CN101940701A - Aloe oculentum and preparation method - Google Patents
Aloe oculentum and preparation method Download PDFInfo
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- CN101940701A CN101940701A CN2010105019792A CN201010501979A CN101940701A CN 101940701 A CN101940701 A CN 101940701A CN 2010105019792 A CN2010105019792 A CN 2010105019792A CN 201010501979 A CN201010501979 A CN 201010501979A CN 101940701 A CN101940701 A CN 101940701A
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- aloe
- aloe gel
- alomycin
- aloin
- cinnamate
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Abstract
The invention relates to aloe oculentum and a preparation method, and belongs to the technical field of eyedrops. The aloe oculentum is characterized by comprising the following medicaments and raw materials in part by weight: 80 to 90 parts of aloe gel, 1 to 5 parts of aloin, 0.1 to 1 part of alomycin, 0.1 to 0.3 part of carbomer, 0.1 to 0.2 part of sodium hyaluronate, 0.1 to 0.2 part of anthraquinone compounds, 0.1 to 0.2 part of cinnamate and 0.2 to 0.5 part of free amino acid. The preparation method comprises the following steps of: extracting the aloe gel from aloe barbadensis by adopting a freezing stabilization method, and converting the aloe gel into aloe gel powder; and mixing the aloe gel powder and water for injection under the acidic condition or neutral condition, of which the PH is between 5.5 and 7.5, mixing the mixture and the aloin, the alomycin, the carbomer, the sodium hyaluronate, the anthraquinone compounds, the cinnamate and the free amino acid, stirring uniformly, regulating the pH value to be neutral, and subpackaging and disinfecting. The aloe oculentum can treat eye diseases such as pterygium, conjunctivochalasis, corneal nebula, chronic dacryocystitis, eye itching, xerophthalmia and the like.
Description
Technical field
The invention belongs to the medicament for the eyes technical field, be specifically related to a kind of Aloe eye ointment and preparation method.
Background technology
Aloe is grown in the area of arid, and this herbal plant when its leaf is severed, can secrete a kind of mucus, can make otch sealing very soon and solidifies.People apply this mucus in incised wound and burn or rot on the wound of skin ulcer, find that it has that wound stops blooding rapidly, the curative effect of evacuation of pus, can promote wound healing, preserve moisture, reduce the scar scar and form.Since the seventies, international Aloe research association (lnternation aloe science council) is studied Aloe glue, confirmation is applied to human body with it, has the multiple regenerated function of tendon of bactericidal antiphlogistic analgesia, and this function is that other herbaceous plant are unrivaled.But how to utilize aloetic above-mentioned functions, the medicine that is developed into diseases related with strong points also has a lot of work to do, particularly, also just be in the preliminary exploratory stage, so still there is not a kind of Aloe medicament for the eyes that becomes commodity so far at the Aloe medicament for the eyes of some ophthalmics.
Summary of the invention
The objective of the invention is to provide a kind of Aloe eye ointment and preparation method, with the Aloe eye ointment of this method preparation, can treat eye surface diseases and lacrimal passage diseases such as pterygium disease, the loose disease of conjunctiva, corneal macula disease, chronic lachrymal capsule inflammation, obstructed lacrimal passage disease, ophthalmic pruritus disease.
Above-mentioned goal of the invention is achieved through the following technical solutions, a kind of Aloe eye ointment and preparation method, its main points are to be made up of following medicine and raw material by weight: Aloe gel 80~90, aloin 1~5, alomycin 0.1~1, card pool nurse 0.1~0.3, hyaluronate sodium 0.1~0.2, anthraquinone analog compound 0.1~0.2, cinnamate 0.1~0.2, free amino acid 0.2~0.5; Or aloe gel powder 80~90, sodium chloride 0.1~1, boric acid 0.5~2, card pool nurse 0.1~0.3, ethyl hydroxybenzoate 0.025~0.1, hyaluronate sodium 0.01~0.1, propylene glycol 0.5~5, Borneolum Syntheticum 0.1~0.5; And make by the method for being prepared as follows:
At first from Aloe vulgaris, adopt " freeze-stable method " to extract Aloe gel, and convert it into aloe gel powder, aloe gel powder is mixed with water for injection under the acidity of PH5.5~7.5 or neutrallty condition, and mix with aloin, alomycin, card pool nurse, hyaluronate sodium, anthraquinone analog compound, cinnamate, free amino acid, stir, transfer pH value to neutral, packing, sterilization; Or aloe gel powder mixed with water for injection under the acidity of PH5.5~7.5 or neutrallty condition, and stir with water-soluble sodium chloride, ethyl hydroxybenzoate, propylene glycol, boric acid, Borneolum Syntheticum respectively, the water that adds 37~40 ℃ all dissolves above-mentioned composition; To block pool nurse solution and be mixed with 1.5~3 percent aqueous solution, add sodium hyaluronate solution again, make clear gel, clear gel will be added in the above-mentioned aqueous solution, and transfer pH value to neutral, packing, sterilization.
