CN103099792B - 一种高载药量、体外快速溶出的iv晶型利奈唑胺片的制备方法 - Google Patents
一种高载药量、体外快速溶出的iv晶型利奈唑胺片的制备方法 Download PDFInfo
- Publication number
- CN103099792B CN103099792B CN201210525618.0A CN201210525618A CN103099792B CN 103099792 B CN103099792 B CN 103099792B CN 201210525618 A CN201210525618 A CN 201210525618A CN 103099792 B CN103099792 B CN 103099792B
- Authority
- CN
- China
- Prior art keywords
- linezolid
- crystal formation
- preparation
- tablet
- mixers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
处方 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
利奈唑胺 | 600mg | 600 mg | 600 mg | 600 | 600mg | 600mg | 600mg |
玉米淀粉 | 5mg | 50 mg | 100mg | 250mg | 20 mg | 55mg | 52mg |
低取代羟丙纤维素 | 10mg | 40 mg | 50mg | 10mg | 100mg | 50mg | 30mg |
微晶纤维素 | 20mg | 30 mg | 60mg | 50 mg | 80 mg | 150mg | 50mg |
羧甲淀粉钠 | 20mg | 50 mg | 100mg | 30 mg | 150mg | 50mg | 50mg |
聚维酮K30 | 20mg | 10 mg | 5mg | 5 mg | 10 mg | 20mg | 10mg |
二氧化硅 | 50mg | 20 mg | 10mg | 10mg | 10mg | 20mg | 20mg |
硬脂酸镁 | 5mg | 5mg | 5mg | 5mg | 20mg | 10mg | 8mg |
异丙醇 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 |
包衣预混粉 | 约20mg | 约20mg | 约20mg | 约20mg | 约20mg | 约20mg | 约20mg |
处方 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
外观 | 白色异形片 | 白色异形片 | 白色异形片 | 白色异形片 | 白色异形片 | 白色异形片 | 白色异形片 |
崩解时限 | 7′45″ | 7′23″ | 7′05″ | 6′45″ | 5′55″ | 5′23″ | 5′43″ |
硬度 | 31.0kg | 33.4kg | 32.1kg | 30.9kg | 30.7kg | 31.9kg | 30.7kg |
脆碎度 | 0.4% | 0.3% | 0.6% | 0.4% | 0.7% | 0.6% | 0.5% |
溶出度 | 97.4% | 96.8% | 95.7% | 96.5% | 97.8% | 98.8% | 97.5% |
处方 | 5min | 10 min | 20 min | 30 min | 45 min |
处方1 | 74.8% | 95.6% | 103.1% | 104.8% | 106.6% |
处方2 | 77.2% | 90.5% | 96.7% | 101.9% | 103.1% |
处方3 | 77.4% | 92.3% | 95.8% | 101.9% | 104.1% |
处方4 | 75.9% | 93% | 99.8% | 101.2% | 104.1% |
处方5 | 79.8% | 97% | 96.9% | 95.6% | 97.9% |
处方6 | 85.8% | 95.8% | 94.8% | 93.5% | 95.1% |
处方7 | 93.5% | 99.5% | 100.5% | 101.2% | 100.2% |
参比药品(RLD) | 84.6% | 92.7% | 94.9% | 97.6% | 98.4% |
Claims (14)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210525618.0A CN103099792B (zh) | 2012-12-10 | 2012-12-10 | 一种高载药量、体外快速溶出的iv晶型利奈唑胺片的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210525618.0A CN103099792B (zh) | 2012-12-10 | 2012-12-10 | 一种高载药量、体外快速溶出的iv晶型利奈唑胺片的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103099792A CN103099792A (zh) | 2013-05-15 |
CN103099792B true CN103099792B (zh) | 2014-11-26 |
Family
ID=48308204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210525618.0A Active CN103099792B (zh) | 2012-12-10 | 2012-12-10 | 一种高载药量、体外快速溶出的iv晶型利奈唑胺片的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103099792B (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104622831B (zh) * | 2013-11-06 | 2018-06-22 | 江苏豪森药业集团有限公司 | 一种口服片剂及其制备方法 |
CN104173303B (zh) * | 2014-08-14 | 2017-01-11 | 杭州华东医药集团新药研究院有限公司 | 一种含有利奈唑胺的组合物及其制备方法 |
CN104586812A (zh) * | 2014-12-25 | 2015-05-06 | 杭州华东医药集团新药研究院有限公司 | 一种含有利奈唑胺的组合物及其制备方法 |
RU2690491C2 (ru) * | 2017-07-19 | 2019-06-04 | Общество с ограниченной ответственностью "МБА-групп" | Твердофазный линезолидсодержащий препарат |
CN108516963A (zh) * | 2018-04-05 | 2018-09-11 | 石家庄科润显示材料有限公司 | 一种利奈唑胺及其组合物的制备工艺 |
CN118059106B (zh) * | 2024-04-17 | 2024-06-28 | 山东新时代药业有限公司 | 一种利奈唑胺抗菌制剂及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1615878A (zh) * | 2004-09-01 | 2005-05-18 | 魏雪纹 | 注射用利奈唑烷粉针剂及制备方法 |
EP1749517B1 (en) * | 2005-07-20 | 2008-07-09 | Teva Pharmaceutical Industries, Inc. | Stable pharmaceutical composition comprising linezolid form IV |
CN101948442A (zh) * | 2009-07-10 | 2011-01-19 | 符健 | 利奈唑胺及其制剂的制备方法 |
CN102643251A (zh) * | 2012-04-17 | 2012-08-22 | 成都自豪药业有限公司 | 利奈唑胺的降解杂质及其制备方法 |
