CN103096901A - 眼用组合物 - Google Patents
眼用组合物 Download PDFInfo
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- CN103096901A CN103096901A CN2011800332340A CN201180033234A CN103096901A CN 103096901 A CN103096901 A CN 103096901A CN 2011800332340 A CN2011800332340 A CN 2011800332340A CN 201180033234 A CN201180033234 A CN 201180033234A CN 103096901 A CN103096901 A CN 103096901A
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- CN
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- Prior art keywords
- dorzolamide
- timolol
- ophthalmic composition
- test
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 141
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims abstract description 178
- 229960004605 timolol Drugs 0.000 claims abstract description 178
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- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims abstract description 37
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims abstract description 36
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- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims abstract description 8
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- LWAFSWPYPHEXKX-UHFFFAOYSA-N carteolol Chemical compound N1C(=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C LWAFSWPYPHEXKX-UHFFFAOYSA-N 0.000 claims abstract description 4
- IXHBTMCLRNMKHZ-LBPRGKRZSA-N levobunolol Chemical compound O=C1CCCC2=C1C=CC=C2OC[C@@H](O)CNC(C)(C)C IXHBTMCLRNMKHZ-LBPRGKRZSA-N 0.000 claims abstract description 4
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- NWIUTZDMDHAVTP-UHFFFAOYSA-N betaxolol Chemical compound C1=CC(OCC(O)CNC(C)C)=CC=C1CCOCC1CC1 NWIUTZDMDHAVTP-UHFFFAOYSA-N 0.000 claims abstract 2
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 claims description 219
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- WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 description 7
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- PQMWYJDJHJQZDE-UHFFFAOYSA-M Methantheline bromide Chemical compound [Br-].C1=CC=C2C(C(=O)OCC[N+](C)(CC)CC)C3=CC=CC=C3OC2=C1 PQMWYJDJHJQZDE-UHFFFAOYSA-M 0.000 description 6
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- CHDPSNLJFOQTRK-UHFFFAOYSA-N betaxolol hydrochloride Chemical compound [Cl-].C1=CC(OCC(O)C[NH2+]C(C)C)=CC=C1CCOCC1CC1 CHDPSNLJFOQTRK-UHFFFAOYSA-N 0.000 description 3
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| PCT/US2011/035147 WO2011140194A1 (en) | 2010-05-05 | 2011-05-04 | Ophthalmic composition |
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| CN103740831A (zh) * | 2014-01-13 | 2014-04-23 | 宁波海尔施基因科技有限公司 | 一种指导β-受体阻断药用药的引物组合物、多重基因检测试剂盒及其使用方法 |
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| CN103189097B (zh) * | 2010-07-29 | 2016-01-06 | 参天制药株式会社 | 带药剂的支承体及其制造方法 |
| WO2013114397A2 (en) * | 2012-01-16 | 2013-08-08 | Biocon Limited | Pharmaceutically acceptable salt of brinzolamide and composition thereof |
| US9820991B2 (en) * | 2013-11-08 | 2017-11-21 | Sentiss Pharma Private Limited | Pharmaceutical composition comprising brinzolamide |
| EP3096740B1 (en) * | 2014-01-24 | 2020-09-30 | Sentiss Pharma Private Limited | Pharmaceutical composition comprising brinzolamide |
| SI3412648T1 (sl) * | 2014-05-16 | 2020-08-31 | Occidental Chemical Corporation | Postopek za izdelavo 1,1,3,3-tetrakloropropena |
| NZ728131A (en) * | 2014-07-11 | 2017-09-29 | Fujifilm Corp | Aqueous ophthalmic composition |
| WO2016022066A1 (en) | 2014-08-04 | 2016-02-11 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| KR101773669B1 (ko) | 2015-07-30 | 2017-08-31 | 포항공과대학교 산학협력단 | 생체적합성 각막세포 전구체 분화방법 및 각막세포 전구체 조성물 |
| JP6050454B1 (ja) * | 2015-09-28 | 2016-12-21 | 参天製薬株式会社 | 水性医薬組成物 |
