CN103209711B - 双-酰化的glp-1衍生物 - Google Patents

双-酰化的glp-1衍生物 Download PDF

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Publication number
CN103209711B
CN103209711B CN201180054077.1A CN201180054077A CN103209711B CN 103209711 B CN103209711 B CN 103209711B CN 201180054077 A CN201180054077 A CN 201180054077A CN 103209711 B CN103209711 B CN 103209711B
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China
Prior art keywords
ethoxy
amino
acetyl
carboxy
butyryl
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Active
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CN201180054077.1A
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English (en)
Chinese (zh)
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CN103209711A (zh
Inventor
A.R.马德森
B.韦乔雷克
J.科费德
J.劳
J.施佩茨勒
J.T.科德拉
L.林德罗特
P.W.加里贝
P.绍尔贝格
T.克鲁泽
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Novo Nordisk AS
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Novo Nordisk AS
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Priority to CN201610182509.1A priority Critical patent/CN105601729A/zh
Publication of CN103209711A publication Critical patent/CN103209711A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201180054077.1A 2010-11-09 2011-11-09 双-酰化的glp-1衍生物 Active CN103209711B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610182509.1A CN105601729A (zh) 2010-11-09 2011-11-09 双-酰化的glp-1衍生物

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP10190515 2010-11-09
EP10190515.6 2010-11-09
US41422110P 2010-11-16 2010-11-16
US61/414221 2010-11-16
EP11169276.0 2011-06-09
EP11169276 2011-06-09
US201161497123P 2011-06-15 2011-06-15
US61/497123 2011-06-15
PCT/EP2011/069738 WO2012062803A1 (en) 2010-11-09 2011-11-09 Double-acylated glp-1 derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610182509.1A Division CN105601729A (zh) 2010-11-09 2011-11-09 双-酰化的glp-1衍生物

Publications (2)

Publication Number Publication Date
CN103209711A CN103209711A (zh) 2013-07-17
CN103209711B true CN103209711B (zh) 2016-04-13

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201180054077.1A Active CN103209711B (zh) 2010-11-09 2011-11-09 双-酰化的glp-1衍生物
CN201610182509.1A Withdrawn CN105601729A (zh) 2010-11-09 2011-11-09 双-酰化的glp-1衍生物
CN201180054105.XA Active CN103200966B (zh) 2010-11-09 2011-11-09 具有接头的双-酰化的glp-1衍生物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201610182509.1A Withdrawn CN105601729A (zh) 2010-11-09 2011-11-09 双-酰化的glp-1衍生物
CN201180054105.XA Active CN103200966B (zh) 2010-11-09 2011-11-09 具有接头的双-酰化的glp-1衍生物

Country Status (6)

Country Link
US (3) US9708383B2 (cg-RX-API-DMAC7.html)
EP (2) EP2637699B1 (cg-RX-API-DMAC7.html)
JP (3) JP6231386B2 (cg-RX-API-DMAC7.html)
CN (3) CN103209711B (cg-RX-API-DMAC7.html)
ES (2) ES2683372T3 (cg-RX-API-DMAC7.html)
WO (2) WO2012062804A1 (cg-RX-API-DMAC7.html)

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CN105451776B (zh) * 2013-08-15 2020-04-17 诺和诺德股份有限公司 Glp-1衍生物及其用途
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TWI847306B (zh) 2017-08-24 2024-07-01 丹麥商諾佛 儂迪克股份有限公司 Ｇｌｐ-１組成物及其用途
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CN113214382B (zh) * 2018-04-19 2024-01-19 杭州先为达生物科技股份有限公司 酰化的glp-1衍生物
TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
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Also Published As

Publication number Publication date
US20130288960A1 (en) 2013-10-31
US9708383B2 (en) 2017-07-18
CN105601729A (zh) 2016-05-25
JP2014501712A (ja) 2014-01-23
EP2637698A1 (en) 2013-09-18
US20130338068A1 (en) 2013-12-19
ES2913803T3 (es) 2022-06-06
US20150210745A1 (en) 2015-07-30
ES2683372T3 (es) 2018-09-26
US9006178B2 (en) 2015-04-14
CN103209711A (zh) 2013-07-17
EP2637699A1 (en) 2013-09-18
EP2637699B1 (en) 2018-05-16
CN103200966A (zh) 2013-07-10
JP6231386B2 (ja) 2017-11-15
WO2012062804A1 (en) 2012-05-18
JP6039569B2 (ja) 2016-12-07
EP2637698B1 (en) 2022-04-20
CN103200966B (zh) 2016-10-12
JP2016188246A (ja) 2016-11-04
JP2013543853A (ja) 2013-12-09
WO2012062803A1 (en) 2012-05-18

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