CN103520206B - External medicinal composition for treating dermatosis and preparation method for external medicinal composition - Google Patents
External medicinal composition for treating dermatosis and preparation method for external medicinal composition Download PDFInfo
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- CN103520206B CN103520206B CN201310479973.3A CN201310479973A CN103520206B CN 103520206 B CN103520206 B CN 103520206B CN 201310479973 A CN201310479973 A CN 201310479973A CN 103520206 B CN103520206 B CN 103520206B
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Abstract
The invention discloses an external medicinal composition for treating dermatosis. The external medicinal composition consists of the following components in percentage by weight: 5 to 12 percent of metronidazole powder, 1 to 4 percent of sulphur powder, 1 to 5 percent of camphor, 25 to 33 percent of clotrimazole cream, 26 to 35 percent of compound miconazole nitrate cream or compound ketoconazole cream and 20 to 40 percent of glycerine for medical purposes. A preparation process comprises the following steps of (1) adding the metronidazole powder, the sulphur powder and the camphor into the glycerine for medical purposes, heating the components to 80 to 100 DEG C, and uniformly mixing the components; (2) sequentially adding the clotrimazole cream and the compound miconazole nitrate cream or the compound ketoconazole cream after the components in the step (1) are cooled to room temperature, and completely and uniformly stirring the components to obtain the external medicinal composition. The external medicinal composition for treating dermatosis is prepared from a plurality of components with sterilization and antibacterial effects, has the effects of resisting fungi and anaerobic bacteria and killing mites, and has remarkable curative effects on allergic dermatitis, contact dermatitis and skin disorder caused by various germs.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of various dermopathic external used medicine be used for the treatment of caused by contact dermatitis, allergic dermatitis and fungus, anaerobe, mite infection etc., the invention still further relates to the preparation method of this medicine for external use.
Background technology
Dermatosis is a kind of common multiple diseases, has higher sickness rate, has had a strong impact on daily life and work.Dermopathic of a great variety, the cause of disease is complicated, and is difficult to radical cure, brings worries in various degree to patient.Be used for the treatment of now dermopathic medicine on the market a lot, but most of external used medicine can only be treated for a certain specific dermatosis, for the dermatosis caused by other cause of disease or Different types of etiopathogenises, therapeutic effect is then relatively poor; And treat dermatosis by innerlich anwenden thing, then can damage organ due to Long-term taking medicine again.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, the dermopathic externally-applied medicinal composition that a kind for the treatment of is caused by different pathogeny or Different types of etiopathogenises is simultaneously provided, therapeutic domain is wide, and therapeutic effect is good, another object of the present invention is to the preparation method providing this external used medicine a kind of.
For achieving the above object, the present invention is achieved through the following technical solutions:
One treats dermopathic externally-applied medicinal composition, by weight percentage, composed of the following components: metronidazole powder 5-12%, Cosan 1-4%, Camphora 1-5%, clotrimazole cream 25-33%, miconazole clobetasol cream or Compound Ketoconazole Cream 26-35%, medical glycerol 20-40%.
Preferably: by weight percentage, composed of the following components: metronidazole powder 8%, Cosan 2%, Camphora 2%, clotrimazole cream 30%, miconazole clobetasol cream 30% and medical glycerol 28%.
Preferably: by weight percentage, composed of the following components: metronidazole powder 12%, Cosan 1%, Camphora 3%, clotrimazole cream 26%, Compound Ketoconazole Cream 35%, medical glycerol 23%.
Preferably: described clotrimazole cream, 0.1 gram of clotrimazole is contained in every 10 grams of clotrimazole creams.
Preferably: described miconazole clobetasol cream, every 10 grams of miconazole clobetasol creams contain 0.2 gram of miconazole nitrate and 5 milligrams of clobetasol propionate.
Preferably: described Compound Ketoconazole Cream, 0.1 gram of ketoconazole and 2.5 milligrams of clobetasol propionate are contained in every 10 grams of Compound Ketoconazole Creams.
