CN103041128A - Bitter almond and perilla leaf pectoral syrup and preparation method thereof - Google Patents
Bitter almond and perilla leaf pectoral syrup and preparation method thereof Download PDFInfo
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- CN103041128A CN103041128A CN2013100323234A CN201310032323A CN103041128A CN 103041128 A CN103041128 A CN 103041128A CN 2013100323234 A CN2013100323234 A CN 2013100323234A CN 201310032323 A CN201310032323 A CN 201310032323A CN 103041128 A CN103041128 A CN 103041128A
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Abstract
The invention discloses a bitter almond and perilla leaf pectoral syrup and a preparation method thereof. The bitter almond and perilla leaf pectoral syrup comprises the following raw materials: perilla leaves, radix platycodi, bitter almond, radix scutellariae, herba ephedra, fritillaria thunbergii, simple syrup, sodium benzoate, ethylparaben and distilled water. The preparation method comprises the following steps of: extracting volatile oil in the perilla leaves through a steam distilling method; mixing the perilla leaf dregs after the oil extraction with the radix platycodi, the bitter almond, the radix scutellariae, the herba ephedra and the fritillaria thunbergii; adding water for the detection; filtrating, and mixing the filtrate; standing and precipitating; taking supernatant; adding the simple syrup, the sodium benzoate and the ethylparaben, and uniformly mixing; boiling; adding the volatile oil; adding the distilled water to the specified amount, thereby obtaining the bitter almond and perilla leaf pectoral syrup. The bitter almond and perilla leaf pectoral syrup provided by the invention is accurate in materials, high in effective component content and remarkable in efficacy. The preparation method of the bitter almond and perilla leaf pectoral syrup can extract effective components in medicinal materials maximally.
Description
Technical field
The present invention relates to a kind of cough syrup, a kind of almond perilla anti-cough syrup specifically the invention still further relates to the preparation method of almond perilla anti-cough syrup.
Technical background
Chronic bronchitis is the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof, is one of China's commonly encountered diseases and frequently-occurring disease.Modern medicine is not yet fully clear about the chronic bronchitis definite cause of disease and pathogenesis.It is generally acknowledged, when Abwehrkraft des Koepers goes down, exist at air flue on the basis of sensitivity in various degree, have one or more exopathogenic factors to exist, comprise the factors such as infection, physics and chemistry allergy, weather, smoking, prolonged and repeated effect can develop into chronic bronchitis.What environment in recent years was polluted increases the weight of and antibiotic abuse, and the more aobvious power single-action of the infection of doctor trained in Western medicine and symptomatic treatment measure is little.
At present, almond perilla anti-cough syrup on the market, complicated process of preparation, and can not fully extract effective ingredient in the medical material, curative effect is not very desirable.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of almond perilla anti-cough syrup, and the accurate and effective component content of these almond perilla anti-cough syrup materials is high, evident in efficacy.Another technical problem that the present invention will solve provides the preparation method of this almond perilla anti-cough syrup, requires the method can farthest extract effective ingredient in the medical material.
For solving the problems of the technologies described above, the invention provides a kind of almond perilla anti-cough syrup, its preparation method may further comprise the steps:
(1) extraction of volatile oil: Folium Perillae 50 g place boiling flask, add the distilled water of 12～18 times of Folium Perillae weight, volatile oil extractor is connected on the boiling flask, in the arm of volatile oil extractor, add entry to overflowing in the round-bottomed flask, on the shape condensing tube of receiving, soak 1～3 h, then begin vapor distillation, stop distillation behind 3～6 h, place 0.5～2 h, oil to volatile oil extractor is limpid, and the residue after collecting respectively volatile oil and carrying oil is for subsequent use;
(2) water extraction: with Radix Platycodonis 30 g, Semen Armeniacae Amarum 30 g, Radix Scutellariae 20 g, Herba Ephedrae 30 g, Bulbus Fritillariae Thunbergii 20 g and the residue after step (1) Folium Perillae is carried oil mix, the distilled water that adds 8～12 times of mixture total weight amounts, heating decocts 1～3 time, filter behind each decoction 1～2 h, merge filtrate, the filtrate after merging is staticly settled rear absorption supernatant, obtain the first supernatant, again with the first supernatant concentrating under reduced pressure, staticly settle, again draw and obtain the second supernatant;
(3) mix: add simple syrup 60 mL, sodium benzoate 0.33 g, ethyl hydroxybenzoate 0.05 g in the second supernatant, boil behind the mix homogeneously, add the volatile oil that step (1) is collected again, adding distil water to 100 mL stirs evenly and namely gets the almond perilla anti-cough syrup.