Above-mentioned a kind of Aloe eye ointment and preparation method, one of its technical scheme are pressed following medicine and raw material and parts by weight and are formed: Aloe gel 85, aloin 3, alomycin 0.5, card pool nurse 0.15, hyaluronate sodium 0.15, anthraquinone analog compound 0.1, cinnamate 0.15, free amino acid 0.3.
The present invention can treat eye surface diseases and lacrimal passage diseases such as pterygium disease, the loose disease of conjunctiva, corneal macula disease, chronic lachrymal capsule inflammation, obstructed lacrimal passage disease, ophthalmic pruritus disease.
Table one Aloe eye ointment is treated the therapeutic effect table of following ophthalmic
Ophthalmic | Case load | Effective case load | The DeGrain case load | Effective percentage |
Corneal macula disease | 15 | 12 | 3 | 80% |
Pterygium disease | 35 | 30 | 5 | 85.7% |
The loose disease of conjunctiva | 12 | 9 | 3 | 75% |
Ophthalmic pruritus disease | 44 | 42 | 2 | 95.4% |
The therapeutic effect table of table two Aloe eye ointment treatment obstructed lacrimal passage disease ophthalmic
The clinical research summary of Aloe eye ointment treatment xerophthalmia is as follows:
Xerophthalmia is the multifactor pathological changes of a kind of tear and eye table, can cause ophthalmic uncomfortable, drying, breakup time of tear film to shorten, reach potential multiple symptom such as table organization's damage and take place,
Purpose: in order to assess effectiveness, the safety of Aloe eye ointment treatment xerophthalmia, with contain sodium chloride, the blended isotonic solution of potassium chloride is done matched group.
Method: picked at random 100 examples from the xerophthalmia patient of ophthalmology outpatient service are divided into test group, each 50 example of matched group; Test group is applied eye, every day three times, medication one month with the Aloe eye ointment; Matched group is with sodium chloride, the blended isotonic solution of potassium chloride, is every day three times equally, medication one month.
The result: two groups by diagnosis and cornea fluorescein, breakup time of tear film inspection finding, compare with matched group, Aloe eye ointment test group, patient's subjective symptoms is eliminated fast, the harmless situation of cornea fluorescent staining, the breakup time of tear film prolongation causes normal, and every index is significantly improved, two groups of significant differences, P<0.005.
Conclusion: the Aloe eye ointment is to alleviating patient symptom, and repairing eye table tear film and prolonging breakup time of tear film has significant curative effect; Have significant curative effect to account for 44 examples in the test group 50 routine cases, the effective percentage of treatment is 88%; And having significant curative effect to account for 24 examples in the matched group 50 routine cases, the effective percentage of treatment is 48%.
Below be the case history for the treatment of several ophthalmics with the present invention:
One, Zhu Jiawu, man, 48 years old, workman
Symptom: furious repeatedly, the more than two decades of shedding tears was once examined in other hospitals and was obstructed lacrimal passage, and was ineffective through intubate, flushing.
Diagnosis: right chronic dacryocystitis, obstructed lacrimal passage;
Treatment: in December in 2007 20 days, under table+local anaesthesia, row lacrimal passage laser operation, postoperative lacrimal passage injection Aloe eye ointment, logotype four times was followed up a case by regular visits to 2 years, healed.
Two, Zhang Jimei, woman, 30 years old, businessman
Symptom: annual autumn and winter season shed tears 5 years, once did the irrigation of lacrimal passage treatment.
Diagnosis: right simple property obstructed lacrimal passage;
Treatment: on November 9th, 2007, under local anaesthesia, the laser therapy of row lacrimal passage, postoperative lacrimal passage immediately injects the Aloe eye ointment, injects the Aloe eye ointment once in later every month in lacrimal passage, and logotype is cured for three times, follows up a case by regular visits to 2 years, does not send out.
Three, Zhang Yonglan, the woman 47 years old, does manual work
Symptom: left eye was shed tears 25 years repeatedly, repeatedly failed to respond to any medical treatment.
Diagnosis: left chronic dacryocystitis, obstructed lacrimal passage;
Treatment: in December in 2008 9 days, in the descending left lacrimal passage laser therapy of local anaesthesia, the postoperative lacrimal passage injected the Aloe eye ointment, injects the Aloe eye ointment during further consultation in later every month in lacrimal passage, cures for totally five times, follows up a case by regular visits to transference cure, recurrence 2 years.
Four, Wu Ruhui, man, 66 years old, peasant
Symptom: the long nebula film of right eye, development gradually covers surplus the cornea 20 year, and is not good with drug effect.
Diagnosis: right super-huge pterygium (having hidden whole pupils);
Treatment: on March 2nd, 2008, under table fiber crops+local anaesthesia, the right simple excision of pterygium of row, postoperative applies the eye first quarter moon with the Aloe eye ointment, cooperates other anti-inflammatory agents, and symptomatic treatment was followed up a case by regular visits to 2 years, not recurrence.
Five, Ran Suxia, woman, 42 years old, computer white collar
Symptom: dry and astringent, the rubescent foreign body sensation of eye, write fatiguability continuously, BUT 3-4 second.
