CN103181837B - 用于治疗睑板腺功能障碍的热处理的系统和装置 - Google Patents
用于治疗睑板腺功能障碍的热处理的系统和装置 Download PDFInfo
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- CN103181837B CN103181837B CN201310017761.3A CN201310017761A CN103181837B CN 103181837 B CN103181837 B CN 103181837B CN 201310017761 A CN201310017761 A CN 201310017761A CN 103181837 B CN103181837 B CN 103181837B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0004—Eyes or part of the face surrounding the eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0086—Heating or cooling appliances for medical or therapeutic treatment of the human body with a thermostat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00718—Restoration of lid function
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
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- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Thermal Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Massaging Devices (AREA)
- Percussion Or Vibration Massage (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88085007P | 2007-01-17 | 2007-01-17 | |
| US60/880,850 | 2007-01-17 | ||
| US60/880850 | 2007-01-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008800087417A Division CN101663064B (zh) | 2007-01-17 | 2008-01-17 | 用于治疗睑板腺功能障碍的热处理的方法、系统和装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103181837A CN103181837A (zh) | 2013-07-03 |
| CN103181837B true CN103181837B (zh) | 2015-04-22 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310017761.3A Active CN103181837B (zh) | 2007-01-17 | 2008-01-17 | 用于治疗睑板腺功能障碍的热处理的系统和装置 |
| CN2008800087417A Active CN101663064B (zh) | 2007-01-17 | 2008-01-17 | 用于治疗睑板腺功能障碍的热处理的方法、系统和装置 |
| CN201310017764.7A Active CN103083131B (zh) | 2007-01-17 | 2008-01-17 | 用于治疗睑板腺功能障碍的热处理的方法、系统和装置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
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| CN2008800087417A Active CN101663064B (zh) | 2007-01-17 | 2008-01-17 | 用于治疗睑板腺功能障碍的热处理的方法、系统和装置 |
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Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US8950405B2 (en) | 2006-05-15 | 2015-02-10 | Tearscience, Inc. | Treatment of obstructive disorders of the eye or eyelid |
| US20070060988A1 (en) | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
| US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
| US20070016256A1 (en) | 2005-07-18 | 2007-01-18 | Korb Donald R | Method and apparatus for treating gland dysfunction |
| US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
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| CN108670190A (zh) | 2013-05-03 | 2018-10-19 | 眼泪科学公司 | 用于对睑板腺进行成像以供睑板腺分析的眼睑照明系统和方法 |
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| JP6927881B2 (ja) * | 2014-10-30 | 2021-09-01 | アルコン インコーポレイティド | 眼の疾患を手当てするシステムおよび方法 |
| CN105520805B (zh) * | 2016-02-04 | 2017-11-07 | 张晨明 | 赶压式睑板腺功能障碍治疗装置 |
| US10974063B2 (en) | 2016-06-30 | 2021-04-13 | Alcon Inc. | Light therapy for eyelash growth |
| TWI772314B (zh) * | 2016-07-12 | 2022-08-01 | 德商得瑪法公司 | 用於瘙癢症的高熱治療之裝置 |
| DK3308752T3 (da) * | 2016-10-11 | 2020-06-22 | Dermapharm Ag | Indretning til hyperthermisk behandling af kløe |
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| WO2020115557A1 (en) * | 2018-12-06 | 2020-06-11 | Alcon Inc. | Systems and methods for the treatment of eye conditions |