Preferably: the granularity of described metronidazole powder is 60-80 order.
Preferably: the granularity of described Cosan is 60-80 order.
A preparation method for externally-applied medicinal composition as above, comprises following preparation process:
1) metronidazole powder, Cosan and Camphora are joined in medical glycerol, be heated to 80-100 DEG C and each component is fully mixed;
2), after the component in step 1) being cooled to room temperature, adding clotrimazole cream, miconazole clobetasol cream or Compound Ketoconazole Cream successively, stir, obtain described externally-applied medicinal composition.
Beneficial effect of the present invention is, externally-applied medicinal composition of the present invention, adopts the multiple component with bactericidal to make, and has antifungal, anaerobe resistant and kills the effect of acarid, for allergic dermatitis, contact dermatitis and by multiple germ dermatosis, therapeutic effect is obvious.
Detailed description of the invention
Below in conjunction with specific embodiment, the specific embodiment of the present invention is described further, but the present invention is not limited in following embodiment.
The dermopathic externally-applied medicinal composition for the treatment of of the present invention, by weight percentage, be made up of 5-12% metronidazole powder, 1-4% Cosan, 1-5% Camphora, 25-33% clotrimazole cream, 26-35% miconazole clobetasol cream or Compound Ketoconazole Cream, 20-40% medical glycerol, each constituent content amounts to 100% above, wherein:
Metronidazole powder: C
6h
9n
3o
3, there is wide spectrum anaerobe resistant, protozoacide and kill the effect of acarid, the preferred 60-80 order of powder size;
Cosan: S, has antifungal and the effect of killing acarid, the preferred 60-80 order of powder size;
Camphora: C
10h
16o, has antifungal, kills acarid and antipruritic effect;
Clotrimazole cream: its specification is containing 0.1g clotrimazole (C in every 10g clotrimazole cream
22h
17clN
2), have antifungal effect, market is bought and can be obtained;
Miconazole clobetasol cream: its specification is that every 10g miconazole clobetasol cream contains 0.2g miconazole nitrate (C
18h
15cl
4n
3o
4) and 5mg clobetasol propionate (C
25h
32clFO
5), have antifungal, antiallergic and antipruritic effect, market is bought and can be obtained;
Compound Ketoconazole Cream: its specification is containing 0.1g ketoconazole (C in every 10g Compound Ketoconazole Cream
26h
28cl
2n
4o
4) and 2.5mg clobetasol propionate (C
25h
32clFO
5), have antifungal, itching-relieving action, market is enough bought and can be obtained;
Medical glycerol: C
3h
8o
3, there is the effect of skin-moisturizing, skin.
Utilize above-mentioned each component to prepare the dermopathic external used medicine of described treatment, its preparation process is as follows:
1) metronidazole powder, Cosan and Camphora are joined in medical glycerol, be heated to 80-100 DEG C and each component is fully mixed;
2), after the component in step 1) being cooled to room temperature, adding clotrimazole cream, miconazole clobetasol cream or Compound Ketoconazole Cream successively, stir, obtain externally-applied medicinal composition of the present invention.
Embodiment 1
One treats dermopathic externally-applied medicinal composition, by weight percentage, composed of the following components: 5% metronidazole powder, 3% Cosan, 2% Camphora, 25% clotrimazole cream, 35% miconazole clobetasol cream and 30% medical glycerol, wherein: 80 mesh sieves crossed by metronidazole powder and Cosan, the specification of clotrimazole cream is containing 0.1g clotrimazole in every 10g clotrimazole cream, manufacturer: beneficial Pharmaceutical (Wuhu) company limited of traditional Chinese medicines group three; The specification of miconazole clobetasol cream is that every 10g miconazole clobetasol cream contains 0.2g miconazole nitrate and 5mg clobetasol propionate, manufacturer: Guangdong Taicheng Pharmaceutical Co., Ltd.