The Folium Perillae main component contains volatile oil, includes perillaldehyde, left-handed limonene and a small amount of australene.The Folium Perillae pharmacological action has calmness, analgesia, analgesic, antitussive, emesis, anti-bacteria and anti-virus, antiinflammatory, anti-allergic effects, is used for anemofrigid cold, cough vomiting and nausea etc.
Semen Armeniacae Amarum contains amygdaloside, fatty oil, emulsin, amygdalase, prunase, estrone, alpha-estradiol, desmosterol etc.Pharmacological action has relieving cough and asthma, loosening bowel to relieve constipation, anti-inflammatory and antalgic, antitumor action, cures mainly cough and asthma, dryness of the intestine constipation etc.Amygdaloside can be produced hydrocyanic acid and the benzaldehyde of trace by enteric microorganism enzyme or the contained emulsin hydrolysis of Semen Armeniacae Amarum itself in vivo, respiratory center is had inhibitory action, the purpose of reach antitussive, relievining asthma.
The Radix Platycodonis nature and flavor are bitter, hot, flat, return lung meridian, have lung qi dispersing, sore-throat relieving, eliminate the phlegm, the effect of evacuation of pus, are used for the diseases such as cough with copious phlegm, smooth, pharyngalgia uncomfortable in chest, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Radix Platycodonis mainly contains Radix Platycodi total saponins, also contains the compositions such as polysaccharide, sterols and glucosides thereof, fatty oil, fatty acid.Pharmacological action has and has eliminating phlegm and relieving cough, anti-inflammatory and antalgic, immunomodulating etc.
Herba Ephedrae contains the compositions such as ephedrine,d-pseudo-ephedrine, volatile oil, 2，3，5，6-tetramethylpyrazine L-α-terpinenol.Pharmacological action has cough-relieving, eliminates the phlegm, relievings asthma, diaphoresis, diuresis, antiallergic action, antiinflammatory, analgesic, resisting pathogenic microbes, stimulating central nervous system system etc.
Bulbs of Fritillaria thunbergii Miq contains peimine, peiminine, Propeimine, also have in addition four kinds of alkaloids that content is few: the not fragrant alkali of Peimidine, shellfish, peimisine and Peimitidine, modern pharmacological research show that the Bulbus Fritillariae Thunbergii pharmacological action has relieving cough and resolving phlegm, heat clearing away eliminating stagnation, lax tracheal smooth muscle, antalgic and inflammation relieving, antibiotic etc.
Radix Scutellariae contains the compositions such as baicalin, wogonoside, wogonin, baicalin, neobaicalein-I, neobaicalein-II, Yang Huangsu, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.
In preparation method of the present invention, with the volatile oil in the extraction by steam distillation Folium Perillae, by the control to amount of water, soak time, extraction time, can reach and be close to 100% extraction volatile oil, both guarantee taking full advantage of of raw material, improved again the active constituent content of almond perilla anti-cough syrup.
In preparation method of the present invention, extract the things such as amygdaloside that remain in a few herbs and the Folium Perillae residue with water extraction method, by to amount of water, extraction time, the control of each extraction time, can farthest extract the active substance in the Chinese medicinal material, further improve the content of almond perilla anti-cough syrup effective ingredient, and then improved the curative effect of almond perilla anti-cough syrup.
Almond perilla anti-cough syrup provided by the invention has that the accurate and effective component content of medication is high, and the characteristics that toxic and side effects is little have good curative effect to chronic bronchitis, is a kind of medicine of desirable treatment chronic bronchitis.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
In the present embodiment, the concrete consumption proportion of used each primary raw material of almond perilla anti-cough syrup is: Folium Perillae 50 g, Radix Platycodonis 30 g, Semen Armeniacae Amarum 30 g, Radix Scutellariae 20 g, Herba Ephedrae 30 g, Bulbus Fritillariae Thunbergii 20 g, simple syrup 60 mL, sodium benzoate 0.33 g, ethyl hydroxybenzoate 0.05 g.
