CN103110658A - Treatment liquid for treating tinea pedis and preparation method thereof - Google Patents
Treatment liquid for treating tinea pedis and preparation method thereof Download PDFInfo
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- CN103110658A CN103110658A CN2012105560566A CN201210556056A CN103110658A CN 103110658 A CN103110658 A CN 103110658A CN 2012105560566 A CN2012105560566 A CN 2012105560566A CN 201210556056 A CN201210556056 A CN 201210556056A CN 103110658 A CN103110658 A CN 103110658A
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- purified water
- glycerol
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Abstract
The invention discloses a treatment liquid for treating tinea pedis and a preparation method thereof. The treatment liquid comprises the following raw materials: iodine chitosan, glacial acetic acid, polysorbate-20, glycerol, potassium iodate, salicylic acid, absolute ethyl alcohol, azone and purified water. The method for preparing the liquid comprises the following steps: (1) weighting the materials; (2) adding glacial acetic acid, polysorbate-20, glycerol and purified water to iodine chitosan, and then completely and uniformly stirring until to completely dissolve; (3) dissolving potassium iodate with little purified water, adding to the spare material, and then mixing and uniformly stirring; (4) dissolving salicylic acid in absolute ethyl alcohol, adding to the material, and then uniformly stirring; (5) adding azone, adding water to 100%, and then uniformly stirring; and (6) filling, and packaging to obtain the product. The treatment liquid disclosed by the invention has the effects of carrying out broad-spectrum sterilization at high efficiency, stopping itching and resisting inflammation, can kill multiple pathogens, including fungus such as candida albicans, epidermophyton and trichophyta, and bacterium such as pseudomonas aeruginosa, and has good stability. The treatment liquid is used for treating the tinea pedis and the tinea manuum.
Description
Technical field
The present invention relates to contain the dressing of polysaccharide derivates, specifically, relate to the chitosan iodine solution for the treatment of tinea pedis.
Background technology
Tinea pedis refers to occur in the fungal dermatoses of toe facies palmaris.Pathogenic factor is because the bright bacterium of epidermis, trichophyton or toes trichophyton are invaded toe.The trichophyton resistance is strong, and is wayward, and defends the rich knot of gas body fluid, poly-and loose, cause xerosis cutis moistening due to.
Chitosan is a kind of macromolecular compound of biological property excellence, and after absorption iodine, the heat stability of iodine improves greatly, and is the same with other povidone iodine, and shell iodine can discharge elemental iodine, thereby has strong sterilization.This product is nontoxic, good stability, nonirritant.Bibliographical information has been arranged the sterilization effect of chitosan iodine (see " laboratory observation of chitosan iodine liquid bactericidal effect ", be stated from Hengyang Medical College's journal (medicine) 05 phase in 2000), its chitosan used is water-soluble chitosan.
It is few that in Chinese patent database, chitosan preparations can be treated the patent application of tinea pedis, and No. 200810016256.6 " chitosan nano silver gel agent and application thereof ", No. 200910018404.2 " preparation method of chitosan and/or its derivant metal complex and application ", No. 200910017600.8 " preparation method and the application of silver, chitosan and/or its derivates nanometer complex " are only arranged.These schemes, first is gel, second, the 3rd is crude drug, needs processing during use.There is no at present the technical scheme of the chitosan iodine solution that is directly used in the treatment tinea pedis.
Summary of the invention
An object of the present invention is to provide the chitosan iodine treatment liquid of tinea pedis, it has good stability, and treatment tinea pedis effect is good, makes it the health service into the mankind.
Another purpose of the present invention is to provide the preparation method for the treatment of tinea pedis treating liquid, enables to realize clinical practical application.
The tinea pedis treating liquid that the inventor provides, take chitosan iodine as main active, its raw material mass mixture ratio is as follows:
Chitosan iodine 0.2%～5%
Glacial acetic acid 0.1%～3%
Tween-20 5%～21%
Glycerol 1%～12%
Potassium iodate 0.005%～0.5%
Salicylic acid 1%～8%
Dehydrated alcohol 7%～15%
Azone 0.6%～5%
Purified water adds to 100%.
The raw material preferred mass proportioning of the chitosan iodine solution for the treatment of tinea pedis is as follows:
Chitosan iodine 1.0%
Glacial acetic acid 0.9%
Tween-20 15%
Glycerol 4%
Potassium iodate 0.1%
Salicylic acid 2.0%
Dehydrated alcohol 7.0%
Azone 1.2%
Purified water adds to 100%.
Above-mentioned chitosan iodine take water-insoluble chitosan as raw material and the iodine complexation make.
Above-mentioned glacial acetic acid, Tween-20, glycerol, potassium iodate, salicylic acid, dehydrated alcohol, azone, purified water all meet the requirement of the Pharmacopoeia of the People's Republic of China.
The inventor provides the preparation method of tinea pedis treating liquid, comprises the following steps:
1. according to the raw material mass mixture ratio weighing, standby;
2. add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully, standby;
3. the purified water that takes a morsel dissolving potassium iodate, and join in standby material and mix, stir;
4. add again in above-mentioned material after salicylic acid being dissolved in dehydrated alcohol, stir;
5. add azone, add to 100% with remaining purified water, stir;
6. fill, packing get product.
Tinea pedis treating liquid usage of the present invention is external, after 1～4 times of thin up, soaks the brothers affected part, 1 day 1 time, and each 10～30min.
