CN103108830B - 通过添加疏水性纳米粒子而改变粒子的溶解速率的方法 - Google Patents

通过添加疏水性纳米粒子而改变粒子的溶解速率的方法 Download PDF

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Publication number
CN103108830B
CN103108830B CN201180044744.8A CN201180044744A CN103108830B CN 103108830 B CN103108830 B CN 103108830B CN 201180044744 A CN201180044744 A CN 201180044744A CN 103108830 B CN103108830 B CN 103108830B
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China
Prior art keywords
particles
water
dissolution rate
modified nanoparticles
nanoparticles
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Expired - Fee Related
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CN201180044744.8A
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English (en)
Chinese (zh)
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CN103108830A (zh
Inventor
J·R·小巴兰
H·塞科拉
R·L·埃弗曼
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3M Innovative Properties Co
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3M Innovative Properties Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Silicon Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201180044744.8A 2010-10-04 2011-09-28 通过添加疏水性纳米粒子而改变粒子的溶解速率的方法 Expired - Fee Related CN103108830B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38940110P 2010-10-04 2010-10-04
US61/389,401 2010-10-04
PCT/US2011/053596 WO2012047691A2 (en) 2010-10-04 2011-09-28 Method of modifying dissolution rate of particles by addition of hydrophobic nanoparticles

Publications (2)

Publication Number Publication Date
CN103108830A CN103108830A (zh) 2013-05-15
CN103108830B true CN103108830B (zh) 2014-07-16

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CN201180044744.8A Expired - Fee Related CN103108830B (zh) 2010-10-04 2011-09-28 通过添加疏水性纳米粒子而改变粒子的溶解速率的方法

Country Status (5)

Country Link
US (1) US8951541B2 (enExample)
EP (1) EP2625135B1 (enExample)
JP (1) JP6016797B2 (enExample)
CN (1) CN103108830B (enExample)
WO (1) WO2012047691A2 (enExample)

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CN105271264B (zh) * 2015-09-28 2017-07-14 常州大学 一种单分散的中空二氧化硅小球的制备方法
US10271435B2 (en) 2016-06-17 2019-04-23 Nanoshield Technology Co., Ltd. Method for coating devices and resulting products
US10327338B2 (en) * 2016-06-17 2019-06-18 Nanoshield Technology Co., Ltd. Method for coating a device and devices having nanofilm thereon
KR101785298B1 (ko) * 2017-06-08 2017-10-17 주식회사재영비즈 핫멜트 접착제 제조방법
CN113856129B (zh) * 2021-11-23 2022-08-12 中国民航大学 一种具有降温功能的复合灭火剂制备方法
CN116474306B (zh) * 2023-05-26 2024-06-28 中国民航大学 一种降温型干粉灭火剂及其制备方法和应用

Citations (3)

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CN101511723A (zh) * 2006-09-15 2009-08-19 3M创新有限公司 纳米粒子表面改性的方法
CN101563400A (zh) * 2006-12-22 2009-10-21 3M创新有限公司 制备分散体的方法
CN101648116A (zh) * 2008-08-15 2010-02-17 富士胶片株式会社 无机纳米粒子分散液及其制备方法和复合组合物

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US6652967B2 (en) 2001-08-08 2003-11-25 Nanoproducts Corporation Nano-dispersed powders and methods for their manufacture
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US20030203019A1 (en) * 2002-04-30 2003-10-30 Cornelius John Mark Coated conditioners for use in foods and pharmaceuticals
US20040242729A1 (en) * 2003-05-30 2004-12-02 3M Innovative Properties Company Stabilized particle dispersions containing surface-modified inorganic nanoparticles
US7109247B2 (en) * 2003-05-30 2006-09-19 3M Innovative Properties Company Stabilized particle dispersions containing nanoparticles
US7189768B2 (en) * 2003-11-25 2007-03-13 3M Innovative Properties Company Solution containing surface-modified nanoparticles
US7998554B2 (en) * 2004-07-06 2011-08-16 Bridgestone Corporation Hydrophobic surfaces with nanoparticles
US8062670B2 (en) 2005-08-05 2011-11-22 3M Innovative Properties Company Compositions exhibiting improved flowability
US20080070030A1 (en) * 2006-09-15 2008-03-20 3M Innovative Properties Company Static dissipative articles
US20080152913A1 (en) 2006-12-22 2008-06-26 3M Innovative Properties Company Method of making compositions including particles
US20080166558A1 (en) 2006-12-22 2008-07-10 3M Innovative Properties Company Compositions of particles
JP5119769B2 (ja) * 2007-07-06 2013-01-16 住友大阪セメント株式会社 炭化ケイ素ナノ粒子分散液の製造方法
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WO2009158300A1 (en) * 2008-06-26 2009-12-30 3M Innovative Properties Company Dry powder pharmaceutical compositions for pulmonary administration, and methods of manufacturing thereof
US20100116172A1 (en) * 2008-11-13 2010-05-13 3M Innovative Properties Company Method for making a dispersion
US20120100373A1 (en) 2009-06-26 2012-04-26 Shinbach Madeline P Method of milling particles with nanoparticles and milled free-flowing powder
US8834618B2 (en) * 2009-12-03 2014-09-16 3M Innovative Properties Company Method of inhibiting water adsorption of powder by addition of hydrophobic nanoparticles

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN101511723A (zh) * 2006-09-15 2009-08-19 3M创新有限公司 纳米粒子表面改性的方法
CN101563400A (zh) * 2006-12-22 2009-10-21 3M创新有限公司 制备分散体的方法
CN101648116A (zh) * 2008-08-15 2010-02-17 富士胶片株式会社 无机纳米粒子分散液及其制备方法和复合组合物

Non-Patent Citations (1)

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Title
《Dissolution enhancement of drugs》;SAHARAN,VIKAS A.et al.;《International Journal of Health Research》;20090228;第2卷(第2期);107-124 *

Also Published As

Publication number Publication date
JP2014500802A (ja) 2014-01-16
US8951541B2 (en) 2015-02-10
EP2625135A2 (en) 2013-08-14
CN103108830A (zh) 2013-05-15
EP2625135A4 (en) 2016-07-27
WO2012047691A3 (en) 2012-06-21
JP6016797B2 (ja) 2016-10-26
US20130195938A1 (en) 2013-08-01
WO2012047691A2 (en) 2012-04-12
EP2625135B1 (en) 2017-08-02

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