CN103169850A - Mongolian medicine for treating peptic ulcer - Google Patents
Mongolian medicine for treating peptic ulcer Download PDFInfo
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Abstract
The invention relates to a drug, namely a mongolian medicine for treating peptic ulcer. The mongolian medicine is characterized in that the drug is prepared from the following crude drugs in parts by weight: 2-6 parts of kanako, 3-9 parts of angelica sinensis, 2-6 parts of trogopterus dung, 5-12 parts of gypsum rubrum, 5-12 parts of myrobalan, 5-12 parts of cuttlebone, 2-6 parts of bulb of fritillary, 2-6 parts of coptis chinensis and 1-5 parts of elecampane. The anaesthetic has the beneficial effects of being significant in curative effect on the peptic ulcer, short in course of treatment, fast to become effective, free of poison and side effects, easy to obtain materials, simple to prepare, low in cost, convenient to use, and wide in application range. Therefore, the mongolian medicine has high use value and a wide market prospect.
Description
Technical field
The present invention relates to a kind of medicine, i.e. a kind of mongolian medicine for the treatment of peptic ulcer.
Background technology
Peptic ulcer (peptic ulcer) mainly refers to betide the duodenal chronic ulcer of harmonization of the stomach, is a frequently-occurring disease, commonly encountered diseases.The patient shows as epigastrium stomachache and acid regurgitation, belch more, feels sick, vomiting etc., and severe patient can cause the even canceration of gastrointestinal hemorrhage, perforation, pyloric obstruction.At present, the Drug therapy of primary disease adopts antacid, gastric acid secretion inhibitor, gastrointestinal protective agent, antibacterial to treat more.Antacid such as sodium bicarbonate, calcium carbonate, aluminium hydroxide, bismuth subcarbonate, its compound preparation commonly used have that gastropine, magnalium mixture, stomach infections are peaceful, roter tablets, compound calcium bismuth magnesium etc.Gastric acid secretion inhibitor such as Semen daturae, atropine, Anisodamine, pyrenzepine, cimetidine, famotidine, losec etc.Protection medicine such as sucralfate, tripotassium two citron complexation bismuths, carbenoxolone.Antibacterial therapy mainly adopts the medicine of anti-helicobacter pylori, as furazolidone etc.Chinese medicine thinks that primary disease belongs to " gastric abscess " category, generally is divided into Four types: one is spleen-stomach deficiency-cold, and the rule for the treatment of is that during warming the spleen stomach invigorating, QI invigorating are good for, the side of representative is Huangqijianzhongtangas as main prescription; Two is caused by hepatic stagnation qi stagnation, and the rule for the treatment of is depressed liver-energy dispersing and QI regulating and stomach and alleviating pain, and the side of representative is the bupleurum powder for relieving liver-qi plus-minus; Three is type of deficiency of stomach yin, and the rule for the treatment of is nourishing stomach-YIN, and the side of representative is YIGUANJIAN or Ophiopogonis Decoction plus-minus; Four is blood stasis type, and the rule for the treatment of is disperse blood stasis and dredge collateral, and the side of representative is the SHIXIAO SAN plus-minus.Mongolian medicine's mongolian medicine is mainly treated according to bag as disease for peptic ulcer, and the prescription of many determined curative effects is arranged, and mongolian medicine adopts the processing mode that crude drug directly is pulverized and mixed more in addition, and effective ingredient keeps more complete, and therapeutic effect relatively protrudes., owing to lack to collect arranging, many prescriptions only in the mode of maintaining secrecy at folklore, what be seen in ancient books and records only has the minority prescriptions such as Mirabilitum crystallina-21, the Radix Aucklandiae-6.Existing medicine, although peptic ulcer is all had certain curative effect,, exist the drawbacks such as the medicine journey is grown, taken effect slowly, expense is high, side effect is large more, some medicament is limited to lenitive symptomatic treatment, is difficult to radical cure, and relapse rate is high, can not meet patient's demand, can not suppress primary disease situation occurred frequently.
