue-relieving of ginsenoside Rg 5 is specifically referred to
Oral liquid and preparation method.
Background technology
Modern society's life rhythm is fast, and operating pressure is big, people is in the state of inferior health, causes immunity low
Lower and sleep insufficiency, makes people easily be attacked by the disease.
Immunity is the defense mechanism of human body itself, is any foreign matter of human bioequivalence and the external intrusion of elimination（It is viral, thin
Bacterium etc.）；Handle aging, damage, death, the own cells of denaturation and identification and processing vivo mutations cell and virus infection is thin
The ability of born of the same parents.Different people's immunity is different, and hypoimmunity is sick inherent, the underlying cause of people.Immunity
Lowly most directly performance is exactly liable to illness.Immune dysfunction or it is low when, the ability of body fight infections can be reduced, drop
Low identification and the histocyte ability for removing itself aging, the ability of reduction killing and removing abnormal sudden change cell in vivo, lead
Cause the decline of human body premunition and vis medicatrix naturae.And modern society, the quickening of rhythm of life, the increase of competitive pressure, daily anxiety
Working and learning can make body be in overdraw state, such as timely cannot rest and adjust, accumulate over a long period, will suppress to exempt from
Epidemic disease function；Meanwhile, nervous working and learning allow more people to have to instant fast food, cause the mistake of endotrophic element
Weighing apparatus, if body is chronically at this state, can decline immunity of organisms, ultimately result in the sub-health state of body.Effectively
Improve the health products of immunity tightly needs for market.
The content of the invention
It is an object of the invention to provide a kind of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5.
It is a further object to provide a kind of preparation of the black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5
Method.
The technical scheme is that：
A kind of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5, is formulated by weight by following raw materials according：Ginseng
60-200 parts, 5-15 parts of gadol extract, 5-15 parts of prepared rehmannia root extract, 5-15 parts of yam extract, wolfberry fruit extract 5-
15 parts, 20-30 parts of white granulated sugar, 1-10 parts of steviol glycoside, 1-5 parts of sodium acid carbonate, 0.1-0.5 parts of potassium sorbate, sodium benzoate
0.2-1 parts, 250-1000 parts of purified water.
Further, the raw material is formulated by weight：120 parts of ginseng, 10 parts of gadol extract, prepared rhizome of rehmannia is carried
Take 10 parts of thing, 8 parts of yam extract, 6 parts of wolfberry fruit extract, 25 parts of white granulated sugar, 5 parts of steviol glycoside, 3 parts of sodium acid carbonate, sorb
Sour 0.3 part of potassium, 0.5 part of sodium benzoate, 600 parts of purified water.
Further, described ginseng is the black ginseng rich in ginsenoside Rg 5, is to be made as follows：Ginseng is clear
Punched after washing, according to ginseng shape and the difference of size, hole depth and be spaced about 0.5-1.2cm, then 3h is soaked with citric acid solution,
Under the conditions of 45-60 DEG C, 1h is dried, is steamed, is steamed after end afterwards, dried under the conditions of 45-65 DEG C, steamed, dry
Dry process is repeated 3 times, and last moisture content reaches 10-20%, and products obtained therefrom is the black ginseng rich in ginsenoside Rg 5.One kind is as above
The preparation method of the described black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5, comprises the following steps：
A, according to parts by weight requirement weigh ginseng, gadol extract, prepared rehmannia root extract, yam extract, matrimony vine extract
Thing, white granulated sugar, steviol glycoside, and sodium acid carbonate, potassium sorbate, sodium benzoate and purified water are added according to actual conditions in right amount；
B, ginseng is cleaned after punch, according to ginseng shape and the difference of size, hole depth and be spaced about 0.5-1.2cm, then use lemon
Acid solution soaks 3h, under the conditions of 45-60 DEG C, dries 1h, is steamed, steamed after end afterwards, entered under the conditions of 45-65 DEG C
Row drying, is steamed, drying course is repeated 3 times, last moisture content is advisable up to 15% or so, and products obtained therefrom is to be rich in ginsenoside
Rg5 black ginseng；
C, by black ginseng coarse crushing, plus 4-5 times is measured 70% ethanol, 85 DEG C, extracts 2 times, 8h/ time, then plus 4-5 times measure water, 85 DEG C, carry
Take 2 times, 8h/ times, merge Aqueous extracts and alcohol extract, and add load weighted gadol extract, prepared rehmannia root extract, Chinese yam and carry
Thing and wolfberry fruit extract are taken, mixed dissolution is uniformly filtered afterwards, centrifuge, be concentrated under reduced pressure, obtain mixing thick paste；
D, white granulated sugar, steviol glycoside, sodium acid carbonate, potassium sorbate and sodium benzoate dissolved with purified water respectively, obtain white sand
Sugar and steviol glycoside mixing molasses, sodium bicarbonate solution, potassium sorbate and sodium benzoate mixed solution；
E, mixing molasses, mixing thick paste, potassium sorbate and sodium benzoate mixed solution sequentially added in material-compound tank, add purifying
Water mixing 5-10min, adds sodium bicarbonate solution, and constant volume obtains the semi-finished product feed liquid that pH value is 5-7；
F, by semi-finished product feed liquid filtering, it is filling, roll lid, moist heat sterilization, obtain black ginseng oral liquid.