Diagnosis: 1, xerophthalmia, asthenopia.2, chronic conjunctivitis;
Treatment: beautiful etc. by the xerophthalmia artificial tears as liking, the conventional therapy DeGrain.The back adds with the Aloe eye ointment and applies eye on the basis of conventional artificial tears's treatment.Every day 2-4 time, after the course of treatment, symptom is obviously improved, breakup time of tear film 7-9 second.
Six, Qiu Yanshu, man, 73 years old, retired teacher
Symptom: dry and astringent, the foreign body sense of discomfort of eye repeatedly, to shed tears surplus in the of 10 year, irrigation of lacrimal passage is unobstructed, and once unsatisfactory curative effect was controlled in many places.
Diagnosis: 1, conjunctiva of both eyes laxity.2, chronic conjunctivitis.3, early cataract.
Treatment: apply a course of treatment with the Aloe eye ointment, after promptly one month, symptom obviously alleviates, and left eye has not had obviously sheds tears, and right eye has reached the IV level because of conjunctivochalasis, so on January 6th, 2009.Row conjunctiva semilune resection operation.On the routine administration and freedom of fatigue basis, add and use the Aloe eye ointment, cure.
The specific embodiment
Below be one embodiment of the invention: form by following medicine and raw material by weight: Aloe gel 85, aloin 3, alomycin 0.5, card pool nurse 0.15, hyaluronate sodium 0.15, anthraquinone analog compound 0.1, cinnamate 0.15, free amino acid 0.3, and make by the method for being prepared as follows:
At first from Aloe vulgaris, adopt " freeze-stable method " to extract Aloe gel, and convert it into aloe gel powder, aloe gel powder is mixed with water for injection under the neutrallty condition of PH7.5, and mix with aloin, alomycin, card pool nurse, hyaluronate sodium, anthraquinone analog compound, cinnamate, free amino acid, stir, transfer pH value to neutral, packing, sterilization.
Claims (2)
1. Aloe eye ointment and preparation method, it is characterized in that forming by following medicine and raw material by weight: Aloe gel 80~90, aloin 1~5, alomycin 0.1~1, card pool nurse 0.1~0.3, hyaluronate sodium 0.1~0.2, anthraquinone analog compound 0.1~0.2, cinnamate 0.1~0.2, free amino acid 0.2~0.5; Or aloe gel powder 80~90, sodium chloride 0.1~1, boric acid 0.5~2, card pool nurse 0.1~0.3, ethyl hydroxybenzoate 0.025~0.1, hyaluronate sodium 0.01~0.1, propylene glycol 0.5~5, Borneolum Syntheticum 0.1~0.5; And make by the method for being prepared as follows:
At first from Aloe vulgaris, adopt " freeze-stable method " to extract Aloe gel, and convert it into aloe gel powder, aloe gel powder is mixed with water for injection under the acidity of PH5.5~7.5 or neutrallty condition, and mix with aloin, alomycin, card pool nurse, hyaluronate sodium, anthraquinone analog compound, cinnamate, free amino acid, stir, transfer pH value to neutral, packing, sterilization; Or aloe gel powder mixed with water for injection under the acidity of PH5.5~7.5 or neutrallty condition, and stir with water-soluble sodium chloride, ethyl hydroxybenzoate, propylene glycol, boric acid, Borneolum Syntheticum respectively, the water that adds 37~40 ℃ all dissolves above-mentioned composition; To block pool nurse solution and be mixed with 1.5~3 percent aqueous solution, add sodium hyaluronate solution again, make clear gel, clear gel will be added in the above-mentioned aqueous solution, and transfer pH value to neutral, packing, sterilization.
2. a kind of Aloe eye ointment according to claim 1 and preparation method, it is characterized in that by following medicine and raw material and parts by weight composition: Aloe coagulates cream 85, aloin 3, alomycin 0.5, card pool nurse 0.15, hyaluronate sodium 0.15, anthraquinone analog compound 0.1, cinnamate 0.15, free amino acid 0.3.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012150583A1 (en) * | 2011-05-05 | 2012-11-08 | Resdevco Research And Development Co. Ltd. | Eye drops for treatment of conjunctivochalasis |
CN108567813A (en) * | 2018-07-20 | 2018-09-25 | 上海市普陀区中心医院 | Treat Chinese medicine composition of conjunctivochalasis and preparation method thereof and Chinese medicine preparation |
-
2010
- 2010-10-11 CN CN2010105019792A patent/CN101940701A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012150583A1 (en) * | 2011-05-05 | 2012-11-08 | Resdevco Research And Development Co. Ltd. | Eye drops for treatment of conjunctivochalasis |
US8912166B2 (en) | 2011-05-05 | 2014-12-16 | Resdevco Research And Development Co. Ltd. | Eye drops for treatment of conjunctivochalasis |
CN108567813A (en) * | 2018-07-20 | 2018-09-25 | 上海市普陀区中心医院 | Treat Chinese medicine composition of conjunctivochalasis and preparation method thereof and Chinese medicine preparation |
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Application publication date: 20110112 |