CN102643245A (zh) * | 2012-04-10 | 2012-08-22 | 杭州华东医药集团生物工程研究所有限公司 | 一种利奈唑胺晶型及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20011088A1 (es) * | 2000-03-22 | 2001-10-04 | Upjohn Co | Tratamiento de infecciones del tracto urinario con oxazolidinonas antibacterianas |
WO2010026597A1 (en) * | 2008-09-02 | 2010-03-11 | Hetero Research Foundation | Oral dosage forms of linezolid and processes for their preparation |
WO2010046933A2 (en) * | 2008-10-22 | 2010-04-29 | Rubicon Research Private Limited | Pharmaceutical compositions of taste-masked linezolid |
-
2012
- 2012-12-10 CN CN201210525618.0A patent/CN103099792B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1615878A (zh) * | 2004-09-01 | 2005-05-18 | 魏雪纹 | 注射用利奈唑烷粉针剂及制备方法 |
EP1749517B1 (en) * | 2005-07-20 | 2008-07-09 | Teva Pharmaceutical Industries, Inc. | Stable pharmaceutical composition comprising linezolid form IV |
CN101262853A (zh) * | 2005-07-20 | 2008-09-10 | 特瓦制药工业有限公司 | 包括利奈唑胺晶型iv的稳定的药物组合物 |
CN101948442A (zh) * | 2009-07-10 | 2011-01-19 | 符健 | 利奈唑胺及其制剂的制备方法 |
CN102643245A (zh) * | 2012-04-10 | 2012-08-22 | 杭州华东医药集团生物工程研究所有限公司 | 一种利奈唑胺晶型及其制备方法 |
CN102643251A (zh) * | 2012-04-17 | 2012-08-22 | 成都自豪药业有限公司 | 利奈唑胺的降解杂质及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN103099792A (zh) | 2013-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103099792B (zh) | 一种高载药量、体外快速溶出的iv晶型利奈唑胺片的制备方法 | |
CN103479592B (zh) | 一种盐酸二甲双胍缓释片及其制备方法 | |
Biedenbach et al. | In vitro activity of oritavancin and comparator agents against staphylococci, streptococci and enterococci from clinical infections in Europe and North America, 2011–2014 | |
CN106074543B (zh) | 一种含阿莫西林的水溶性增效组合物及其应用 | |
US8299052B2 (en) | Pharmaceutical compositions and methods for improved bacterial eradication | |
CN102935084A (zh) | 一种复方伊维菌素缓释片及其制备方法 | |
US20150157628A1 (en) | Pharmaceutical compositions of Lurasidone and Process for preparation thereof | |
CN105343028B (zh) | 一种诺氟沙星的药物组合物及其制备方法 | |
CN100381116C (zh) | 普卢利沙星分散片 | |
CN102525948A (zh) | 一种头孢泊肟酯组合物干混悬剂及其制备方法 | |
CN103127108B (zh) | 替米沙坦氨氯地平片及其制备方法和用途 | |
CN102861015B (zh) | 一种稳定的阿莫西林克拉维酸钾缓释制剂及其制备工艺 | |
CN105769883A (zh) | 一种复方磺胺甲噁唑分散片及其制备方法 | |
CN111557897B (zh) | 一种含有硝呋太尔的药物组合物及其制备方法 | |
CN102525982A (zh) | 一种稳定的盐酸莫西沙星药物组合物 | |
CN103463082A (zh) | 一种替米沙坦氨氯地平双层片及其制备方法 | |
JP6272561B2 (ja) | ドキシラミン並びにピリドキシン及び/またはそれらの代謝産物もしくは塩の多峰性放出製剤 | |
CN104586812A (zh) | 一种含有利奈唑胺的组合物及其制备方法 | |
CN107625737B (zh) | 一种磷酸特地唑胺组合物片剂的制备方法 | |
CN112263569B (zh) | 一种阿莫西林胶囊及其制备方法 | |
CN104337783B (zh) | 一种卡培他滨片剂及其制备方法 | |
AU2006321782B2 (en) | Pharmaceutical compositions and methods for improved bacterial eradication | |
CN105560191B (zh) | 一种硝呋太尔固体制剂及其制备方法 | |
CN106924209A (zh) | 红霉素肠溶片及其制备方法 | |
CN107625738B (zh) | 一种磷酸特地唑胺组合物片剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20130515 Assignee: Chengdu Qingcang Medical Technology Co Ltd Assignor: Chengdu Xinjie Hi-Tech Development Co., Ltd. Contract record no.: 2015510000039 Denomination of invention: Preparation method of IV crystal linezolid tablets having high drug loading capacity and capable of quickly dissolving Granted publication date: 20141126 License type: Exclusive License Record date: 20150515 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: 88 building B7, No. 501 South Garden Road, Chengdu hi tech Zone, Sichuan 610041, China Patentee after: CHENGDU XINJIE HI-TECH DEVELOPMENT CO., LTD. Address before: 88 building B7, No. 501 South Garden Road, Chengdu hi tech Zone, Sichuan 610041, China Patentee before: Chengdu Xinjie Hi-Tech Development Co., Ltd. |
|
EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Chengdu Qingcang Medical Technology Co Ltd Assignor: Chengdu Xinjie Hi-Tech Development Co., Ltd. Contract record no.: 2015510000039 Date of cancellation: 20161114 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model |