Further, the concentration of citric acid solution is 2%-5% in described step b.
Further, the temperature of ginseng steaming is 115-125 DEG C in described step b；The time of ginseng steaming is by ginseng shape
Size is divided into：Big ginseng 4.5h, middle ginseng 3.5h, small ginseng 3h.
Further, filtering described in described step c is filtered using plate-frame filtering or 300 mesh silks；What is centrifuged reports
For 13000r/min；The temperature that is concentrated under reduced pressure is 90 DEG C.
Further, the mixing thick paste in described step c is at 80 DEG C, and relative density is 1.10-1.20.
Further, the temperature of moist heat sterilization is 105 DEG C in described step e, and the time is 20-30min.
In the present invention, the fleshy root of ginseng is famous strong tonic, it is adaptable to adjusts blood pressure, recover cardiac function, god
Through the disease such as weak and in poor health, also there is the effects such as eliminating the phlegm, stomach invigorating, diuresis, excitement.Mainly contain 18 kinds（More than totally 40 plant）Ginseng
Saponin(e：Ro, Rb1, Rb2, Rb3, Rc, Re, Rf, Rf2, Rg1, Rg2 etc., wherein Rb groups are also known as panoxadiol type, and R is also known as ginseng
Three alcohol type, Ro groups then claim oleanolic acid type.What wherein content was high has Rb1, Rb2, Rc, Re and Rg1.Order contains panaxan（7%~
9%）, oligomeric peptides and amino acid, inorganic salts, vitamin and essential oil etc..The physiological function of ginseng：1. antifatigue effect：Drop
The oxygen demand of low body, is the fatigability reduction of brain excitement process.2. ginseng Central nervous system has excitation, and
There is inhibitory action on the contrary when a large amount of.Excitement and the process of inhibition of animal higher nervous activity can be strengthened.And body can be strengthened to one
The adaptability of nonspecific stimulation is cut, sense of fatigue can be reduced.3. brain tonic, increasing intelligence effect.4. anti-aging.5. Auto-regulator generation
Thank.6. to the effect of cardiovascular system：Cardiotonic, resist myocardial ischemia, expand blood vessel.7. blood is influenceed：Make red blood cell, it is white
Cell, amount of hemoglobin increase；Promote marrow DNA RNA protein lipid synthesis.8. the influence of Endocrine system.
9. antitumor action.10. immunologic function is adjusted：The activity of the physical phagocyte of enhancing；Body fight is stimulated to originate in raw corresponding anti-
Body；Promote T cell and B cell proliferation.Fresh ginseng is steamed through three times, after three drying, the black ginseng of gained can make
With the monomer saponin content increase of physical fatigue is alleviated, while producing some new rare saponin(es, such as：Ginsenoside Re, Rg1
With Rg5 etc..Ginsenoside Re suppresses nervous centralis, promotes DNA, RNA synthesis.The effect of plasma corticosterone is raised, blood vessel is expanded.