Summary of the invention
The purpose of this invention is to provide and a kind of peptic ulcer is had significant curative effect, and short treating period, instant effect, cure rate is high, cost is low mongolian medicine.
Above-mentioned purpose is realized by following technical scheme: a kind of mongolian medicine for the treatment of peptic ulcer is provided, is characterized in: this medicine is to be made by following crude drug by weight: Semen Coriandri 2-6 part, Radix Angelicae Sinensis 3-9 part, Oletum Trogopterori 2-6 part, Mirabilitum crystallina 5-12 part, Fructus Chebulae 5-12 part, Endoconcha Sepiae 5-12 part, Bulbus Fritillariae Uninbracteatae 2-6 part, Rhizoma Coptidis 2-6 part, Radix Aucklandiae 1-5 part.
The optimization weight portion prescription of said medicine is: 4 parts of Semen Coriandris, 6 parts of Radix Angelicae Sinensis, 4 parts of Oletum Trogopteroris, 9 parts of Mirabilitum crystallinas, 9 parts of Fructus Chebulaes, 9 parts of Endoconcha Sepiaes, 4 parts of Bulbus Fritillariae Uninbracteataes, 4 parts of Rhizoma Coptidis, 3 parts of the Radix Aucklandiae.
The optimization weight portion prescription of said medicine is: Semen Coriandri 2g, Radix Angelicae Sinensis 3g, Oletum Trogopterori 2g, Mirabilitum crystallina 5g, Fructus Chebulae 5g, Endoconcha Sepiae 5g, Bulbus Fritillariae Uninbracteatae 2g, Rhizoma Coptidis 2g, Radix Aucklandiae 1g.
The optimization weight portion prescription of said medicine is: Semen Coriandri 4g, Radix Angelicae Sinensis 6g, Oletum Trogopterori 4g, Mirabilitum crystallina 9g, Fructus Chebulae 9g, Endoconcha Sepiae 9g, Bulbus Fritillariae Uninbracteatae 4g, Rhizoma Coptidis 4g, Radix Aucklandiae 3g.
The optimization weight portion prescription of said medicine is: Semen Coriandri 6g, Radix Angelicae Sinensis 9g, Oletum Trogopterori 6g, Mirabilitum crystallina 12g, Fructus Chebulae 12g, Endoconcha Sepiae 12g, Bulbus Fritillariae Uninbracteatae 6g, Rhizoma Coptidis 6g, Radix Aucklandiae 5g.
The optimization weight portion prescription of said medicine is: Semen Coriandri 2g, Radix Angelicae Sinensis 6g, Oletum Trogopterori 6g, Mirabilitum crystallina 12g, Fructus Chebulae 9g, Endoconcha Sepiae 12g, Bulbus Fritillariae Uninbracteatae 3g, Rhizoma Coptidis 3g, Radix Aucklandiae 2g.
The manufacture method of said medicine is: pulverized 80 orders with top sieve, and made powder or tablet or pill.
The manufacture method of said medicine is: Radix Angelicae Sinensis, Rhizoma Coptidis, Fructus Chebulae are carried out respectively reflux, extract, three times: add for the first time 5ml/g distilled water backflow 1h, add for the second time 3ml/g distilled water backflow 1h, add for the third time 1ml/g distilled water backflow 1h, merge three times extracting solution, after placing the water-bath oven dry, pulverizing obtains water extract, other crude drug were pulverized 100 mesh sieves, mixed with above-mentioned water extract.
The invention has the beneficial effects as follows: peptic ulcer there is significant curative effect, short treating period, instant effect has no side effect, and draws materials easily, makes simply, and is with low cost, easy to use, wide accommodation, thereby have higher use value and wide market prospect.
