CN105343478A

CN105343478A - Compound traditional Chinese medicinal cough suppressant syrup

Info

Publication number: CN105343478A
Application number: CN201510756611.3A
Authority: CN
Inventors: 张海涛
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-11-09
Filing date: 2015-11-09
Publication date: 2016-02-24

Abstract

The invention relates to cough suppressant syrup which is used for treating cough caused by common cold due to wind cold. The cough suppressant syrup is prepared by combining radix rehmanniae praeparata, rhizoma discoreae, codonopsis pilosula, angelica sinensis, cornu cervi, almond paste, fritillaria cirrhosa, root bark of white mulberry, dried orange peel, scutellaria baicalensis, white poria, bombyx batryticatus, liquorice root, endothelium corneum gigeriae galli and roasted herba ephedra; and the syrup is prepared through a hot-melting method by fully extracting active ingredients from medicines respectively through a water extraction method and an alcohol extraction method, and adding a flavoring agent, a preservative and a cosolvent. The prepared cough suppressant syrup is high in content of active ingredients, low in content of impurities, stable in medicine nature, relatively good in smell and taste, and easy to be accepted by people at various ages.

Description

A kind of Chinese medicine compound cough syrup

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to the preparation method of a kind of Traditional Chinese medicine compound composition and syrup thereof.

Background technology

Cough is a kind of common clinical disease, and its inducement has dissimilar, and cough is divided into more typical wind-cold type, anemopyretic, dryness-heat impairing the lung type, phlegm dampness in lungs type etc. by the traditional Chinese medical science, and treatment needs to nurse one's health according to dissimilar.The suitable expelling wind and cold for the treatment of of wind cold type cough, lung qi dispersing cough-relieving; The suitable wind and heat dispersing for the treatment of of anemopyretic cough, dispersing lung-QI and dissipating phlegm.Cough is defined as a kind of protectiveness respiratory reflex action of human body by modern medicine, removes respiratory secretions or foreign body by coughre flex.Cough inducement may be upper respiratory tract infection, bronchitis, pneumonia, acute laryngitis etc.Cough inducement is different, suits the remedy to the case so treatment will be particular about.

Usual cough is caused by flu, again based on anemofrigid cold, therefore the invention provides a kind for the treatment of anemofrigid cold that is exclusively used in and causes the cough syrup agent of cough.In the medicine of existing treatment cough, Western medicine antitussive medicine is divided into the central antitussive suppressing oblongata coughing centre, as dextromethorphan, pentoxyverine etc. with suppress coughre flex sensor, import into or the peripheral antitussive drugs of nervus centrifugalis, as benproperine, benzonatate etc., its mechanism of action in simple terms, is all suppress nerve impulse conduction, this kind of drug side effect is strong, central medicine even causes dependency, and it is relief of symptoms in effective blood drug concentration just, can not from root dispelling disease.Western medicine compared by Chinese medicine, and advantage is that composition is natural, and side effect is little, and hold disease from entirety and nurse one's health, existing market upper medicine compound syrup agent is more, but cough kind is many, and the cough specific aim of which kind of symptom of drug treatment is unclear; In addition, most cough syrup only adopts decocting method water extraction medicine, and effective ingredient can not stripping to greatest extent, a kind of lung heat-cleaning throat-moistening cough-relieving syrup disclosed in CN101099825A.Therefore, the invention provides a kind of fully can extract crude drug effective ingredient be used for the treatment of the cough syrup that wind-chill cold causes cough.

Summary of the invention

The object of the invention is to overcome existing cough syrup agent effective ingredient low, the shortcoming that impurity is many, the problem that treatment disease specific aim is not strong, provide a kind of active constituent content high, drug substance stable, cause the cough syrup of cough specially for wind-chill cold.

The formula of this product is as follows:

The process preparing cough syrup agent by above-mentioned formula is as follows:

1) effective ingredient is extracted

Take crude drug by above-mentioned weight proportion precision, break into coarse powder, sieve, by molten for the ethanol of medicine equal volume amounts invade bubble 30min after, 0.5 ~ 3h is extracted in the alcoholic solution condensation adding 3 ~ 5 times amount, extracts three times, filters, then merge and extract medicinal liquid three times, distillation and concentration, to simmer down to paste, reclaims ethanol, concentrated extract to be reduced pressure cold drying, shatter into most fine powder.

Add 3 ~ 5 times amount sterilized water by filtering gained medicinal residues after alcohol extraction, extract 3 times with decocting method, each 0.5 ~ 3h, then filters, and merges three Aqueous extracts, and is concentrated into appropriate by medicinal liquid evaporation.

2) syrup is prepared

The drug formulation prepared needed for syrup is as follows:

Concrete preparation process is: 1. get glycerol, adds appropriate distilled water, and be dissolved in glycerite by ethanol extract medicated powder, ground and mixed is even.2. get 450 parts of distilled water, boil, with sucrose, be stirred to dissolve, continue to be heated to 100 DEG C, filter with absorbent cotton, on filter, add appropriate hot water, be the simple syrup of sugar content more than 85%.3. in prepared simple syrup, add water extraction medicinal liquid and 1. dissolved glycerite, then press recipe quantity interpolation sorbic acid successively, menthol, Pericarpium Citri junoris tincture, citric acid stirs, mix homogeneously.4. be the syrup of sugar content 85% under made syrup being concentrated into again room temperature.