The contraction in guinea pig in vitro uterus caused by acetylcholine can be reduced.There are reducing heart rate and Bipolar blood pressure to rat（Fall after rising）
Effect.Behavior and electroencephalogram to cat show medium suppression.There is antifatigue effect.Ginsenoside Rg1 can rapid recovery fatigue,
Improve learning and memory, anti-aging, with stimulating central nervous system effect, suppress platelet aggregation effect.Ginsenoside Rg 5 is two
Product of the alcohol saponin(e by hydrolysis.Ginsenoside Rg 5 can significantly reduce the incidence of lung cancer.It is considered as anticancer in red ginseng
Active material.Suppress cancer cell infiltration, antitumor cell transfer, promote apoptosis of tumor cells, suppress growth of tumour cell.Simultaneously
With the effect for alleviating physical fatigue.
Rhodiola root is herbaceos perennial, and modern medicine study is proved, 35 kinds of trace elements, 18 kinds are contained in rhodiola root
Amino acid, vitamin A. D. E and activity of fighting against senium superoxides, its nutritional ingredient is complete and compatibility is reasonable, is found at present
Plant in be rare.In terms of pharmacology, have been demonstrated that rhodiola root has central excitation to act on and " adapting to as former state " effect, energy
People " tired " is eliminated, strengthens memory and notice, the heart of quickening contraction frequency is recovered normal.The pharmacy of recent domestic
Worker conducts in-depth research to rhodiola root, it is proposed that rhodiola root has " adapting to as former state " of similar ginseng " strengthening the body resistance to consolidate the constitution "
Effect, and ginseng is also advantageous in some aspects, without the too strong deficiency of ginseng excitation.Active ingredient contained by rhodiola root
With cardiac stimulant is calm, regulation is metabolic, adjust nervous system and internal system bidirectional modulation blood glucose, the effect of blood pressure, use
In treatment cranial vascular disease, the disease such as senile myocardial failure, diabetes, low blood pressure, be also used for it is physically weak after being ill, old,
Nerve is weak etc..
Prepared rhizome of rehmannia is sweet, tepor.Return liver and kidney channel.Prepared rhizome of rehmannia has cardiac stimulant, diuresis, hypoglycemic and rise peripheral leukocytes, increases
The effects such as strong immunologic function.
Chinese yam is the medicine in mountain, the medicine in food.Health food, and the medicinal valency with recuperating disease can not only be made
Value.《Compendium of Materia Medica》Point out：Chinese yam controls weakness, treats general debility, decaptitating seborrheic dematitis, stops pain in the back, relieving restlessness heat, bushing gas not
Foot, reach heart hole, many accounts, kidney-nourishing gas, strengthening the spleen and stomach, antidiarrheal dysentery, profit fur, it is raw to smash that patch is swollen, hard poison be controlled；《Join in medical science inner feelings
West record》In good wine soup and grow training soup, with Chinese yam match somebody with somebody the Radix Astragali, can control quench one's thirst, consumptive disease breathes heavily inverse, often combine with the fruit of Chinese wolfberry, mulberry fruit
Son wait these integration of drinking and medicinal herbs Chinese medicine do tea bubble drink, can kidney-tonifying health-care, build up resistance, preferable health care can be played
Effect.Research in the last few years shows that there is Chinese yam induction to produce interferon, strengthens the effect of immune function of human body.Contained by it
Choline and lecithin are favorably improved man memory power, often to eat can body-building, anti-aging, be the health care that people are liked
Good merchantable brand.Based on Chinese yam, it is aided with the bionic foods that konjaku is made, the effect of with nutritious, healthcare, skin maintenance,
It is rare health-nutrition cuisines.
Matrimony vine contains glycine betaine, polysaccharide, crude fat, crude protein, carrotene, vitamin A, vitamin C, vitamin B1, dimension
The raw element nutritional ingredient such as B2 and calcium, phosphorus, iron, zinc, manganese, linoleic acid.There is enhancing nospecific immunity effect, suppress tumour, drop blood
Sugar, reducing blood lipid is antifatigue to wait function.
White granulated sugar：For most widely used sugar in daily life, the crystalline solid containing sucrose more than 95% is in formula
Sweetener.
