CN101129409B

CN101129409B - Antimycotic externally used drug

Info

Publication number: CN101129409B
Application number: CN2007100550552A
Authority: CN
Inventors: 程贵昌
Original assignee: Individual
Current assignee: Individual
Priority date: 2007-08-30
Filing date: 2007-08-30
Publication date: 2011-06-01
Anticipated expiration: 2027-08-30
Also published as: CN101129409A

Abstract

The invention discloses an externally-used medicament for treating skin mycosis diseases, which is prepared from the raw materials of (by weight percent) terbinafine hydrochloride or miconazole or ketoconazole 0. 5-2%, Clobetasol Propionate 0. 01-0. 2%, neomycin sulphate 0. 3-1%, bee glue 5-25%, and balancing distilled water.

Description

A kind of antimycotic externally used drug

Technical field

The present invention relates to a kind of external preparation for skin medicine, relate in particular to the medicine for external use of treatment dermatomycosis.

Background technology

The dermatosis that fungal infection causes is a kind of relatively more obstinate, be difficult to the thoroughly disease of healing, common have a tinea capitis, tinea manus and pedis, tinea cruris, tinea corporis etc., often Pruritus unbearably, certain infectiousness is arranged, bring many inconvenience for people's live and work, the dermopathic topical agent of general treatment antimycotic has miconazole, ketoconazole, clotrimazole, salicylic acid, acetic acid etc., how based on pure Western medicine, the topical agent of Chinese medicine is less, and with regard to existing medicament, medicament takes effect slower mostly, skin there is certain zest, and cause the skin drug resistance easily, recurrence easily, the treatment dermatosis antimycotic externally used drug that Chinese medicine and western medicine combines does not appear in the newspapers at present.

Summary of the invention

Be directed to present antimycotic treatment external use medicine for treating dermatosis present situation, the object of the invention is, provides a kind of compatibility simple, reasonable, the Chinese and Western combination, and instant effect is difficult for recurrence, and the little medicine for external use of toxic and side effects.

For realizing the object of the invention, technical scheme is passed through following each component compatibility as effective ingredient, each component is by weight percentage: TER-HCL or miconazole or ketoconazole 0.5%--2%, clobetasol propionate 0.01-0.2%, polygynax 0.3-1%, propolis 5-25%, surplus is stayed water for steaming.

This medicament preparation method is as follows: liquid paraffin 6-10%, octadecanol 5-8%, monoglyceride 2% are made an amount of oil phase, add TER-HCL or ketoconazole or miconazole 0.5%--2%, clobetasol propionate 0.01-0.2% in 80 degree; With glycerol 5%, peregal 2%, propylene glycol 3%, that formicester 0.03% is made water is an amount of.In the 60-80 degree oil phase is added water, stir.Be cooled to the 50-60 degree and add 0.3-1% polygynax and stirring.Treat that temperature reduces to 40 degree and add propolis 5-25%, cross the ultrasonic emulsification machine, make this ointment agent, also can add medicinal spray substrate and make spray.

Innovation of the present invention is: existing anti-microbial type Western medicine has been carried out screening, combination, select existing anti-microbial type medicine for use: TER-HCL or miconazole or ketoconazole, clobetasol propionate, polygynax, and added natural antibacterial composition---propolis on this basis.

Anti-microbial type medicine TER-HCL or miconazole or ketoconazole have better therapeutic effect to tinea corporis, tinea cruris, the tinea manuum etc.; Polygynax has good killing effect to gram negative bacteria and gram positive bacteria; Clobetasol propionate can improve antibiotic property and antipruritic, antiallergic at this; And contain in the propolis trace aminoacid: valine, lysine, arginine, leucine, glutamic acid, different propylhomoserin, cysteine etc., most aminoacid are essential by human body, some or even human body can not be synthetic, in addition, also contain abundant mineral and trace element zinc, selenium, calcium etc. and vitamin B1, vitamin B2, vitamin B3, vitamin E etc. in the propolis, of paramount importance be propolis contain multiple organic acid such as: benzoic acid, ferulic acid, caffeic acid, benzoic acid have anticorrosion, phlegm-dispelling functions; Ferulic acid has antiinflammatory, analgesic effect; Caffeic acid has effects such as hemostasis.Natural and complexity based on the propolis composition, propolis has broad spectrum antibacterial function, 10 kinds of tinea bacterium there are stronger antibacterial, antibacterial action, malignant bacteria, virus, protozoon etc. are had suppress or killing action, for this reason, utilize the above-mentioned characteristic of propolis, be applied in the anti-microbial type medicament, be used in combination, to improve the antibiotic strength of antimicrobial drug with above-mentioned selected anti-microbial type medicine, prolong its antibacterial activity, strengthen the curative effect of anti-microbial type medicine.To treatment human body dermatitis and eczema, tinea corporis, tinea cruris, the tinea manuum, pruritus vulvae, beriberi etc. are had better therapeutic effect by the dermatosis of fungus/bacterial infection, play health-care effect preferably.