In syrup formula of the present invention, Radix Codonopsis is put down, and sweet in the mouth, has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Herba Ephedrae has ephedrine can diaphoresis cold expelling, depressed lung-energy dispersing, is used for asthma and cough.Radix Rehmanniae Preparata, Rhizoma dioscoreae all have effect of invigorating the spleen and replenishing QI.This product scientific compatibility, has good therapeutic effect for the cough caused by anemofrigid cold.Mouthfeel is easy to accept, and is applicable to the patient of each age level.

Anemofrigid cold cough patients is all respond well after using this product, and after taking medicine on request, symptom is obviously alleviated, and uses the classical case of this product as follows:

1, Wang: man's 12 years old people from Chengguan District, Lanzhou City, Gansu Province anemofrigid cold, cough, has expectorant, laryngopharynx swelling and pain.Take this product 5ml by every 8h, take three onsets, cough with copious phlegm symptom is alleviated, and fully recovers, continue to strengthen treatment two days after continuing to take three days, without recurrence.

2, week certain: female's 26 years old people from Baiyin City, gansu Province anemofrigid cold, myasthenia of limbs, cough with copious phlegm, the edema of the face, takes this product, and every 8h administration 5ml, fully recovered after one week.

3, Liu: man 52 years old Lanzhou City, Gansu Province Dingyuan people from town headache, heating, cough with copious phlegm, distending pain uncomfortable in chest, takes this product every 8h administration 5ml, fully recover after one week.

Detailed description of the invention

Because of the interior variation in a big way again of each group component of this product, recommend an optimization formula, and as specific embodiment, the present invention program is described.

Various raw medicinal herbs is taken by following formula precision:

1) effective ingredient is extracted

Take crude drug by above-mentioned weight proportion precision, break into coarse powder, sieve, by molten for the ethanol of medicine equal volume amounts invade bubble 30min after, extraction three times is extracted in the alcoholic solution condensation adding 3 times amount, and first time extracts 1h, extract 30min latter twice at every turn, filter, then merge three times and extract medicinal liquid, distillation and concentration, to simmer down to paste, reclaim ethanol, cold drying of being reduced pressure by concentrated extract, shatter into most fine powder.

Add 3 times amount sterilized water by filtering gained medicinal residues after alcohol extraction, extract 3 times with decocting method, each 30min, then filters, and merges three Aqueous extracts, and is concentrated into appropriate by medicinal liquid evaporation.

3) syrup is prepared

The drug formulation prepared needed for syrup is as follows:

Concrete preparation process is: 1. get glycerol, adds appropriate distilled water, and be dissolved in glycerite by ethanol extract medicated powder, ground and mixed is even.2. get 450ml distilled water, boil, with sucrose, be stirred to dissolve, continue to be heated to 100 DEG C, filter with absorbent cotton, on filter, add appropriate hot water, be the simple syrup of sugar content more than 85%.3. in prepared simple syrup, add water extraction medicinal liquid and 1. dissolved glycerite, then press recipe quantity interpolation sorbic acid successively, menthol, Pericarpium Citri junoris tincture, citric acid stirs, mix homogeneously.4. be the syrup of sugar content 85% under made syrup being concentrated into again room temperature.

Adopt crude drug amount >=3g/ml contained by the Chinese medicine compound cough syrup prepared by this programme.

Claims

1. a Chinese medicine compound cough syrup, is characterized in that formula is as follows:

2. a preparation method for Chinese medicine compound cough syrup, prepared by it is characterized in that according to the following steps:

1) effective ingredient is extracted

Take crude drug by above-mentioned weight proportion precision, break into coarse powder, sieve, by molten for the ethanol of medicine equal volume amounts invade bubble 30min after, 0.5 ~ 3h is extracted in the alcoholic solution condensation adding 3 ~ 5 times amount, extracts three times, filters, then merge and extract medicinal liquid three times, distillation and concentration, to simmer down to paste, reclaims ethanol, concentrated extract to be reduced pressure cold drying, shatter into most fine powder;

Add 3 ~ 5 times amount sterilized water by filtering gained medicinal residues after alcohol extraction, extract 3 times with decocting method, each 0.5 ~ 3h, then filters, and merges three Aqueous extracts, and is concentrated into appropriate by medicinal liquid evaporation;

2) syrup is prepared

The drug formulation prepared needed for syrup is as follows:

Concrete preparation process is:

1. get glycerol, add appropriate distilled water, be dissolved in glycerite by ethanol extract medicated powder, ground and mixed is equal.

2. get 450 parts of distilled water, boil, with sucrose, be stirred to dissolve, continue to be heated to 100 DEG C, filter with absorbent cotton, on filter, add appropriate hot water, be the simple syrup of sugar content more than 85%;

3. in prepared simple syrup, add water extraction medicinal liquid and 1. dissolved glycerite, then press recipe quantity interpolation sorbic acid successively, menthol, Pericarpium Citri junoris tincture, citric acid stirs, mix homogeneously;

4. be the syrup of sugar content 85% under made syrup being concentrated into again room temperature.

3. the preparation method of a kind of Chinese medicine compound cough syrup as claimed in claim 2, is characterized in that the method that extraction adopts alcohol extraction, water extraction combines of effective ingredient.

4. the preparation method of a kind of Chinese medicine compound cough syrup as claimed in claim 2, it is characterized in that preparing the adjuvant antiseptic that syrup adds is benzoic acid, parabens, one or more in sorbic acid; Cosolvent is Tweens, glycerol, one or more in Polyethylene Glycol; Correctives is fruity flavor, menthol, sucrose, fructose, citric acid, one or more in Aspartame.