Stevioside：（It is commonly called as stevioside, steviol glycoside）It is a kind of from catananche's STEVIA REBAUDIANA（Or stevia rebaudian leaf）
The new type natural sweetener that middle essence is carried.
Sodium acid carbonate：Food-grade, is acidity regulator in formula, improves the effect of finished product clarity.
Potassium sorbate：Food-grade, is preservative, antioxidant, stabilizer.
Sodium benzoate：Food-grade, is preservative.
Ginseng, gadol extract, prepared rehmannia root extract, yam extract, wolfberry fruit extract in the present invention, for original
Material, white granulated sugar, steviol glycoside, sodium acid carbonate, potassium sorbate, sodium benzoate are auxiliary material.Above-mentioned raw materials and auxiliary material all can be by these
Art personnel conventional method is obtained, such as commercially available, gadol extract（Xi'an Bai Chuan bio tech ltd, lot number：
BC20160709-1）, prepared rehmannia root extract（Xi'an Bai Chuan bio tech ltd, lot number：BC20170121-1）, Chinese yam carries
Take thing（Xi'an Bai Chuan bio tech ltd, lot number：BC20160811）, wolfberry fruit extract（Xi'an Bai Chuan biotechnologies have
Limit company, lot number：BC20161003-2）.
Compared with prior art, beneficial effects of the present invention are：
Ginseng selected by the black ginseng oral liquid of the present invention passes through the processing of citric acid solution, the black ginseng processed, ginseng soap
Glycosides Rg5 content is significantly improved.
The black ginseng oral liquid mouthfeel of the present invention is soft, no astringent sense.
The black ginseng oral liquid of the present invention can alleviate physical fatigue, it is adaptable to be chronically at the crowd moiled.
The preparation method of the black ginseng oral liquid of the present invention, by techniques such as centrifugation, filtering, regulation pH values, solves black ginseng
The problem of oral liquid clarity, product stability and effect are significantly improved, method is simple to operation, be easy to industrialize continuous life
Production.
Determine the anti-fatigue test of the black ginseng Oral Liquid On Mice endurance influence of the present invention
Test method：Take inbred mouse (20-22g) 40, single sex is randomly divided into 4 groups, blank control group and medicine
Group.Drug component is basic, normal, high 3 dosage groups, black ginseng oral liquid is dissolved into physiological saline, compound concentration is followed successively by
100、250、500mg/kg；Blank control group gives isometric physiological saline.It is 0.2ml/10g, gavage 1 to give volume
Times/day, mouse, in 30 minutes after last dose, is put into swimming trunk by successive administration 15 days（50cm*50cm*60cm）Swum
Swimming experiment, the depth of water is not less than 30cm, and 20 DEG C of water temperature is born a heavy burden per rat-tail portion for the galvanized wire of body weight 5%.It is put into swimming pool and starts timing,
Terminate to dead mouse, record every mouse swimming time.
Result of the test：The influence of black ginseng Oral Liquid On Mice swimming endurance
Note：Compared * P ＜ 0.05, * * P ＜ 0.01 with blank group.
Conclusion (of pressure testing)：Compared with blank control group, the present invention is black, and ginseng oral liquid middle dose group can extend mouse swimming time,
With significant difference（P ＜ 0.05）；High dose group can significantly extend mouse swimming time, with pole significant (P ＜
0.01), show that the present composition has antifatigue effect, and in dosage effect dependence.
In summary, black ginseng oral liquid of the invention, with good anti-fatigue effect, and in dosage effect dependence,
It can show that the black ginseng oral liquid of the present invention can effectively improve human immunity power accordingly.
Brief description of the drawings
Fig. 1 is the process chart of preparation method of the present invention.
Embodiment
In order to further appreciate that the present invention, the preferred embodiments of the invention are retouched with reference to embodiment
State, it is to be understood that, these descriptions are simply to further illustrate the features and advantages of the invention, rather than patent of the present invention is wanted
The limitation asked.
Embodiment 1
The preferred weight number of black each raw material of ginseng oral liquid of the present invention is respectively：120 parts of ginseng, 10 parts of gadol extract,
10 parts of prepared rehmannia root extract, 8 parts of yam extract, 6 parts of wolfberry fruit extract, 25 parts of white granulated sugar, 5 parts of steviol glycoside, sodium acid carbonate 3
Part, 0.3 part of potassium sorbate, 0.5 part of sodium benzoate, 600 parts of purified water.
