CN102526196A - Externally applied plaster formulation for treating respiratory tract infection - Google Patents
Externally applied plaster formulation for treating respiratory tract infection Download PDFInfo
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- CN102526196A CN102526196A CN2012100060357A CN201210006035A CN102526196A CN 102526196 A CN102526196 A CN 102526196A CN 2012100060357 A CN2012100060357 A CN 2012100060357A CN 201210006035 A CN201210006035 A CN 201210006035A CN 102526196 A CN102526196 A CN 102526196A
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- tract infection
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Abstract
The invention belongs to an externally applied medicament for respiratory tract infection, and in particular relates to an externally applied plaster formulation for treating respiratory tract infection. The formulation is prepared from the following medicaments in part by weight: 20 to 30 parts of astragalus root, 20 to 40 parts of gallnut, 20 to 40 parts of platycodon grandiflorum, 20 to 40 parts of liquorice, 10 to 20 parts of cinnamon, 10 to 20 parts of netmeg, 1 to 2 parts of ginsenoside, and borneol or glycerol serving as an auxiliary component. The externally applied plaster formulation for treating the respiratory tract infection is formed by repeated clinical experimental research according to the Chinese medicine treatment dialectical theory, is high in healing rate, novel and simple in formula, is externally applied, and is suitable for adults and children; moreover, the externally applied plaster formulation is easily accepted by children compared with conventional decoction, and is high in purification rate of effective ingredients of Chinese medicaments and quick in skin permeation, and the skin permeation rate is 70 to 80 percent of the absorption rate of the oral mode; and treatment and recovery of patients are greatly facilitated.
Description
Technical field
The invention belongs to a kind of respiratory tract infection the external application medicine, particularly a kind of externally applied plaster dosage form of treating respiratory tract infection.
Background technology
The agent of traditional Chinese medical science patch is with a long history, and is of long standing and well established, in Chinese medicine, occupies an important position, because it is easy to use, evident in efficacy, no pain is trusted by the patient deeply and accepted.
Respiratory tract infection often is accompanied by diseases such as cat fever, cough, asthma as commonly encountered diseases, the frequently-occurring disease of department of pediatrics; The treatment pediatric disease often makes the household worn out mentally and physically, the oral and injection for curing of employing commonly used, and expense is high; Though can take effect sometimes immediately, because child's resistance is poor, state of an illness rate repeatedly is high; The continued treatment Drug resistance strengthens, and drug side effect is bigger, influences child's growth of normally growing up; The basic reason of infantile respiratory tract infection repeatedly belongs to the empty susceptible ailment said due to cold or exposure person of body at empty, the positive QI-insufficiency of children's year germling, exterior deficiency, and when pathogen was invaded, the intravital healthy energy of children's was not enough to resist extraneous pathogen; Resistance against diseases is reduced, a series of infection diseases of outbreak repeatedly therefore occur, Chinese medicine is effective aspect the opposing of conditioning human body; Few side effects, but because adopt decocts oral way more, boiling wastes time and energy; And multi-flavor is bitter, is not easy to children's and accepts, to treating inconvenience.
The existing market tradition boils black plaster, and effective ingredient is low, and absorbance is low, and lead content is high, and some plaster is Chinese medicine to be pulverized the back add auxiliary type agent in addition, processes paste, absorbs not obviously, and application is inconvenient, and drug waste is serious.
Summary of the invention
The object of the invention is to overcome the deficiency of prior art, provides a kind of easy to use, absorbs soon the externally applied plaster dosage form of obvious results treatment respiratory tract infection.
Technical scheme of the present invention is following:
A kind of externally applied plaster dosage form of treating respiratory tract infection is processed by following medicaments in part by weight: 20～30 parts of the Radixs Astragali; 20～40 parts of Galla Chinensiss; 20～40 parts of Radix Platycodoniss; 20～40 parts in Radix Glycyrrhizae; 10～20 parts of Cortex Cinnamomis; 10～20 parts of Semen Myristicaes; 1～2 part of ginsenoside.
The externally applied plaster dosage form of above-mentioned treatment respiratory tract infection, its preparation method is:
A, the medicine that takes by weighing formula ratio add 8 times of amount 75% alcohol reflux 2 times, and 2 hours for the first time, 1.5 hours for the second time;
B, 2 reflux, extract, filtratings of merging are reclaimed ethanol, and the paste that filtrating is concentrated into relative density about 1.2～1.3 is subsequent use.
Described thick paste medicine layer is sealed in the medical sponge circle, and sponge ring one side is band release paper adhesive-layer, and a side is a protecting film.
