CN103221384A - 具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途 - Google Patents

具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途 Download PDF

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CN103221384A
CN103221384A CN2011800532493A CN201180053249A CN103221384A CN 103221384 A CN103221384 A CN 103221384A CN 2011800532493 A CN2011800532493 A CN 2011800532493A CN 201180053249 A CN201180053249 A CN 201180053249A CN 103221384 A CN103221384 A CN 103221384A
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unsubstituted
substituted
compound
acetenyl
ring
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CN103221384B (zh
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白骅
赵旭阳
龚永祥
钟金清
朱齐凤
刘晓宇
刘礼飞
周其贤
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Zhejiang Hisun Pharmaceutical Co Ltd
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Zhejiang Hisun Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C07C233/92—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
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    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

提供式（I）所示的苯甲酰胺衍生物或其药学上可接受的盐，及其制备方法和在制备治疗癌症的药物上的用途，其中式（I）中的基团定义如说明书中所述。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201180053249.3A 2010-11-05 2011-11-03 具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途 Expired - Fee Related CN103221384B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201180053249.3A CN103221384B (zh) 2010-11-05 2011-11-03 具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201010532658.9 2010-11-05
CN201010532658 2010-11-05
CN2010105326589 2010-11-05
PCT/CN2011/001854 WO2012058866A1 (zh) 2010-11-05 2011-11-03 具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途
CN201180053249.3A CN103221384B (zh) 2010-11-05 2011-11-03 具有抗癌活性的苯甲酰胺衍生物及其制备方法和用途

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CN103221384A true CN103221384A (zh) 2013-07-24
CN103221384B CN103221384B (zh) 2015-05-13

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Country Status (10)

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US (1) US8946478B2 (zh)
EP (1) EP2636667B1 (zh)
JP (1) JP5735122B2 (zh)
KR (1) KR101532850B1 (zh)
CN (1) CN103221384B (zh)
AU (1) AU2011325809B2 (zh)
BR (1) BR112013011135A2 (zh)
NZ (1) NZ610449A (zh)
RU (1) RU2565079C2 (zh)
WO (1) WO2012058866A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102119150B1 (ko) * 2018-10-23 2020-06-04 한국원자력의학원 N-1h-벤지미다졸-2-일-3-(1h-피롤-1-일) 벤자미드를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4101481A (en) * 1976-07-02 1978-07-18 Societe Distugil Process for the manufacture of stable polychloroprene latex
US5464871A (en) * 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
CN1150947A (zh) * 1995-08-24 1997-06-04 默克专利股份有限公司 链烯基-苯甲酰胍衍生物
CN101654416A (zh) * 2009-09-16 2010-02-24 成都神黄医药科技开发有限公司 N-[3-硝基-4-甲基-苯基]-4-醛基-苯甲酰胺及其制备方法以及其衍生物的制备方法
CN101827830A (zh) * 2007-10-17 2010-09-08 先正达参股股份有限公司 杀昆虫的化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1041031A3 (ru) * 1981-02-16 1983-09-07 Дзе Дау Кемикал Компани (Фирма) Способ получени замещенных бензонитрилов
ZA875840B (en) * 1986-08-09 1988-04-27 Bayer Ag Alkoximinoalkylamides
DE3709780A1 (de) * 1986-08-09 1988-02-11 Bayer Ag Alkoximinoalkylamide
CA2536313A1 (en) 2003-08-22 2005-03-03 Takeda Pharmaceutical Company Limited Fused pyrimidine derivative and use thereof
BRPI0719126B1 (pt) * 2006-12-21 2016-10-18 Syngenta Participations Ag composto, método para combater e controlar insetos, acarinos, nematódeos ou moluscos, e, composição inseticida, acaricida ou nematicida
MX2010005221A (es) 2007-11-12 2010-09-28 Bipar Sciences Inc Tratamiento de cancer de utero y cancer de ovario con un inhibidor de parp solo o en combinacion con agentes antitumorales.
JP2011503111A (ja) 2007-11-12 2011-01-27 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療
KR20100102637A (ko) 2007-12-07 2010-09-24 바이파 사이언스 인코포레이티드 토포이소머라제 억제제 및 ｐａｒｐ 억제제의 병용물에 의한 암의 치료

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4101481A (en) * 1976-07-02 1978-07-18 Societe Distugil Process for the manufacture of stable polychloroprene latex
US5464871A (en) * 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
CN1150947A (zh) * 1995-08-24 1997-06-04 默克专利股份有限公司 链烯基-苯甲酰胍衍生物
CN101827830A (zh) * 2007-10-17 2010-09-08 先正达参股股份有限公司 杀昆虫的化合物
CN101654416A (zh) * 2009-09-16 2010-02-24 成都神黄医药科技开发有限公司 N-[3-硝基-4-甲基-苯基]-4-醛基-苯甲酰胺及其制备方法以及其衍生物的制备方法

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Publication number Publication date
NZ610449A (en) 2014-12-24
RU2565079C2 (ru) 2015-10-20
RU2013125721A (ru) 2014-12-10
CN103221384B (zh) 2015-05-13
AU2011325809A1 (en) 2013-05-30
EP2636667A1 (en) 2013-09-11
WO2012058866A1 (zh) 2012-05-10
KR101532850B1 (ko) 2015-06-30
US20130225810A1 (en) 2013-08-29
EP2636667B1 (en) 2019-01-09
US8946478B2 (en) 2015-02-03
BR112013011135A2 (pt) 2016-08-02
JP2014504266A (ja) 2014-02-20
AU2011325809B2 (en) 2015-09-24
EP2636667A4 (en) 2015-08-12
KR20130083921A (ko) 2013-07-23
JP5735122B2 (ja) 2015-06-17

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