The specific embodiment
The first embodiment: get by weight crude drug Semen Coriandri 2g, Radix Angelicae Sinensis 3g, Oletum Trogopterori 2g, Mirabilitum crystallina 5g, Fructus Chebulae 5g, Endoconcha Sepiae 5g, Bulbus Fritillariae Uninbracteatae 2g, Rhizoma Coptidis 2g, Radix Aucklandiae 1g, pulverized 80 orders with top sieve, make powder, tablet or pill.Also can with reference to above-mentioned prescription, carry out batch formulation.Radix Angelicae Sinensis, Rhizoma Coptidis, Fructus Chebulae can be carried out respectively reflux, extract, three times, namely add 5ml/g distilled water backflow 1h, then add 3ml/g distilled water backflow 1h, then add 1ml/g distilled water backflow 1h, merge three times extracting solution, place the rear pulverizing of water-bath oven dry.Other crude drug were pulverized 100 mesh sieves, with above-mentioned water extract mix preparation.
Method of administration: 2-3 time on the one, a 3-9g, warm water delivery service.
Since 2008, carried out respectively pharmacology, toxicity, the test of pesticide effectiveness with this side, prove to have no side effect that slight chronic peptic ulcer is had good efficacy.
The second embodiment: get by weight crude drug Semen Coriandri 4g, Radix Angelicae Sinensis 6g, Oletum Trogopterori 4g, Mirabilitum crystallina 9g, Fructus Chebulae 9g, Endoconcha Sepiae 9g, Bulbus Fritillariae Uninbracteatae 4g, Rhizoma Coptidis 4g, Radix Aucklandiae 3g, pulverized 80 orders with top sieve, make powder, tablet or pill.Also can with reference to above-mentioned prescription, carry out batch formulation.Radix Angelicae Sinensis, Rhizoma Coptidis, Fructus Chebulae can be carried out respectively reflux, extract, three times, namely add 5ml/g distilled water backflow 1h, then add 3ml/g distilled water backflow 1h, then add 1ml/g distilled water backflow 1h, merge three times extracting solution, place the rear pulverizing of water-bath oven dry.Other crude drug were pulverized 100 mesh sieves, with above-mentioned water extract mix preparation.
Method of administration: 2-3 time on the one, a 3-9g, warm water delivery service.
The third embodiment: get by weight crude drug Semen Coriandri 6g, Radix Angelicae Sinensis 9g, Oletum Trogopterori 6g, Mirabilitum crystallina 12g, Fructus Chebulae 12g, Endoconcha Sepiae 12g, Bulbus Fritillariae Uninbracteatae 6g, Rhizoma Coptidis 6g, Radix Aucklandiae 5g, pulverized 80 orders with top sieve, make powder, tablet or pill.Also can with reference to above-mentioned prescription, carry out batch formulation.Radix Angelicae Sinensis, Rhizoma Coptidis, Fructus Chebulae can be carried out respectively reflux, extract, three times, namely add 5ml/g distilled water backflow 1h, then add 3ml/g distilled water backflow 1h, then add 1ml/g distilled water backflow 1h, merge three times extracting solution, place the rear pulverizing of water-bath oven dry.Other crude drug were pulverized 100 mesh sieves, with above-mentioned water extract mix preparation.
Method of administration: 2-3 time on the one, a 3-9g, warm water delivery service.
The 4th kind of embodiment: get by weight 2 parts of crude drug Semen Coriandris, 6 parts of Radix Angelicae Sinensis, 6 parts of Oletum Trogopteroris, 12 parts of Mirabilitum crystallinas, 9 parts of Fructus Chebulaes, 12 parts of Endoconcha Sepiaes, 3 parts of Bulbus Fritillariae Uninbracteataes, 3 parts of Rhizoma Coptidis, 2 parts of the Radix Aucklandiae.Pulverize 80 orders with top sieve, made powder, tablet or pill.