Described sponge ring and protecting film are provided with loam cake, and loam cake can be buckled on the sponge ring, both couplings.
To the cough with asthma that infantile common cold causes, when using this external application dosage form, loam cake is removed, open protecting film, tear release paper, plaster is affixed on TIANTU acupoint or DAZHUI acupoint, changed once in per 12 hours.
The externally applied plaster dosage form of described treatment respiratory tract infection, the ingredient of its water solublity dosage form also comprises: 1～2 part of Borneolum Syntheticum; Its preparation method is:
A, take by weighing formula ratio medicine except that Borneolum Syntheticum, add 8 times of amount 75% alcohol reflux 2 times, 2 hours for the first time, 1.5 hours for the second time;
B, 2 reflux, extract, filtratings of merging are reclaimed ethanol, filtrating are concentrated into the thick paste of relative density about 1.2～1.3;
C, the Borneolum Syntheticum powder of formula ratio is broken into fine powder, cross 100 mesh sieves after, add thick paste among the b, stir, subsequent use.
The externally applied plaster dosage form of described treatment respiratory tract infection, the ingredient of its fat-soluble dosage form also comprises: 1～2 part of glycerol; Its preparation method is:
A, take by weighing formula ratio medicine except that glycerol, add 8 times of amount 75% alcohol reflux 2 times, 2 hours for the first time, 1.5 hours for the second time;
B, 2 reflux, extract, filtratings of merging are reclaimed ethanol, filtrating are concentrated into the thick paste of relative density about 1.2～1.3;
In c, the glycerol adding thick paste, stir formula ratio, subsequent use.
Each composition main pharmacological:
The Radix Astragali " benefiting QI for strengthening the superficies " is primarily aimed at deficiency of vital energy and physically weak, can strengthen opposing, avoids regular flu.
But the Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough.
Galla Chinensis can be astringed the lung through superficial heat, is the eliminating dampness by diuresis of reducing phlegm, pathogenic fire reducing astringent therapy.
But the Radix Platycodonis lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.
The ginsenoside has " the BAICAO king of medicine " Radix Ginseng extract, has the multiple health preserving effect that gets rid of illness, and enough consolidates Hui Yuan, and protect life and keep fit, life lengthening, health invigorating improves immunity.
Beneficial effect
1, the externally applied plaster dosage form of treatment respiratory tract infection of the present invention is according to the dialectical theory of Chinese traditional treatment, and warp clinical experimental study repeatedly forms the clinical cure rate height, and prescription is novel; Prescription is simple; The external application drug of topical application, the adult child all can, particularly pediatric patient is compared traditional decoction and more be prone to be accepted.
2, the externally applied plaster dosage form of treatment respiratory tract infection of the present invention combines traditional compatibility, makes the coordination complementary action of every kind of medicine of its performance, and the plaster patch skin surface of processing produces effects rapidly, and curative effect is obvious, lasting medicine, safety easy to use, few side effects.
3, the externally applied plaster dosage form processing technique of treatment respiratory tract infection of the present invention, middle pharmaceutically active ingredient purification rate is high, and dermal osmosis is fast, can bring up to oral way 70～80%, greatly is convenient to the patient treatment rehabilitation.
4, clinical trial
This group patient on probation is totally 40 examples, all from the out-patient.The course of disease is the shortest 4 days, and is the longest 15 days.On the disease kind distributes, cough with asthma 12 examples that flu causes, tracheitis 24 examples, bronchitis 4 examples.
The case choice criteria
(1) includes the case standard in: the caused cough with asthma of infantile common cold, tracheitis, bronchitis symptom person;
(2) get rid of have cough, expectorant, asthma shape, respiratory tract infection, local skin burster, allergic skin person's other diseases.
The crowd of being suitable for
The caused cough with asthma of infantile common cold, tracheitis, bronchitic crowd.
Method for using
When being used for the caused cough with asthma of infantile common cold, tracheitis, bronchitis, plaster is affixed on " TIANTU acupoint " or " DAZHUI acupoint ", each 1-2 pastes, and changes once in per 24 hours.
Mild symptoms weight classification standard
Flu: gently have a fever and be interrupted cough with asthma;
Middle cough headache, dizziness repeatedly, but do not influence work;
Accent pain, dizziness be heavier, frequently repeatedly, influence work and rest.
Efficacy assessment standard
Invalid: as not reach effective standard
Effectively: bring down a fever, have a headache, dizzy, feeling of fullness in the head takes a turn for the better
Produce effects: bring down a fever, headache, dizziness, feeling of fullness in the head is clearly better, and cough reduces
Observed result: wherein reach produce effects 28 examples, effective 10 examples, invalid 2 examples.