As shown in figure 1, the preparation method of the black ginseng oral liquid of the present invention, step is as follows：
A, according to parts by weight requirement weigh ginseng, gadol extract, prepared rehmannia root extract, yam extract, matrimony vine extract
Thing, white granulated sugar, steviol glycoside, and sodium acid carbonate, potassium sorbate, sodium benzoate and purified water are added according to actual conditions in right amount；
B, ginseng is cleaned after punch, according to ginseng shape and the difference of size, hole depth and be spaced about 0.5-1.2cm, then use 2%-5%
Citric acid solution soaks 3h, under the conditions of 45-60 DEG C, dries 1h, is steamed afterwards, and steaming temperature is 120 DEG C, steaming time
（Big ginseng 4.5h, middle ginseng 3.5h, small ginseng 3h）.Steam after end, dried under the conditions of 45-60 DEG C, steamed, drying course weight
Multiple 3 times, last moisture content is advisable up to 15% or so, and products obtained therefrom is the black ginseng rich in ginseng sapoglycoside Rg 3；
C, by black ginseng coarse crushing, plus 4-5 times is measured 70% ethanol, 85 DEG C, extracts 2 times, 8h/ time, then plus 4-5 times measure water, 85 DEG C, carry
Take 2 times, 8h/ times, merge Aqueous extracts and alcohol extract, and add load weighted gadol extract, prepared rehmannia root extract, Chinese yam and carry
Thing and wolfberry fruit extract are taken, mixed dissolution is uniformly filtered afterwards（300 mesh silks）, centrifugation（13000r/min）, it is concentrated under reduced pressure（Concentration
Temperature is 90 DEG C）, obtain mixing thick paste（80 DEG C of relative density is 1.10-1.20）；
D, white granulated sugar, steviol glycoside, sodium acid carbonate, potassium sorbate and sodium benzoate dissolved with purified water respectively, obtain white sand
Sugar and steviol glycoside mixing molasses, sodium bicarbonate solution, potassium sorbate and sodium benzoate mixed solution；
E, mixing molasses, mixing thick paste, potassium sorbate and sodium benzoate mixed solution sequentially added in material-compound tank, add purifying
Water mixing 5-10min, adds sodium bicarbonate solution, and constant volume obtains the semi-finished product feed liquid that pH value is 5-7；
F, by semi-finished product feed liquid filtering, it is filling, roll lid, moist heat sterilization, obtain black ginseng oral liquid.Wherein, filtering can use qualitative
Filter paper, quantitative filter paper, miillpore filter etc., preferably qualitative filter paper.The temperature of moist heat sterilization is 105 DEG C, and the time is 20-30min.It is real
Border production in, after moist heat sterilization can further to it is black ginseng oral liquid be cooled down, lamp inspection, packaging.
Embodiment 2
The parts by weight of each raw material are respectively in black ginseng oral liquid, prescription：120 parts of ginseng, 10 parts of gadol extract, prepared rhizome of rehmannia
10 parts of extract, 10 parts of yam extract, 10 parts of wolfberry fruit extract, 25 parts of white granulated sugar, 3 parts of steviol glycoside, 4 parts of sodium acid carbonate,
0.4 part of potassium sorbate, 0.6 part of sodium benzoate, 700 parts of purified water.