Also Radix Angelicae Sinensis, Rhizoma Coptidis, Fructus Chebulae can be carried out respectively reflux, extract, three times, namely add 5ml/g distilled water backflow 1h, then add 3ml/g distilled water backflow 1h, then add 1ml/g distilled water backflow 1h, merge three times extracting solution, place the rear pulverizing of water-bath oven dry.Other crude drug were pulverized 100 mesh sieves, with above-mentioned water extract mix preparation.
Method of administration: 2-3 time on the one, a 3-9g, warm water delivery service.
Experimental analysis
One, prescription analysis: peptic ulcer is a kind of multi-pathogenesis disease, and the theoretical more complicated of relevant this disease of Mongolian medicine be it is generally acknowledged to belong to gastropathy, comprises that the stomach bag is as sick and intestinal bag such as disease.In addition, stomach is conspicuous draws disease, stomach Ba Da to do the symptom such as disease and medication also to exist with primary disease and intersect according to disease, stomach are uncommon.Chinese medicine thinks that primary disease belongs to " gastric abscess " category, generally is divided into spleen-stomach deficiency-cold, caused by hepatic stagnation qi stagnation, type of deficiency of stomach yin, blood stasis type.It is relevant with gastric acid, pepsin, infection, heredity, body constitution, environment, diet, living habit, neural Nervous and Mental Factors etc. that modern medicine is thought, take dysequilibrium between gastric acid, pepsic digestion power and gastric mucosal barrier function and Helicobacter pylori infection as main pathogenic.This medicine is on the basis of a large amount of Mongolian medicine of collection proved recipes, and with reference to Mongolian medicine, the traditional Chinese medical science and modern medical theory, screening forms through great many of experiments.Wherein: Semen Coriandri is the dry mature fruit of samphire coriander (Coriandrum sativum L.), another name Fructus Coriandri, ceriander seed contain volatile oil, fat, saccharide, nitrogen substance, and acrid in the mouth is cool in nature, attach to the lung and stomach meridians, have the effect of regulating gastrointestinal peristalsis and heat-clearing and toxic substances removing.Radix Angelicae Sinensis (Chinese Angelica) is the root of umbelliferae angelica, another name: driedly return, horse hair Radix Angelicae Sinensis, the Qin which, horse hair are returned, cloud is returned, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Mongolian claims DANGGONG, the composition that contains volatile oil and a kind of energy excited uterus, contain again sucrose, vitamin B12 etc., warm in nature, sweet-bitter flavor has antiinflammatory, analgesia, raising immunity and improves the merits such as blood circulation.Oletum Trogopterori (Trogopterus Dung, dung of Complex-toothed Flying Squirrel) be the dry feces of flying squirrel section animal trogopterus xanthipes Milne-Edwards, another name: half congealed Oletum Trogopterori, Oletum Trogopterori, Mongolian claims that Ha Dun-Hai Lumole, Ba Lage are suitable, sweet in flavor and warm in property, contain retinoid material, resin etc., have the effect of promoting blood circulation and stopping pain, removing stasis to stop bleeding, removing food stagnancy detoxifcation, be usually used in treating the stagnant stomachache of the stasis of blood in puerperal, metrostaxis, infantile malnutrition, snakes and scorpions centipete bite etc., usual amounts 6-9g.Mirabilitum crystallina (Caleitum) is the crystal of Sulfates mineral Natrii Sulfas, i.e. calcium carbonate (CaCO
