CN103153986B - 丙型肝炎病毒抑制剂 - Google Patents
丙型肝炎病毒抑制剂 Download PDFInfo
- Publication number
- CN103153986B CN103153986B CN201080069468.6A CN201080069468A CN103153986B CN 103153986 B CN103153986 B CN 103153986B CN 201080069468 A CN201080069468 A CN 201080069468A CN 103153986 B CN103153986 B CN 103153986B
- Authority
- CN
- China
- Prior art keywords
- mmol
- cap
- methyl
- mixture
- calcd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*[C@@](c1ccccc1)N Chemical compound C*[C@@](c1ccccc1)N 0.000 description 7
- LHDYFLVJCRWJKY-UHFFFAOYSA-N Brc1nc(N2CCOCC2)cc2ccccc12 Chemical compound Brc1nc(N2CCOCC2)cc2ccccc12 LHDYFLVJCRWJKY-UHFFFAOYSA-N 0.000 description 1
- JNBBBOKQGHDYHW-UJOTVTMRSA-N C(C1)C11[C@@H](C2)[C@]2(c2nc(cc(cc3)C#Cc4cc5ccc6nc([C@]78NCC9(CC9)C7C8)[nH]c6c5cc4)c3[nH]2)NC1 Chemical compound C(C1)C11[C@@H](C2)[C@]2(c2nc(cc(cc3)C#Cc4cc5ccc6nc([C@]78NCC9(CC9)C7C8)[nH]c6c5cc4)c3[nH]2)NC1 JNBBBOKQGHDYHW-UJOTVTMRSA-N 0.000 description 1
- KFTBJDMZNBWAOE-UHFFFAOYSA-N C=[Br]c1ccc(C2N=C(C3NCCC4C3C4)NC2CCC2)c2c1 Chemical compound C=[Br]c1ccc(C2N=C(C3NCCC4C3C4)NC2CCC2)c2c1 KFTBJDMZNBWAOE-UHFFFAOYSA-N 0.000 description 1
- PATDKANMIKOPKI-KRWDZBQOSA-N CC(C)(C)OC(N(CCC1)[C@@H]1c1nc(cc(cc2)C#[Si](C)(C)C)c2[nH]1)=O Chemical compound CC(C)(C)OC(N(CCC1)[C@@H]1c1nc(cc(cc2)C#[Si](C)(C)C)c2[nH]1)=O PATDKANMIKOPKI-KRWDZBQOSA-N 0.000 description 1
- CPGFRDOQLWPLQQ-SVHVEYBNSA-N CC(C)(C)OC(N(CCC1)[C@@H]1c1nc2cc(C(NCC(c3cc(NC([C@H](CCC4)N4C(C(C4)(C4NC(OC)=O)c4ccccc4)=O)=O)c(C)cc3)=O)=O)ccc2[nH]1)=O Chemical compound CC(C)(C)OC(N(CCC1)[C@@H]1c1nc2cc(C(NCC(c3cc(NC([C@H](CCC4)N4C(C(C4)(C4NC(OC)=O)c4ccccc4)=O)=O)c(C)cc3)=O)=O)ccc2[nH]1)=O CPGFRDOQLWPLQQ-SVHVEYBNSA-N 0.000 description 1
- HJLYKRGXTOVWFL-SNVBAGLBSA-N CC(C)(C)OC([C@@H](c1ccccc1)N)=O Chemical compound CC(C)(C)OC([C@@H](c1ccccc1)N)=O HJLYKRGXTOVWFL-SNVBAGLBSA-N 0.000 description 1
- HQDWPVYKOJWACL-OAHLLOKOSA-N CC(C)(C)OC([C@@H](c1ccccc1)NC(NC1CCCC1)=O)=O Chemical compound CC(C)(C)OC([C@@H](c1ccccc1)NC(NC1CCCC1)=O)=O HQDWPVYKOJWACL-OAHLLOKOSA-N 0.000 description 1
- CEFVHPDFGLDQKU-UHFFFAOYSA-N CC(C)C(C(O)=O)NC(OC)=O Chemical compound CC(C)C(C(O)=O)NC(OC)=O CEFVHPDFGLDQKU-UHFFFAOYSA-N 0.000 description 1
- ZJVJPPNOQCMEPI-SNVBAGLBSA-N CCN(C)[C@@H](C(O)=O)c1ccccc1 Chemical compound CCN(C)[C@@H](C(O)=O)c1ccccc1 ZJVJPPNOQCMEPI-SNVBAGLBSA-N 0.000 description 1
- CVMBPUGMKLAFOL-UHFFFAOYSA-N CN(C)c(c1c2)cccc1c(C#N)nc2Cl Chemical compound CN(C)c(c1c2)cccc1c(C#N)nc2Cl CVMBPUGMKLAFOL-UHFFFAOYSA-N 0.000 description 1
- OZKZHAPLKMRAQT-UHFFFAOYSA-N CN(CC(O)=O)Cc1ccccc1 Chemical compound CN(CC(O)=O)Cc1ccccc1 OZKZHAPLKMRAQT-UHFFFAOYSA-N 0.000 description 1
- NBOYYCGPEMOUDO-ZBHICJROSA-N C[C@@H](C1(O)OC1)N(C)C Chemical compound C[C@@H](C1(O)OC1)N(C)C NBOYYCGPEMOUDO-ZBHICJROSA-N 0.000 description 1