By aforesaid preparation process, metronidazole powder, Cosan and Camphora in above-mentioned each component are joined in medical glycerol, being heated to 80-100 DEG C makes each component fully mix, then after component being cooled to room temperature, add clotrimazole cream, miconazole clobetasol cream successively, stir, obtain externally-applied medicinal composition of the present invention.
For the externally-applied medicinal composition of embodiment 1, add up the treatment situation of 100 people, the cure rate for the treatment of skin pruritus or external skin pathological changes is 100%, a wherein model case, Cai, female, 60 years old, Hong Kong helper, suffers from the hand desquamation caused by anaerobic infection, be in a bad way, all there is hand desquamation symptom in various degree throughout the year, especially the most serious with spring and autumn, used the external used medicine of commercially available multiple treatment skin, but often recur, fail to effect a radical cure, externally-applied medicinal composition through embodiment 1 is treated, be applied in site of disease 2 times on the one, within 1 week, rear peeling symptom is alleviated to some extent, cure after 2 weeks, do not recur again more than 1 year.
Another model case, Lee, man, 25 years old, student, the toe space suffered from caused by anaerobic infection is itched rotten, and the externally-applied medicinal composition through embodiment 1 is treated, and is applied in site of disease 2 times on the one, after 3 days, pruritis is alleviated to some extent, after 1 week, rotten position starts healing, within 10 days, cures, comes not recur more 2 years again.
A model case again, flood certain, man, 70 years old, before suffering from the right lower extremity shin caused by mite infection, pruritus reaches 8 years, seeks medical advice and medicine everywhere, all fails to cure, suffer untold misery, externally-applied medicinal composition through embodiment 1 is treated, and be applied in site of disease 2 times on the one, after 8 days, pruritus is eliminated substantially, within 30 days, cured, come 1 year not recur again more.
Embodiment 2
One treats dermopathic externally-applied medicinal composition, by weight percentage, composed of the following components: 8% metronidazole powder, 2% Cosan, 2% Camphora, 30% clotrimazole cream, 30% miconazole clobetasol cream and 28% medical glycerol, wherein, 70 mesh sieves crossed by metronidazole powder and Cosan, the specification of clotrimazole cream is containing 0.1g clotrimazole in every 10g clotrimazole cream, manufacturer: Harbin Pharmaceutical Group Sanchine UK-USA Pharmaceutical Co., Ltd.; The specification of miconazole clobetasol cream is that every 10g miconazole clobetasol cream contains 0.2g miconazole nitrate and 5mg clobetasol propionate, manufacturer: Zhejiang Sheng Ji pharmaceutcal corporation, Ltd.By the preparation process of previous embodiment 1, obtain externally-applied medicinal composition of the present invention.
For the externally-applied medicinal composition of embodiment 2, add up the treatment situation of 100 people, the dermopathic cure rate for the treatment of caused by fungal infection is 100%, a wherein model case, Wang, man, 32 years old, suffers from the hip pruritus caused by anaerobic infection, externally-applied medicinal composition through embodiment 2 is treated, and be applied in site of disease 2 times on the one, after 5 days, pruritus is eliminated substantially, cured after 10 days, do not recurred over 3 years.
Another model case, Wang, female, 16 years old, suffers from the whole body pruritus caused by mite infection, and the externally-applied medicinal composition through embodiment 2 is treated, and be applied in site of disease 2 times on the one, after 2 days, pruritus is eliminated substantially, is cured after 5 days, does not recur over 1 year.
Embodiment 3
One treats dermopathic externally-applied medicinal composition, by weight percentage, composed of the following components: 10% metronidazole powder, 4% Cosan, 5% Camphora, 33% clotrimazole cream, 26% miconazole clobetasol cream and 22% medical glycerol, wherein, 60 mesh sieves crossed by metronidazole powder and Cosan, the specification of clotrimazole cream is containing 0.1g clotrimazole in every 10g clotrimazole cream, manufacturer: Guangdong ShunFeng Pharmaceutical Co., Ltd.; The specification of miconazole clobetasol cream is that every 10g miconazole clobetasol cream contains 0.2g miconazole nitrate and 5mg clobetasol propionate, manufacturer: new east station of Guangzhou health pharmaceutcal corporation, Ltd; By the preparation process of previous embodiment 1, obtain externally-applied medicinal composition of the present invention.