3), another name Mirabilitum crystallina, plain boiled water stone, CALCITUM GYPSUM RUBRUM, salt essence, water stone, BINGSHI, magpie stone, salt essence stone, mud essence, salt pillow, salt root, Mongolian claims Ge Re-Zhong Xi, steeps secondary, Chu Lunei-Tong loud, high-pitched sound clarke, the nature and flavor suffering is salty-cold, can be analgesic, antiinflammatory, relieving constipation, pathogenic fire reducing, sharp key, detumescence, row calentura, accumulated heat excessive thirst, vomiting and diarrhoea, edema, urine retention, bleeding from the gum, erysipelas, scald etc. when being usually used in treating.The Fructus Chebulae calls that chebule, Da Jin fruit, fiber crops come, scold pears, scold multitude, fragrant bavin, microtriche Fructus Chebulae, son with the wind, title " Fructus Chebulae " person is arranged in multiple publication, dry fruit for Combretum Racemosum Terminalia plant terminalia chebula Retz (Terminalia chebula Retz.) or Terminalia chebula Retz. var. tomentella Kurt., my smooth father-in-law's trrellis diagram-ARULA of Mongolia name, Si Ridaoke-ARULA, Pu Lejide-ARULA, puckery is flat, has three of conditionings, suppresses uncommon and draw, restrain wound, granulation promoting, helps digestion, the effect of detoxifcation.Endoconcha Sepiae (Cuttlebone) is tropical off-lying sea property kind, another name: black Quarry bone, sepia bone, Os Sepiae, cuttlebone, cuttlefish lid, Mongolian claims Bai Hetuzha loud, high-pitched sound Song-Ya Su, Bai Hetu-Xi Su loud, high-pitched sound, contain calcium carbonate, calcium phosphate, chitin, colloid, salty in the mouth adstringency temperature, but astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore are usually used in treating spitting blood, metrorrhagia, have blood in stool, epistaxis, wound hemorrhage, emission due to deficiency of the kidney spermatorrhea, leucorrhea with red and white discharge, stomachache are noisy, belch pantothenic acid, eczema, ulcer.Bulbus Fritillariae Uninbracteatae (fritillary) is the Liliaceae dry bulb of herbaceous plant Bulbus Fritillariae Thunbergii Fritillaria unibracteata Hsiao et K.C.Hsia or Bulbus Fritillariae Cirrhosae F.cirrhosa D.Don, Bulbus Fritillariae cirrhosae F.delavayi Fr., Gansu Bulbus Fritillariae Uninbracteatae F.przewalskii Maxim.ex.Batalin for many years, another name: Bulbus Fritillariae Thunbergii, pearl shellfish, BULBUS FRITILLARIAE THUNBERGII, resemble shellfish, Mongolian claims Nuo Getu Ru Wusibu, Buddhist nun than savart, contains peimine (C
27H
45O
3N), peiminine (C
27H
43O
3N), the fragrant (C of Bulbus Fritillariae Uninbracteatae
27H
46O
3N) etc., nature and flavor are bitter, sweet, are slightly cold, and are usually used in treating phlegm heat cough, exogenous cough, cough due to yin deficiency, the few parched throat of expectorant, the diseases such as Huang is thick, lung abscess, acute mastitis, carbuncle pyogenic infections from tumour or sore, scrofula of coughing up phlegm.Rhizoma Coptidis is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch. Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Chenget Hsiao or Coptis Teeta Wall Coptis teeta Wall., the another name flavor connects, Mongolian claims Xi La-Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), rather-Ba Ri, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)-Si Ribu, contains berberine (C
20H
19O
5N), Golden seal (C
19H
15O
5N), palmatine (C
21H
23O
5N), worenine (C
20H
17O
5N), nature and flavor bitter cold, but heat clearing and damp drying, eliminating fire and detoxication.The Radix Aucklandiae (Costustoot, Common Vladimiria Root) be the root of Compositae herbaceos perennial Saussurea lappa Clarke Aucklandia lappa Decne., Radix Vladimiriae Vladimiria souliei (Franch.) Ling, another name: honey perfume, Radix Aristolochiae, spices, five Radix Aucklandiae, Radix Aristolochiae yunnanensis, Radix Aucklandiae (Radix Vladimiriae), Saussurea lappa Clarke, Mongolian claim as reach, husky bubble as reach, the agate slave is as reaching, and contains constuslactone (C
15H
20O
2), costic acid (C
15H
22O
2), costol (C
15H
24O) etc., acrid in the mouth, bitterness temperature, but promoting the circulation of QI to relieve pain, transfer in intestinal stasis relieving, be usually used in treating born of the same parents and coerce distension, abdominal distention, tell and have loose bowels, heavily wait after dysentery.The said medicine synergism, receive altogether three seven elements of conditioning, go bag as, suppress uncommon and draw, dispel that Ba Da is xeothermic, the sticking merit of detoxifying, disappear, reach the stomachache of releiving, comprehensive gastric acid, improve digestive function, strengthen the stomach blood circulation, softening gastric deposit, promote ulcer convergence and even the purpose that heals.