- ROFVLTUQPIDLFK-KXFIGUGUSA-N C[n]1cnc(/C=C(/C(O)=O)\N)c1 Chemical compound C[n]1cnc(/C=C(/C(O)=O)\N)c1 ROFVLTUQPIDLFK-KXFIGUGUSA-N 0.000 description 1
- OEPLXFQYVFZKPJ-UHFFFAOYSA-N N#Cc1cc(cccc2)c2c(-c2ccc[o]2)n1 Chemical compound N#Cc1cc(cccc2)c2c(-c2ccc[o]2)n1 OEPLXFQYVFZKPJ-UHFFFAOYSA-N 0.000 description 1
- NKXZWOVJAKICNE-UHFFFAOYSA-N OC(CCCCc1cc(Br)ccc1)=O Chemical compound OC(CCCCc1cc(Br)ccc1)=O NKXZWOVJAKICNE-UHFFFAOYSA-N 0.000 description 1
- KGSVNOLLROCJQM-UHFFFAOYSA-N OC(CNCc1ccccc1)=O Chemical compound OC(CNCc1ccccc1)=O KGSVNOLLROCJQM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/044356 WO2012018325A1 (en) | 2010-08-04 | 2010-08-04 | Hepatitis c virus inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103153986A CN103153986A (zh) | 2013-06-12 |
| CN103153986B true CN103153986B (zh) | 2014-11-05 |
Family
ID=43640063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080069468.6A Expired - Fee Related CN103153986B (zh) | 2010-08-04 | 2010-08-04 | 丙型肝炎病毒抑制剂 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2601188B1 (enExample) |
| JP (1) | JP5596861B2 (enExample) |
| KR (1) | KR20140045903A (enExample) |
| CN (1) | CN103153986B (enExample) |
| AU (1) | AU2010358561B2 (enExample) |
| BR (1) | BR112013002729A2 (enExample) |
| CA (1) | CA2807305A1 (enExample) |
| EA (1) | EA022127B1 (enExample) |
| IL (1) | IL224298A (enExample) |
| MX (1) | MX337936B (enExample) |
| SG (1) | SG187183A1 (enExample) |
| WO (1) | WO2012018325A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8673954B2 (en) * | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| CN102656160A (zh) | 2009-07-16 | 2012-09-05 | 顶点制药公司 | 用于治疗或预防黄病毒感染的苯并咪唑类似物 |
| JP2013522375A (ja) | 2010-03-24 | 2013-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染を処置または予防するためのアナログ |
| BR112013004520A2 (pt) | 2010-08-26 | 2016-06-07 | Univ Emory | inibidores potentes e seletivos do virus da hepatite c |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN103687489A (zh) | 2011-05-18 | 2014-03-26 | 埃南塔制药公司 | 制备5-氮杂螺[2.4]庚烷-6-甲酸及其衍生物的方法 |
| WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| AU2013217224B2 (en) | 2012-02-10 | 2017-04-06 | Lupin Limited | Antiviral compounds with a dibenzooxaheterocycle moiety |
| CA2869908C (en) * | 2012-04-25 | 2018-02-20 | Theravance Biopharma R&D Ip, Llc | Hepatitis c virus inhibitors |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| WO2015009744A1 (en) | 2013-07-17 | 2015-01-22 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of hcv |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JPWO2018212162A1 (ja) | 2017-05-17 | 2020-03-19 | 株式会社トクヤマ | ジアミノベンゼン化合物の製造方法 |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| US20210246108A1 (en) | 2018-06-28 | 2021-08-12 | Tokuyama Corporation | Method for Producing Alpha-Azidoaniline Derivative or Alpha,AlphaPrime-Diazide Derivative |