| TW201733577A (zh) * | 2016-03-14 | 2017-10-01 | Santen Pharmaceutical Co Ltd | 含有多佐胺、噻嗎洛爾和界面活性劑之醫藥組成物 |
| KR20250065422A (ko) | 2017-12-15 | 2025-05-12 | 타르서스 파마수티칼스, 아이엔씨. | 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법 |
| US20220265695A1 (en) | 2019-07-26 | 2022-08-25 | Proqr Therapeutics Ii B.V. | Opthalmic compositions comprising viscosifying polymers and nucleic acids |
| WO2023140357A1 (ja) | 2022-01-21 | 2023-07-27 | センジュ ユーエスエー、インコーポレイテッド | 水性液剤 |
| CN118978426B (zh) * | 2024-10-22 | 2025-05-16 | 浙江大学 | 一种甘油的酸化处理方法、酸化甘油及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060204472A1 (en) * | 2003-02-13 | 2006-09-14 | Constantinos Paleos | Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems |
| US20070048337A1 (en) * | 2005-08-24 | 2007-03-01 | Arthur Samuel D | Aldol-crosslinked polymeric hydrogel adhesives |
| US20080180803A1 (en) * | 2007-01-26 | 2008-07-31 | Seybert Kevin W | Optical elements comprising compatiblizing coatings and methods of making the same |
| US20100008993A1 (en) * | 2008-07-14 | 2010-01-14 | Proksch Joel W | Compositions and Methods for Increasing Bioavailability of Topical Ophthalmic Drugs |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5136014A (en) * | 1990-06-22 | 1992-08-04 | E. I. Du Pont De Nemours And Company | Hyperbranched polyesters |
| IL101537A (en) * | 1991-04-17 | 1997-11-20 | Merck & Co Inc | OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF A CARBONIC ANHYDRASE INHIBITOR AND A b-ADRENERGIC ANTAGONIST |
| US6316443B1 (en) * | 1994-08-04 | 2001-11-13 | Merck & Co., Inc. | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist |
| DE19726186A1 (de) * | 1997-06-20 | 1998-12-24 | Boehringer Ingelheim Int | Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen |
| FR2772771B1 (fr) * | 1997-12-19 | 2000-01-28 | Oreal | Utilisation de polymeres hyperbranches et de dendrimeres comportant un groupement particulier, en tant qu'agent filmogene, les compositions filmogenes les comprenant et leur utilisation notamment en cosmetique ou en pharmacie |
| WO2000063409A1 (en) | 1999-04-21 | 2000-10-26 | Massachusetts Institute Of Technology | Endosomolytic agents and cell delivery systems |
| US7030097B1 (en) | 1999-07-14 | 2006-04-18 | Cornell Research Foundation, Inc. | Controlled nucleic acid delivery systems |
| SK282717B6 (sk) | 2000-03-10 | 2002-11-06 | �Stav Experiment�Lnej Farmakol�Gie Sav | Spôsob prípravy ultravysokomolekulových hyalurónanov |
| AU2001295073A1 (en) | 2000-09-29 | 2002-04-08 | The Regents Of The University Of California | Dendrimeric support or carrier macromolecule |
| CA2438193A1 (en) | 2001-02-26 | 2002-09-06 | Duke University | Novel dendritic polymers and their biomedical uses |
| BR0207638A (pt) | 2001-03-08 | 2004-07-27 | Nymox Pharmaceuticals Corp | Métodos de uso de proteìna de filamento neural para tratar tumores e outras condições que requerem a remoção ou destruição de células |
| FR2830450B1 (fr) * | 2001-10-09 | 2004-02-06 | Univ Pasteur | Utilisation de dendrimeres dans une composition ophtalmique |
| TWI255224B (en) | 2002-01-09 | 2006-05-21 | Novartis Ag | Polymeric articles having a lubricious coating and method for making the same |
| GB0209022D0 (en) | 2002-04-19 | 2002-05-29 | Imp College Innovations Ltd | Compounds |
| WO2004060283A2 (en) | 2002-12-16 | 2004-07-22 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
| JP2005008614A (ja) | 2003-03-28 | 2005-01-13 | Nano Career Kk | 高分子ミセルを用いた眼科用ドラッグデリバリーシステム |
| US7109247B2 (en) | 2003-05-30 | 2006-09-19 | 3M Innovative Properties Company | Stabilized particle dispersions containing nanoparticles |
| US7189456B2 (en) | 2004-03-04 | 2007-03-13 | Transitions Optical, Inc. | Photochromic optical article |