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| CN111658305A (zh) * | 2020-05-21 | 2020-09-15 | 李秀岩 | 一种带眼压传感器的温控眼压感应眼加热电热膜 |
| CN115957067A (zh) * | 2021-10-09 | 2023-04-14 | 上海臻复医疗科技有限公司 | 眼部冷敷装置 |
| CN114081716B (zh) * | 2022-01-22 | 2022-04-12 | 南方医科大学深圳医院 | 用于向睑板腺递送药物的装置 |
| CN117562733A (zh) * | 2022-08-08 | 2024-02-20 | 上海臻复医疗科技有限公司 | 眼杯以及眼部治疗装置 |
| WO2025143964A1 (ko) * | 2023-12-26 | 2025-07-03 | 주식회사 옵트로쓰 | 온열 시스템을 구비하는 스마트 콘택트렌즈 |
| WO2025199573A1 (en) * | 2024-03-27 | 2025-10-02 | Nthalmic Holding Pty Ltd | Smart wearable device to treat meibomian gland deficiencies |
| CN119235542B (zh) * | 2024-10-31 | 2025-07-29 | 华创视康(深圳)医疗科技有限公司 | 眼睑热敷装置 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908195B2 (en) * | 2002-01-24 | 2005-06-21 | John Robert Fuller | Therapeutic eye and eye lid cover |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3140390A (en) * | 1963-06-12 | 1964-07-07 | Smith Percy | Therapeutic appliance |
| US6107289A (en) | 1992-04-21 | 2000-08-22 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens or TGF-β |
| US5958912A (en) | 1992-04-21 | 1999-09-28 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β |
| JPH06269473A (ja) * | 1993-03-19 | 1994-09-27 | Santen Pharmaceut Co Ltd | 携帯式眼部加温器 |
| WO1997020578A1 (en) | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
| JPH11221247A (ja) * | 1997-08-25 | 1999-08-17 | Seputo:Kk | 温熱付眼鏡 |
| ATE319456T1 (de) | 1998-05-08 | 2006-03-15 | Univ Miami | Verwendung von tetracyclinen zur behandlung von störungen der meibomschen drüsen |
| TW539564B (en) * | 1999-05-25 | 2003-07-01 | Iomed Inc | Methods and apparatus for ocular iontophoresis |
| JP3613634B2 (ja) * | 2001-11-06 | 2005-01-26 | 得一郎 長谷川 | 視力矯正装置 |
| GB0225795D0 (en) * | 2002-11-05 | 2002-12-11 | Guillon Michael | Wipes |
| US7513893B2 (en) * | 2004-03-12 | 2009-04-07 | Abraham Ebbie Soroudi | Device and method for treatment of eyelid diseases |
| ATE501684T1 (de) * | 2004-11-23 | 2011-04-15 | Edward Wong | Medizinische vorrichtung zur temperaturregelung und behandlung des auges sowie des umgebenden gewebes |
| JP2006198249A (ja) * | 2005-01-21 | 2006-08-03 | Rohto Pharmaceut Co Ltd | ドライアイ治療用具 |
| US20070016256A1 (en) | 2005-07-18 | 2007-01-18 | Korb Donald R | Method and apparatus for treating gland dysfunction |
| EP3078358B1 (en) * | 2006-08-21 | 2021-01-06 | Tearscience, Inc. | Apparatus for treating gland dysfunction |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6908195B2 (en) * | 2002-01-24 | 2005-06-21 | John Robert Fuller | Therapeutic eye and eye lid cover |
Also Published As
| Publication number | Publication date |
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| EP2121109A4 (en) | 2013-01-23 |
| CN101663064B (zh) | 2013-03-06 |
| EP2121109B1 (en) | 2018-09-05 |
| EP2121109A1 (en) | 2009-11-25 |
| CN101663064A (zh) | 2010-03-03 |
| IL199920A0 (en) | 2010-04-15 |
| SG177990A1 (en) | 2012-02-28 |
| JP5406728B2 (ja) | 2014-02-05 |
| CN103181837A (zh) | 2013-07-03 |
| WO2008089327A1 (en) | 2008-07-24 |
| JP2010516343A (ja) | 2010-05-20 |
| CN103083131B (zh) | 2015-07-22 |
| CN103083131A (zh) | 2013-05-08 |
| EP3434313A1 (en) | 2019-01-30 |
| SG177991A1 (en) | 2012-02-28 |
| BRPI0806635A2 (pt) | 2011-09-06 |
| JP2014087649A (ja) | 2014-05-15 |
| ES2692434T3 (es) | 2018-12-03 |
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