Untoward reaction: it is overworked, rubescent that scabies appears in the individual patient local skin, disappears voluntarily after the drug withdrawal, and other do not find obvious adverse reaction.
The specific embodiment
Embodiment one,
A kind of externally applied plaster dosage form of treating respiratory tract infection is processed by following medicaments in part by weight: 20 parts of the Radixs Astragali; 10 parts of Galla Chinensiss; 30 parts of Radix Platycodoniss; 20 parts in Radix Glycyrrhizae; 10 parts of Cortex Cinnamomis; 10 parts of Semen Myristicaes; 2 parts of ginsenosides; 1 part of Borneolum Syntheticum.
The externally applied plaster dosage form of above-mentioned treatment respiratory tract infection, its preparation method is:
A, take by weighing formula ratio medicine except that Borneolum Syntheticum, add 8 times of amount 75% alcohol reflux 2 times, 2 hours for the first time, 1.5 hours for the second time;
B, 2 reflux, extract, filtratings of merging are reclaimed ethanol, filtrating are concentrated into the thick paste of relative density about 1.2～1.3;
C, the Borneolum Syntheticum powder of formula ratio is broken into fine powder, cross 100 mesh sieves after, add thick paste among the b, stir, subsequent use.
Described sponge ring and protecting film are provided with loam cake, and loam cake can be buckled on the sponge ring, both couplings.
To the cough with asthma that infantile common cold causes, when using this external application dosage form, loam cake is removed, open protecting film, tear release paper, plaster is affixed on TIANTU acupoint or DAZHUI acupoint, changed once in per 12 hours.
Embodiment two,
A kind of externally applied plaster dosage form of treating respiratory tract infection is processed by following medicaments in part by weight: 20 parts of the Radixs Astragali; 10 parts of Galla Chinensiss; 30 parts of Radix Platycodoniss; 20 parts in Radix Glycyrrhizae; 10 parts of Cortex Cinnamomis; 10 parts of Semen Myristicaes; 2 parts of ginsenosides; 2 parts of glycerol.
The externally applied plaster dosage form of above-mentioned treatment respiratory tract infection, its preparation method is:
A, take by weighing formula ratio medicine except that glycerol, add 8 times of amount 75% alcohol reflux 2 times, 2 hours for the first time, 1.5 hours for the second time;
B, 2 reflux, extract, filtratings of merging are reclaimed ethanol, filtrating are concentrated into the thick paste of relative density about 1.2～1.3;
In c, the glycerol adding thick paste, stir formula ratio, subsequent use
Described thick paste medicine layer is sealed in the medical sponge circle, and sponge ring one side is band release paper adhesive-layer, and a side is a protecting film.
Described sponge ring and protecting film are provided with loam cake, and loam cake can be buckled on the sponge ring, both couplings.To the cough with asthma that infantile common cold causes, when using this external application dosage form, loam cake is removed, open protecting film, tear release paper, plaster is affixed on TIANTU acupoint or DAZHUI acupoint, changed once in per 12 hours.
Claims (8)
1. externally applied plaster dosage form of treating respiratory tract infection is characterized in that being processed by following medicaments in part by weight:
20～30 parts of the Radixs Astragali; 20～40 parts of Galla Chinensiss; 20～40 parts of Radix Platycodoniss; 20～40 parts in Radix Glycyrrhizae; 10～20 parts of Cortex Cinnamomis; 10～20 parts of Semen Myristicaes; 1～2 part of ginsenoside.
2. the externally applied plaster dosage form of treatment respiratory tract infection according to claim 1 is characterized in that ingredient also comprises: 1～2 part of Borneolum Syntheticum.
3. the externally applied plaster dosage form of treatment respiratory tract infection according to claim 1 is characterized in that ingredient also comprises:
1～2 part of glycerol.
4. the externally applied plaster dosage form of treatment respiratory tract infection according to claim 1 is characterized in that method for preparing is:
A, the medicine that takes by weighing formula ratio add 8 times of amount 75% alcohol reflux 2 times, and 2 hours for the first time, 1.5 hours for the second time;
B, 2 reflux, extract, filtratings of merging are reclaimed ethanol, and the paste that filtrating is concentrated into relative density about 1.2～1.3 is subsequent use.
5. the externally applied plaster dosage form of treatment respiratory tract infection according to claim 2 is characterized in that method for preparing is:
A, take by weighing formula ratio medicine except that Borneolum Syntheticum, add 8 times of amount 75% alcohol reflux 2 times, 2 hours for the first time, 1.5 hours for the second time;
B, 2 reflux, extract, filtratings of merging are reclaimed ethanol, filtrating are concentrated into the thick paste of relative density about 1.2～1.3;
C, the Borneolum Syntheticum powder of formula ratio is broken into fine powder, cross 100 mesh sieves after, add thick paste among the b, stir, subsequent use.
