CN103058865A - 蒽羧酸衍生物的晶型和药物组合物 - Google Patents
蒽羧酸衍生物的晶型和药物组合物 Download PDFInfo
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- CN103058865A CN103058865A CN2013100006272A CN201310000627A CN103058865A CN 103058865 A CN103058865 A CN 103058865A CN 2013100006272 A CN2013100006272 A CN 2013100006272A CN 201310000627 A CN201310000627 A CN 201310000627A CN 103058865 A CN103058865 A CN 103058865A
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- diacerein
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Abstract
Description
参数 | 胶囊5 | 市售品 |
tmax(h) | 2.4±0.6 | 2.4±0.8 |
Cmax(μg/L) | 4863.4±2242.1 | 4535.4±2318.5 |
AUC(0-t)(μg·h/L) | 37347.4±18434.2 | 25854.3±14654.7 |
AUC(0-∞)(μg·h/L) | 40265.8±19423.6 | 27324.1±15436.3 |
T1/2(h) | 4.4±1.6 | 4.5±1.3 |
Claims (10)
Priority Applications (1)
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CN201310000627.2A CN103058865B (zh) | 2013-01-01 | 2013-01-01 | 蒽羧酸衍生物的晶型和药物组合物 |
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CN201310000627.2A CN103058865B (zh) | 2013-01-01 | 2013-01-01 | 蒽羧酸衍生物的晶型和药物组合物 |
Publications (2)
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CN103058865A true CN103058865A (zh) | 2013-04-24 |
CN103058865B CN103058865B (zh) | 2014-07-09 |
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CN201310000627.2A Expired - Fee Related CN103058865B (zh) | 2013-01-01 | 2013-01-01 | 蒽羧酸衍生物的晶型和药物组合物 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104774150A (zh) * | 2014-01-14 | 2015-07-15 | 北京万生药业有限责任公司 | 一种双醋瑞因晶体及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001096276A1 (en) * | 2000-06-13 | 2001-12-20 | Synteco S.P.A. | A process for the purification of diacerein |
CN1717386A (zh) * | 2002-11-29 | 2006-01-04 | 辛泰可股份公司 | 提纯双醋瑞因的方法 |
EP1669344A1 (en) * | 2003-09-23 | 2006-06-14 | Interquim, S.A. De C.V. | Method for the purification of crude diacerein by means of toluene |
CN101104583A (zh) * | 2006-07-13 | 2008-01-16 | 上海汇瑞生物科技有限公司 | 两步氧化法制备双醋瑞因的新工艺 |
KR20080102804A (ko) * | 2007-05-22 | 2008-11-26 | 주식회사 엔지켐 | 디아세레인의 정제 방법 |
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2013
- 2013-01-01 CN CN201310000627.2A patent/CN103058865B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001096276A1 (en) * | 2000-06-13 | 2001-12-20 | Synteco S.P.A. | A process for the purification of diacerein |
CN1717386A (zh) * | 2002-11-29 | 2006-01-04 | 辛泰可股份公司 | 提纯双醋瑞因的方法 |
EP1669344A1 (en) * | 2003-09-23 | 2006-06-14 | Interquim, S.A. De C.V. | Method for the purification of crude diacerein by means of toluene |
CN101104583A (zh) * | 2006-07-13 | 2008-01-16 | 上海汇瑞生物科技有限公司 | 两步氧化法制备双醋瑞因的新工艺 |
KR20080102804A (ko) * | 2007-05-22 | 2008-11-26 | 주식회사 엔지켐 | 디아세레인의 정제 방법 |
Non-Patent Citations (1)
Title |
---|
朱兴一等: "合成双醋瑞因的新方法", 《合成化学》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104774150A (zh) * | 2014-01-14 | 2015-07-15 | 北京万生药业有限责任公司 | 一种双醋瑞因晶体及其制备方法 |
CN104774150B (zh) * | 2014-01-14 | 2017-04-12 | 北京万生药业有限责任公司 | 一种双醋瑞因晶体及其制备方法 |
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CN103058865B (zh) | 2014-07-09 |
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Owner name: LI YOUXIANG Free format text: FORMER OWNER: LIU WEI Effective date: 20140606 |
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