| WO2006031358A2 (en) | 2004-08-13 | 2006-03-23 | Hyperbranch Medical Technology, Inc. | Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses |
| US20060057215A1 (en) * | 2004-09-15 | 2006-03-16 | Raiche Adrian T | Method for the production of nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility |
| US7837986B2 (en) | 2004-12-01 | 2010-11-23 | E. I. Du Pont De Nemours And Company | Protein-based polymer tissue adhesives for medical use |
| CA2598184A1 (en) * | 2005-02-21 | 2006-08-24 | Basf Aktiengesellschaft | Active substance composition comprising at least one nitrogen atom-containing, hyperbranched polymer |
| US20060257359A1 (en) | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
| US7666331B2 (en) | 2005-08-31 | 2010-02-23 | Transitions Optical, Inc. | Photochromic article |
| CA2636599C (en) | 2006-01-20 | 2014-07-15 | Starpharma Pty Limited | Modified macromolecule |
| US20090012033A1 (en) | 2006-03-03 | 2009-01-08 | Demattei Cordell R | Delivery of Biologically Active Materials Using Core-Shell Tecto(Dendritic Polymers) |
| US20080031916A1 (en) * | 2006-04-24 | 2008-02-07 | Heather Sheardown | Dendrimer cross-linked collagen |
| WO2008027340A2 (en) * | 2006-08-30 | 2008-03-06 | Merck & Co., Inc. | Topical ophthalmic formulations |
| US20090324742A1 (en) | 2006-09-08 | 2009-12-31 | Sonke Svenson | Peham dendrimers as excipients |
| ZA200902587B (en) * | 2006-11-09 | 2010-06-30 | Alcon Res Ltd | Water insoluble polymer matrix for drug delivery |
| JP5484339B2 (ja) * | 2007-10-05 | 2014-05-07 | ウェイン ステート ユニバーシティー | 合成物の持続的な放出のためのデンドリマー |
| US8426492B2 (en) | 2007-11-14 | 2013-04-23 | Actamax Surgical Materials, Llc | Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use |
| WO2010017184A2 (en) * | 2008-08-08 | 2010-02-11 | Virginia Commonwealth University | Dendrimer hydrogels |
-
2010
- 2010-05-05 US US12/774,419 patent/US8211450B2/en not_active Expired - Fee Related
-
2011
- 2011-05-04 EP EP20110778244 patent/EP2566487A4/en not_active Withdrawn
- 2011-05-04 CA CA2797123A patent/CA2797123A1/en not_active Abandoned
- 2011-05-04 WO PCT/US2011/035147 patent/WO2011140194A1/en not_active Ceased
- 2011-05-04 US US13/695,930 patent/US20130053374A1/en not_active Abandoned
- 2011-05-04 KR KR1020127031915A patent/KR20130121685A/ko not_active Withdrawn
- 2011-05-04 JP JP2013509213A patent/JP2013528589A/ja active Pending
- 2011-05-04 CN CN2011800332340A patent/CN103096901A/zh active Pending
- 2011-05-04 MX MX2012012846A patent/MX2012012846A/es not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060204472A1 (en) * | 2003-02-13 | 2006-09-14 | Constantinos Paleos | Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems |
| US20070048337A1 (en) * | 2005-08-24 | 2007-03-01 | Arthur Samuel D | Aldol-crosslinked polymeric hydrogel adhesives |
| US20080180803A1 (en) * | 2007-01-26 | 2008-07-31 | Seybert Kevin W | Optical elements comprising compatiblizing coatings and methods of making the same |
| US20100008993A1 (en) * | 2008-07-14 | 2010-01-14 | Proksch Joel W | Compositions and Methods for Increasing Bioavailability of Topical Ophthalmic Drugs |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103740831A (zh) * | 2014-01-13 | 2014-04-23 | 宁波海尔施基因科技有限公司 | 一种指导β-受体阻断药用药的引物组合物、多重基因检测试剂盒及其使用方法 |
Also Published As
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|---|---|
| MX2012012846A (es) | 2013-05-22 |
| US8211450B2 (en) | 2012-07-03 |
| KR20130121685A (ko) | 2013-11-06 |
| EP2566487A1 (en) | 2013-03-13 |
| CA2797123A1 (en) | 2011-11-10 |
| JP2013528589A (ja) | 2013-07-11 |
| WO2011140194A1 (en) | 2011-11-10 |
| US20130053374A1 (en) | 2013-02-28 |
| EP2566487A4 (en) | 2014-06-18 |
| US20110275617A1 (en) | 2011-11-10 |
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