Two, toxicity test: in acute toxicity testing research, at first measured the median lethal dose(LD 50) (LD50) of this mongolian medicine, but failed to measure its LD50, illustrated that this mongolian medicine acute toxicity is less.And then measure its maximum dosage-feeding: medicine is made into the Cmax that mice can be accepted, with the maximum volume gastric infusion, one day 3 times, observed 15 days.Dosage is pressed per weight and is calculated, and reaches 56 times of people's dosage, and death or other abnormal phenomenas do not appear in all mices, illustrate that its safety is very high.Put down in writing according to interrelated data, the Fructus Chebulae has certain toxicity, white mice LD50=500mg/kg, and this medicament calculates by people 50kg body weight, and medicine is with full pulverizing calculatings of being used as medicine, and Fructus Chebulae's maximum daily intaking amount only has 36mg/kg, belong to safety range, through producing the process of preparing Chinese medicine, its intake should be far below this numerical value, therefore can think safe.Put down in writing according to another data: Oletum Trogopterori easily injures one's stomach, and research on maximum utilized quantity 9g/ day, the maximum dose of this medicine Oletum Trogopterori is roughly equal to 3g/ day, belongs to safety range.
Three, zoopery: for verifying the therapeutical effect of this medicine; the inventor has carried out animal pharmacodynamics experimentation; result confirms that this mongolian medicine is remarkable to the protective effect of gastric mucosa, and the gastric ulcer model that stress ulcer disease model, ethanol are caused, the gastric ulcer model of pyloric ligation all have preventive effect.Experimental result is as follows:
1. on the impact of stress in rats gastric ulcer, the results are shown in Table 1
The impact of table 1 on the stress in rats gastric ulcer
Compare with model group, ranitidine group and high, medium and low 3 dosage group ulcer areas all obviously reduce, and there were significant differences (P＜0.05 or P＜0.01); Each administration group Area of ulcer has no obvious minimizing, without significant difference.
2. rat ethanol is caused the impact of gastric ulcer, the results are shown in Table 2:
Table 2 causes the impact of gastric ulcer on rat ethanol
Annotate: compare with model group
1)P＜0.05,
2)P＜0.01; Compare P＜0.05 with colloidal bismmth pectin.
Compare with model group, high, the middle dosage group Area of ulcer of colloidal bismmth pectin combination obviously reduces, and there were significant differences (P＜0.05), and the low dose group Area of ulcer has no minimizing, without significant difference; The colloidal bismmth pectin group, high, medium and low dosage group ulcer area obviously reduces, and there were significant differences (P＜0.01).
Compare with the colloidal bismmth pectin group, the high dose group Area of ulcer obviously reduces, and there were significant differences (P＜0.05); High dose group and middle dosage group ulcer area are less than the colloidal bismmth pectin group, and there were significant differences (P＜0.05), and the low dose group ulcer area is without significant difference.
3. the rat pylorus ligation is caused the impact of gastric ulcer, the results are shown in Table 3:
The impact of table 3 on rat gastric acid stomach function regulating proteinase activity
Annotate: compare with model group
1)P＜0.05.