Compound preparation of the present invention can be made various dosage forms, for example solution, aerosol, ointment etc.Usage: put body surface fungal infection place outward on the skin, common dose: should clean before the medication and dry affected part every day 1-2 time, then medicament is applied to affected part and on every side, and gently be rubbed, if affected part intertrigo, available especially at night gauze applies lid after embrocating.The course of treatment: tinea corporis, 1～2 week of tinea cruris, 2～3 weeks of tinea pedis, tinea versicolor 1-3 week.

With its ointment is example, and the animal efficacy of medicine observing of this ointment anti-fungal infection of external is as follows:

Each 30 of Cavia porcelluss, male and female are not limit, and are divided into three groups, 10 every group.The back unhairing is used the sand paper scratch mark, inoculates the normal saline solution of Trichophyton mentagrophytes, makes the infection model of Trichophyton mentagrophytes, occurs erythema and edema after three days, implements administration.Give normal saline first group of every day, give hydrochloric acid Te Naifen second group of every day, spray with spray of the present invention the 3rd group of every day.Once a day, each consumption is that medicinal liquid evenly covers affected part.Administration is the 5th day and 10 days respectively, and the skin lesion of observing Cavia porcellus improves situation and fungus removing situation.The index that skin lesion obviously improves is no erythema, no edema.Fungus removing situation investigation method is that the tissue of getting infection site is cultivated, and observes whether conk is arranged, and is fungus as no conk and thoroughly removes.Observed result sees Table 1.

Table 1 preparation of the present invention is to the animal efficacy of medicine observing

As shown in Table 1, medicament of the present invention infects the very obvious and short treating period of Cavia porcellus therapeutic effect to Trichophyton mentagrophytes.

Beneficial effect of the present invention is, use through tinea corporis, tinea cruris, tinea manus and pedis, tinea versicolor and seborrheic dermatitis of head patient, product behind the proof interpolation propolis is with respect to the product of pure western medicine composition, curative effect improves a lot, through 265 routine patient's usefulness, cure rate average 84%, effective percentage average 99%, and shorten the course of treatment, is difficult for recurrence, and because of adding propolis the regenerated effect of the histiocyte of promotion is arranged.

Promote the experiment of histiocyte regeneration, cause 4 place's skin injurys on the ear of rabbit, coat preparation of the present invention at two place's wound surface then, other two places are left intact, in contrast.Two place's epidermises that the result coats preparation of the present invention were just fully recovered at the 6th day, ulcer occurred without two place's wound surface of any processing, only saw that at the ulcer edge a small amount of epithelial cell growth is arranged, and did not see recovery from illness.Description of test, preparation of the present invention have the regenerated effect of the histiocyte of promotion.

This medicament clinical observation result such as following table:

Criterion of therapeutical effect: cure: use 1-3 after week continuously, skin lesion improves: disappearance is oozed out in erosion, desquamation disappears, and pruritus disappears.

Produce effects: use 1-3 after week continuously, skin lesion improves (erosion ooze out alleviate, desquamation reduces), and more than 60%, pruritus obviously alleviates.

Take a turn for the better: use 1-3 after week continuously, skin lesion improves (erosion ooze out alleviate, desquamation reduces), and more than the 60%-20%, pruritus alleviates.

Invalid: as to use 1-3 after week continuously, state of an illness no change.

The specific embodiment

For better illustrating as follows for embodiment to the present invention:

Embodiment

Get liquid paraffin 10g, octadecanol 5g, monoglyceride 2g makes an amount of oil phase, adds 1g TER-HCL or ketoconazole, clobetasol propionate 0.02g under 80 temperature; Get glycerol 5g, peregal 2g, propylene glycol 3g, formicester 0.03g make water.Under the 60-80 temperature, oil phase is added water, stir; Being cooled to 50-60 degree adding polygynax 0.3g then stirs.Add water-soluble bee glue 20g when spending when temperature is cooled to 40, cross ultrasonic emulsification machine-processed unguentum 100g.

Typical case's case history

Certain male people from Zhengzhou City, 45 years old, beriberi ulceration patient suffered from vitamin B1 deficiency for many years, uses Western medicine for many years, and recurrence often very is worried, uses this preparation, and the beriberi of showing effect repeatedly after 14 days is cured, the skin that the ulceration director makes new advances.

Certain male people from Kaifeng, 56 years old, the psoriatic suffered from psoriasis for many years, used existing Western medicine, and this preparation is used in outbreak repeatedly, and psoriasis is completely cured after 10 days, short treating period, effect is better, welcome by it.

Certain women people from Luoyang 40 years old, tinea manuum patient suffers from the tinea manuum for many years, uses existing Western medicine obstinate, uses this preparation, and the tinea manuum is cured after 7 days, does not have recurrence, short treating period, effect is better.

Certain women people from Luoyang 40 years old, the dermatitis and eczema patient suffers from dermatitis and eczema for many years, uses existing Western medicine obstinate, uses this preparation, and the tinea manuum is cured after 12 days, does not have recurrence, short treating period, effect is better.

Claims

1. an antimycotic externally used drug is characterized in that, contains following component, each component by weight percentage: TER-HCL 0.5%-2%, clobetasol propionate 0.01-0.2%, polygynax 0.3-1%, propolis 5-25%, surplus is a distilled water.