For the externally-applied medicinal composition of embodiment 3, add up the treatment situation of 50 people, the cure rate for the treatment of anaphylaxis dermatosis is 100%, a wherein model case, Guo, man, 28 years old, workman, suffered from allergic dermatitis, very easily allergic symptom is produced to metal species material, externally-applied medicinal composition through embodiment 3 is treated, and is applied in site of disease 2 times on the one, and after 10 days, symptom is eliminated and cured, when not contacting metal, do not recur over 1 year.
Another model case, Wu, female, 25 years old, chemical fibre factory workman, suffers from allergic dermatitis, and trick place has the red point of pruritus, and the externally-applied medicinal composition through embodiment 3 is treated, be applied in site of disease 2 times on the one, after 3 days, the red elimination of pruritus, is cured after 8 days, is not recurred over the past half year.
Embodiment 4
One treats dermopathic externally-applied medicinal composition, by weight percentage, composed of the following components: 12% metronidazole powder, 1% Cosan, 3% Camphora, 26% clotrimazole cream, 35% Compound Ketoconazole Cream and 23% medical glycerol, wherein, 80 mesh sieves crossed by metronidazole powder and Cosan, the specification of clotrimazole cream is containing 0.1g clotrimazole in every 10g clotrimazole cream, manufacturer: safe pharmaceutical Co. Ltd tomorrow of Fujian Province three; The specification of Compound Ketoconazole Cream is containing 0.1g ketoconazole and 2.5mg clobetasol propionate in every 10g Compound Ketoconazole Cream, manufacturer: Dihon Pharmaceutical Group Co., Ltd..
By aforesaid preparation process, metronidazole powder, Cosan and Camphora in above-mentioned each component are joined in medical glycerol, being heated to 80-100 DEG C makes each component fully mix, then after component being cooled to room temperature, add clotrimazole cream, Compound Ketoconazole Cream successively, stir, obtain externally-applied medicinal composition of the present invention.
For the externally-applied medicinal composition of embodiment 4, add up the treatment situation of 200 people, treating fungus-caused dermopathic cure rate is 100%, a wherein model case, Zhan, man, 25 years old, workman, suffers from the serious tinea manuum, and the externally-applied medicinal composition through embodiment 4 is treated, be applied in site of disease 2 times on the one, after 1 week, symptom is alleviated substantially, cures, do not recur over 1 year again after 10 days.
Another model case, Chen, man, 37 years old, workman, suffered from slight tinea pedis, and the externally-applied medicinal composition through embodiment 4 is treated, and was applied in site of disease, cured after 10 days, do not recur over 1 year again for 2 times on the one.
Embodiment 5
One treats dermopathic externally-applied medicinal composition, by weight percentage, composed of the following components: 6% metronidazole powder, 2% Cosan, 1% Camphora, 27% clotrimazole cream, 33% Compound Ketoconazole Cream and 31% medical glycerol, wherein, 70 mesh sieves crossed by metronidazole powder and Cosan, the specification of clotrimazole cream is containing 0.1g clotrimazole in every 10g clotrimazole cream, manufacturer: Yongan, Fujian Province Pharmaceutical Co., Ltd; The specification of Compound Ketoconazole Cream is containing 0.1g ketoconazole and 2.5mg clobetasol propionate in every 10g Compound Ketoconazole Cream, manufacturer: Wuhan Nuoan Pharmacy Co., Ltd..By the preparation process of previous embodiment 4, obtain externally-applied medicinal composition of the present invention.
For the externally-applied medicinal composition of embodiment 5, add up the treatment situation of 100 people, the dermopathic cure rate that treatment Different types of etiopathogenises causes is 100%, a wherein model case, Lee, female, 20 years old, student, suffers from the acne rosacea caused by mite infection, and the externally-applied medicinal composition through embodiment 5 is treated, be applied in site of disease 2 times on the one, after 2 weeks, symptom is alleviated substantially, cures, do not recur over 1 year again after 15 days.