| IL286326B2 (en) | 2019-03-15 | 2025-10-01 | Medimmune Ltd | Azatidobenzodiazepine dimers and conjugates containing them for use in the treatment of cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830905A (en) * | 1996-03-29 | 1998-11-03 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
| US6448281B1 (en) * | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| AU2003264038A1 (en) | 2002-08-12 | 2004-02-25 | Bristol-Myers Squibb Company | Combination pharmaceutical agents as inhibitors of hcv replication |
| WO2004026318A1 (ja) * | 2002-09-20 | 2004-04-01 | Kirin Beer Kabushiki Kaisha | α-グリコシルセラミドを有効成分とするＣ型肝炎ウイルス抑制剤 |
| WO2006093867A1 (en) | 2005-02-28 | 2006-09-08 | The Rockefeller University | Structure of the hepatitits c virus ns5a protein |
| US8303944B2 (en) | 2006-08-11 | 2012-11-06 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8147818B2 (en) * | 2008-02-13 | 2012-04-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2010065681A1 (en) * | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| TWI438200B (zh) * | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
-
2010
- 2010-08-04 EP EP10740116.8A patent/EP2601188B1/en not_active Not-in-force
- 2010-08-04 SG SG2013005558A patent/SG187183A1/en unknown
- 2010-08-04 MX MX2013001237A patent/MX337936B/es active IP Right Grant
- 2010-08-04 CA CA2807305A patent/CA2807305A1/en not_active Abandoned
- 2010-08-04 WO PCT/US2010/044356 patent/WO2012018325A1/en not_active Ceased
- 2010-08-04 AU AU2010358561A patent/AU2010358561B2/en not_active Ceased
- 2010-08-04 JP JP2013523129A patent/JP5596861B2/ja not_active Expired - Fee Related
- 2010-08-04 EA EA201370017A patent/EA022127B1/ru not_active IP Right Cessation
- 2010-08-04 CN CN201080069468.6A patent/CN103153986B/zh not_active Expired - Fee Related
- 2010-08-04 BR BR112013002729A patent/BR112013002729A2/pt not_active IP Right Cessation
- 2010-08-04 KR KR1020137005316A patent/KR20140045903A/ko not_active Abandoned
-
2013
- 2013-01-17 IL IL224298A patent/IL224298A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013532725A (ja) | 2013-08-19 |
| EA022127B1 (ru) | 2015-11-30 |
| BR112013002729A2 (pt) | 2016-05-31 |
| WO2012018325A1 (en) | 2012-02-09 |
| CA2807305A1 (en) | 2012-02-09 |
| EP2601188A1 (en) | 2013-06-12 |
| AU2010358561A1 (en) | 2013-03-21 |
| KR20140045903A (ko) | 2014-04-17 |
| MX337936B (es) | 2016-03-29 |
| CN103153986A (zh) | 2013-06-12 |
| SG187183A1 (en) | 2013-02-28 |
| MX2013001237A (es) | 2013-05-28 |
| IL224298A (en) | 2015-08-31 |
| AU2010358561B2 (en) | 2016-06-02 |
| JP5596861B2 (ja) | 2014-09-24 |
| EA201370017A1 (ru) | 2013-05-30 |
| EP2601188B1 (en) | 2017-10-18 |
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