CN103180312B - 用于治疗或预防因血清素、去甲肾上腺素或多巴胺的神经传导的降低所导致的紊乱的杂环化合物 - Google Patents

用于治疗或预防因血清素、去甲肾上腺素或多巴胺的神经传导的降低所导致的紊乱的杂环化合物 Download PDF

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CN103180312B
CN103180312B CN201180044090.9A CN201180044090A CN103180312B CN 103180312 B CN103180312 B CN 103180312B CN 201180044090 A CN201180044090 A CN 201180044090A CN 103180312 B CN103180312 B CN 103180312B
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alkyl
group
disorder
phenyl
absolute configuration
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CN103180312A (zh
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伊藤展明
佐佐木博文
田井国宪
篠原友一
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Otsuka Pharmaceutical Co Ltd
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WO2013137479A1 (en) * 2012-03-12 2013-09-19 Otsuka Pharmaceutical Co., Ltd. Decahydroquinoxaline derivatives and analogs thereof
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0726899B1 (de) * 1993-11-04 2000-01-19 Boehringer Ingelheim Pharma KG Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln
WO2000067735A2 (en) * 1999-05-07 2000-11-16 Recordati Industria Chimica E Farmaceutica Spa USE OF SELECTIVE ANTAGONISTS OF THE α1b-ADRENERGIC RECEPTOR FOR IMPROVEMENT OF SEXUAL DYSFUNCTION
WO2004056784A1 (de) * 2002-12-19 2004-07-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
WO2008019372A2 (en) * 2006-08-07 2008-02-14 Albany Molecular Research, Inc. 2-aminobenzoxazole carboxamides as 5ht3 modulators
WO2008023239A1 (en) * 2006-08-23 2008-02-28 Pfizer Products Inc. Pyrimidone compounds as gsk-3 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU390391A1 (ru) 1971-04-12 1973-07-11 УСТРОЙСТВО дл ИЗМЕРЕНИЯ ДАВЛЕНИЯ
SU390091A1 (ru) * 1971-07-12 1973-07-11 С. И. Бурмистров, Н. В. Макаревич , Л. Я. Кравченко Днепропетровский химико технологический институт Дзержинского Способ получения 1-аренсульфонил-4- -арилдекагидрохиноксалинов
DE4210941A1 (de) 1992-04-02 1993-10-07 Bayer Ag Neue 9-Fluor-7.oxo-7H-pyrido[1,2,3-d,e][1,4]benzoxacin-6-carbonsäuren und -ester
AU1303897A (en) * 1996-01-05 1997-08-01 Ciba-Geigy Ag Herbicidal 1,2,4,6-thiatriazines
DE69919436T2 (de) * 1998-04-16 2005-09-15 Pfizer Products Inc., Groton N-Acyl und N-Aroyl Aralkylamide
UA108596C2 (xx) * 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
TWM369750U (en) 2009-06-03 2009-12-01 Yu-Hao Shen Self-rotation mop structure
JP2012528871A (ja) * 2009-06-03 2012-11-15 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー メラニン凝集ホルモン受容体１アンタゴニストとしてのビス−ピリジルピリドン類
WO2011068171A1 (ja) * 2009-12-03 2011-06-09 第一三共株式会社 二環性含窒素飽和へテロ環誘導体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0726899B1 (de) * 1993-11-04 2000-01-19 Boehringer Ingelheim Pharma KG Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln
WO2000067735A2 (en) * 1999-05-07 2000-11-16 Recordati Industria Chimica E Farmaceutica Spa USE OF SELECTIVE ANTAGONISTS OF THE α1b-ADRENERGIC RECEPTOR FOR IMPROVEMENT OF SEXUAL DYSFUNCTION
WO2004056784A1 (de) * 2002-12-19 2004-07-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
WO2008019372A2 (en) * 2006-08-07 2008-02-14 Albany Molecular Research, Inc. 2-aminobenzoxazole carboxamides as 5ht3 modulators
WO2008023239A1 (en) * 2006-08-23 2008-02-28 Pfizer Products Inc. Pyrimidone compounds as gsk-3 inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis and a1-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin;Gianni Sagratini, et al.;《Bioorganic & Medicinal Chemistry》;20070119;第15卷;2334–2345 *

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