CN103249727B - 联芳酰胺衍生物 - Google Patents

联芳酰胺衍生物 Download PDF

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Publication number
CN103249727B
CN103249727B CN201180059302.0A CN201180059302A CN103249727B CN 103249727 B CN103249727 B CN 103249727B CN 201180059302 A CN201180059302 A CN 201180059302A CN 103249727 B CN103249727 B CN 103249727B
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CN
China
Prior art keywords
fluoro
base
methyl
chloro
amide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201180059302.0A
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English (en)
Chinese (zh)
Other versions
CN103249727A (zh
Inventor
约翰尼斯·埃比
阿尔弗雷德·宾格里
科妮莉亚·赫特尔
安尼施·阿索克·康卡尔
豪格·屈内
贝恩德·库恩
汉斯·P·梅尔基
王海燕
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
CN201180059302.0A 2010-12-27 2011-12-22 联芳酰胺衍生物 Expired - Fee Related CN103249727B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10197030.9 2010-12-27
EP10197030 2010-12-27
PCT/EP2011/073717 WO2012089601A1 (en) 2010-12-27 2011-12-22 New biaryl amide derivatives

Publications (2)

Publication Number Publication Date
CN103249727A CN103249727A (zh) 2013-08-14
CN103249727B true CN103249727B (zh) 2016-08-10

Family

ID=45401081

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180059302.0A Expired - Fee Related CN103249727B (zh) 2010-12-27 2011-12-22 联芳酰胺衍生物

Country Status (11)

Country Link
US (2) US8912221B2 (enExample)
EP (1) EP2658848A1 (enExample)
JP (1) JP2014501266A (enExample)
KR (1) KR20140014114A (enExample)
CN (1) CN103249727B (enExample)
AR (1) AR084606A1 (enExample)
BR (1) BR112013016431A2 (enExample)
CA (1) CA2822188A1 (enExample)
MX (1) MX2013005753A (enExample)
RU (1) RU2013133280A (enExample)
WO (1) WO2012089601A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
CN105294520A (zh) * 2015-11-23 2016-02-03 大连九信生物化工科技有限公司 一种2-（2’,2’-二氟乙氧基）-6-三氟甲基苯基丙基硫醚的合成工艺
IL291783A (en) * 2019-10-02 2022-06-01 Domain Therapeutics ep4 prostaglandin e2 receptor antagonists
TW202120479A (zh) 2019-11-27 2021-06-01 瑞士商先正達農作物保護公司 用於製備具有3-含硫取代基的5-氯-吡啶-2-羧酸及羧酸酯之方法
TW202134214A (zh) 2020-03-04 2021-09-16 瑞士商先正達農作物保護公司 用於製備具有3-含硫取代基的5-氯-吡啶-2-甲酸醯胺以及甲酸鹽之方法
JP2023545399A (ja) * 2020-10-01 2023-10-30 バイエル アクチェンゲゼルシャフト ベンズアルデヒドオキシムおよびその製造方法
TW202229238A (zh) 2020-10-09 2022-08-01 瑞士商先正達農作物保護公司 用於製備５－（１－氰基環丙基）－吡啶－２－甲酸、酯、醯胺和腈之方法
CN114671747B (zh) * 2022-04-08 2024-10-29 浙江永太科技股份有限公司 一种4-氯-2-氟苯甲醛的合成方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1630633A (zh) * 2002-02-08 2005-06-22 麦克公司 用作缓激肽拮抗剂的在其甲基上具有取代基的n－联苯甲基氨基环烷烃羧酰胺衍生物
CN1678320A (zh) * 2002-08-29 2005-10-05 麦克公司 N－联芳基甲基氨基环烷酰胺衍生物
CN1832922A (zh) * 2003-08-07 2006-09-13 默克公司 磺酰基取代的n－(联芳基甲基)氨基环丙烷甲酰胺类
CN1926136A (zh) * 2004-03-02 2007-03-07 默克公司 作为缓激肽拮抗剂的氨基环丙烷羧酰胺衍生物
CN101528685A (zh) * 2006-10-27 2009-09-09 吉瑞工厂 作为缓激肽拮抗剂的新苯甲酰胺衍生物
WO2010097374A1 (de) * 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Verbindungen als bradykinin-b1-antagonisten
WO2010097372A1 (de) * 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Verbindungen als bradykinin-b1-antagonisten

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070012552A (ko) * 2004-05-13 2007-01-25 베링거 인겔하임 인터내셔날 게엠베하 신규한 치환된 티오펜카복스아미드, 이의 제조방법 및약제로서의 이의 용도
DE102004047840A1 (de) * 2004-09-29 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
PL2225238T3 (pl) * 2007-11-29 2015-03-31 Boehringer Ingelheim Int Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego
US8470820B2 (en) * 2010-01-22 2013-06-25 Hoffman-La Roche Inc. Nitrogen-containing heteroaryl derivatives
JP5911503B2 (ja) * 2010-11-15 2016-04-27 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． アミロイド線維形成関連状態を処置するためのジペプチドアナログ
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
US8592426B2 (en) * 2011-01-24 2013-11-26 Hoffmann—La Roche Inc. Aryl-benzocycloalkyl amide derivatives
SA112330989B1 (ar) * 2011-11-17 2015-07-07 فايزر انك ببتيدات سامة للخلايا ومواد اقتران جسم مضاد وعقار منها
US9326973B2 (en) * 2012-01-13 2016-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1630633A (zh) * 2002-02-08 2005-06-22 麦克公司 用作缓激肽拮抗剂的在其甲基上具有取代基的n－联苯甲基氨基环烷烃羧酰胺衍生物
CN1678320A (zh) * 2002-08-29 2005-10-05 麦克公司 N－联芳基甲基氨基环烷酰胺衍生物
CN1832922A (zh) * 2003-08-07 2006-09-13 默克公司 磺酰基取代的n－(联芳基甲基)氨基环丙烷甲酰胺类
CN1926136A (zh) * 2004-03-02 2007-03-07 默克公司 作为缓激肽拮抗剂的氨基环丙烷羧酰胺衍生物
CN101528685A (zh) * 2006-10-27 2009-09-09 吉瑞工厂 作为缓激肽拮抗剂的新苯甲酰胺衍生物
WO2010097374A1 (de) * 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Verbindungen als bradykinin-b1-antagonisten
WO2010097372A1 (de) * 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Verbindungen als bradykinin-b1-antagonisten

Also Published As

Publication number Publication date
US20120165338A1 (en) 2012-06-28
US8912221B2 (en) 2014-12-16
AR084606A1 (es) 2013-05-29
HK1186464A1 (zh) 2014-03-14
US20150065516A1 (en) 2015-03-05
WO2012089601A1 (en) 2012-07-05
CN103249727A (zh) 2013-08-14
JP2014501266A (ja) 2014-01-20
BR112013016431A2 (pt) 2016-10-04
KR20140014114A (ko) 2014-02-05
CA2822188A1 (en) 2012-07-05
RU2013133280A (ru) 2015-02-10
MX2013005753A (es) 2013-08-01
EP2658848A1 (en) 2013-11-06

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