Compare with model group, in KUIYANG SAN, low dosage obviously descends to the rat gastric ulcer total acidity gastric juice, there were significant differences (P＜0.05); The low dose group pepsin activity obviously reduces, and there were significant differences (P＜0.05).Each administration group free acid amount is without significant change, without significant difference.A mistake! Do not find Reference source.
Four, clinical experiment: since 2008, " internal medicine " that the Li Zhen suzerainty who published in 1999 according to the People's Health Publisher compiles provides diagnosis and treatment standard, the modern times such as the detection that employing gastroscopy, x-ray barium meal examination, HP infect, gastric analysis are made a definite diagnosis means, accept patient's many cases for medical treatment, adopt this pharmaceutical treatment, reaction is good.Only accepted patient's 66 examples for medical treatment, treatment situation such as following table in Tongliao, Inner Mongolia many, city hospital in 2012:
| Type | Number of cases | Cure | Produce effects | Invalid | Cure rate % | Total effective rate % |
| Gastric ulcer | 56 | 41 | 8 | 7 | 73.2 | 87.5 |
| Duodenal ulcer | 18 | 12 | 2 | 4 | 66.7 | 77.7 |
| Add up to | 74 | 53 | 10 | 11 | 74.2 | 85.1 |
Be limited to condition, direct contrast is not done in clinical experiment, but the first three years similar patient treatment situation of accepting for medical treatment is compared therewith, and the therapeutic effect of this medicine significantly strengthens.Particularly this medicine treatment cycle mostly was for 2-3 weeks, shortened on year-on-year basis 30% left and right, and the expenses for medicine cost is more than 40%.Followed up a case by regular visits to after healing 5 years, relapse rate is lower than 30%, and 5 years relapse rates that being starkly lower than interrelated data provides reach 50% statistical indicator, and find that not yet medication causes the case of other diseases, illustrate that this medicine has higher clinical value.
Claims (8)
1. mongolian medicine for the treatment of peptic ulcer, it is characterized in that: this medicine is to be made by following crude drug by weight: Semen Coriandri 2-6 part, Radix Angelicae Sinensis 3-9 part, Oletum Trogopterori 2-6 part, Mirabilitum crystallina 5-12 part, Fructus Chebulae 5-12 part, Endoconcha Sepiae 5-12 part, Bulbus Fritillariae Uninbracteatae 2-6 part, Rhizoma Coptidis 2-6 part, Radix Aucklandiae 1-5 part.
2. a kind of mongolian medicine for the treatment of peptic ulcer according to claim 1, it is characterized in that: the optimization weight portion prescription of said medicine is: 4 parts of Semen Coriandris, 6 parts of Radix Angelicae Sinensis, 4 parts of Oletum Trogopteroris, 9 parts of Mirabilitum crystallinas, 9 parts of Fructus Chebulaes, 9 parts of Endoconcha Sepiaes, 4 parts of Bulbus Fritillariae Uninbracteataes, 4 parts of Rhizoma Coptidis, 3 parts of the Radix Aucklandiae.
3. a kind of mongolian medicine for the treatment of peptic ulcer according to claim 1, it is characterized in that: the optimization weight portion prescription of said medicine is: Semen Coriandri 2g, Radix Angelicae Sinensis 3g, Oletum Trogopterori 2g, Mirabilitum crystallina 5g, Fructus Chebulae 5g, Endoconcha Sepiae 5g, Bulbus Fritillariae Uninbracteatae 2g, Rhizoma Coptidis 2g, Radix Aucklandiae 1g.
4. a kind of mongolian medicine for the treatment of peptic ulcer according to claim 1, it is characterized in that: the optimization weight portion prescription of said medicine is: Semen Coriandri 4g, Radix Angelicae Sinensis 6g, Oletum Trogopterori 4g, Mirabilitum crystallina 9g, Fructus Chebulae 9g, Endoconcha Sepiae 9g, Bulbus Fritillariae Uninbracteatae 4g, Rhizoma Coptidis 4g, Radix Aucklandiae 3g.
