CN1453026A - Compound couth-relieving aster medicine and its prepn - Google Patents

Abstract

The present invention relates to one kind of cough-relieving medicine and its preparation process. The compound cough-relieving aster medicine is prepared with aster, sessile stemona root, schizonepeta herb, perilla leaf, balloonflower root and other four kinds of Chinese medicinal materials. The preparation process includes decoction of partial materials, distillation to obtain volatile oil, merging the water solution after distillation and the decoction, decompression concentrating to obtain extract of 1.3 g/cu cm over relative density, drying and forming the extract, spraying the volatile oil to the formed extract and sealing to obtain the medicine product. The medicine has mild nature, no toxic side effect, and high curative effect on cough caused by bronchitis, pneumonitis, the cold, chin cough, etc.

Description

Compound recipe Radix Asteris antitussive and preparation technology thereof

Technical field the present invention relates to a kind of medicine and preparation technology thereof who is used for cough-relieving.

The background technology cough is that lung is a kind of commonly encountered diseases in the illness, all can take place throughout the year, and You Yidong, spring are many.Cough has the branch of diseases caused by exogenous pathogenic factor, internal injury, and the exogenous cough has the difference of wind-cold affecting lung, wind-heat invading the lung, wind-dryness impairing the lung again, and is wherein common with wind-cold affecting lung.Wind-cold affecting lung, external beam flesh table, sweat pore obstruction, lung qi lifting must not be freely, go up and cough, out of breath uncomfortable in chest, the lung key is unfavorable, nasal obstruction watery nasal discharge, itching throat, and with headache, aversion to cold, heating, disease such as lossless, the patient is very painful.

The physician Shen Jin of Qing Dynasty huge legendary turtle is pointed out " lid lung do not hinder do not cough, spleen do not hinder not chronic cough, stomach not hinder fire not vehement " in " miscellaneous diseases source and course rhinoceros candle ", point out that not only lung spleen kidney is the major lesions place of cough, and what point out pathological changes is again to kidney, by marking this by lung and spleen through change.Cheng Kun makes " Zhisou San " medicament age for this reason, it is formulated by Radix Asteris, Rhizoma Cynanchi Stauntonii, Jing Jie, Radix Glycyrrhizae, white portion, Radix Platycodonis, Pericarpium Citri Reticulatae, Jie's Fang Zhongjing dispelling wind to relieve the exterior syndrome, the Radix Stemonae, Radix Asteris warming the lung antitussive, Rhizoma Cynanchi Stauntonii, Pericarpium Citri Reticulatae, Radix Platycodonis promoting the circulation of QI reduce phlegm, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, with Radix Platycodonis with opening lung qi dispersing, play antitussive altogether and reduce phlegm and separate the merit of pathogenic factor in the exterior.Though it uses permanent, effective percentage is very not high.Control cough patient 100 examples as Hebei College of Traditional Chinese Medicine with Zhisou San extractum, convulsion is 66 examples, the convulsion rate 66% that heals more; Produce effects 21 examples, effective 10 examples, invalid 3 examples.

The cough that in clinical trial, has to the wind and cold initiation, on the basis, agent side of Zhisou San, added different pharmaceutical, rate is still not high but convulsion heals, and adds Radix Saposhnikoviae, Folium Perillae as clinic of Guangzhou Automobile Factory with Zhisou San, controls more 42 examples, the convulsion rate 75% that heals of exogenous cough patient's 56 examples, convulsion; 11 examples that take a turn for the better are 20%; Invalid 3 examples are 5%, total effective rate 95%.The Fujian Province hospitals of traditional Chinese and western medicine that establish the city add the Rhizoma Pinelliae, Bulbus Fritillariae Cirrhosae etc. with Zhisou San and control more 112 examples of exogenous cough's 150 routine convulsions, cure rate 74.7%; Take a turn for the better 32 examples, produce effects 21 examples, invalid 3 examples, total effective rate 96%.For this reason, if can add suitable medicine, particularly necessary with the convulsion that the improves treatment rate that heals.

The summary of the invention the purpose of this utility model is based on Zhisou San, makes a kind of to cough due to wind and cold, wind and cold hold concurrently cough caused by pathogenic damp cough effective percentage, compound recipe Radix Asteris antitussive that cure rate is high.