6. the externally applied plaster dosage form of treatment respiratory tract infection according to claim 3 is characterized in that method for preparing is:
A, take by weighing formula ratio medicine except that glycerol, add 8 times of amount 75% alcohol reflux 2 times, 2 hours for the first time, 1.5 hours for the second time;
B, 2 reflux, extract, filtratings of merging are reclaimed ethanol, filtrating are concentrated into the thick paste of relative density about 1.2～1.3;
In c, the glycerol adding thick paste, stir formula ratio, subsequent use.
7. according to the externally applied plaster dosage form of any described treatment respiratory tract infection of claim 4～6, it is characterized in that: described thick paste medicine layer is sealed in the medical sponge circle, and sponge ring one side is band release paper adhesive-layer, and a side is a protecting film.
8. the externally applied plaster dosage form of treatment respiratory tract infection according to claim 7 is characterized in that: described sponge ring and protecting film are provided with loam cake, and loam cake can be buckled on the sponge ring, both couplings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100060357A CN102526196A (en) | 2012-01-11 | 2012-01-11 | Externally applied plaster formulation for treating respiratory tract infection |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100060357A CN102526196A (en) | 2012-01-11 | 2012-01-11 | Externally applied plaster formulation for treating respiratory tract infection |
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| Publication Number | Publication Date |
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| CN102526196A true CN102526196A (en) | 2012-07-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012100060357A Pending CN102526196A (en) | 2012-01-11 | 2012-01-11 | Externally applied plaster formulation for treating respiratory tract infection |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734732A (en) * | 2014-01-27 | 2014-04-23 | 杨子驿 | Throat-clearing and qi-benefiting food for respiratory tract health care |
| CN108524699A (en) * | 2018-07-12 | 2018-09-14 | 刘永利 | Treat the outer patch cream form of respiratory tract infection |
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| US6551626B1 (en) * | 1998-08-26 | 2003-04-22 | Weber & Weber Gmbh & Co. Kg | Composition containing pyrrolizidine-alkaloid-free petasites |
| WO2003049726A1 (en) * | 2001-12-07 | 2003-06-19 | Eden Research Plc | Respiratory infection prevention and treatment with terpene-containing compositions |
| KR100643880B1 (en) * | 2005-09-27 | 2006-11-10 | 황호근 | Composition of medicinal herbs for treating rhinitis, empyema, bronchitis and tympanitis |
| CN101036770A (en) * | 2007-04-16 | 2007-09-19 | 左耀武 | External emplastrum for treating deficiency-cold for children |
| CN101199740A (en) * | 2006-12-15 | 2008-06-18 | 天津市中宝制药有限公司 | Medicament for treating chronicity bronchitis |
| CN101647979A (en) * | 2009-09-14 | 2010-02-17 | 胡慧梅 | Traditional Chinese medicine for treating bronchial asthma |
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2012
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551626B1 (en) * | 1998-08-26 | 2003-04-22 | Weber & Weber Gmbh & Co. Kg | Composition containing pyrrolizidine-alkaloid-free petasites |
| WO2003049726A1 (en) * | 2001-12-07 | 2003-06-19 | Eden Research Plc | Respiratory infection prevention and treatment with terpene-containing compositions |
| KR100643880B1 (en) * | 2005-09-27 | 2006-11-10 | 황호근 | Composition of medicinal herbs for treating rhinitis, empyema, bronchitis and tympanitis |
| CN101199740A (en) * | 2006-12-15 | 2008-06-18 | 天津市中宝制药有限公司 | Medicament for treating chronicity bronchitis |
| CN101036770A (en) * | 2007-04-16 | 2007-09-19 | 左耀武 | External emplastrum for treating deficiency-cold for children |
| CN101647979A (en) * | 2009-09-14 | 2010-02-17 | 胡慧梅 | Traditional Chinese medicine for treating bronchial asthma |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734732A (en) * | 2014-01-27 | 2014-04-23 | 杨子驿 | Throat-clearing and qi-benefiting food for respiratory tract health care |
| CN103734732B (en) * | 2014-01-27 | 2015-08-05 | 杨子驿 | The clearing profit gas, food of respiratory health |
| CN108524699A (en) * | 2018-07-12 | 2018-09-14 | 刘永利 | Treat the outer patch cream form of respiratory tract infection |
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Application publication date: 20120704 |