The preparation method of above-mentioned black ginseng oral liquid, step is as follows：
A, according to parts by weight requirement weigh ginseng, gadol extract, prepared rehmannia root extract, yam extract, matrimony vine extract
Thing, white granulated sugar, steviol glycoside, and sodium acid carbonate, potassium sorbate, sodium benzoate and purified water are added according to actual conditions in right amount；
B, ginseng is cleaned after punch, according to ginseng shape and the difference of size, hole depth and be spaced about 0.5-1.2cm, then use 4% lemon
Lemon acid solution soaks 3h, under the conditions of 50 DEG C, dries 1h, steams, steamed after end under the conditions of 115 DEG C, under the conditions of 50 DEG C
Dried, steamed, drying course is repeated 3 times, to moisture content up to 15%, products obtained therefrom is black rich in ginseng sapoglycoside Rg 3
Ginseng；
C, by black ginseng coarse crushing, plus 5 times of 70% ethanol of amount, extract 2 times by 85 DEG C, 8h/ time, then add 5 times of amount water, 85 DEG C, extraction 2
It is secondary, 8h/ times, merge Aqueous extracts and alcohol extract, and load weighted gadol extract, prepared rehmannia root extract are added, Chinese yam is extracted
Thing and wolfberry fruit extract, mixed dissolution are uniformly filtered with 300 mesh silks afterwards, centrifugation（13000r/min）, it is concentrated under reduced pressure, is mixed
Thick paste is closed, relative density is 1.10（80 DEG C of surveys）；
D, white granulated sugar, steviol glycoside, sodium acid carbonate, potassium sorbate and sodium benzoate dissolved with purified water respectively, obtain white sand
Sugar and steviol glycoside mixing molasses, sodium bicarbonate solution, potassium sorbate and sodium benzoate mixed solution；
E, mixing molasses, mixing thick paste, potassium sorbate and sodium benzoate mixed solution sequentially added in material-compound tank, add purifying
Water mixing 5min, adds sodium bicarbonate solution, and constant volume obtains the semi-finished product feed liquid that pH value is 5；
F, semi-finished product feed liquid is filtered with qualitative filter paper after, filling, roll lid, moist heat sterilization, the temperature of moist heat sterilization temperature is 105
DEG C, the time is 20min, obtains black ginseng oral liquid.
Embodiment 3,
The parts by weight of each raw material are respectively in black ginseng oral liquid, prescription：180 parts of ginseng, 12 parts of gadol extract, prepared rhizome of rehmannia
12 parts of extract, 8 parts of yam extract, 8 parts of wolfberry fruit extract, 30 parts of white granulated sugar, 2 parts of steviol glycoside, 4 parts of sodium acid carbonate, mountain
0.4 part of potassium sorbate, 0.8 part of sodium benzoate, 850 parts of purified water.
The preparation method of above-mentioned black ginseng oral liquid, step is as follows：
A, according to parts by weight requirement weigh ginseng, gadol extract, prepared rehmannia root extract, yam extract, matrimony vine extract
Thing, white granulated sugar, steviol glycoside, and sodium acid carbonate, potassium sorbate, sodium benzoate and purified water are added according to actual conditions in right amount；
B, ginseng is cleaned after punch, according to ginseng shape and the difference of size, hole depth and be spaced about 0.5-1.2cm, then use 2% lemon
Lemon acid solution soaks 3h, under the conditions of 55 DEG C, dries 1h, steams, steamed after end under the conditions of 125 DEG C, under the conditions of 55 DEG C
Dried, steamed, drying course is repeated 3 times, to moisture content up to 15%, products obtained therefrom is black rich in ginseng sapoglycoside Rg 3
Ginseng；
C, by black ginseng coarse crushing, plus 5 times of 70% ethanol of amount, extract 2 times by 85 DEG C, 8h/ time, then add 5 times of amount water, 85 DEG C, extraction 2
It is secondary, 8h/ times, merge Aqueous extracts and alcohol extract, and add load weighted gadol extract, prepared rehmannia root extract, Chinese yam and extract
Thing and wolfberry fruit extract, mixed dissolution are uniformly filtered with 300 mesh silks afterwards, centrifugation（13000r/min）, it is concentrated under reduced pressure, is mixed
Thick paste is closed, relative density is 1.15（80 DEG C of surveys）；
D, white granulated sugar, steviol glycoside, sodium acid carbonate, potassium sorbate and sodium benzoate dissolved with purified water respectively, obtain white sand
Sugar and steviol glycoside mixing molasses, sodium bicarbonate solution, potassium sorbate and sodium benzoate mixed solution；
E, mixing molasses, mixing thick paste, potassium sorbate and sodium benzoate mixed solution sequentially added in material-compound tank, add purifying
Water mixing 10min, adds sodium bicarbonate solution, and constant volume obtains the semi-finished product feed liquid that pH value is 6；
F, semi-finished product feed liquid is filtered with qualitative filter paper after, filling, roll lid, moist heat sterilization, the temperature of moist heat sterilization temperature is 105
DEG C, the time is 25min, obtains black ginseng oral liquid.