The implementation of this utility model purpose is, compound recipe Radix Asteris antitussive, and formulated by Radix Asteris, the Radix Stemonae, Jing Jie, Folium Perillae, Radix Platycodonis, Rhizoma Cynanchi Stauntonii, Radix Polygalae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the weight proportion of each several part (g) is:

Radix Asteris 130-170 Radix Stemonae 130-170 Jing Jie 65-85

Folium Perillae 65-85 Radix Platycodonis 130-170 Rhizoma Cynanchi Stauntonii 130-170

Radix Polygalae 130-170 Pericarpium Citri Reticulatae 43-57 Radix Glycyrrhizae 43-57 optimum formula (g) is

Radix Asteris 145-155 Radix Stemonae 145-155 Jing Jie 72.5-77.5

Folium Perillae 72.5-77.5 Radix Platycodonis 145-155 Rhizoma Cynanchi Stauntonii 145-155

The preparation technology of Radix Polygalae 145-155 Pericarpium Citri Reticulatae 48-51 Radix Glycyrrhizae 48-51 compound recipe Radix Asteris antitussive, specific embodiment is:

(1) concoct after Radix Asteris, Radix Polygalae, the Radix Stemonae are cleaned, dry, cut off, Rhizoma Cynanchi Stauntonii, Radix Platycodonis are cleaned, and Pericarpium Citri Reticulatae, Folium Perillae, Jing Jie pulverize,

(2) with behind 65-85g Jing Jie, 65-85g Folium Perillae, the 43-57g Pericarpium Citri Reticulatae usefulness water infiltration 2h, water steam distillation extracts 0.5-8h, collects volatile oil,

(3) medicinal residues with volatile oil mix with 130-170g, Radix Asteris 130-170g, Radix Polygalae 130-170g, the Radix Stemonae, 145-155g, Rhizoma Cynanchi Stauntonii 145-155g Radix Platycodonis, 48-51g Radix Glycyrrhizae, add the decocting that 5-18 doubly measures and boil 0.5-4h, get decoction liquor, decoct 1.5h again, get decoction liquor, twice decoction liquor merges, filters, and gets filtrate

(4) aqueous solution behind the distillation and filtrate are merged, under 1-10atm, be evaporated to relative density＞1.3g/cm ³Extractum,

(5) extractum 70-80 ℃ down dry, be cooled to room temperature, spray volatile oil, mixing, seal patent medicine.

The agent of patent medicine add-on type can be made into products such as granule, capsule, tablet.

The present invention fills a prescription rationally, Radix Asteris in the side, and bitter relaxing the bowels with purgatives of warm nature gas is not and dry, and sweet gentle lung is and oiliness, and when going into lung meridian, merit is apt to relieving cough and asthma, moistening the lung and resolving phlegm; The sweet profit hardship of the Radix Stemonae is fallen, and property is flat not dry, and the special and Radix Asteris of nourishing the lung to arrest cough merit is monarch drug in the side of work altogether, to play the merit of relieving cough and resolving phlegm.The Jing Jie acrid in the mouth, slightly warm in nature is gone into lung, Liver Channel, and the kind dispelling wind of merit is separated appearance; The Folium Perillae acrid in the mouth is warm in nature, goes into lung, spleen, and through being longer than relieving the exterior syndrome by diaphoresis, so the two discongests the next wind and cold pathogenic factor in the exterior of off-balancesheet, makes the lung qi lifting freely, and a surname falls and has the right, with the principal drug assistance relieving cough and resolving phlegm, so ministerial drug in the side of being.Radix Platycodonis bitter in the mouth, toil, property is flat, returns lung meridian, the logical part of the body cavity above the diaphragm housing the heart and lungs of kind a surname, dispersing and elevation lung qi and sharp chest and diaphragm throat eliminates the phlegm with a surname; Radix Polygalae bitter in the mouth, suffering, warm in nature, GUIXIN, kidney, lung meridian, but resolving depression reduces phlegm, calms the nerves, eliminates the phlegm and have one's ideas straightened out; Pericarpium Citri Reticulatae acrid in the mouth, hardship, warm in nature, go into spleen, lung meridian, but circulation of qi promoting, fall, reduce phlegm; The Radix Polygalae antitussive reduces phlegm, more than three medicines mutually 5, a surname falls and has both, the sharp lung that eliminates the phlegm, it is normal to make lung qi a surname send out lifting, assistant monarch drug relieving cough and resolving phlegm is adjuvant drug in the side altogether.But Radix Glycyrrhizae is coordinating the actions of various ingredients in a prescription both, reduces phlegm but join the Radix Platycodonis smooth throat to stop cough again, is messenger drug in the side.All medicines share, and focus on relieving cough and resolving phlegm, and double dispelling wind and ventilating the lung induces sweat, and cautiously grasping pathogenesis is the effective agent that treatment cough endogenous cold is attacked the lung disease.