The preparation method of the almond perilla anti-cough syrup of present embodiment may further comprise the steps:
(1) extraction of volatile oil: take by weighing 50 g Folium Perillaes and place boiling flask, add the distilled water of 12～18 times of Folium Perillae weight, volatile oil extractor is connected on the boiling flask, in the arm of volatile oil extractor, add entry to overflowing in the round-bottomed flask, on the shape condensing tube of receiving, soak 1～3 h, the beginning vapor distillation stops distillation behind 3～6 h, place 0.5～2 h, oil to volatile oil extractor is limpid, and the residue after collecting respectively volatile oil and carrying oil is for subsequent use;
(2) water extraction: take by weighing Semen Armeniacae Amarum 30 g, Radix Platycodonis 30 g, Herba Ephedrae 30 g, Bulbus Fritillariae Thunbergii 20 g, Radix Scutellariae 20 g, mix with the residue after step (1) Folium Perillae is carried oil, the distilled water that adds 8～12 times of mixture total weight amounts, heating decocts 1～3 time, filters behind each decocting time 1～2 h, merges filtrate, filtrate after the merging staticly settles rear absorption supernatant, obtain the first supernatant, again with the first supernatant concentrating under reduced pressure, staticly settle, again draw and obtain the second supernatant;
(3) mix: add simple syrup 60mL, sodium benzoate 0.33 g, ethyl hydroxybenzoate 0.05 g in the second supernatant, boil behind the mix homogeneously, add the volatile oil that step (1) is collected again, adding distil water to 100 mL stirs evenly and namely gets the almond perilla anti-cough syrup.
In the suitability for industrialized production, the almond perilla anti-cough syrup that makes is carried out tinning, sealing, can sell patient's taking convenience.
In order to verify the curative effect of the made almond perilla anti-cough syrup of the present invention, further specify its beneficial effect by following contrast test:
1, strong aqua ammonia nebulization research almond perilla anti-cough syrup antitussive effect
Kunming mouse, body weight 18～22 g, male and female half and half, put in the airtight glass box of 4 L, evenly spray the strong aqua ammonia aerosol with ultrasound atomizer constant voltage in the case, take out immediately behind 5 s, shrink take the mice abdominal muscle and magnify simultaneously or with coughing sound as index, observe and record mouse cough incubation period (being begun to the cough required time by spraying ammonia) and the interior cough of 2 min number of times, 2 not cough of min persons abandon after the spraying.Qualified mice random packet after 2 days.
50 of qualified mices arrange 5 groups: the high, medium and low dosage group of almond perilla anti-cough syrup, matched group (normal saline group).Every Mus gives medicinal liquid or normal saline by 0.2 mL/10 g, once a day, continuous 7 days, 1 h puts mice respectively in the airtight glass box after the last administration, evenly sprays the strong aqua ammonia aerosol with ultrasound atomizer constant voltage in the case, and spray time is about 10 s, about 3 mL of spouting liquid, cause the mouse cough reaction, time and the interior mouse cough number of times of 2 min of cough appears in the record mice, and test data represents with mean ± standard deviation.
Result of the test shows that the middle and high dosage group of almond perilla anti-cough syrup can obviously reduce the mouse cough number of times; Simultaneously, high dose group, middle dosage group can obviously prolong mice and draw and cough incubation period.See Table 1.
Table 1
2, almond perilla anti-cough syrup phlegm-dispelling functions research
50 of mices, male and female half and half, body weight 18～22 g are divided into 5 groups at random: the high, medium and low dosage group of almond perilla anti-cough syrup, matched group (normal saline group).Every Mus gives medicinal liquid or normal saline by 0.2 mL/10 g, once a day, continuous 7 days, behind 30 min after the last administration, every Mus lumbar injection 0.5% phenol red physiological salt liquid 0.5 mL.After injecting phenol red liquid 30 min, take off cervical vertebra and put to death mice.Separate trachea, cut one section trachea to the trachea crotch from the thyroid cartilage lower edge, put into the test tube of 2ml normal saline, 20 min were washed in ultrasonic concussion after the vortex oscillation device shook 5 min, add 50 g/L sodium bicarbonate solutions, 1 mL, 1500 rev/mins of centrifugal 10 min get supernatant, with 5% sodium bicarbonate as blank, measure absorbance in spectrophotometer 546 nm places, with concentration known phenol red solution-absorbance regression equation calculation sample phenol red concentration.Test data represents with mean ± standard deviation.
Result of the test shows that the almond perilla anti-cough syrup can increase mice phenol red output.See Table 2.