Embodiment 4
The parts by weight of each raw material are respectively in black ginseng oral liquid, prescription：150 parts of ginseng, 12 parts of gadol extract, prepared rhizome of rehmannia
10 parts of extract, 10 parts of yam extract, 10 parts of wolfberry fruit extract, 30 parts of white granulated sugar, 5 parts of steviol glycoside, 4 parts of sodium acid carbonate,
0.5 part of potassium sorbate, 0.8 part of sodium benzoate, 900 parts of purified water.
The preparation method of above-mentioned black ginseng oral liquid, step is as follows：
A, according to parts by weight requirement weigh ginseng, gadol extract, prepared rehmannia root extract, yam extract, matrimony vine extract
Thing, white granulated sugar, steviol glycoside, and sodium acid carbonate, potassium sorbate, sodium benzoate and purified water are added according to actual conditions in right amount；
B, ginseng is cleaned after punch, according to ginseng shape and the difference of size, hole depth and be spaced about 0.5-1.2cm, then use 3% lemon
Lemon acid solution soaks 3h, under the conditions of 50 DEG C, dries 1h, steams, steamed after end under the conditions of 120 DEG C, under the conditions of 50 DEG C
Dried, steamed, drying course is repeated 3 times, to moisture content up to 15%, products obtained therefrom is black rich in ginseng sapoglycoside Rg 3
Ginseng；
C, by black ginseng coarse crushing, plus 5 times of 70% ethanol of amount, extract 2 times by 85 DEG C, 8h/ time, then add 5 times of amount water, 85 DEG C, extraction 2
It is secondary, 8h/ times, merge Aqueous extracts and alcohol extract, and add load weighted gadol extract, prepared rehmannia root extract, Chinese yam and extract
Thing and wolfberry fruit extract, mixed dissolution uniformly use plate-frame filtering afterwards, centrifugation（13000r/min）, it is concentrated under reduced pressure（90 DEG C of temperature）,
Obtain mixing thick paste, relative density is 1.10（80 DEG C of surveys）；
D, white granulated sugar, steviol glycoside, sodium acid carbonate, potassium sorbate and sodium benzoate dissolved with purified water respectively, obtain white sand
Sugar and steviol glycoside mixing molasses, sodium bicarbonate solution, potassium sorbate and sodium benzoate mixed solution；
E, mixing molasses, mixing thick paste, potassium sorbate and sodium benzoate mixed solution sequentially added in material-compound tank, add purifying
Water mixing 5min, adds sodium bicarbonate solution, and constant volume obtains the semi-finished product feed liquid that pH value is 6.5；
F, semi-finished product feed liquid is filtered with qualitative filter paper after, filling, roll lid, moist heat sterilization, the temperature of moist heat sterilization temperature is 105
DEG C, the time is 30min, obtains black ginseng oral liquid.
Obviously, the explanation of above example is only applicable to the method and its core concept for helping to understand the present invention.It should refer to
Go out, can also be to this hair for the those of ordinary skill of the technical field, then without departing from the principles of the invention
Bright to carry out some improvement and modification, these are improved and modification is also fallen into the protection domain of the claims in the present invention.
Claims (9)
1. a kind of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5, is formulated by weight by following raw materials according：People
60-200 parts of ginseng, 5-15 parts of gadol extract, 5-15 parts of prepared rehmannia root extract, 5-15 parts of yam extract, wolfberry fruit extract
5-15 parts, 20-30 parts of white granulated sugar, 1-10 parts of steviol glycoside, 1-5 parts of sodium acid carbonate, 0.1-0.5 parts of potassium sorbate, sodium benzoate
0.2-1 parts, 250-1000 parts of purified water.