Another model case, flood certain, man, 20 years old, workman, suffered from tinea cruris, and the externally-applied medicinal composition through embodiment 5 is treated, and was applied in site of disease, cured after 10 days, do not recur over 2 years again for 2 times on the one.
Specific embodiment described in the invention is only for being used for the treatment of to of the present invention the detailed description that the specific implementation process of compositions is wanted in dermopathic external, instead of the restriction to its implementation procedure.Any modification of carrying out the method and improvement, the substituting and using of similar or close material in the scope of the claims or category, all belongs to scope of patent protection of the present invention.
Claims (8)
1. the dermopathic externally-applied medicinal composition for the treatment of, it is characterized in that: by weight percentage, composed of the following components: metronidazole powder 5-12%, Cosan 1-4%, Camphora 1-5%, clotrimazole cream 25-33%, miconazole clobetasol cream or Compound Ketoconazole Cream 26-35%, medical glycerol 20-40%; Its preparation process comprises:
1) metronidazole powder, Cosan and Camphora are joined in medical glycerol, be heated to 80-100 DEG C and each component is fully mixed;
2) by step 1) in component be cooled to room temperature after, add clotrimazole cream, miconazole clobetasol cream or Compound Ketoconazole Cream successively, stir, obtain described externally-applied medicinal composition.
2. externally-applied medicinal composition according to claim 1, it is characterized in that: by weight percentage, composed of the following components: metronidazole powder 8%, Cosan 2%, Camphora 2%, clotrimazole cream 30%, miconazole clobetasol cream 30% and medical glycerol 28%.
3. externally-applied medicinal composition according to claim 1, it is characterized in that: by weight percentage, composed of the following components: metronidazole powder 12%, Cosan 1%, Camphora 3%, clotrimazole cream 26%, Compound Ketoconazole Cream 35%, medical glycerol 23%.
4. the externally-applied medicinal composition according to claim 1 or 2 or 3, is characterized in that: described clotrimazole cream, containing 0.1 gram of clotrimazole in every 10 grams of clotrimazole creams.
5. externally-applied medicinal composition according to claim 1 and 2, is characterized in that: described miconazole clobetasol cream, and every 10 grams of miconazole clobetasol creams contain 0.2 gram of miconazole nitrate and 5 milligrams of clobetasol propionate.
6. the externally-applied medicinal composition according to claim 1 or 3, is characterized in that: described Compound Ketoconazole Cream, containing 0.1 gram of ketoconazole and 2.5 milligrams of clobetasol propionate in every 10 grams of Compound Ketoconazole Creams.
7. the externally-applied medicinal composition according to claim 1 or 2 or 3, is characterized in that: the granularity of described metronidazole powder is 60-80 order.
8. the externally-applied medicinal composition according to claim 1 or 2 or 3, is characterized in that: the granularity of described Cosan is 60-80 order.
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| CN104398522A (en) * | 2014-12-16 | 2015-03-11 | 吴书清 | Medicine for treating fungal dermatoses and eczema infection and preparation method thereof |
| CN110169986A (en) * | 2019-07-04 | 2019-08-27 | 陈少飞 | It is a kind of to treat tinea pedis, the quick-acting bastes of skirt-roof snake and its preparation application method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130065A (en) * | 1995-10-23 | 1996-09-04 | 滇虹天然药物厂 | Compound ketoconazole external-use preparation |
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2013
- 2013-10-15 CN CN201310479973.3A patent/CN103520206B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130065A (en) * | 1995-10-23 | 1996-09-04 | 滇虹天然药物厂 | Compound ketoconazole external-use preparation |
Non-Patent Citations (1)
| Title |
|---|
| 复方四甲硝唑软膏治疗疥疮52例;李凯;《西南国防医药》;19971231;第7卷(第2期);第82页 * |
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