Table 2
3, almond perilla anti-cough syrup Study on Antiasthmatic
Kunming mouse, body weight 18～22g, male and female half and half, put in the airtight glass box of 4 L, with 2% acecoline and the quantitative constant-pressure atomization of 0.1% histamine mixed liquor (1:1) aerosol, take out immediately behind 5 s, the record Cavia porcellus begins incubation period of falling to the tic of panting property occurring from accepting spraying, draws to breathe heavily to surpass 120 s Cavia porcelluss incubation period and give up.50 of qualified mices, the male and female dual-purpose is divided into 5 groups at random: the high, medium and low dosage group of almond perilla anti-cough syrup, matched group (normal saline group).Every Mus gives medicinal liquid or normal saline by 0.2 mL/10 g gavage, once a day, continuous 7 days, 1 h puts mice respectively in the airtight glass box of volume 4 L after the last administration, evenly sprays into 2% acecoline and 0.1% histamine mixed liquor (1:1) aerosol with ultrasound atomizer constant voltage in the case, and spray time is about 15 s, observing the mice self-spray begins to asthma attack, dyspnea surpasses the 120 s persons of not falling and calculates by 120 s until the time of twitching and falling breathes heavily incubation period as drawing.Test data represents with mean ± standard deviation.
Result of the test shows that almond perilla anti-cough syrup high dose group, middle dosage group have obvious antiasthmatic effect.See Table 3.
Table 3
4, almond perilla anti-cough syrup antiinflammatory action research
50 of mices, male and female half and half, body weight 18～22g is divided into 5 groups at random: the high, medium and low dosage group of almond perilla anti-cough syrup, matched group (normal saline group).Every Mus gives medicinal liquid or positive drug by 0.2 mL/10 g, 1 h after the administration, intravenous injection 0.5% azovan blue normal saline 0.1 mL/10 g, lumbar injection 0.6% ethanol 0.2 mL/ only takes off neck and puts to death mice behind 20 min immediately, cut off skin of abdomen muscle, divide several to wash the abdominal cavity with 10 mL normal saline, suction pipe sucking-off cleaning mixture merges rear with 3000 rev/mins of centrifugal 15 min, get supernatant and measure absorbance in 590 nm places, test data represents with mean ± standard deviation.
Result of the test shows that almond perilla anti-cough syrup high dose group can obviously suppress H
+Induced mice abdominal cavity capillary tube blood vessel permeability increases.See Table 4.Table 4
This test of pesticide effectiveness result has affirmed that almond perilla anti-cough syrup of the present invention has antitussive, eliminates the phlegm, relievings asthma and the effect of antiinflammatory, has significant curative effect to the treatment chronic bronchitis.
Claims (2)
1. the preparation method of almond perilla anti-cough syrup may further comprise the steps:
(1) extraction of volatile oil: Folium Perillae 50 g place boiling flask, add the distilled water of 12～18 times of Folium Perillae weight, volatile oil extractor is connected on the boiling flask, in the arm of volatile oil extractor, add entry to overflowing in the round-bottomed flask, on the shape condensing tube of receiving, soak 1～3 h, then begin vapor distillation, stop distillation behind 3～6 h, place 0.5～2 h, oil to volatile oil extractor is limpid, and the residue after collecting respectively volatile oil and carrying oil is for subsequent use;
(2) water extraction: with Radix Platycodonis 30 g, Semen Armeniacae Amarum 30 g, Radix Scutellariae 20 g, Herba Ephedrae 30 g, Bulbus Fritillariae Thunbergii 20 g and the residue after step (1) Folium Perillae is carried oil mix, the distilled water that adds 8～12 times of mixture total weight amounts, heating decocts 1～3 time, filter behind each decoction 1～2 h, merge filtrate, the filtrate after merging is staticly settled rear absorption supernatant, obtain the first supernatant, again with the first supernatant concentrating under reduced pressure, staticly settle, again draw and obtain the second supernatant;
(3) mix: add simple syrup 60 mL, sodium benzoate 0.33 g, ethyl hydroxybenzoate 0.05 g in the second supernatant, boil behind the mix homogeneously, add the volatile oil that step (1) is collected again, adding distil water to 100 mL stirs evenly and namely gets the almond perilla anti-cough syrup.
2. the almond perilla anti-cough syrup that makes of according to claim 1 preparation method.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1453026A (en) * | 2003-03-13 | 2003-11-05 | 红桃开集团股份有限公司 | Compound couth-relieving aster medicine and its prepn |
| CN1824097A (en) * | 2005-12-27 | 2006-08-30 | 广西桂西制药有限公司 | Chinese medicinal preparation for treating cough and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1453026A (en) * | 2003-03-13 | 2003-11-05 | 红桃开集团股份有限公司 | Compound couth-relieving aster medicine and its prepn |
| CN1824097A (en) * | 2005-12-27 | 2006-08-30 | 广西桂西制药有限公司 | Chinese medicinal preparation for treating cough and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 张士勇等: "杏苏止咳糖浆的药效学研究", 《医药导报》 * |
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