In tinea pedis treating liquid provided by the invention, chitosan iodine plays disinfection, promotes healing, glacial acetic acid is used for regulating pH value, and plays collaborative solubilizing effect, and Tween-20 mainly plays solubilization, glycerol plays blending and moisture-keeping function, potassium iodate plays stabilizer function, and salicylic acid plays a part to increase bactericidal effect, and dehydrated alcohol is solvent, azone is volatilizer, and purified water is diluent.Therefore, the chitosan iodine of tinea pedis of the present invention treatment liquid has the effect of high-efficiency broad spectrum sterilization, antipruritic, antiinflammatory, can kill multiple pathogens, comprises the antibacterials such as the fungus such as Candida albicans, epidermophyton, trichophyton and Pseudomonas aeruginosa, and good stability.Be applicable to treat tinea pedis, the tinea manuum.
The effect of clinical practice is: tinea pedis and tinea manuum patient use tinea pedis treating liquid of the present invention, and effective percentage reaches 90%, and cure rate reaches more than 80%.Typical case is: 1. certain female, 27 years old, people from Zunyi City, Guizhou Province suffers from tinea pedis because infecting in the foot bath shop, itches hard to bear, uses treatment liquid of the present invention to treat for 1 week, and be antipruritic, afterwards 1 week of continual cure, fully recovers.2. certain man, people from Kerry, Guizhou Province, 43 years old, moist because of foot, perspire and lack good ventilation, suffer from " tinea pedis ", between toe, skin peels off, splits, and very itches; Soaked the affected part 6 with treatment liquid of the present invention, antipruritic, continue to use and namely fully recovered in 2 weeks.3. certain female, 49 years old, people from Chishui City, Guizhou Province because of through the Chishui River underwater work of being everlasting, caused the hands tinea; Adopt treatment liquid soaking therapy of the present invention, each 10min, i.e. recovery from illness on the 4th.
The specific embodiment
Describe the specific embodiment of the inventive method in detail by the following example:
EXAMPLE l
Prepare burden according to following formula: chitosan iodine 0.2g, glacial acetic acid 0.1g, Tween-20 5g, glycerol 1g, potassium iodate 0.005g, salicylic acid 1g, dehydrated alcohol 7g, azone 0.6g, purified water adds to 100g.Method for making is to add glacial acetic acid, Tween-20, glycerol, purified water to stir in chitosan iodine, makes dissolving fully, and is standby; The purified water that takes a morsel afterwards dissolving potassium iodate, and join in standby material and mix, stir; Add again in above-mentioned material after salicylic acid being dissolved in dehydrated alcohol again, stir; Then add azone, add to 100g with purified water, stir; Last fill, packing get product.
Embodiment 2
Prepare burden according to following formula: chitosan iodine 1.0g, glacial acetic acid 0.9g, Tween-20 15g, glycerol 4.0g, potassium iodate 0.1g, salicylic acid 2.0g, dehydrated alcohol 7.0g, azone 1.2g, purified water adds to 100g.Method for making obtains tinea pedis treating liquid with embodiment 1.
Embodiment 3
Prepare burden according to following formula: chitosan iodine 5g, glacial acetic acid 3g, Tween-20 21g, glycerol 12g, potassium iodate 0.5g, salicylic acid 8g, dehydrated alcohol 15g, azone 5g, purified water adds to 100g.Method for making obtains tinea pedis treating liquid with embodiment 1.
Claims (4)
1. a tinea pedis treating liquid, is characterized in that this treatment liquid take chitosan iodine as main active, and its raw material mass mixture ratio is as follows:
Chitosan iodine 0.2%～5%
Glacial acetic acid 0.1%～3%
Tween-20 5%～21%
Glycerol 1%～12%
Potassium iodate 0.005%～0.5%
Salicylic acid 1%～8%
Dehydrated alcohol 7%～15%
Azone 0.6%～5%
Purified water adds to 100%.
2. treatment liquid as claimed in claim 1, is characterized in that this treatment liquid take chitosan iodine as main active, and its raw material mass mixture ratio is as follows:
Chitosan iodine 1.0%
Glacial acetic acid 0.9%
Tween-20 15%
Glycerol 4.0%
Potassium iodate 0.1%
Salicylic acid 2.0%
Dehydrated alcohol 7.0%
Azone 1.2%
Purified water adds to 100%.
3. treatment liquid as described in one of claim 1 or 2 is characterized in that described chitosan iodine take water-insoluble chitosan as raw material and the iodine complexation makes.
4. the method for preparing the described chitosan iodine solution in one of claim 1 or 2, its feature comprises the following steps:
1. according to the raw material mass mixture ratio weighing, standby;
2. add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully, standby;
3. the purified water that takes a morsel dissolving potassium iodate, and join in standby material and mix, stir;
4. add again in above-mentioned material after salicylic acid being dissolved in dehydrated alcohol, stir;
5. add azone, add to 100% with remaining purified water, stir;
6. fill, packing get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105560566A CN103110658A (en) | 2012-12-20 | 2012-12-20 | Treatment liquid for treating tinea pedis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105560566A CN103110658A (en) | 2012-12-20 | 2012-12-20 | Treatment liquid for treating tinea pedis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103110658A true CN103110658A (en) | 2013-05-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012105560566A Pending CN103110658A (en) | 2012-12-20 | 2012-12-20 | Treatment liquid for treating tinea pedis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983796A (en) * | 2016-01-20 | 2017-07-28 | 刘运柱 | A kind of external used medicine for treating tinea pedis |
-
2012
- 2012-12-20 CN CN2012105560566A patent/CN103110658A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 王科兵等: "壳聚糖碘液体外抗真菌活性研究", 《解放军药学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983796A (en) * | 2016-01-20 | 2017-07-28 | 刘运柱 | A kind of external used medicine for treating tinea pedis |
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Application publication date: 20130522 |