Cough from the beginning of belong to wind and cold person ten occupy its nine, therefore, control the cough that wind and cold causes, dispersing wind-cold is a main method.The present invention is on the prescription basis of former Zhisou San, add the Folium Perillae that is used in endogenous cold, cough and deliver cold expelling, with be longer than the Radix Polygalae that expectorant is had one's ideas straightened out, lung qi is advocated, be of value to and breathe heavily flat only coughing, so the eliminating evil effect of having strengthened inducing sweat of two medicines, make cough due to wind and cold, wind and cold the cough cure rate of treatment of cough caused by pathogenic damp of holding concurrently is significantly improved.

This medicine is a pure Chinese medicinal preparation for this medicine, the property of medicine is gentle, have no side effect, low price, mouthfeel are good, to the treatment of cough effective percentage that causes because of diseases such as bronchitis, pneumonia, flu, pertussis up to 98%, cure rate 85.7%, want high many with respect to 66%, 74.7%.

Enumerate formulation Example of the present invention below the specific embodiment:

This medicine has been done following test by scientific and technological consulting services center, Nanchang, Jiangxi Province:

Draw by ammonia spraying test and Cavia porcellus citric acid and to cough test, confirm to truly have antitussive effect, calculate EDT50, K value＞130%, the inferior difference (P＜0.01) that highly significant is arranged of coughing;

Adopt the trachea section to divide phenol red method and capillary glass-tube test eliminating phlegm and stopping cough effect, compare, the difference (P＜0.01) of highly significant is arranged with the normal saline matched group, approaching with No. 1 preserved snake gall orange peel powder effect;

Atmosphere method and isolated tracheal method confirm its antiasthmatic effect, are better than preserved snake gall orange peel powder, inferior to the aminophylline matched group;

The external antibacterial and interior infection test of body confirmation: this medicine all has certain inhibition ability to 11 kinds of pathogenic bacterium such as staphylococcus aureus, Diplococcus pneumoniae, Hemolytic streptococcuss, coincide with the data introduction, and antiviral trend is still arranged;

The mice carbon granule cleaned up with tardy property immunoreation influence test confirm to have certain raise immunity effect (P＜0.05).

Acute toxicity test confirms: with the adult once 547.5 times of amount (10g/kg) to give white mice serve as the test consumption, death, lumbar injection LD appear ₅₀Reach 12388.6mg/kg.

Long term toxicity test administration group and matched group compare, and body weight, activity, length, feces, hematological examination, hepatic and renal function inspection all belong to normally, and animal section, microscopy are not seen pathological changes yet, thereby prove that this medicine safety coefficient is bigger, can supply clinical practice.

This medicine Nanchang City's pharmaceutical developments portion with this medicine to cough due to wind and cold, wind and cold the cough caused by pathogenic damp treatment of coughing of holding concurrently done clinical trial in a year, cough due to wind and cold patient's 60 examples wherein, 54 examples of fully recovering, cure rate 90%, 6 examples that take a turn for the better, total effective rate 100%; Wind and cold cough caused by pathogenic damp patient's 45 examples of coughing of holding concurrently, 36 examples of fully recovering, cure rate 80%, 7 examples that take a turn for the better, invalid 2 examples, total effective rate 96%; Total case 105 examples, cure rate 85.7%, effective percentage 98%.

Cough due to wind and cold patient's symptom is: cough, itching throat, thin sputum, nasal obstruction, watery nasal discharge or the headache of holding concurrently, lossless, thin white fur of tongue, arteries and veins are thick.Cough patient's symptom of the cold cough caused by pathogenic damp of holding concurrently of rheumatism is: cough with copious phlegm, have concurrently breast do vexed, white and greasy fur.