5. a kind of mongolian medicine for the treatment of peptic ulcer according to claim 1, it is characterized in that: the optimization weight portion prescription of said medicine is: Semen Coriandri 6g, Radix Angelicae Sinensis 9g, Oletum Trogopterori 6g, Mirabilitum crystallina 12g, Fructus Chebulae 12g, Endoconcha Sepiae 12g, Bulbus Fritillariae Uninbracteatae 6g, Rhizoma Coptidis 6g, Radix Aucklandiae 5g.
6. a kind of mongolian medicine for the treatment of peptic ulcer according to claim 1, it is characterized in that: the optimization weight portion prescription of said medicine is: Semen Coriandri 2g, Radix Angelicae Sinensis 6g, Oletum Trogopterori 6g, Mirabilitum crystallina 12g, Fructus Chebulae 9g, Endoconcha Sepiae 12g, Bulbus Fritillariae Uninbracteatae 3g, Rhizoma Coptidis 3g, Radix Aucklandiae 2g.
7. a kind of mongolian medicine for the treatment of peptic ulcer according to claim 1, it is characterized in that: the manufacture method of said medicine is: each crude drug was pulverized 80 orders with top sieve, make powder or tablet or pill.
8. a kind of mongolian medicine for the treatment of peptic ulcer according to claim 1, it is characterized in that: the manufacture method of said medicine is: Radix Angelicae Sinensis, Rhizoma Coptidis, Fructus Chebulae are carried out respectively reflux, extract, three times: add for the first time 5ml/g distilled water backflow 1h, add for the second time 3ml/g distilled water backflow 1h, add for the third time 1ml/g distilled water backflow 1h, merge three times extracting solution, after placing the water-bath oven dry, pulverizing obtains water extract, and other crude drug were pulverized 100 mesh sieves, mixed with above-mentioned water extract.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075272A (en) * | 2016-07-22 | 2016-11-09 | 内蒙古锡林郭勒盟蒙医医院 | A kind of mongolian medicine treating peptic ulcer and preparation method thereof |
| CN117837693A (en) * | 2024-03-07 | 2024-04-09 | 长春中医药大学 | Feed additive for preventing/treating gastric ulcer of pet mice and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188614A (en) * | 2009-05-27 | 2011-09-21 | 成仕孝 | Capsule for gastric ulcer |
| CN102671098A (en) * | 2012-05-15 | 2012-09-19 | 宋协勘 | Traditional Chinese medicine for treating peptic ulcer |
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2013
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Patent Citations (2)
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|---|---|---|---|---|
| CN102188614A (en) * | 2009-05-27 | 2011-09-21 | 成仕孝 | Capsule for gastric ulcer |
| CN102671098A (en) * | 2012-05-15 | 2012-09-19 | 宋协勘 | Traditional Chinese medicine for treating peptic ulcer |
Non-Patent Citations (1)
| Title |
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| 吴七十三等: "蒙药验方溃疡散对实验性大鼠胃溃疡的作用", 《中国实验方剂学杂志》, vol. 19, no. 6, 31 March 2013 (2013-03-31), pages 257 - 259 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075272A (en) * | 2016-07-22 | 2016-11-09 | 内蒙古锡林郭勒盟蒙医医院 | A kind of mongolian medicine treating peptic ulcer and preparation method thereof |
| CN106075272B (en) * | 2016-07-22 | 2020-06-19 | 内蒙古锡林郭勒盟蒙医医院 | Mongolian medicine for treating peptic ulcer and preparation method thereof |
| CN117837693A (en) * | 2024-03-07 | 2024-04-09 | 长春中医药大学 | Feed additive for preventing/treating gastric ulcer of pet mice and application thereof |
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|---|---|
| CN103169850B (en) | 2015-05-13 |
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