2. a kind of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5 according to claim 1, it is characterised in that institute
Raw material is stated to be formulated by weight：120 parts of ginseng, 10 parts of gadol extract, 10 parts of prepared rehmannia root extract, yam extract
8 parts, 6 parts of wolfberry fruit extract, 25 parts of white granulated sugar, 5 parts of steviol glycoside, 3 parts of sodium acid carbonate, 0.3 part of potassium sorbate, sodium benzoate
0.5 part, 600 parts of purified water.
3. a kind of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5 according to claim 1 or 2, its feature exists
It is the black ginseng rich in ginsenoside Rg 5 in described ginseng, is to be made as follows：Punched after ginseng is cleaned, according to ginseng
The difference of shape and size, hole depth and is spaced about 0.5-1.2cm, then soaks 3h with citric acid solution, under the conditions of 45-60 DEG C,
1h is dried, is steamed, is steamed after end afterwards, dried under the conditions of 45-65 DEG C, steamed, drying course is repeated 3 times,
Last moisture content reaches 10-20%, and products obtained therefrom is the black ginseng rich in ginsenoside Rg 5.
4. a kind of preparation method of the black ginseng oral liquid as claimed in claim 1 rich in the fatigue-relieving of ginsenoside Rg 5, including
Following steps：
A, according to parts by weight requirement weigh ginseng, gadol extract, prepared rehmannia root extract, yam extract, matrimony vine extract
Thing, white granulated sugar, steviol glycoside, and sodium acid carbonate, potassium sorbate, sodium benzoate and purified water are added according to actual conditions in right amount；
B, ginseng is cleaned after punch, according to ginseng shape and the difference of size, hole depth and be spaced about 0.5-1.2cm, then use lemon
Acid solution soaks 3h, under the conditions of 45-60 DEG C, dries 1h, is steamed, steamed after end afterwards, entered under the conditions of 45-65 DEG C
Row drying, is steamed, drying course is repeated 3 times, last moisture content is advisable up to 15% or so, and products obtained therefrom is to be rich in ginsenoside
Rg5 black ginseng；
C, by black ginseng coarse crushing, plus 4-5 times is measured 70% ethanol, 85 DEG C, extracts 2 times, 8h/ time, then plus 4-5 times measure water, 85 DEG C, carry
Take 2 times, 8h/ times, merge Aqueous extracts and alcohol extract, and add load weighted gadol extract, prepared rehmannia root extract, Chinese yam and carry
Thing and wolfberry fruit extract are taken, mixed dissolution is uniformly filtered afterwards, centrifuge, be concentrated under reduced pressure, obtain mixing thick paste；
D, white granulated sugar, steviol glycoside, sodium acid carbonate, potassium sorbate and sodium benzoate dissolved with purified water respectively, obtain white sand
Sugar and steviol glycoside mixing molasses, sodium bicarbonate solution, potassium sorbate and sodium benzoate mixed solution；
E, mixing molasses, mixing thick paste, potassium sorbate and sodium benzoate mixed solution sequentially added in material-compound tank, add purifying
Water mixing 5-10min, adds sodium bicarbonate solution, and constant volume obtains the semi-finished product feed liquid that pH value is 5-7；
F, by semi-finished product feed liquid filtering, it is filling, roll lid, moist heat sterilization, obtain black ginseng oral liquid.
5. a kind of preparation method of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5 according to claim 4, its
The concentration for being characterised by citric acid solution in described step b is 2%-5%.
6. a kind of preparation method of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5 according to claim 4, its
The temperature for being characterised by ginseng steaming in described step b is 115-125 DEG C；The time of ginseng steaming is divided into by ginseng shape size：
Big ginseng 4.5h, middle ginseng 3.5h, small ginseng 3h.
7. a kind of preparation method of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5 according to claim 4, its
Filtering described in step c described in being characterised by is filtered using plate-frame filtering or 300 mesh silks；What is centrifuged reports as 13000r/
min；The temperature that is concentrated under reduced pressure is 90 DEG C.
8. a kind of preparation method of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5 according to claim 4, its
The mixing thick paste in described step c is characterised by 80 DEG C, relative density is 1.10-1.20.
9. a kind of preparation method of black ginseng oral liquid rich in the fatigue-relieving of ginsenoside Rg 5 according to claim 4, its
The temperature for being characterised by moist heat sterilization in described step e is 105 DEG C, and the time is 20-30min.
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