Enumerate several cases below with the treatment of this medicine:

Example 1 model *, man, 3 years old

Cough one day, nasal obstruction, rhinorrhea, the noisy discomfort of crying, the heating floating pulse, white and thin fur, having a blood test resembles 1000/mm of total white blood cells, belong to wind and cold and violate lung, suitable expelling wind and cold, relieving cough and resolving phlegm is taken this medicine, cough in second day alleviates, and serve on 5 days, and malaise symptoms such as cough disappear, and infant is stable as usual.

Example 2 Xiao * *, 55 years old, peasant (cough due to wind and cold)

Cough, breathe heavily and cough 9 years, four seasons morbidity, the Winter-Spring aggravation, bring out because of suffering from cold one day; paroxysm of cough, dyspnea with rapid and short breath is breathed hard, and the not well first quarter moon of coughing up phlegm was once taken niuhuang shedan chuanbei mixture 6 days; effect does not show, cold physique, and diet reduces, two pulmonary rales (+), wheezing sound (+); Chest X-rays: lung marking increases, thin white fur of tongue, and arteries and veins: little cunning belongs to the cough due to wind and cold; suitable expelling phlegm for arresting cough, suitable smooth lung qi, warming the lung is relievingd asthma, through taking this medicine; the cough symptom takes a turn for the better, and amount of expectoration reduces, and serve on 10 days, and cough phlegm dyspnea disease disappears substantially.

Claims (4)

1, compound recipe Radix Asteris antitussive is characterized in that by Radix Asteris, the Radix Stemonae, Jing Jie, Folium Perillae, Radix Platycodonis, Rhizoma Cynanchi Stauntonii, Radix Polygalae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae formulatedly, and the weight proportion of each several part (g) is:

Radix Asteris 130-170 Radix Stemonae 130-170 Jing Jie 65-85

Folium Perillae 65-85 Radix Platycodonis 130-170 Rhizoma Cynanchi Stauntonii 130-170

Radix Polygalae 130-170 Pericarpium Citri Reticulatae 43-57 Radix Glycyrrhizae 43-57

2, compound recipe Radix Asteris antitussive according to claim 1 is characterized in that the weight proportion (g) of each several part is:

Radix Asteris 145-155 Radix Stemonae 145-155 Jing Jie 72.5-77.5

Folium Perillae 72.5-77.5 Radix Platycodonis 145-155 Rhizoma Cynanchi Stauntonii 145-155

Radix Polygalae 145-155 Pericarpium Citri Reticulatae 48-51 Radix Glycyrrhizae 48-51

3, the preparation technology of compound recipe Radix Asteris antitussive is characterized in that specific embodiment is:

(1) concoct after Radix Asteris, Radix Polygalae, the Radix Stemonae are cleaned, dry, cut off, Rhizoma Cynanchi Stauntonii, Radix Platycodonis are cleaned, and Pericarpium Citri Reticulatae, Folium Perillae, Jing Jie pulverize,

(2) with behind 65-85g Jing Jie, 65-85g Folium Perillae, the 43-57g Pericarpium Citri Reticulatae usefulness water infiltration 2h, water steam distillation extracts 0.5-8h, collects volatile oil,

(3) with the medicinal residues of volatile oil and 130-170g, Radix Asteris 130-170g, Radix Polygalae 130-170g, the Radix Stemonae, 145-155

G, Rhizoma Cynanchi Stauntonii 145-155g Radix Platycodonis, 48-51g Radix Glycyrrhizae mix, and add the decocting that 5-18 doubly measures and boil 0.5-4h, get decoction liquor, decoct 1.5h again, get decoction liquor, and twice decoction liquor merges, filters, and gets filtrate,

(4) aqueous solution behind the distillation and filtrate are merged, under 1-10atm, be evaporated to relative density＞1.3g/cm ³Extractum,

(5) extractum 70-80 ℃ down dry, be cooled to room temperature, spray volatile oil, mixing, seal patent medicine.

4, preparation technology according to claim 2 is characterized in that granule, capsule, tablet product are made in the agent of patent medicine add-on type.